EP1180058A1 - Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression - Google Patents

Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression

Info

Publication number
EP1180058A1
EP1180058A1 EP00913490A EP00913490A EP1180058A1 EP 1180058 A1 EP1180058 A1 EP 1180058A1 EP 00913490 A EP00913490 A EP 00913490A EP 00913490 A EP00913490 A EP 00913490A EP 1180058 A1 EP1180058 A1 EP 1180058A1
Authority
EP
European Patent Office
Prior art keywords
formula
gabapentin
hydrogen
composition
gaba analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00913490A
Other languages
German (de)
English (en)
Inventor
Leslie Magnus
Douglas A. Saltel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of EP1180058A1 publication Critical patent/EP1180058A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Definitions

  • the invention includes treating depression with a compound of Formula II.
  • R ⁇ is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne une technique utilisant certains analogues d'acide glutamique et d'acide gamma-aminobutyrique associés à des composés tricycliques, afin de traiter la dépression.
EP00913490A 1999-04-09 2000-02-16 Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression Withdrawn EP1180058A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12857199P 1999-04-09 1999-04-09
US128571P 1999-04-09
PCT/US2000/003983 WO2000061234A1 (fr) 1999-04-09 2000-02-16 Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression

Publications (1)

Publication Number Publication Date
EP1180058A1 true EP1180058A1 (fr) 2002-02-20

Family

ID=22435960

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00913490A Withdrawn EP1180058A1 (fr) 1999-04-09 2000-02-16 Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression

Country Status (11)

Country Link
EP (1) EP1180058A1 (fr)
JP (1) JP2002541224A (fr)
KR (1) KR20010108466A (fr)
AU (1) AU3492900A (fr)
CA (1) CA2367494A1 (fr)
HU (1) HUP0200733A3 (fr)
IL (1) IL145736A0 (fr)
NZ (1) NZ514401A (fr)
TR (1) TR200102850T2 (fr)
WO (1) WO2000061234A1 (fr)
ZA (1) ZA200108259B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
JP2005518411A (ja) * 2002-01-16 2005-06-23 エンド ファーマシューティカルズ インコーポレーテッド 中枢神経系の障害を治療する製薬組成物及び方法
CA2538412A1 (fr) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Combinaison comportant un ligand alpha-2-delta et un inhibiteur selectif du recaptage de la serotonine et/ou un inhibiteur selectif du recaptage de la noradrenaline et permettant le traitement de la depression et des troubles anxieux
NZ545494A (en) * 2003-09-12 2009-10-30 Pfizer Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2410821A1 (de) * 1974-03-07 1975-09-18 Hoechst Ag Pharmazeutische kombinationspraeparate mit psychotroper wirkung und verfahren zu ihrer herstellung
FR2453643A2 (fr) * 1977-06-24 1980-11-07 Synthelabo Compositions pharmaceutiques actives sur le systeme nerveux central
US5025035A (en) * 1990-10-12 1991-06-18 Warner-Lambert Company Method of treating depression
WO1992009560A1 (fr) * 1990-11-27 1992-06-11 Northwestern University Analogues de l'acide gamma-aminobutyrique (gaba) et de l'acide l-glutamique utilises dans le traitement contre les attaques
EP0726073A3 (fr) * 1995-02-10 1998-07-08 Eduardo Samuel Bleiweiss Compositions pharmaceutique contenant au moins un composé choisi parmi le haloperidol, imipramine et le trifluoroperazine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0061234A1 *

Also Published As

Publication number Publication date
IL145736A0 (en) 2002-07-25
HUP0200733A3 (en) 2003-04-28
AU3492900A (en) 2000-11-14
JP2002541224A (ja) 2002-12-03
ZA200108259B (en) 2003-03-26
NZ514401A (en) 2003-10-31
WO2000061234A1 (fr) 2000-10-19
HUP0200733A2 (hu) 2002-07-29
TR200102850T2 (tr) 2002-03-21
KR20010108466A (ko) 2001-12-07
CA2367494A1 (fr) 2000-10-19

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Legal Events

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Effective date: 20050524