EP1222185A1 - Derives de tetrahydrobenzynedolone, leur preparation et leur utilisation en tant qu'antagonistes des recepteurs 5-ht 7 - Google Patents

Derives de tetrahydrobenzynedolone, leur preparation et leur utilisation en tant qu'antagonistes des recepteurs 5-ht 7

Info

Publication number
EP1222185A1
EP1222185A1 EP00971384A EP00971384A EP1222185A1 EP 1222185 A1 EP1222185 A1 EP 1222185A1 EP 00971384 A EP00971384 A EP 00971384A EP 00971384 A EP00971384 A EP 00971384A EP 1222185 A1 EP1222185 A1 EP 1222185A1
Authority
EP
European Patent Office
Prior art keywords
indol
benzo
tetrahydro
butyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00971384A
Other languages
German (de)
English (en)
Inventor
Steven Mark SmithKline Beecham Pharmac. BROMIDGE
Andrew D. SmithKline Beecham Pharmaceu. GRIBBLE
Peter John SmithKline Beecham Pharmaceu. LOVELL
Jason Smithkline Beecham Pharmac. WITHERINGTON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9924628.2A external-priority patent/GB9924628D0/en
Priority claimed from GB0006168A external-priority patent/GB0006168D0/en
Priority claimed from GB0018952A external-priority patent/GB0018952D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of EP1222185A1 publication Critical patent/EP1222185A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

  • This invention relates to novel compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
  • Kikuchi et al. J. Med. Chem., 1999, 42, 533 describes tetrahydrobenzindolone compounds as selective antagonists of the 5-HT7 receptor.
  • Patent applications WO 98/00400, WO 99/33804 and WO 99/54303 also disclose tetrahydrobenzindolone compounds as 5-HT ⁇ receptor antagonists. Such compounds are claimed to be useful in the treatment of various CNS diseases.
  • a structurally novel class of compounds has now been found which also possess 5-HT7 receptor activity.
  • the present invention therefore provides, in a first aspect, a compound of formula (I) or a pharmaceutically acceptable salt thereof:
  • R.1 is halogen, C ⁇ alkyl, hydroxy, C galkoxy, Ci-galkylthio, Cj-galkylsulphinyl, C j -galkylsulphonyl, amino, mono- or di-Cj-galkylamino, carboxy, carboxamido, hydroxyC ⁇ -galkyl, mono- or di-Ci-galkylaminocarbonyl, sulphonamido, mono- or di-Ci-galkylaminosulphonyl or C j -6alkoxycarbonyl; R2 is hydrogen, C 1 -6 l yl or arylC ⁇ - alkyl; p is 0, 1, 2 or 3;
  • R3 is hydrogen or C ⁇ galkyl; n is 2, 3, 4, 5 or 6;
  • A is nitrogen, carbon or CH, is a single bond when A is nitrogen or CH or
  • R4 is halogen, Ci- ⁇ lkyl, cyano, CF3, C ⁇ - cycloalkyl, Cj-galkoxy, hydroxy, amino, mono- or di-C 1 -galkylamino, acylamino, nitro, C i-galkoxycarbonyl, Cj-galkylthio, Ci-galkylsulphinyl, Ci-galkylsulphonyl, sulphamoyl, mono- and di-C ⁇ -5alkylsulphamoyl, carbamoyl, mono- and di-Cj-galkylcarbamoyl,
  • C ⁇ alkyl groups whether alone or as part of another group may be straight chain or branched.
  • the term 'halogen' is used herein to describe, unless otherwise stated, a group selected from fluorine, chlorine, bromine or iodine.
  • the term 'aryl', whether alone or as part of another group, is used herein to describe, unless otherwise stated, a group such as phenyl or naphthyl. Such aryl groups may be optionally substituted by one or more C ⁇ alkyl, halogen, CF3 or C ⁇ -galkoxy.
  • R ⁇ is preferably halogen (particularly fluorine or chlorine) or a C ⁇ alkyl (particularly methyl).
  • R* may be the same or different.
  • p is 0 or 1, most preferably 0.
  • R ⁇ is hydrogen
  • n is 4 or 5, most preferably 4.
  • R ⁇ is hydrogen
  • X is N.
  • Y is O, S or NH;
  • R ⁇ is preferably halogen (particularly fluorine or chlorine), a C ⁇ alkyl (particularly methyl), C ⁇ _6 lkoxy (particularly methoxy), CF3 or hydroxy.
  • a preferred site for substitution of R ⁇ groups is at the 4, 5 or 6 position of the benzo fused heteroaryl ring.
  • R ⁇ may be the same or different.
  • m is 0 or 1.
  • Preferred compounds of this invention include examples El - E41 (as shown below) or a pharmaceutically acceptable salt thereof.
  • Particularly preferred compounds of this invention include: 2a- ⁇ 4-[4-(lH-Benzimidazol-2-yl)-piperidin-l-yl]-butyl ⁇ -2a, 3, 4, 5-tetrahydro-lH- benzo[c,d]indol-2-one,
  • the compounds of formula (I) can form acid addition salts thereof. It will be appreciated that for use in medicine the salts of the compounds of formula (I) should be pharmaceutically acceptable. Suitable pharmaceutically acceptable salts will be apparent to those skilled in the art and include those described in J. Pharm. Sci., 1977, 66, 1-19, such as acid addition salts formed with inorganic acids e.g. hydrochloric, hydrobromic, sulfuric, nitric or phosphoric acid; and organic acids e.g. succinic, maleic, acetic, fumaric, citric, tartaric, benzoic, p-toluenesulfonic, methanesulfonic or naphthalenesulfonic acid.
  • inorganic acids e.g. hydrochloric, hydrobromic, sulfuric, nitric or phosphoric acid
  • organic acids e.g. succinic, maleic, acetic, fumaric, citric, tartaric, benzoic, p-
  • the compounds of formula (I) may be prepared in crystalline or non-crystalline form, and, if crystalline, may optionally be hydrated or solvated.
  • This invention includes within its scope stoichiometric hydrates as well as compounds containing variable amounts of water.
  • Certain compounds of formula (I) are capable of existing in stereoisomeric forms (e.g. diastereomers and enantiomers) and the invention extends to each of these stereoisomeric forms and to mixtures thereof including racemates.
  • the different stereoisomeric forms may be separated one from the other by the usual methods, or any given isomer may be obtained by stereospecific or asymmetric synthesis.
  • the invention also extends to any tautomeric forms and mixtures thereof.
  • the present invention also provides a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, which process comprises coupling a compound of formula (II):
  • Suitable leaving groups L include halogen, preferably chlorine or bromine, and -OSO2Ar groups such as tosylate.
  • the reaction of a compounds of formulae (II) and (III) is preferably carried out in a solvent such as dichloromethane or acetonitrile optionally in the presence of sodium iodide and a base such as potassium carbonate.
  • a solvent such as dichloromethane or acetonitrile
  • compounds of formula (II) and formula (III) are reacted together in the presence of a polymer supported base in a solvent such as DMF.
  • Suitable protecting groups and methods for their attachment and removal are conventional in the art of organic chemistry, such as those described in Greene T.W. 'Protective groups in organic synthesis' New York, Wiley (1981).
  • Compounds of formula (I) and their pharmaceutically acceptable salts have 5- HT7 receptor antagonist activity and are believed to be of potential use for the treatment or prophylaxis of CNS and other disorders such as anxiety, depression, obsessive compulsive disorder, schizophrenia, attention deficit disorders, sleep disorders (including disturbances of circadian rhythms), migraine, neurodegenerative disorders such as Parkinson's disease and Alzheimers disease, pain disorders, feeding disorders such as anorexia and bulimia, sexual dysfunction, ocular disorders, asthma, epilepsy, hypothalamic diseases, inflammation, renal disorders, hypotension, cardiovascular shock, stroke including neurodegeneration resulting from stroke, septic shock and gastrointestinal diseases such as spastic colon and IBS (irritable bowel syndrome).
  • CNS and other disorders
  • other disorders such as anxiety, depression, obsessive compulsive disorder, schizophrenia, attention deficit disorders, sleep disorders (including disturbances of circadian rhythms), migraine, neurodegenerative disorders such as Parkinson's disease and Alzheimers disease, pain disorders, feeding disorders such as anorexia
  • the invention also provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for use as a therapeutic substance, in particular in the treatment or prophylaxis of the above disorders.
  • the invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof for use in the treatment or prophylaxis of depression, anxiety, migraine and/or sleep disorders.
  • the invention further provides a method of treatment or prophylaxis of disorders where an antagonist of the 5-HT receptor is beneficial, particularly the aforementioned disorders, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
  • the invention provides the use of a compound of formula
  • the present invention also provides a pharmaceutical composition, which comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
  • a pharmaceutical composition of the invention which may be prepared by admixture, suitably at ambient temperature and atmospheric pressure, is usually adapted for oral, parenteral or rectal administration and, as such, may be in the form of tablets, capsules, oral liquid preparations, powders, granules, lozenges, reconstitutable powders, injectable or infusable solutions or suspensions or suppositories. Orally administrable compositions are generally preferred.
  • Tablets and capsules for oral administration may be in unit dose form, and may contain conventional excipients, such as binding agents, fillers, tabletting lubricants, disintegrants and acceptable wetting agents.
  • the tablets may be coated according to methods well known in normal pharmaceutical practice.
  • Oral liquid preparations may be in the form of, for example, aqueous or oily suspension, solutions, emulsions, syrups or elixirs, or may be in the form of a dry product for reconstitution with water or other suitable vehicle before use.
  • Such liquid preparations may contain conventional additives such as suspending agents, emulsifying agents, non-aqueous vehicles (which may include edible oils), preservatives, and, if desired, conventional flavourings or colourants.
  • fluid unit dosage forms are prepared utilising a compound of the invention or pharmaceutically acceptable salt thereof and a sterile vehicle.
  • the compound depending on the vehicle and concentration used, can be either suspended or dissolved in the vehicle.
  • the compound can be dissolved for injection and filter sterilised before filling into a suitable vial or ampoule and sealing.
  • adjuvants such as a local anaesthetic, preservatives and buffering agents are dissolved in the vehicle.
  • the composition can be frozen after filling into the vial and the water removed under vacuum.
  • Parenteral suspensions are prepared in substantially the same manner, except that the compound is suspended in the vehicle instead of being dissolved, and sterilization cannot be accomplished by filtration.
  • the compound can be sterilised by exposure to ethylene oxide before suspension in a sterile vehicle.
  • a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the compound.
  • the composition may contain from 0.1% to 99% by weight, preferably from 10 to 60% by weight, of the active material, depending on the method of administration.
  • the dose of the compound used in the treatment of the aforementioned disorders will vary in the usual way with the seriousness of the disorders, the weight of the sufferer, and other similar factors.
  • suitable unit doses may be 0.05 to 1000 mg, more suitably 0.05 to 20.0 mg, for example 0.2 to 5 mg; and such unit doses may be administered more than once a day, for example two or three times a day, so that the total daily dosage is in the range of about 0.5 to 100 mg; and such therapy may extend for a number of weeks or months.
  • Triazabicyclo[4.4.0]dec-5-ene bound to polystyrene cross-linked with 2% DVB 500 mg, 1.3 mmol was added to a shaken solution of 4-benzimidazol-2-yl-piperidine (100 mg, 0.5 mmol) and 2a-(4-bromobutyl) 2a,3,4,5-tetrahydro-lH-benzo[c,d]indol- 2-one2 (200 mg, 0.6 mmol) in DMF (10 ml). After 3 days the solution was decanted onto SCX resin and eluted with methanol (20 ml) followed by IN methano lie- ammonia (20 ml).
  • Racemic 2a- ⁇ 4-[4-(lH-benzimidazol-2-yl)-piperidin-l-yl]-butyl ⁇ -2a, 3, 4, 5- tetrahydro-lH-benzo[c,d]indol-2-one (El) was subjected to preparative ⁇ PLC on a Chiralpak AD column, eluting with 30% ethanol-hexane, to afford the enantiomer 1 title compound as the faster running component with a retention time of 7.8 minutes.
  • Racemic 2a- ⁇ 4-[4-(benzoxazol-2-yl)-piperidin-l-yl]-butyl ⁇ -2a, 3, 4, 5-tetrahydro-lH- benzo[c,d]indol-2-one (E3) was subjected to preparative ⁇ PLC on a Chiralpak AD column, eluting with 15% ethanol-hexane, to afford the enantiomer 1 title compound as the faster running component with a retention time of 17 minutes.
  • Racemic 2a- ⁇ 4-[4-(6-fluorobenzoxazol-2-yl)-piperidin-l-yl]-butyl ⁇ -2a, 3, 4, 5- tetrahydro-lH-benzo[c,d]indol-2-one (E39) was subjected to preparative ⁇ PLC on a Chiralpak AD column, eluting with 10% ethanol-hexane, to afford the enantiomer 1 title compound as the faster running component with a retention time of 19 minutes.
  • Racemic 2a- ⁇ 4-[4-(6-fluorobenzoxazol-2-yl)-piperidin-l-yl]-butyl ⁇ -2a, 3, 4, 5- tetrahydro-lH-benzo[c,d]indol-2-one (E39) was subjected to preparative ⁇ PLC on a Chiralpak AD column, eluting with 10% ethanol-hexane, to afford the enantiomer 2 title compound as the slower running component with a retention time of 29.5 minutes.
  • reaction mixture was loaded onto an SCX cartridge and washed with methanol (50ml) and then 5% aqueous ammonia/methanol (25ml).
  • the ammonia/methanol washing was concentrated in vacuo and the residue purified by column chromatography (5% then 10% methanol/chloroform) to give the title compound as a pale yellow solid (0.020 g, 13.4 %).
  • the affinity of the compounds of this invention for the 5-HT ⁇ receptor binding site can be determined by methods described in WO 97/29097. All compounds tested had a pKi greater than 6.0. Preferred examples had a pKi in the range 8.0 - 9.2.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I) ou leurs sels acceptables sur le plan pharmaceutique. Dans la formule (I), R1 est halogène, C¿1-6?alkyle, hydroxy, C1-6alcoxy, C1-6alkylthio, C1-6alkylsulfinyle, C1-6alkylsufonyle, amino, mono-ou di-C1-6alkylamino, carboxy, carboxamido, hydroxyC1-6alkyle, mono- ou di-C1-6alklyaminocarbonyle, sulfonamido, C1-6alkylsufonylamino, aminoC1-6alkyle, mono- ou di-C1-6alkylaminosulfonyle ou C1-6alcoxycarbonyle; R?2¿ est hydrogène, C¿1-6?alkyle ou arylC1-6alkyle; p est égal à 0, 1, 2 ou 3; R?3¿ est hydrogène ou C¿1-6?alkyle; n est égal à 2, 3, 4, 5 ou 6. A représente l'azote, le carbone ou CH, .....désigne une liaison simple quand A représente l'azote ou CH ou .....désigne une double liaison quand A représente le carbone ; X représente l'azote ou CH ; Y représente O, S, NH ou N-C1-6alkyle; R?4¿ est halogène, C¿1-6?alkyle, cyano, CF3, C3-7cycloalkyle, C1-6alcoxy, hydroxy, amino, mono- ou di-C1-6alkylamino, acylamino, nitro, C1-6alcoxycarbonyle, C1-6alkylthio, C1-6alkylsulfinyle, C1-6alkylsulfonyle, sulfamoyle, mono- et di-C1-6alkylsulfamoyle, carbamoyle, mono- et di- C1-6alkylcarbamoyle, C1-6allkylsulfonamido, arylsulfonamido, aryle, arylC1-6alkyle, arylC1-6alcoxy, aryloxy et arylthio ; m est égal à 0, 1, 2 ou 3. Ces composés une activité antagoniste vis à vis de la 5-HT7. L'invention concerne également des procédés pour la préparation de ces composés, des compositions les renfermant et leur utilisation dans le traitement des troubles du système nerveux central (SNC) et d'autres maladies.
EP00971384A 1999-10-18 2000-10-13 Derives de tetrahydrobenzynedolone, leur preparation et leur utilisation en tant qu'antagonistes des recepteurs 5-ht 7 Withdrawn EP1222185A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9924628 1999-10-18
GBGB9924628.2A GB9924628D0 (en) 1999-10-18 1999-10-18 Novel compounds
GB0006168A GB0006168D0 (en) 2000-03-14 2000-03-14 Novel compounds
GB0006168 2000-03-14
GB0018952A GB0018952D0 (en) 2000-08-03 2000-08-03 Novel compounds
GB0018952 2000-08-03
PCT/EP2000/010149 WO2001029029A1 (fr) 1999-10-18 2000-10-13 Derives de tetrahydrobenzynedolone, leur preparation et leur utilisation en tant qu'antagonistes des recepteurs 5-ht¿7?

Publications (1)

Publication Number Publication Date
EP1222185A1 true EP1222185A1 (fr) 2002-07-17

Family

ID=27255596

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00971384A Withdrawn EP1222185A1 (fr) 1999-10-18 2000-10-13 Derives de tetrahydrobenzynedolone, leur preparation et leur utilisation en tant qu'antagonistes des recepteurs 5-ht 7

Country Status (5)

Country Link
EP (1) EP1222185A1 (fr)
JP (1) JP2003512372A (fr)
AU (1) AU1025601A (fr)
HK (1) HK1049151A1 (fr)
WO (1) WO2001029029A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003220886A1 (en) 2002-03-29 2003-10-13 Mitsubishi Pharma Corporation Remedy for sleep disturbance
CN103788089A (zh) 2003-09-17 2014-05-14 詹森药业有限公司 作为血清素受体调节剂的稠合杂环化合物
US7598255B2 (en) 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
EP1875899A1 (fr) * 2006-06-29 2008-01-09 Laboratorios Del Dr. Esteve, S.A. Utilisation d'agonistes de récepteur de 5HT7 pour traiter la douleur
WO2018144900A1 (fr) * 2017-02-03 2018-08-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Antagonistes à petites molécules de la modification liée au sumo de crmp2 et leurs utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4076234B2 (ja) * 1996-06-28 2008-04-16 明治製菓株式会社 テトラヒドロベンズインドール化合物
CN1129578C (zh) * 1997-12-25 2003-12-03 明治制果株式会社 四氢苯并吲哚衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0129029A1 *

Also Published As

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HK1049151A1 (zh) 2003-05-02
WO2001029029A1 (fr) 2001-04-26
JP2003512372A (ja) 2003-04-02
AU1025601A (en) 2001-04-30

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