CA2388432A1 - Modification post-traductionnelle de proteines de recombinaison produites dans les plantes - Google Patents
Modification post-traductionnelle de proteines de recombinaison produites dans les plantes Download PDFInfo
- Publication number
- CA2388432A1 CA2388432A1 CA002388432A CA2388432A CA2388432A1 CA 2388432 A1 CA2388432 A1 CA 2388432A1 CA 002388432 A CA002388432 A CA 002388432A CA 2388432 A CA2388432 A CA 2388432A CA 2388432 A1 CA2388432 A1 CA 2388432A1
- Authority
- CA
- Canada
- Prior art keywords
- plant
- host system
- post
- plant host
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne un procédé relatif à la production de protéines ou de polypeptides par le biais de plantes ou cellules de plantes manipulées génétiquement, ainsi que des plantes ou cellules de plantes manipulées génétiquement proprement dites (y compris les parties de ces plantes manipulées), le matériau de protéine hétérologue (par exemple, protéine, polypeptide et autre) que l'on produit à l'aide desdites plantes ou cellules de plantes manipulées, et enfin les polynucléotides de recombinaison (ADN ou ARN) utilisés pour la manipulation génétique.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16075899P | 1999-10-21 | 1999-10-21 | |
US60/160,758 | 1999-10-21 | ||
US19528200P | 2000-04-07 | 2000-04-07 | |
US60/195,282 | 2000-04-07 | ||
PCT/US2000/029027 WO2001029242A2 (fr) | 1999-10-21 | 2000-10-20 | Modification post-traductionnelle de proteines de recombinaison produites dans les plantes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2388432A1 true CA2388432A1 (fr) | 2001-04-26 |
Family
ID=26857200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002388432A Abandoned CA2388432A1 (fr) | 1999-10-21 | 2000-10-20 | Modification post-traductionnelle de proteines de recombinaison produites dans les plantes |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1224309A2 (fr) |
AU (1) | AU1573601A (fr) |
BR (1) | BR0014945A (fr) |
CA (1) | CA2388432A1 (fr) |
WO (1) | WO2001029242A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020176972A1 (fr) * | 2019-03-06 | 2020-09-10 | Plantform Corporation | Vecteurs d'adn-t ayant des séquences 5' modifiées en amont d'enzymes de modification post-traductionnelles et leurs procédés d'utilisation |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US6998267B1 (en) | 1998-12-09 | 2006-02-14 | The Dow Chemical Company | Method for manufacturing glycoproteins having human-type glycosylation |
PT1772518E (pt) * | 1999-10-26 | 2010-10-28 | Stichting Dienst Landbouwkundi | Glicosilação do tipo mamífero em plantas |
AT409381B (de) * | 2000-03-03 | 2002-07-25 | Gloessl Josef Dr | Xylosyltransferase-gen |
AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7598055B2 (en) * | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
JP2005505234A (ja) | 2001-01-19 | 2005-02-24 | ザ ダウ ケミカル カンパニー | 植物細胞によるヒト型糖鎖をもつ糖タンパク質の分泌生産方法 |
EP1399572A4 (fr) * | 2001-06-05 | 2005-02-09 | Karen K Oishi | Expression genique et production de proteines tgf-b comprenant une substance inhibitrice mullerienne bioactive issue de vegetaux |
EP1404851A4 (fr) * | 2001-06-08 | 2005-05-25 | Icon Genetics Inc | Production de proteines vegetales |
EP2990417A1 (fr) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Protéines de fusion d'albumine et insuline |
CN101613705A (zh) * | 2002-03-19 | 2009-12-30 | 国际植物研究所 | 在植物中优化聚糖生成 |
AU2008202355B2 (en) * | 2002-03-19 | 2011-04-07 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
NZ534881A (en) | 2002-03-19 | 2006-09-29 | Plant Res Internat B | Mammalian GnTIII expression in plants |
CL2003002461A1 (es) | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
AU2003294912B2 (en) * | 2002-12-20 | 2009-06-04 | Greenovation Biotech Gmbh | Production of heterologous glycosylated proteins in bryophyte cells |
PT1431394E (pt) * | 2002-12-20 | 2006-12-29 | Greenovation Biotech Gmbh | Metodo de produção de proteinas glicosiladas heterologas em celulas de briofitos |
WO2004067029A1 (fr) * | 2002-12-27 | 2004-08-12 | Shenzhen Tsinghua Yuanxing Bio-Pharm Science & Technology Co., Ltd. | Procede de preparation d'un vaccin et vaccins antitumoraux |
PL222221B1 (pl) * | 2003-01-22 | 2016-07-29 | Glycart Biotechnology Ag | Sposób wytwarzania polipeptydu w komórce gospodarza |
CN100427599C (zh) * | 2003-12-26 | 2008-10-22 | 吉林大学第一医院 | Albsin/il-18mat杂交细胞因子 |
EP3088528B1 (fr) * | 2004-09-29 | 2019-07-03 | Collplant Ltd. | Plantes produisant du collagene et procedes de generation et d'utilisation de celles-ci |
US8455717B2 (en) | 2004-09-29 | 2013-06-04 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
WO2007084922A2 (fr) | 2006-01-17 | 2007-07-26 | Biolex Therapeutics, Inc. | Compositions et procédés d'humanisation et optimisation de n-glycanes chez les plantes |
EP1816201A1 (fr) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée |
JP5568702B2 (ja) * | 2006-11-08 | 2014-08-13 | サントル ナショナル ドゥ ラ ルシェルシュ スィヤンティフィック(セーエヌエルエス) | 組換えポリペプチドの発現および翻訳後修飾の制御を標的化するための配列を有するポリペプチド |
WO2008125972A2 (fr) | 2007-04-17 | 2008-10-23 | Plant Research International B.V. | Glycosylation de type mammifère dans des plantes par l'expression de glycosyltransférases non mammifères |
NZ598417A (en) * | 2007-06-15 | 2013-06-28 | Centre Nat Rech Scient | Modifying glycoprotein production in plants |
EP2205728A1 (fr) * | 2007-10-31 | 2010-07-14 | Bayer BioScience N.V. | Procédé de production de plantes modifiées à schéma de n-glycosylation modifié |
ES2883176T3 (es) | 2007-11-08 | 2021-12-07 | Prec Biologics Inc | Anticuerpos monoclonales recombinantes y antígenos correspondientes para cánceres de colon y de páncreas |
MX370690B (es) | 2008-07-18 | 2019-12-19 | Medicago Inc | Epitopo de inmunizacion de nuevo virus de la influenza. |
EP2773964A4 (fr) * | 2011-11-03 | 2015-06-24 | Stc Biolog Inc | Procédé de détermination de propriétés pharmacologiques de protéines recombinantes |
WO2014130922A1 (fr) | 2013-02-25 | 2014-08-28 | Trustees Of Boston University | Compositions et procédés pour le traitement d'infections fongiques |
GB201308120D0 (en) | 2013-05-06 | 2013-06-12 | Baden Wuerttemberg Stiftung Gmbh | Recombinant protein and method for its production |
CN105517572B (zh) | 2013-07-05 | 2019-05-31 | 华盛顿大学商业中心 | 用于治疗癌症的中和可溶性mic的单克隆抗体 |
JPWO2015050005A1 (ja) * | 2013-10-02 | 2017-03-09 | 株式会社UniBio | Egf受容体を介して細胞増殖を促進するタンパク質組成物 |
BR112017010555A2 (pt) | 2014-11-20 | 2018-02-27 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | composições e métodos para produção de polipeptídeos com padrão de glicosilação modificado em células vegetais |
MA44873A (fr) | 2016-04-15 | 2019-03-13 | Univ Pennsylvania | Composition pour le traitement de la dégénérescence maculaire liée a l'âge exsudative |
SG11201808440YA (en) * | 2016-04-15 | 2018-10-30 | Regenxbio Inc | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
CA3184940A1 (fr) | 2020-07-07 | 2022-01-13 | Jennifer Donglan WU | Anticorps mic et agents de liaison et leurs procedes d'utilisation |
CA3209479A1 (fr) | 2021-02-03 | 2022-08-11 | Mozart Therapeutics, Inc. | Agents de liaison et leurs methodes d'utilisation |
AU2022253902A1 (en) | 2021-04-10 | 2023-11-02 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
TW202308699A (zh) | 2021-04-23 | 2023-03-01 | 美商普方生物製藥美國公司 | Cd70結合劑、其結合物及其使用方法 |
TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
AU2022310688A1 (en) | 2021-07-13 | 2024-01-18 | Keystone Bio, Inc. | Diagnostics for porphyromonas gingivalis |
WO2023076876A1 (fr) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation de réponses immunitaires à des vecteurs viraux |
CA3238167A1 (fr) | 2021-11-19 | 2023-05-25 | Maria Leia Smith | Agents de liaison de gpc3, leurs conjugues et leurs procedes d'utilisation |
WO2024030956A2 (fr) | 2022-08-03 | 2024-02-08 | Mozart Therapeutics, Inc. | Agents de liaison se liant spécifiquement à cd39 et leurs méthodes d'utilisation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
DE19754622A1 (de) * | 1997-12-09 | 1999-06-10 | Antje Von Dr Schaewen | Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität |
US6998267B1 (en) * | 1998-12-09 | 2006-02-14 | The Dow Chemical Company | Method for manufacturing glycoproteins having human-type glycosylation |
PT1772518E (pt) * | 1999-10-26 | 2010-10-28 | Stichting Dienst Landbouwkundi | Glicosilação do tipo mamífero em plantas |
WO2001031044A1 (fr) * | 1999-10-26 | 2001-05-03 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Gonadotrophines dans les plantes |
-
2000
- 2000-10-20 AU AU15736/01A patent/AU1573601A/en not_active Abandoned
- 2000-10-20 CA CA002388432A patent/CA2388432A1/fr not_active Abandoned
- 2000-10-20 WO PCT/US2000/029027 patent/WO2001029242A2/fr not_active Application Discontinuation
- 2000-10-20 EP EP00978257A patent/EP1224309A2/fr not_active Withdrawn
- 2000-10-20 BR BR0014945-4A patent/BR0014945A/pt not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020176972A1 (fr) * | 2019-03-06 | 2020-09-10 | Plantform Corporation | Vecteurs d'adn-t ayant des séquences 5' modifiées en amont d'enzymes de modification post-traductionnelles et leurs procédés d'utilisation |
EP3935180A4 (fr) * | 2019-03-06 | 2022-12-28 | Plantform Corporation | Vecteurs d'adn-t ayant des séquences 5' modifiées en amont d'enzymes de modification post-traductionnelles et leurs procédés d'utilisation |
Also Published As
Publication number | Publication date |
---|---|
AU1573601A (en) | 2001-04-30 |
BR0014945A (pt) | 2004-08-31 |
WO2001029242A2 (fr) | 2001-04-26 |
WO2001029242A3 (fr) | 2002-02-21 |
EP1224309A2 (fr) | 2002-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |