EP1224309A2 - Modification post-traductionnelle de proteines de recombinaison produites dans les plantes - Google Patents

Modification post-traductionnelle de proteines de recombinaison produites dans les plantes

Info

Publication number
EP1224309A2
EP1224309A2 EP00978257A EP00978257A EP1224309A2 EP 1224309 A2 EP1224309 A2 EP 1224309A2 EP 00978257 A EP00978257 A EP 00978257A EP 00978257 A EP00978257 A EP 00978257A EP 1224309 A2 EP1224309 A2 EP 1224309A2
Authority
EP
European Patent Office
Prior art keywords
plant
host system
post
plant host
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00978257A
Other languages
German (de)
English (en)
Inventor
Douglas Russell
Siva Manjunath
Ronald Bassuner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Technology LLC
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of EP1224309A2 publication Critical patent/EP1224309A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Abstract

L'invention concerne un procédé relatif à la production de protéines ou de polypeptides par le biais de plantes ou cellules de plantes manipulées génétiquement, ainsi que des plantes ou cellules de plantes manipulées génétiquement proprement dites (y compris les parties de ces plantes manipulées), le matériau de protéine hétérologue (par exemple, protéine, polypeptide et autre) que l'on produit à l'aide desdites plantes ou cellules de plantes manipulées, et enfin les polynucléotides de recombinaison (ADN ou ARN) utilisés pour la manipulation génétique.
EP00978257A 1999-10-21 2000-10-20 Modification post-traductionnelle de proteines de recombinaison produites dans les plantes Withdrawn EP1224309A2 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16075899P 1999-10-21 1999-10-21
US19528200P 2000-04-07 2000-04-07
US195282P 2000-04-07
PCT/US2000/029027 WO2001029242A2 (fr) 1999-10-21 2000-10-20 Modification post-traductionnelle de proteines de recombinaison produites dans les plantes
US160758P 2009-03-17

Publications (1)

Publication Number Publication Date
EP1224309A2 true EP1224309A2 (fr) 2002-07-24

Family

ID=26857200

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00978257A Withdrawn EP1224309A2 (fr) 1999-10-21 2000-10-20 Modification post-traductionnelle de proteines de recombinaison produites dans les plantes

Country Status (5)

Country Link
EP (1) EP1224309A2 (fr)
AU (1) AU1573601A (fr)
BR (1) BR0014945A (fr)
CA (1) CA2388432A1 (fr)
WO (1) WO2001029242A2 (fr)

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CA2471363C (fr) 2001-12-21 2014-02-11 Human Genome Sciences, Inc. Proteines hybrides d'albumine
AU2008202355B2 (en) * 2002-03-19 2011-04-07 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
EP1485492B1 (fr) * 2002-03-19 2011-12-21 Stichting Dienst Landbouwkundig Onderzoek Expression de gntiii (udp-n-acetylglucosamine: beta -d mannoside beta (1,4)-n-acetylglucosaminyltransferase iii) dans des plantes.
EP2339004B1 (fr) 2002-03-19 2015-02-25 Stichting Dienst Landbouwkundig Onderzoek Optimisation du traitement du glycane chez les plantes
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
AU2003294912B2 (en) * 2002-12-20 2009-06-04 Greenovation Biotech Gmbh Production of heterologous glycosylated proteins in bryophyte cells
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NZ541503A (en) * 2003-01-22 2008-09-26 Glycart Biotechnology Ag Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
CN100427599C (zh) * 2003-12-26 2008-10-22 吉林大学第一医院 Albsin/il－18mat杂交细胞因子
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EP1809751B1 (fr) * 2004-09-29 2010-09-01 CollPlant Ltd. Collagène recombinant produit dans une plante
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EP1816201A1 (fr) 2006-02-06 2007-08-08 CSL Behring GmbH Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée
BRPI0716711A2 (pt) * 2006-11-08 2013-10-01 Centre Nat Rech Scient "seqÜencia de aminoÁcido, proteÍna recombinanate, seqÜncia de Ácido nuclÉico, vetor de Ácido nuclÉico, cÉlula vegetal, vegetal e mÉtodo para produÇço de um polipeptideo modificado pàs-traducionalmente"
CA2684370C (fr) 2007-04-17 2017-10-17 Plant Research International B.V. Glycosylation de type mammifere dans des plantes par l'expression de glycosyltransferases non mammiferes
HUE031698T2 (en) * 2007-06-15 2017-07-28 Medicago Inc Modification of glycoprotein production in plants
US20100242128A1 (en) * 2007-10-31 2010-09-23 Bayer BioSceince NV Method to produce modified plants with altered n-glycosylation pattern
MX2010004910A (es) 2007-11-08 2010-05-14 Neogenix Oncology Inc Anticuerpos monoclonales recombinantes y antigenos correspondientes para canceres colonico y pancreatico.
WO2010006452A1 (fr) 2008-07-18 2010-01-21 Medicago Inc. Nouvel épitope d’immunisation contre l’influenzavirus
US20140302999A1 (en) * 2011-11-03 2014-10-09 Magdalena Leszczyniecka Method for determination of pharmacological properties of recombinant proteins
WO2014130922A1 (fr) 2013-02-25 2014-08-28 Trustees Of Boston University Compositions et procédés pour le traitement d'infections fongiques
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JP6450381B2 (ja) 2013-07-05 2019-01-09 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション がんを処置するための可溶性ｍｉｃ中和モノクローナル抗体
WO2015050005A1 (fr) * 2013-10-02 2015-04-09 株式会社ＵｎｉＢｉｏ Composition protéique stimulant la prolifération cellulaire via le récepteur de l'egf
EP3221455B1 (fr) 2014-11-20 2020-08-12 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Compositions et procédés de production de polypeptides présentant un schéma de glycosylation modifié dans des cellules végétales
SG10202008378UA (en) * 2016-04-15 2020-10-29 Regenxbio Inc Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab
EP3452103A1 (fr) 2016-04-15 2019-03-13 The Trustees Of The University Of Pennsylvania Composition pour le traitement de la dégénérescence maculaire liée a l'âge exsudative
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JP2024505600A (ja) 2021-02-03 2024-02-06 モーツァルト セラピューティクス， インコーポレイテッド 結合剤およびそれを使用する方法
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See references of WO0129242A3 *

Also Published As

Publication number Publication date
WO2001029242A2 (fr) 2001-04-26
AU1573601A (en) 2001-04-30
BR0014945A (pt) 2004-08-31
WO2001029242A3 (fr) 2002-02-21
CA2388432A1 (fr) 2001-04-26

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