EP1251740A2 - Kombination biologischer und chemischer nagetierbekämpfung - Google Patents
Kombination biologischer und chemischer nagetierbekämpfungInfo
- Publication number
- EP1251740A2 EP1251740A2 EP01902296A EP01902296A EP1251740A2 EP 1251740 A2 EP1251740 A2 EP 1251740A2 EP 01902296 A EP01902296 A EP 01902296A EP 01902296 A EP01902296 A EP 01902296A EP 1251740 A2 EP1251740 A2 EP 1251740A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- sporocysts
- rodents
- combination
- phenyl
- anticoagulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
- A01N25/004—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits rodenticidal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
Definitions
- the present invention relates to agents containing pathogenic unicellular organisms and anticoagulants, and to the use thereof for controlling rodents.
- Indanedione derivatives and 4-hydroxy coumarins are known to be antagonists of vitamin K and lower the level of blood prothrombin. This reduces the blood's ability to clot. These compounds also increase the permeability of the microcapillaries. Rodents in particular are very sensitive to these substances. These derivatives are therefore used as rodenticidal active ingredients (cf. for example DE-OS 25 06 769, JP-A 48 023 942, CH-OS 481 580, Tammes PML et al. 1967 Acta Physiol. Pharmacol. Neer. 14, 423-433 , Paposci L 1974 Supplements Z. Angew. Zool., 155, DE 2 506 769).
- the acute toxicity of the currently marketed active substances in this group is 0.2 mg kg to 30 mg / kg (LD50 rat).
- the LD50 is approximately 16.5 mg / kg.
- the acute LD50 for second generation anticoagulants is 0.2 mg / kg (Brodifacoum) to 2.0 mg / kg (bromadiolone).
- the respective LD50 can be 10-100 times higher.
- Nosokia, Mus are pathogenic and, if administered in sufficient doses, lead to the death of the animals (Rzepczyk 1974, Intern. J. Parasitol. 4, 447-449; Brehm, Frank 1980, Z. Parasitenkd. 62, 15-30).
- a parasite of this group which is particularly pathogenic for several rat species is Sarcocystis singaporensis (Zamann et al. 1975, Z. Parasitenkd. 47, 169-185).
- the final hosts of the parasites are predators or omnivores, for S. singaporensis they are snakes, e.g. B. the net python.
- the parasite forms sporocysts in the intestine of the end host. These permanent stages are excreted with the faeces. If an intermediate host, in S. singaporensis z. B. a rat, orally infected with these sporocysts, sporozoites hatch in the intestine of the rat and penetrate the intestinal wall. These stages reach other organs via the bloodstream, where they can multiply by division (schizogony).
- the rat falls ill during the second schizogony of the parasite around the 16th day p.i. and usually dies within a few hours.
- a dosage of the anticoagulant is sufficient, which is well below the LD50 for normally sensitive animals (see example). Less than half of the LD50 (acute oral) is required to achieve 100 percent mortality. For coumatetralyl, for example, 6 mg / kg is already sufficient for Rattus norvegicus.
- anticoagulants which normally only take effect after repeated ingestion, are sufficient to achieve 100% mortality with a single low dose.
- sporozoa Species of the subclass Coccidia are particularly suitable. Representatives of the submission Eimeriina are particularly suitable. The species of the genus Sarcocystis, such as S. singaporensis, may be mentioned as examples, but not by way of limitation.
- anticoagulant rodenticidal active substances are suitable as synergists for an infection with sarcosporidia in the system according to the invention.
- anticoagulants such as the 4-hydroxycoumarin derivatives (1-phenyl-2-acetyl) -3-ethyl-4-hydroxycoumarin ("Warfarine”), 3- ( ⁇ -acetonyl-4-chlorobenzyl) - 4-hydroxycoumarin ("Coumachlore”), [3-
- the active substances of the first generation chlorophacinone, warfarin, coumatetralyl and those of the early second generation, are particularly, but not restrictive,
- the agent according to the invention can be incorporated into all the recipes conventionally used for the production of feeding baits for rodents, for example into cereal-based baits, pastes, gels and
- Wax blocks and in extruded mixtures of cereals and formulation aids It is also possible to offer the pathogens in water-based drinking baits.
- the baits in the sense of the invention are used like conventional baits for combating rodents. They can be laid out in the enclosed space and in the open, depending on the target species and density of the bait points with 5 g to 500 g per bait point. They can also be placed in the entrances to the rodents to be controlled.
- the dosage of the pathogens in the bait should be 500 to 200,000 sporocysts per gram of bait. Concentrations of 2,000 to 50,000 sporocysts per gram are preferred, 10,000 sporocysts per gram are particularly preferred. Higher doses are also possible, but are generally not required. Sporocysts of only one type of pathogen, but also mixtures of the sporocysts of different pathogens can be used.
- the concentration of the anticoagulant active ingredients should be approx. 10% to 150% of the commonly used or registered concentrations, for example as follows:
- the active ingredients in the range from 10% to 25% of the commonly used or registered concentrations.
- a single active ingredient or a mixture of different suitable active ingredients can be used.
- Parasite and anticoagulant agent, or agent mixture can be offered at the same time or offset in separate baits. But it is also possible to mix both in one bait and to fight rodents with this combination bait.
- the combination in a bait is a particularly practical one
- Rodents or rodents to be controlled are rodents of the order Rodentia in the sense of the invention.
- the genera Rattus, Mus, Bandicota, Nosokia and Microtus are particularly important.
- the representatives of the genera Rattus and Bandicota e.g. R. rattus, R. norvegicus, B. bengalensis, B. indica.
- the use of the system according to the invention makes it possible to limit the use of anticoagulants and pathogenic organisms quantitatively.
- the Enrichment of the anticoagulants in the organisms is reduced because only a low concentration of the anticoagulant in the bait is required.
- the use of the system according to the invention ensures that initially only subletally infected rodents are killed during the control measure. Repeated infection of these animals would no longer be possible since they would be immune after the first infection.
- the present invention is based on the synergistic effect of two active principles. This combination is part of the "Integrated Pest Management" with the aim to achieve a more effective control of harmful organisms by using smaller amounts of active ingredients and thus reduced pollution of the environment.
- the rats were raised in the laboratory under standard conditions. During the trial and the 2-week preparation, they were kept individually in Makrolon cages. The sporocyst suspension and the coumatetralyl were applied with a pharyngeal tube, while the animals were subjected to a slight diethyl ether anesthetic.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catching Or Destruction (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10001801 | 2000-01-18 | ||
DE10001801A DE10001801A1 (de) | 2000-01-18 | 2000-01-18 | Kombination biologischer und chemischer Nagetierbekämpfung |
PCT/EP2001/000091 WO2001052654A2 (de) | 2000-01-18 | 2001-01-05 | Kombination biologischer und chemischer nagetierbekämpfung |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1251740A2 true EP1251740A2 (de) | 2002-10-30 |
Family
ID=7627813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01902296A Withdrawn EP1251740A2 (de) | 2000-01-18 | 2001-01-05 | Kombination biologischer und chemischer nagetierbekämpfung |
Country Status (14)
Country | Link |
---|---|
US (1) | US7008632B2 (de) |
EP (1) | EP1251740A2 (de) |
JP (1) | JP2004504265A (de) |
KR (1) | KR20020065914A (de) |
CN (1) | CN100521944C (de) |
AR (1) | AR026813A1 (de) |
AU (1) | AU3017201A (de) |
BR (1) | BR0107647A (de) |
CA (1) | CA2396975A1 (de) |
DE (1) | DE10001801A1 (de) |
MX (1) | MXPA02007008A (de) |
MY (1) | MY130532A (de) |
TW (1) | TWI226218B (de) |
WO (1) | WO2001052654A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2338434C (en) * | 1998-07-08 | 2008-03-25 | Kiwicare Corporation Limited | Pesticide in gel form |
DE10023401A1 (de) * | 2000-05-12 | 2001-11-15 | Bayer Ag | Formulierung von Mikroorganismen für die Nagertierbekämpfung in Ködergel |
PL373245A1 (en) * | 2002-05-07 | 2005-08-22 | Bayer Cropscience Aktiengesellschaft | Rodenticidal bait system |
JP2012505259A (ja) * | 2008-10-14 | 2012-03-01 | バイエル・クロップサイエンス・アーゲー | 相乗的な殺鼠剤 |
GB201221069D0 (en) * | 2012-11-23 | 2013-01-09 | Univ Reading | Control method |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2957804A (en) * | 1958-06-06 | 1960-10-25 | Harlan R Shuyler | Pesticide |
AT275956B (de) | 1966-11-11 | 1969-11-10 | Bernhard Haas | Rattenvertilgungsmittel |
GB1371135A (en) * | 1972-03-03 | 1974-10-23 | Ward Blenkinsop & Co Ltd | Rodenticidal compositions |
US3882104A (en) | 1973-04-25 | 1975-05-06 | Richardson Merrell Inc | 2-Azacycloalkylmethyl substituted phenyl carbinols and ketones |
LU69428A1 (de) | 1974-02-20 | 1975-12-09 | ||
CN1011786B (zh) * | 1984-09-26 | 1991-02-27 | 国际壳牌研究有限公司 | 4-羟基香豆素衍生物的制备方法 |
US5132321A (en) * | 1985-09-25 | 1992-07-21 | Sterling Drug Inc. | Anticoagulant/surfactant rodenticidal compositions and method |
US6202656B1 (en) | 1998-03-03 | 2001-03-20 | Applied Materials, Inc. | Uniform heat trace and secondary containment for delivery lines for processing system |
CA2323433A1 (en) * | 1998-03-09 | 1999-09-16 | Reckitt Benckiser Inc. | Enhancing the toxicity of warfarin in rodents |
-
2000
- 2000-01-18 DE DE10001801A patent/DE10001801A1/de not_active Withdrawn
-
2001
- 2001-01-05 WO PCT/EP2001/000091 patent/WO2001052654A2/de not_active Application Discontinuation
- 2001-01-05 KR KR1020027008292A patent/KR20020065914A/ko not_active Application Discontinuation
- 2001-01-05 CN CNB018038808A patent/CN100521944C/zh not_active Expired - Fee Related
- 2001-01-05 JP JP2001552716A patent/JP2004504265A/ja active Pending
- 2001-01-05 MX MXPA02007008A patent/MXPA02007008A/es unknown
- 2001-01-05 AU AU30172/01A patent/AU3017201A/en not_active Abandoned
- 2001-01-05 BR BR0107647-7A patent/BR0107647A/pt not_active Application Discontinuation
- 2001-01-05 EP EP01902296A patent/EP1251740A2/de not_active Withdrawn
- 2001-01-05 US US10/181,341 patent/US7008632B2/en not_active Expired - Fee Related
- 2001-01-05 CA CA002396975A patent/CA2396975A1/en not_active Abandoned
- 2001-01-08 AR ARP010100074A patent/AR026813A1/es unknown
- 2001-01-16 MY MYPI20010187A patent/MY130532A/en unknown
- 2001-01-18 TW TW090100886A patent/TWI226218B/zh not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
See references of WO0152654A2 * |
Also Published As
Publication number | Publication date |
---|---|
AR026813A1 (es) | 2003-02-26 |
WO2001052654A2 (de) | 2001-07-26 |
DE10001801A1 (de) | 2001-07-19 |
KR20020065914A (ko) | 2002-08-14 |
WO2001052654A3 (de) | 2001-12-06 |
CA2396975A1 (en) | 2001-07-26 |
BR0107647A (pt) | 2002-10-08 |
AU3017201A (en) | 2001-07-31 |
US20040028713A1 (en) | 2004-02-12 |
JP2004504265A (ja) | 2004-02-12 |
US7008632B2 (en) | 2006-03-07 |
CN1395468A (zh) | 2003-02-05 |
MXPA02007008A (es) | 2003-01-28 |
TWI226218B (en) | 2005-01-11 |
MY130532A (en) | 2007-06-29 |
CN100521944C (zh) | 2009-08-05 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20020819 |
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AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
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AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BAYER CROPSCIENCE AG |
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17Q | First examination report despatched |
Effective date: 20021120 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20030401 |
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RBV | Designated contracting states (corrected) |
Designated state(s): DE FR GB IT NL |