EP1172649A1 - Dispositif de mesure a biodetecteur, biodetecteur utilise pour ce dispositif, et liquide standard y relatif - Google Patents

Dispositif de mesure a biodetecteur, biodetecteur utilise pour ce dispositif, et liquide standard y relatif Download PDF

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Publication number
EP1172649A1
EP1172649A1 EP01946936A EP01946936A EP1172649A1 EP 1172649 A1 EP1172649 A1 EP 1172649A1 EP 01946936 A EP01946936 A EP 01946936A EP 01946936 A EP01946936 A EP 01946936A EP 1172649 A1 EP1172649 A1 EP 1172649A1
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EP
European Patent Office
Prior art keywords
electrode
biosensor
current value
measured
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01946936A
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German (de)
English (en)
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EP1172649A4 (fr
EP1172649B1 (fr
Inventor
Hiroyuki Tokunaga
Shoji Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Corp
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Matsushita Electric Industrial Co Ltd
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Publication date
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Publication of EP1172649A1 publication Critical patent/EP1172649A1/fr
Publication of EP1172649A4 publication Critical patent/EP1172649A4/fr
Application granted granted Critical
Publication of EP1172649B1 publication Critical patent/EP1172649B1/fr
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry

Definitions

  • the present invention relates to a measuring apparatus using an electrode type of biosensor, a biosensor used therefor, and an exclusive standard solution.
  • FIG. 4 is an exploded perspective view illustrating an example of a structure of a glucose sensor, and silver leads 4 and 5 are formed by a screen printing or the like on an insulating substrate 7 of PET (Polyethylene Terephthalate).
  • PET Polyethylene Terephthalate
  • a quadrangular working electrode 1 is formed by carbon on the tip of the silver lead 4, and a counter electrode 2 is formed so as to have a predetermined gap between the silver lead 5 and the working electrode 1 on the tip of the silver lead 5 and surround the working electrode 1.
  • Terminal parts 4a and 5a connected to a measuring device at the measurement are formed on the other ends of the silver leads 4 and 5, respectively.
  • a reaction layer 12 comprising a CMC (Carboxyl Methyl Cellulose) layer which is a hydrophilic polymer, GOD (Glucose Oxidase) as an enzyme, and potassium ferricyanide as a mediator is formed so as to bridge and cover both of the electrodes 1 and 2.
  • a cover 8 on the tip of which à sample supplying groove 10 having an opening 9 is formed over the layer 12 is attached on the substrate 7 such that an end part of the sample supplying groove 10 is located on the reaction layer 12, and an air hole 11 is formed on an end part of the sample supplying groove 10.
  • the apparatus In the small-sized simple measuring apparatus as described above, recently, the emphasis has been, more particularly, on the field of data management such as the management and processing of the measurement data, and, for example, the apparatus is constructed such that the measuring apparatus successively stores a measured value and can easily ascertain variations per hour, an average value or the like. Further, when accurate data management is made, it is required to maintain and manage the accuracy of the biosensor and the measuring apparatus. Therefore, the apparatus regularly makes measurement using an exclusive glucose standard solution, thereby performing accuracy management thereof.
  • a specified manual operation is performed on the measuring apparatus beforehand so as not to confuse the measurement data for accuracy management using the exclusive glucose standard solution with the measurement data using blood normally used as a sample, and switching is performed to a standard solution measurement mode when the measurement is made by the standard solution, where the apparatus is devised so as to discriminate between the blood measurement data and the exclusive glucose standard solution measurement data or the like.
  • the present invention is made to solve the above-described problems and has, for its object, to provide a measuring apparatus which can automatically judge types of sample solution without artificial operations, a biosensor used therefor, and an exclusive standard solution.
  • Claim 1 of the present invention in a measuring apparatus using a biosensor, which has a reaction layer which reacts with a substance to be measured in a sample solution, on a working electrode, a counter electrode, and a third electrode provided on an insulating substrate, so as to bridge the respective electrodes, the content of the substance to be measured is measured from a current value which is produced by a reaction between the substance to be measured and the reaction layer, which reaction is obtained between the working electrode and the counter electrode, and the types of sample solution are judged on the basis of an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode.
  • the types of sample solution can be automatically judged on the basis of an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode, and the types of the sample solution can be automatically judged without artificial preoperation.
  • judgment between the types of sample solution based on the oxidation current value is made by comparing an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode to a predetermined fixed threshold value.
  • the types of sample solution can be automatically judged on the basis of an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode, and the types of the sample solution can be automatically judged without artificial preoperation.
  • the types of sample solution can be automatically judged on the basis of an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode, and the types of the sample solution can be automatically judged without artificial preoperation.
  • the oxidation current value used for the judgment is the one which is measured at the point of time when a fixed time has further elapsed after the current value reaches a predetermined current value, which current flows between the third electrode and the counter electrode or between the third electrode and the working electrode.
  • the types of sample solution can be automatically judged with higher accuracy on the basis of an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode, and the types of the sample solution can be automatically judged without artificial preoperation.
  • a biosensor comprises: a reaction layer which reacts with a substance to be measured in a sample solution so as to bridge the respective electrodes on a working electrode, a counter electrode, and a third electrode provided on an insulting substrate; and a connection terminal which is electrically connected to the working electrode, the counter electrode and the third electrode, respectively, on the insulating substrate.
  • an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode can be measured by the measuring apparatus using the biosensor, and the types of the sample solution can be automatically judged without artificial preoperation.
  • the third electrode consists of easily oxidized materials as compared with the working electrode and the counter electrode.
  • the oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode and its variation characters are significantly different in accordance with whether or not organic acid is included in the sample solution introduced into the biosensor. Therefore, the types of the sample solution can be automatically judged by the measuring apparatus using the biosensor without artificial preoperation.
  • materials of the third electrode are the ones having lower dissolution potential than a voltage applied to the biosensor.
  • an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode can be measured by the measuring apparatus using the biosensor, and the types of the sample solution can be automatically judged without artificial preoperation.
  • materials of the third electrode are silver, copper, zinc, or mixed materials including silver, copper, and zinc.
  • an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode can be measured by the measuring apparatus using the biosensor, and the types of the sample solution can be automatically judged without artificial preoperation.
  • a biosensor's exclusive standard solution used for a measuring apparatus using a biosensor which apparatus measures the content of the substance to be measured from a current value which is produced by a reaction between the substance to be measured and the reaction layer, which reaction is obtained between the working electrode and the counter electrode, and judges types of sample solution on the basis of an oxidation current value obtained between the third electrode and the counter electrode or between the third electrode and the working electrode, by using a biosensor providing a reaction layer which reacts with a substance to be measured in a sample solution so as to bridge the respective electrodes on a working electrode, a counter electrode, and a third electrode provided on an insulting substrate, a substance which suppresses oxidation current obtained by an oxidation of the third electrode is merged.
  • an oxidation current value which is produced from the third electrode when this exclusive standard solution is introduced, and an oxidation current value which is produced from the third electrode when blood is measured are significantly different. Therefore, the types of the sample solution can be automatically judged by utilizing the above-described measuring apparatus using the biosensor without artificial preoperation.
  • a substance which suppresses oxidation current obtained by an oxidation of the third electrode is organic acid.
  • an oxidation current value which is produced from the third electrode when this exclusive standard solution is introduced, and an oxidation current value which is produced from the third electrode when blood is measured are significantly different. Therefore, the types of the sample solution can be automatically judged by utilizing the above-described measuring apparatus using the biosensor without artificial preoperation.
  • the organic acid is at least one of benzoic acid, citric acid, salicylic acid, sorbic acid, dehydroacetic acid, propionic acid.
  • an oxidation current value which is produced from the third electrode when this exclusive standard solution is introduced, and an oxidation current value which is produced from the third electrode when blood is measured are significantly different. Therefore, the types of the sample solution can be automatically judged by utilizing the above-described measuring apparatus using the biosensor without artificial preoperation.
  • FIG 1 is an exploded perspective view illustrating a structure of a glucose sensor according to an embodiment of the present invention.
  • the same numerals are given to the similar components as those of the conventional sensor shown in figure 4.
  • a point that the sensor is different from the conventional sensor is that a silver lead 6 is further provided besides silver leads 4 and 5.
  • a third electrode 3 for judging types of sample solution is arranged on an air hole 11 side in the vicinity of the working electrode 1 and the counter electrode 2, and, on the other end, a connection terminal part 6a is further formed.
  • the reaction layer 12 is formed so as to bridge and cover the working electrode 1, the counter electrode 2, and the third electrode 3. Further, as long as this third electrode 3 is arranged in a position where the third electrode 3 comes in contact with the measurement sample, it may be arranged in any position.
  • the third electrode 3 consists of easily oxidized materials as compared with the working electrode 1 and the counter electrode 2, and, for example, silver, copper, zinc, or mixed materials including them correspond to the easily oxidized materials.
  • a silver electrode is employed as the third electrode 3.
  • a measuring device one which is shown in figure 2 is employed.
  • the power to a measuring device 14 is turned on, and the measuring device is in a stand-by condition where a voltage of 0.5V is applied between the working electrode 1 and the third electrode 3 or between the counter 2 and the third electrode 3.
  • This applied voltage values are different in accordance with the materials of the third electrode 3.
  • a fixed quantity here, as approximately 3 ⁇ L
  • oxidation current which is measured in the third electrode 3 is the fixed quantity (here, as 0.3 ⁇ A/0.5 second) or more
  • an application of the voltage to the sensor 13 is once stopped, and the reaction proceeds for a predetermined time.
  • the voltage is applied again, and the current value corresponding to glucose level is measured.
  • the measurement of the current value corresponding to this glucose level is made, specifically, by applying a voltage of 0.5V between the working electrode 1 and the counter electrode 2 or among the working electrode 1, the counter electrode 2, and the third electrode 3, and measuring the current value obtained in the working electrode 1 at that time.
  • the exclusive standard solution is characterized by further merging a substance which suppresses oxidation current with a conventional standard solution containing a fixed quantity of glucose.
  • substances which suppress the oxidation current any organic acid is possible, and, for example, benzoic acid, citric acid, salicylic acid, sorbic acid, dehydroacetic acid, propionic acid, and the like are listed.
  • benzoic acid citric acid, salicylic acid, sorbic acid, dehydroacetic acid, propionic acid, and the like are listed.
  • benzoic acid citric acid, salicylic acid, sorbic acid, dehydroacetic acid, propionic acid, and the like are listed.
  • the addition amount of benzoic acid is 0.01 weight % or more.
  • the voltage of 0.5V is applied to the third electrode 3 shown in figure 1, using the counter electrode 2 as reference, and stand-by is performed until the measurement sample is introduced. Further, while a description is given of a case where the voltage of 0.5V is applied to the third electrode 3, using the counter electrode 2 as reference, the voltage of 0.5V may be applied to the third electrode 3, using the working electrode 1 as reference.
  • the measurement sample is introduced from the opening 9 of the sample supplying groove 10, and, when the sample reaches the third electrode 3, oxidation current is produced in the third electrode 3.
  • Figures 3 illustrate oxidation current values obtained by the third electrode 3 after introducing the measurement sample.
  • Figure 3(a) illustrates the oxidation current values at normal blood measurement
  • figure 3(b) illustrates the oxidation current values at exclusive standard solution measurement.
  • the rising degree of the current value of the exclusive standard solution as shown in figure 3(b) is significantly smaller than the rising degree of the current value at normal blood measurement as shown in figure 3(a) with the passage of time, because the oxidation current at exclusive standard solution measurement is suppressed by an effect of benzoic acid in the standard solution.
  • the measuring device 14 detects the oxidation current value obtained from the third electrode 3 after a predetermined time has elapsed since the measurement sample is introduced into the sensor 13, and can automatically judge whether a type of sample solution is a standard solution sample or blood sample by comparing the detected oxidation current value to a predetermined threshold value.
  • the oxidation current value obtained from the third electrode 3 immediately before making measurement of the current value corresponding to the glucose level by applying a voltage again is used for the judgment of the types of sample solution, thereby more accurately judging types of sample solution.
  • the threshold value is determined in view of the effect of the glucose concentration, thereby making more precise judgment.
  • Blood samples having three types of the glucose concentrations, 50, 200, 600 (mg/dl), respectively, and a standard solution sample are prepared as measurement samples. Further, benzoic acid is merged with the standard solution at a weight ratio of 0.1 %.
  • the threshold value is determined by applying a voltage of 0.5V to the third electrode 3 shown in figure 1 using the working electrode 1 as reference, then introducing these six types of samples into the sensor 13, thereafter measuring the oxidation current value obtained from the third electrode 3 for every 0.5 seconds, after once stopping the measurement at a point of time when a rise of the current value for the 0.5 seconds reaches 0.3 A, and measuring and comparing the oxidation current values for each sample after one second has elapsed since the point of time.
  • the measurement result of six types of samples according to the above-described measurement is as in table 1.
  • the oxidation current value of the standard solution is significantly small as compared with the oxidation current value of a whole blood sample. Therefore, when the glucose concentration is 20 ⁇ 600 (mg/dl), a discrimination can be performed between the blood sample and the standard solution sample by using the threshold value as described below.
  • the oxidation current value obtained from the third electrode 3 after a predetermined fixed time has elapsed is detected, and the detected oxidation current value is compared with the predetermined threshold value, thereby automatically judging whether the type of sample solution is the standard solution sample or the blood sample. Further, if the foregoing is previously programmed in the measuring device 14, when the current value corresponding to glucose level after applying the voltage again is displayed and stored, the whole blood sample and the standard solution sample can be full-automatically discriminated between to be displayed and stored.
  • glucose sensor is taken as an example in this embodiment, the similar effect can be obtained as long as a measuring device for a simple type electrode biosensor, a sensor, and a standard solution are used for cholesterol, lactic acid or the like.
  • the judgment of the types of sample solution may be made on the basis of a difference between the time variations of the oxidation current values obtained from the third electrode 3.
  • the present invention provides a measuring apparatus which can automatically judge types of sample solution without artificial preoperation, a sensor used therefor, and an exclusive standard solution, comprises a third electrode besides a working electrode and a counter electrode, and judges types of sample solution by utilizing the fact that an oxidation current value obtained from the third electrode when the exclusive standard solution is a sample is significantly different from the oxidation current value obtained from the third electrode when blood is a sample.

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EP01946936A 2000-01-25 2001-01-25 Dispositif de mesure du glucose et methode composant biodetecteur et solution etalon exclusive de glucose Expired - Lifetime EP1172649B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000015320 2000-01-25
JP2000015320A JP3982133B2 (ja) 2000-01-25 2000-01-25 バイオセンサを用いた測定装置並びにそれに使用されるバイオセンサおよび専用標準液
PCT/JP2001/000471 WO2001055712A1 (fr) 2000-01-25 2001-01-25 Dispositif de mesure a biodetecteur, biodetecteur utilise pour ce dispositif, et liquide standard y relatif

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EP1172649A1 true EP1172649A1 (fr) 2002-01-16
EP1172649A4 EP1172649A4 (fr) 2002-05-08
EP1172649B1 EP1172649B1 (fr) 2009-06-03

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US (1) US6881322B2 (fr)
EP (1) EP1172649B1 (fr)
JP (1) JP3982133B2 (fr)
CN (1) CN1172182C (fr)
DE (1) DE60138856D1 (fr)
WO (1) WO2001055712A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1357194A3 (fr) * 2002-04-26 2004-01-02 Matsushita Electric Industrial Co., Ltd. adaptateur pour la connection d'un capteur biologique avec un dispositif de mesure
US7351323B2 (en) 2001-01-17 2008-04-01 Arkray, Inc. Quantitative analyzing method and quantitative analyzer using sensor
CN101504408A (zh) * 2007-09-28 2009-08-12 生命扫描有限公司 区分对照溶液与生理学样本的系统和方法
EP2267149A1 (fr) * 2006-03-31 2010-12-29 LifeScan, Inc. Pprocédé de discrimination entre une solution de contrôle et un échantillon physiologique
US8551320B2 (en) 2008-06-09 2013-10-08 Lifescan, Inc. System and method for measuring an analyte in a sample
US8603768B2 (en) 2008-01-17 2013-12-10 Lifescan, Inc. System and method for measuring an analyte in a sample

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20050103624A1 (en) * 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
JP4209767B2 (ja) 2001-06-12 2009-01-14 ペリカン テクノロジーズ インコーポレイテッド 皮膚の性状の一時的変化に対する適応手段を備えた自動最適化形切開器具
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100460A2 (fr) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Actionneur electrique de lancette
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
WO2002100252A2 (fr) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Appareil de prelevement sanguin et procede connexe
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
JP4031322B2 (ja) * 2002-08-26 2008-01-09 独立行政法人科学技術振興機構 液滴操作装置
EP1557662B1 (fr) * 2002-10-31 2016-07-13 Panasonic Healthcare Holdings Co., Ltd. Procede de determination servant a identifier automatiquement un liquide a analyser, et solution-etalon pour biocapteur
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
WO2004107964A2 (fr) 2003-06-06 2004-12-16 Pelikan Technologies, Inc. Procede et appareil d'echantillonnage de fluides anatomiques et d'examen de l'analysat
WO2006001797A1 (fr) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Element penetrant peu douloureux
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US8071030B2 (en) 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US8679853B2 (en) 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
CN1846131B (zh) 2003-06-20 2012-01-18 霍夫曼-拉罗奇有限公司 制备窄的均匀试剂条的方法和试剂
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
EP1678491B1 (fr) * 2003-10-31 2010-03-10 Lifescan Scotland Ltd Metre utilise dans un procede ameliore permettant de reduire les interferences dans un capteur electrochimique au moyen de deux potentiels differents appliques
US7655119B2 (en) * 2003-10-31 2010-02-02 Lifescan Scotland Limited Meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (fr) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Procédé et appareil permettant d'améliorer le flux fluidique et le prélèvement d'échantillons
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
EP1765194A4 (fr) 2004-06-03 2010-09-29 Pelikan Technologies Inc Procede et appareil pour la fabrication d'un dispositif d'echantillonnage de liquides
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
TW200641352A (en) 2005-04-08 2006-12-01 Bayer Healthcare Llc Oxidizable species as an internal reference in control solutions for biosensors
US20070235346A1 (en) * 2006-04-11 2007-10-11 Popovich Natasha D System and methods for providing corrected analyte concentration measurements
US7909983B2 (en) * 2006-05-04 2011-03-22 Nipro Diagnostics, Inc. System and methods for automatically recognizing a control solution
WO2007132903A1 (fr) 2006-05-16 2007-11-22 Arkray, Inc. Procédé d'identification automatique de liquide de commande
EP2116844A1 (fr) 2007-01-23 2009-11-11 Arkray, Inc. Procede de determination de liquide de commande et dispositif d'analyse
US20100264942A1 (en) * 2007-10-31 2010-10-21 Arkray, Inc. Control Liquid Identifying Method and Analysis Device
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CN111198218B (zh) * 2020-02-27 2021-04-16 浙江大学 一种高温油基钻井液电特性测量方法与装置

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2023846A (en) * 1978-06-16 1980-01-03 Inst Sieroterapico Measurement electrode system
US4431507A (en) * 1981-01-14 1984-02-14 Matsushita Electric Industrial Co., Ltd. Enzyme electrode
JPS63139245A (ja) * 1986-12-01 1988-06-11 Matsushita Electric Ind Co Ltd バイオセンサ
JPS63317097A (ja) * 1987-06-19 1988-12-26 Matsushita Electric Ind Co Ltd バイオセンサ
JPH01134246A (ja) * 1987-11-19 1989-05-26 Matsushita Electric Ind Co Ltd バイオセンサ
JPH0262952A (ja) * 1988-01-29 1990-03-02 Matsushita Electric Ind Co Ltd バイオセンサ及びその製造方法
EP0732406A1 (fr) * 1995-03-17 1996-09-18 Matsushita Electric Industrial Co., Ltd. Procédé et dispositif de quantification d'un substrat dans un échantillon liquide avec un capteur biologique
US5650062A (en) * 1995-03-17 1997-07-22 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264103A (en) * 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
FR2701117B1 (fr) * 1993-02-04 1995-03-10 Asulab Sa Système de mesures électrochimiques à capteur multizones, et son application au dosage du glucose.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2023846A (en) * 1978-06-16 1980-01-03 Inst Sieroterapico Measurement electrode system
US4431507A (en) * 1981-01-14 1984-02-14 Matsushita Electric Industrial Co., Ltd. Enzyme electrode
JPS63139245A (ja) * 1986-12-01 1988-06-11 Matsushita Electric Ind Co Ltd バイオセンサ
JPS63317097A (ja) * 1987-06-19 1988-12-26 Matsushita Electric Ind Co Ltd バイオセンサ
JPH01134246A (ja) * 1987-11-19 1989-05-26 Matsushita Electric Ind Co Ltd バイオセンサ
JPH0262952A (ja) * 1988-01-29 1990-03-02 Matsushita Electric Ind Co Ltd バイオセンサ及びその製造方法
EP0732406A1 (fr) * 1995-03-17 1996-09-18 Matsushita Electric Industrial Co., Ltd. Procédé et dispositif de quantification d'un substrat dans un échantillon liquide avec un capteur biologique
US5650062A (en) * 1995-03-17 1997-07-22 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 012, no. 399 (P-775), 24 October 1988 (1988-10-24) & JP 63 139245 A (MATSUSHITA ELECTRIC IND CO LTD), 11 June 1988 (1988-06-11) *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 169 (C-587), 21 April 1989 (1989-04-21) & JP 63 317097 A (MATSUSHITA ELECTRIC IND CO LTD), 26 December 1988 (1988-12-26) *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 382 (P-923), 24 August 1989 (1989-08-24) & JP 01 134246 A (MATSUSHITA ELECTRIC IND CO LTD), 26 May 1989 (1989-05-26) *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 245 (P-1052), 24 May 1990 (1990-05-24) & JP 02 062952 A (MATSUSHITA ELECTRIC IND CO LTD), 2 March 1990 (1990-03-02) *
See also references of WO0155712A1 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351323B2 (en) 2001-01-17 2008-04-01 Arkray, Inc. Quantitative analyzing method and quantitative analyzer using sensor
EP1357194A3 (fr) * 2002-04-26 2004-01-02 Matsushita Electric Industrial Co., Ltd. adaptateur pour la connection d'un capteur biologique avec un dispositif de mesure
EP2267149A1 (fr) * 2006-03-31 2010-12-29 LifeScan, Inc. Pprocédé de discrimination entre une solution de contrôle et un échantillon physiologique
US8449740B2 (en) 2006-03-31 2013-05-28 Lifescan, Inc. Systems and methods for discriminating control solution from a physiological sample
US8778168B2 (en) 2007-09-28 2014-07-15 Lifescan, Inc. Systems and methods of discriminating control solution from a physiological sample
EP2042865A3 (fr) * 2007-09-28 2010-12-22 LifeScan, Inc. Systèmes et procédé pour distinguer de solution de contrôle d'un échantillon physiologique
CN101504408A (zh) * 2007-09-28 2009-08-12 生命扫描有限公司 区分对照溶液与生理学样本的系统和方法
CN101504408B (zh) * 2007-09-28 2014-07-23 生命扫描有限公司 区分对照溶液与生理学样本的系统和方法
US9157110B2 (en) 2007-09-28 2015-10-13 Lifescan, Inc. Systems and methods of discriminating control solution from a physiological sample
US8603768B2 (en) 2008-01-17 2013-12-10 Lifescan, Inc. System and method for measuring an analyte in a sample
US8709739B2 (en) 2008-01-17 2014-04-29 Lifescan, Inc. System and method for measuring an analyte in a sample
US8916040B2 (en) 2008-01-17 2014-12-23 Lifescan, Inc. System and method for measuring an analyte in a sample
US9739749B2 (en) 2008-01-17 2017-08-22 Lifescan, Inc. System and method for measuring an analyte in a sample
US8551320B2 (en) 2008-06-09 2013-10-08 Lifescan, Inc. System and method for measuring an analyte in a sample
US9784707B2 (en) 2008-06-09 2017-10-10 Lifescan, Inc. System and method for measuring an analyte in a sample

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JP2001208718A (ja) 2001-08-03
EP1172649A4 (fr) 2002-05-08
EP1172649B1 (fr) 2009-06-03
US6881322B2 (en) 2005-04-19
US20020179440A1 (en) 2002-12-05
CN1172182C (zh) 2004-10-20
WO2001055712A1 (fr) 2001-08-02
DE60138856D1 (de) 2009-07-16
CN1363037A (zh) 2002-08-07
JP3982133B2 (ja) 2007-09-26

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