EP1093365A2 - Compositions renfermant des analogues d'acide gamma-aminobutyrique (gaba) et un decongestionnant destinees a soulager des cephalees localisees dans les sinus - Google Patents
Compositions renfermant des analogues d'acide gamma-aminobutyrique (gaba) et un decongestionnant destinees a soulager des cephalees localisees dans les sinusInfo
- Publication number
- EP1093365A2 EP1093365A2 EP99928815A EP99928815A EP1093365A2 EP 1093365 A2 EP1093365 A2 EP 1093365A2 EP 99928815 A EP99928815 A EP 99928815A EP 99928815 A EP99928815 A EP 99928815A EP 1093365 A2 EP1093365 A2 EP 1093365A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- decongestant
- gabapentin
- hydrogen
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to compositions comprising analogs of glutamic acid and gamma-aminobutyric acid (GABA) in combination with a decongestant for the treatment of sinus headache pain.
- GABA gamma-aminobutyric acid
- GABA analogs are known agents useful in antiseizure therapy for central nervous system disorders such as epilepsy, Huntington's chorea, cerebral ischemia, Parkinson's disease, tardive dyskinesia, and spasticity. It has also been suggested that the compounds can be used as antidepressants, anxiolytics, and antipsychotics. See WO 92/09560 (United States Serial Number 618,692 filed November 27, 1990) and WP 93/23383 (United States Serial Number 886,080 filed May 20, 1992).
- WO 97/33858 teaches that compounds related to gabapentin are useful or treating epilespy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders. WO 97/33858 does not specify what forms of pain are treated.
- the compounds of the invention are known for treatment of neuropathic pain.
- Ann Pharmacother 1997 Sep, 31:9, 1082-3; Zapp JJ., Postpoliomyelitis pain treated with gabapentin [letter].
- Sinus headaches result from the inflammation of the sinus linings resulting in sinus pressure and pain. Sinus headaches are a common problem for adults over the age of 35 year and are often precipitated by the common cold or allergic rhinits. Common treatments include analgesics and decongestants.
- This invention provides a method for treating sinus headache comprising administering to a subject suffering from sinus headache an effective amount of a GABA analog in combination with a decongestant.
- a preferred GABA analog utilizes a cyclic amino acid compound of Formula I
- Rj is hydrogen or lower alkyl and n is an integer of from 4 to 6, and the pharmaceutically acceptable salts thereof.
- An especially preferred embodiment utilizes a compound of Formula I where R ⁇ is hydrogen and n is 4, which compound is l-(aminomethyl)-cyclohexane acetic acid, known genetically as gabapentin.
- the decongestants useful in the present invention include various sympathomimetic drugs such as pseudoephedrine, ephedrine, phenylephrine and pharmaceutically acceptable salts thereof.
- An additional decongestant useful in the present invention is the complementary medicine ma huong, which is known for its decongestant properties. These decongestants are known to those skilled in the art as therapeutic agents effective in the relief of nasal congestion.
- the invention includes treating sinus headache or sinus pain with a compound of Formula II in combination with a decongestant.
- Formula II is
- R2 is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms;
- Preferred compounds of the invention are those wherein R4 and R3 are hydrogen, and R2 is -(CH2) ⁇ -2 ⁇ i C4H9 as an (R), (S), or (R,S) isomer.
- the more preferred compounds of Formula II invention are (S)-3- (aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methyl-hexanoic acid, now known generically as pregabalin.
- the method of this invention utilizes any GABA analog.
- a GABA analog is any compound derived from or based upon gamma-aminobutyric acid.
- the compounds are readily available, either commercially, or by synthetic methodology well-known to those skilled in the art of organic chemistry.
- the preferred GABA analogs to be utilized in the method of this invention are cyclic amino acids of Formula I. These are described in U.S. Patent 4,024,175, which is incorporated herein by reference.
- Another preferred method utilizes the GABA analogs of Formula II, and these are described in U.S. Patent 5,563,175 which is incorporated herein by reference.
- All that is required to practice the method of this invention is to administer a GABA analog and a decongestant in an amount that is effective to treat the sinus headache or sinus pain.
- the amount of the GABA analog will generally be from about 1 to about 300 mg per kg of subject body weight. Typical doses will be from about 10 to about 5000 mg per day for an adult subject of normal weight. It is expected that common doses that might be administered could be from 100 mg three times a day up to 600 mg four times a day.
- Commercially available capsules of 100 mg, 300 mg and 400 mg of gabapentin can be administered. Alternate forms include liquids and film-coated tablets.
- the dosage level is one sixth that of gabapentin.
- the dosage range for pregabalin is from about 0.15 mg to about 50 mg per kg per day of subject body weight. Typical dosages for pregabalin will be from about 1.6 mg to about 840 mg per day with individual dosages ranging from abut 0.15 mg to about 65 mg per dose.
- a therapeutically effective decongestant amount of a sympathomimetic drug is that amount which produces the desired decongestant therapeutic response upon oral administration and can be readily determined by one skilled in the art by the use of conventional techniques and by observing results obtained under analogous circumstances. In determining the therapeutically effective amount, a number of factors are considered, including but not limited to: the particular compound administered; the bioavailability characteristics of the pharmaceutical composition administered; the dose regimen selected; and other relevant circumstances.
- a therapeutically effective decongestant amount of a sympathomimetic drug will vary from about 1 mg to about 200 mg. Preferred amounts will vary from about 5 mg to about 150 mg.
- These sympathomimetic drugs are generally effective when administered orally in unit dosage form on a four times a day dosage schedule wherein the unit dosage form provides immediate-release of the active medicament.
- the recommended dosage for pseudoephedrine hydrochloride in adults is 60 mg every 6 hr (q.i.d.).
- unit dosage forms containing sympathomimetic drugs can be formulated to provide prolonged release of the active medicament so as to allow the effective daily dose to be administered on a less frequent dosage schedule.
- the recommended dosage for pseudoephedrine hydrochloride in a prolonged-release formulation can be 120 mg. b.i.d.
- compositions according to the present invention can be administered concomitantly with antihistamines for relief of nasal congestion associated with allergic rhinitis.
- antihistamines include, but are not limited to, the following: chlorpheniramine, brompheniramine, dexchlorpheniramine, dexbrompheniramine, tripolidine, diphenhydramine, doxylamine, tripelennamine, cyproheptadine, carbinoxamine, bromodiphenhydramine, phenindamine, pyrilamine, azatadine, terfenadine, astemizole, loratadine, acrivastine, cetirizine, azalastine, evastine, levocabastine, and pharmaceutically acceptable salts thereof.
- compositions of the present invention can also include a second pain reliever.
- pain relievers include analgesics such as aspirin, acetaminophen, ibuprofen, flurbiprofen, naproxen, mefenamic acid, ketoprofen, indomethacin, indoprofen, azapropazone, dicclofenac, difluisal, fenbufen, fenoprofen, piroxicam, sulindac, suprofen, tiaprofenic acid, tolmetin, droxicam, meloxicam, tenoxicam, etodolac, oxindanac or mixtures thereof.
- analgesics such as aspirin, acetaminophen, ibuprofen, flurbiprofen, naproxen, mefenamic acid, ketoprofen, indomethacin, indoprofen, azapropazone
- compositions of the present invention can also include an antitussive such as, but not limited to, the following: dextromethorphan, codeine, terpin hydrate and pharmaceutically acceptable salts thereof.
- an antitussive such as, but not limited to, the following: dextromethorphan, codeine, terpin hydrate and pharmaceutically acceptable salts thereof.
- compositions of the present invention can also include an expectorant.
- the expectorants useful in the present invention include, but are not limited to, the following: guaifenesin, potassium guaicolsulfonate, potassium iodide, potassium citrate, iodinated glycerol, acetylcysteine, carboxymethylcysteine, ambroxol, sobrerol, and pharmaceutically acceptable salts thereof.
- the GABA compounds of the present invention may form pharmaceutically acceptable salts with both organic and inorganic acids or bases.
- the acid addition salts of the basic compounds are prepared either by dissolving the free base in aqueous or aqueous alcohol solution or other suitable solvents containing the appropriate acid and isolating the salt by evaporating the solution.
- pharmaceutically acceptable salts are hydrochlorides, hydrobromides, hydrosulfates, etc. as well as sodium, potassium, and magnesium, etc. salts.
- the compounds of Formula II can contain one or several asymmetric carbon atoms.
- the invention includes the individual diastereomers or enantiomers, and the mixtures thereof.
- the individual diastereomers or enantiomers may be prepared or isolated by methods already well-known in the art.
- compositions of the compound of the present invention or its salts are produced by formulating the active compound in dosage unit form with a pharmaceutical carrier.
- dosage unit forms are tablets, capsules, pills, powders, aqueous and nonaqueous oral solutions and suspensions, and parenteral solutions packaged in containers containing either one or some larger number of dosage units and capable of being subdivided into individual doses.
- suitable pharmaceutical carriers are gelatin capsules; sugars such as lactose and sucrose; starches such as corn starch and potato starch, cellulose derivatives such as sodium carboxymethyl cellulose, ethyl cellulose, methyl cellulose, and cellulose acetate phthalate; gelatin; talc; stearic acid; magnesium stearate; vegetable oils such as peanut oil, cottonseed oil, sesame oil, olive oil, corn oil, and oil of theobroma; propylene glycol, glycerin; sorbitol; polyethylene glycol; water; agar; alginic acid; isotonic saline, and phosphate buffer solutions; as well as other compatible substances normally used in pharmaceutical formulations.
- the compositions of the invention can also contain other components such as coloring agents, flavoring agents, and/or preservatives. These materials, if present, are usually used in relatively small amounts.
- the compositions can, if desired, also contain other therapeutic agents.
- the percentage of the active ingredients in the foregoing compositions can be varied within wide limits, but for practical purposes it is preferably present in a concentration of at least 10% in a solid composition and at least 2% in a primary liquid composition.
- the most satisfactory compositions are those in which a much higher proportion of the active ingredient is present.
- GABA analogs or their salts are oral or parenteral.
- a useful intravenous dose is between 5 and 50 mg of GABA analog and a useful oral dosage of GABA analog is between 20 and 800 mg.
- the dosage is within the dosing range used in treatment of pain or as would be with the needs of the patient as described by the physician.
- the advantages of using the compounds of Formula I and II, especially gabapentin and pregabalin, in the instant invention include the relatively nontoxic nature of the compounds, the ease of preparation, the fact that the compounds are well-tolerated, and the ease of IV administration of the drugs.
- Gabapentin has few interactions with major classes of drugs since it is not metabolized in the liver, but rather excreted unchanged from the body. Further, the drugs are not metabolized in the body.
- the subjects treated with the method of the present invention are mammals, including humans.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9214698P | 1998-07-09 | 1998-07-09 | |
US92146P | 1998-07-09 | ||
PCT/US1999/013946 WO2000002545A2 (fr) | 1998-07-09 | 1999-06-18 | Compositions renfermant des analogues d'acide gamma-aminobutyrique (gaba) et un decongestionnant destinees a soulager des cephalees localisees dans les sinus |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1093365A2 true EP1093365A2 (fr) | 2001-04-25 |
Family
ID=22231857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99928815A Withdrawn EP1093365A2 (fr) | 1998-07-09 | 1999-06-18 | Compositions renfermant des analogues d'acide gamma-aminobutyrique (gaba) et un decongestionnant destinees a soulager des cephalees localisees dans les sinus |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1093365A2 (fr) |
JP (1) | JP2002520276A (fr) |
KR (1) | KR20010074682A (fr) |
AU (1) | AU758103B2 (fr) |
BR (1) | BR9911943A (fr) |
CA (1) | CA2332927A1 (fr) |
ID (1) | ID28972A (fr) |
NO (1) | NO20010118L (fr) |
NZ (1) | NZ508491A (fr) |
PL (1) | PL345703A1 (fr) |
WO (1) | WO2000002545A2 (fr) |
ZA (1) | ZA200007170B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10048714A1 (de) | 2000-09-30 | 2002-04-11 | Gruenenthal Gmbh | 5-Amino-1-penlen-3-ol-Derivate |
JP2005518411A (ja) * | 2002-01-16 | 2005-06-23 | エンド ファーマシューティカルズ インコーポレーテッド | 中枢神経系の障害を治療する製薬組成物及び方法 |
JP2008512436A (ja) * | 2004-09-07 | 2008-04-24 | ファイザー・インク | 片頭痛治療用の5−HT(1)受容体アゴニストとα2δリガンドの組み合わせ |
JP2010088301A (ja) | 2007-02-01 | 2010-04-22 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU1801483C (ru) * | 1990-03-19 | 1993-03-15 | Волгоградский государственный медицинский институт | Композици , обладающа гипертензивным действием |
US5478565A (en) * | 1990-03-27 | 1995-12-26 | Warner-Lambert Company | Treatment of sinus headache |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
KR100491282B1 (ko) * | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
-
1999
- 1999-06-18 JP JP2000558805A patent/JP2002520276A/ja active Pending
- 1999-06-18 ID IDW20010055A patent/ID28972A/id unknown
- 1999-06-18 KR KR1020017000259A patent/KR20010074682A/ko not_active Application Discontinuation
- 1999-06-18 BR BR9911943-9A patent/BR9911943A/pt not_active IP Right Cessation
- 1999-06-18 NZ NZ508491A patent/NZ508491A/en unknown
- 1999-06-18 CA CA002332927A patent/CA2332927A1/fr not_active Abandoned
- 1999-06-18 AU AU45799/99A patent/AU758103B2/en not_active Ceased
- 1999-06-18 EP EP99928815A patent/EP1093365A2/fr not_active Withdrawn
- 1999-06-18 WO PCT/US1999/013946 patent/WO2000002545A2/fr not_active Application Discontinuation
- 1999-06-18 PL PL99345703A patent/PL345703A1/xx unknown
-
2000
- 2000-12-04 ZA ZA200007170A patent/ZA200007170B/en unknown
-
2001
- 2001-01-08 NO NO20010118A patent/NO20010118L/no not_active Application Discontinuation
Non-Patent Citations (1)
Title |
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See references of WO0002545A2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000002545A2 (fr) | 2000-01-20 |
NO20010118D0 (no) | 2001-01-08 |
BR9911943A (pt) | 2001-05-29 |
CA2332927A1 (fr) | 2000-01-20 |
NO20010118L (no) | 2001-01-08 |
JP2002520276A (ja) | 2002-07-09 |
ID28972A (id) | 2001-07-19 |
WO2000002545A3 (fr) | 2000-04-13 |
AU4579999A (en) | 2000-02-01 |
ZA200007170B (en) | 2002-03-04 |
NZ508491A (en) | 2003-09-26 |
KR20010074682A (ko) | 2001-08-09 |
AU758103B2 (en) | 2003-03-13 |
PL345703A1 (en) | 2002-01-02 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Effective date: 20010209 |
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Effective date: 20041008 |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: WARNER-LAMBERT COMPANY LLC |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20050419 |