CA2367494A1 - Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression - Google Patents
Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression Download PDFInfo
- Publication number
- CA2367494A1 CA2367494A1 CA002367494A CA2367494A CA2367494A1 CA 2367494 A1 CA2367494 A1 CA 2367494A1 CA 002367494 A CA002367494 A CA 002367494A CA 2367494 A CA2367494 A CA 2367494A CA 2367494 A1 CA2367494 A1 CA 2367494A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- gabapentin
- hydrogen
- composition
- gaba analog
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 30
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 22
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 22
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne une technique utilisant certains analogues d'acide glutamique et d'acide gamma-aminobutyrique associés à des composés tricycliques, afin de traiter la dépression.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12857199P | 1999-04-09 | 1999-04-09 | |
| US60/128,571 | 1999-04-09 | ||
| PCT/US2000/003983 WO2000061234A1 (fr) | 1999-04-09 | 2000-02-16 | Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367494A1 true CA2367494A1 (fr) | 2000-10-19 |
Family
ID=22435960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367494A Abandoned CA2367494A1 (fr) | 1999-04-09 | 2000-02-16 | Combinaisons d'analogues d'acide glutamique et d'acide gamma-aminobutyrique (gaba) et de composes tricycliques permettant de traiter la depression |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1180058A1 (fr) |
| JP (1) | JP2002541224A (fr) |
| KR (1) | KR20010108466A (fr) |
| AU (1) | AU3492900A (fr) |
| CA (1) | CA2367494A1 (fr) |
| HU (1) | HUP0200733A3 (fr) |
| IL (1) | IL145736A0 (fr) |
| NZ (1) | NZ514401A (fr) |
| TR (1) | TR200102850T2 (fr) |
| WO (1) | WO2000061234A1 (fr) |
| ZA (1) | ZA200108259B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9710536A (pt) | 1996-07-24 | 1999-08-17 | Warner Lambert Co | Isobutilgaba e seus derivados para o tratamento da dor |
| US20060167032A1 (en) * | 2002-01-16 | 2006-07-27 | Galer Bradley S | Pharmaceutical composition and method for treating disorders of the central nervous system |
| BRPI0414343A (pt) * | 2003-09-12 | 2006-11-07 | Pfizer | combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina |
| KR20060087560A (ko) * | 2003-09-12 | 2006-08-02 | 워너-램버트 캄파니 엘엘씨 | 알파-2-델타 리간드 및 ｓｓｒｉ 및/또는 ｓｎｒｉ를포함하는 우울증 및 불안 장애 치료용 조합물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2410821A1 (de) * | 1974-03-07 | 1975-09-18 | Hoechst Ag | Pharmazeutische kombinationspraeparate mit psychotroper wirkung und verfahren zu ihrer herstellung |
| FR2453643A2 (fr) * | 1977-06-24 | 1980-11-07 | Synthelabo | Compositions pharmaceutiques actives sur le systeme nerveux central |
| US5025035A (en) * | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
| AU9137091A (en) * | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
| EP0726073A3 (fr) * | 1995-02-10 | 1998-07-08 | Eduardo Samuel Bleiweiss | Compositions pharmaceutique contenant au moins un composé choisi parmi le haloperidol, imipramine et le trifluoroperazine |
-
2000
- 2000-02-16 TR TR2001/02850T patent/TR200102850T2/xx unknown
- 2000-02-16 JP JP2000610562A patent/JP2002541224A/ja active Pending
- 2000-02-16 EP EP00913490A patent/EP1180058A1/fr not_active Withdrawn
- 2000-02-16 IL IL14573600A patent/IL145736A0/xx unknown
- 2000-02-16 NZ NZ514401A patent/NZ514401A/en unknown
- 2000-02-16 HU HU0200733A patent/HUP0200733A3/hu unknown
- 2000-02-16 WO PCT/US2000/003983 patent/WO2000061234A1/fr not_active Application Discontinuation
- 2000-02-16 AU AU34929/00A patent/AU3492900A/en not_active Abandoned
- 2000-02-16 CA CA002367494A patent/CA2367494A1/fr not_active Abandoned
- 2000-02-16 KR KR1020017012788A patent/KR20010108466A/ko not_active Application Discontinuation
-
2001
- 2001-10-08 ZA ZA200108259A patent/ZA200108259B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010108466A (ko) | 2001-12-07 |
| AU3492900A (en) | 2000-11-14 |
| EP1180058A1 (fr) | 2002-02-20 |
| HUP0200733A3 (en) | 2003-04-28 |
| TR200102850T2 (tr) | 2002-03-21 |
| HUP0200733A2 (hu) | 2002-07-29 |
| JP2002541224A (ja) | 2002-12-03 |
| WO2000061234A1 (fr) | 2000-10-19 |
| NZ514401A (en) | 2003-10-31 |
| ZA200108259B (en) | 2003-03-26 |
| IL145736A0 (en) | 2002-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |