EP1161217A1 - Device for two-way transfer of a liquid between a bottle and a cartridge - Google Patents

Device for two-way transfer of a liquid between a bottle and a cartridge

Info

Publication number
EP1161217A1
EP1161217A1 EP00910990A EP00910990A EP1161217A1 EP 1161217 A1 EP1161217 A1 EP 1161217A1 EP 00910990 A EP00910990 A EP 00910990A EP 00910990 A EP00910990 A EP 00910990A EP 1161217 A1 EP1161217 A1 EP 1161217A1
Authority
EP
European Patent Office
Prior art keywords
cartridge
piston
bottle
shuttle
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00910990A
Other languages
German (de)
French (fr)
Other versions
EP1161217B1 (en
Inventor
Yves Arnissolle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sedat SAS
Original Assignee
Sedat SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sedat SAS filed Critical Sedat SAS
Publication of EP1161217A1 publication Critical patent/EP1161217A1/en
Application granted granted Critical
Publication of EP1161217B1 publication Critical patent/EP1161217B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/905—Aseptic connectors or couplings, e.g. frangible, piercable

Definitions

  • B idirec tional transfer device for a liquid between a vial and a cartridge.
  • the present invention relates to a device for bidirectional transfer of a liquid between a bottle provided with a perforable cap and a cartridge comprising a cylindrical reservoir in which slides a perforable piston
  • the practitioner first injects all the liquid contained in the syringe into the vial. For this purpose, he pierces the stopper of the vial using the needle provided on the syringe and intended to carry out the injection itself
  • the mixture obtained is drawn back into the syringe through the injection needle. After withdrawal of the needle from the vial, the actual injection is carried out on the patient. extemporaneous with such means is relatively awkward and moreover presents the risk that the injection needle becomes soiled when it is introduced into the vial
  • Fluid transfer devices are also known between a bottle and a flexible bag intended in particular for transfusion. However, these devices are not adapted to allow bidirectional transfer of a liquid between a bottle and a syringe.
  • the object of the invention is to provide a solution to the problem of the bidirectional transfer of a liquid between a vial and an injection syringe by providing a device which is easy to handle, and guarantees satisfactory asepsis.
  • the subject of the invention is a device for bidirectional transfer of a liquid between a bottle provided with a perforable cap and a cartridge comprising a cylindrical reservoir in which slides a perforable piston, characterized in that it comprises a body comprising means for hooking the bottle, a member for connecting the perforable piston to the body and a shuttle displaceable relative to the body and to said connecting member, the shuttle carrying a hollow needle whose first end is suitable for perforation of the piston and the second end of which is suitable for perforating the plug O 00/54723 _ PCTtFROO / 00671
  • the transfer device comprises one or more of the following characteristics
  • Said member connecting the piston to the body comprises means for hooking on the body and is movable relative to the body from an initial position in which the hooking means are not in engagement with the body, and a final position in which the attachment means are engaged with the body, thus ensuring the connection of the piston to the body,
  • said connecting member of the piston to the body comprises a threaded protuberance for fixing it in a threaded recess of the piston
  • said shuttle is slidably mounted in a conduit of said piston connecting member to the body
  • said conduit internally comprises a stop limiting the displacement travel of the shuttle
  • a protective cap in the form of a cap initially mounted on the body, which protective cap comprises means for hooking onto the reservoir of the cartridge,
  • the body has an extension surrounding said shuttle and extending beyond the first end of the needle
  • It includes at least one stop limiting the axial displacement of the reservoir with respect to the connecting member, preventing the extraction of the piston from the reservoir -
  • the invention also relates to an injection kit comprising a bidirectional transfer device as defined above, as well as a pule and a vial, in which the carpule is initially linked to the organ of solidarity and the vial is initially e to the body
  • FIG. 1 is a longitudinal sectional view of the transfer device according to the invention in its storage position
  • FIGS. 2 and 3 are views respectively in longitudinal section and in perspective with partial cutaway of the transfer device in its initial phase of use
  • FIG. 4 is a longitudinal sectional view of the transfer device after penetration of the ends of the needle into the vial and the cartridge
  • - Figure 5 is a longitudinal sectional view of the transfer device during the transfer phase of the fluid from the cartridge to the bottle
  • - Figure 6 is a longitudinal sectional view of the transfer device when all the liquid has been transferred to the bottle
  • FIG. 7 is a view in longitudinal section of the transfer device during the collection of the mixture from the bottle to the cartridge
  • FIG. 8 is a section view of an alternative embodiment of the transfer device according to the invention.
  • FIG. 9 is a partial perspective view of the connecting member of the device of Figure 8.
  • the transfer device 10 shown in FIG. 1 is suitable for the bidirectional transfer of fluid between a cartridge 12 and a bottle 14
  • This device is generally of revolution around its longitudinal axis II essentially comprises a body 16, a protective cap 18, a shuttle 20 carrying a hollow needle 22 and a screw pusher or connecting member 24 intended to ensure the axial so da ⁇ sation of the movable piston of the cartridge 12 and the body 16
  • FIG. 1 the transfer device 10, fitted with the cartridge 12 and the bottle 14, is shown in the storage position before use.
  • the cartridge 12 is intended to carry out an injection after having been extracted from the transfer device and equipped with an injection needle and an actuating pusher. It comprises a cylindrical reservoir 26 having at at the front a narrowed neck 28 closed by a perforated cap 30 supported by a head 31 The cap 30 is adapted to be perforated because an injection needle mounted on the head 31 of the cartridge for the purpose of carrying out an injection
  • the rear end denoted 32 of the reservoir 26 which is opposite the head 31, is closed by a perforable piston 34 mounted to slide in leaktight manner inside the reservoir 26
  • the piston 34 has axially a recess 36 opening out of the carpule This recess is internally threaded, in order to subsequently ensure the mounting by screwing of an actuating pusher in order to inject the liquid contained in the carpule
  • the piston 34 is made of a polymer material of given shore hardness
  • the cartridge 12 is initially filled with an injectable liquid 38
  • the bottle 14 comprises a glass body 40 having a neck 42 closed by a perforable cap 44
  • the neck 42 has a peripheral rim 46 defining a shoulder 48
  • the perforable cover 44 is made of a polymer material having substantially the same shore hardness as that in which the piston 34 is formed. Thus, the piston 34 and the cover 44 have the same resistance to the penetration of a point. materials in which the cover 44 and the piston 34 are made are the same In addition, their thicknesses measured along the axis XX are substantially identical
  • the bottle 14 is filled with a lyophilisa 50 constituting a powdered medicinal substance.
  • the lyophilisa 50 only partially fills the bottle.
  • the bottle is sealed under vacuum, so that the pressure prevailing inside the bottle is much lower than atmospheric pressure
  • the body 16 is traversed axially right through by a conduit 60
  • the conduit 60 defines a housing 62 for receiving the bottle
  • This housing has a counterbore 64 for receiving the rim 46 of the bottle 14 in order to ensure the 'hooking of the latter
  • the counterbore 64 is delimited by projections 66 defining hooking profiles of the bottle They are adapted to cooperate with the shoulder 48 delimited by the neck of the bottle
  • the projections 66 have converging ramps from the open end of the housing 62, in order to facilitate the introduction of the bottle into the body
  • the conduit 60 has a cylindrical chamber 70 in which the shuttle 20 and the connecting member 24 are received.
  • the chambers 62 and 70 are linked by an intermediate section 74 of reduced diameter.
  • the chamber 70 has a diameter sufficient to allow the passage of the reservoir 26
  • the total length of the chamber 70 and of the section 74 is advantageously greater than that of the hollow needle 22
  • the section 74 is partially closed at its end opening into the chamber 62 by a diaphragm 75 defining a sufficient opening for the passage of the needle 22 This diaphragm 75 partially covers the membrane 44 of the bottle 14
  • the body 16 presents externally a shoulder 76 reducing the thickness of the body. This is suitable for mounting the protective cap 18.
  • the protective cap 18 generally has the shape of a cap and defines a housing 78 capable of receiving the cartridge 16 and of being engaged from its open end partially around the body 16 It also comprises externally, at its blind end, means 80 for attachment to the head 31 of the cartridge As shown in perspective in FIG. 3, the means 80 comprise a fork 82 delimited by two arms defining a notch 84 extending radially, and the width of which corresponds to the diameter of the narrowed neck 28 In rear of the fork 82, is provided in the protective cap 80, a chamber 86 for receiving the head 31
  • the connecting member 24 has a tubular shape II has a cylindrical side wall 90 delimiting a conduit 91 II is closed at an upper end by a threaded protuberance 92 projecting outwards This protuberance 92 is screwed inside I 'tapped recess 36 and thus ensures the axial solida ⁇ sation of the connecting member 24 and the piston 34
  • the protuberance 92 is pierced axially with a conduit 94 whose diameter corresponds substantially to the outside diameter of the needle 22
  • the connecting member 24 has on the outer surface of its wall 90 two successive grooves 96A, 96B spaced axially These are separated by a distance
  • the grooves 96A and 96B are adapted to cooperate with a peripheral bead 98 formed in the pipe 60 of the body
  • the bead is provided at the end of the intermediate section 74 opening into the chamber 70
  • the groove 96 and the peripheral bead 98 are adapted to ensure the attachment of the connecting member 24 and the body 16 Initially, the bead 98 is engaged in the lower groove 96A
  • the distance ⁇ ⁇ is chosen to be less than the length of the section intermediate 74 shortened diaphragm thickness 75
  • the wall 90 of the connecting member 24 has internally a peripheral bead 100, delimiting in the space circumscribed by the wall 90, a chamber 102 for confining the shuttle 20
  • the bead 100 forms an axial stop for stopping shuttle 20
  • the shuttle 20 consists of a cylindrical neck 1 10 crossed axially right through by the hollow needle 22
  • a first end 112 of the needle protrudes beyond the slide 110 and is received initially in the passage 94
  • the second end noted 114 of the needle 22 protrudes behind the couhsseau 110 and is initially disposed opposite the lid 44 of the bottle.
  • the two ends of the needles have similar bevels, so that they have points having the same profiles opposite the piston 34 and the cover 44
  • the diameter of the neck 110 is greater than the diameter of the passage defined by the diaphragm 75
  • the longitudinal cylinder 110 has, over part of its length received in the confinement chamber 102, longitudinal ribs 1 16 (FIG. 3) defining a shoulder 1 18 adapted to cooperate with the peripheral bead 100 forming a stop
  • the longitudinal ribs 1 16 provide guiding in translation of the shuttle 20 inside the connecting member 24
  • the length of the ribs 116 is less than the length of the confinement chamber 1 12 defined between the protuberance 92 and the bead 100 This difference in length is noted ⁇ 2
  • the connecting member 24 is released from the body 16, so that the hooking means consisting of the groove 96A and the bead 98 are engaged.
  • the shuttle 20 is pressed on the peripheral bead 100 by means of the shoulder 118, so that the end 112 of the needle extends inside the protuberance 92. It is thus separated of the perforable piston 34. The shuttle is then moved away from the distance l 2 of the protuberance 92.
  • the end 114 of the hollow needle is kept apart from the cover 44 by pressing the lower end of the connecting member 24 on the peripheral bead 98 and pressing the shuttle 20 on the bead 100 L the lower end of the couiisseau 110 is then separated by a distance l 3 from the cover 44
  • the use of the transfer device 10 is carried out as follows
  • the protective cap 18 is first removed and returned.
  • the attachment means 80 are engaged around the head 31 of the cartridge, as shown in FIGS. 2 and 3
  • the protective cap 18 and the body 16 are then brought towards each other in the direction of the arrow F4, as shown in FIG. 4 During this axial movement, the shuttle 20 moves relative to the body 16 until a transfer position in which the end 1 12 projects inside the cartridge 12 after having crossed the piston 34 and the end 114 projects inside the bottle 14 after having crossed the cover 44
  • the movement of the protective cap 18 causes the cartridge 12 to sink into the chamber 70 of the body.
  • the connecting member 24 is moved towards the bottle 14 by being pushed by the cartridge La groove 96A emerges from the peripheral flange 98 and the lower end of the member 24 moves until the flange 98 is received in the peripheral groove 96B
  • the elastic engagement of the flange let 98 in the groove 96B ensures the final axial attachment of the connecting member 24 and the body 16
  • the couch 1 10 comes to bear, on the one hand, on the end protuberance 92 of the connecting member and, on the other hand, against the diaphragm 75 s extending above the cover 44 closing the bottle In this position, shown in FIG. 4, the hollow needle 22 ensures communication between the bottle 14 and the cartridge 12
  • the filling of the bottle 14 is made possible since it is initially at a pressure below atmospheric pressure
  • the transfer device 10 is turned over as shown in FIG. 7 then the protective cap 18 is separated from the body 16 in order to suck the extemporaneous mixture in the cartridge
  • the piston 34 is retained integral with the body 16 by means of the connecting member 24 attached to the body by the cooperation of the groove 96B and peripheral bead 98
  • the transfer device thus devoid of the cartridge is then discarded. It should be noted that in this position, the end 112 of the needle is protected due to the extension of the body 16, thus avoiding any risk of accidental puncture
  • the length of the body 16 is chosen to be sufficient to extend beyond the end 12 of the hollow needle
  • the device according to the invention allows a transfer of the liquid between the cartridge and the bottle without risk of contamination of the liquid.
  • the two ends of the hollow needle are constantly protected inside the closed space delimited by the connecting member 24, the body 16 and the bottle 14
  • This protection is further reinforced by the presence of the protective cap 18 during the device storage phases. Furthermore, the simultaneous penetration of the two ends of the needles avoids any risk of entry of ambient air into the cartridge or the vial.
  • the transfer device When the transfer device is pre-equipped with a bottle 14 and a cartridge 12 before delivery, the transfer can be carried out without it being Make sure that the cartridge or the bottle comes into contact with your hand. Thus, any risk of manual soiling is eliminated.
  • This figure shows a transfer device 200 associated with a cartridge 12 and a bottle 14 containing a lyophilisa.
  • the transfer device 200 comprises a body 16 in which the bottle 14 is axially mobilized, a connecting member 24 sliding relative to the body and a needle-holder shuttle 20 freely sliding along the axis of the connecting member 24 .
  • the transfer device 200 further comprises a cartridge support 202 comprising means 203 for axially hooking the cap 18.
  • the connecting member 24 comprises, in addition to the cylindrical wall 90, an external sleeve 204 coaxial surrounding the cylindrical wall 90 and connected thereto by an annular wall 206.
  • the sleeve 204 is slidably mounted inside the body 16. It has protruding and recessed profiles 208 adapted to cooperate with complementary profiles carried by the side wall of the body 16, in order to ensure their axial solidarisatio ⁇ after perforation of the cover 44 by the end 1 14 of the hollow needle.
  • the sleeve 204 extends beyond the threaded protuberance 92 screwed into the piston 34 of the cartridge.
  • the sleeve 204 has in its side wall two pairs of longitudinal slots 210, 212 offset angularly by 90 °.
  • the slots 210 have a double length of the slots 212.
  • the cartridge holder 202 comprises an inner tube 220 for receiving the body 26 of the cartridge. It is partially closed at its lower end by a shoulder 222 on which the open end of the reservoir 26 of the cartridge is supported axially. The shoulder 222 is extended by a tubular section 224 sliding along the cylindrical wall 90 of the connecting member.
  • the tube 220 is surrounded in its lower part by a coaxial sleeve 230 carrying two diametrically opposite projections 232 adapted to slide inside one or the other of the pairs of slots 210, 212.
  • the projections 232 are introduced into one or the other of the pairs of slots.
  • the projections 232 are arranged in the short slots 212.
  • the transfer device when used with a cartridge with a capacity of 2.3 ml, that is to say a cartridge whose body length is double that of a cartridge of 1.3 ml, the projections 232 are engaged in slots 210.
  • cartridge holder 202 provides axial guidance of the cartridge 12 when it slides relative to the connecting member 24.
  • the presence of the two pairs of slots on the sleeve 204 of the connecting member makes it possible to use the same transfer device with cartridges of two different capacities.
  • the mixture thus formed is drawn back into the cartridge 12 through the needle.
  • the reservoir of the cartridge is pulled by means of the cap hung on the needle holder 202.
  • the projections 232 slide along the length of the slots 210 or 212. When the projections 232 come into contact with the end of these slots, they form a stop and oppose the subsequent displacement of the cartridge 12.
  • the projections 232 forming a stop.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Opening Bottles Or Cans (AREA)

Abstract

The invention concerns a device for the two-way transfer of a liquid (38) between a bottle (14) provided with a cap (44) capable of being perforated at a cartridge (12) comprising a cylindrical reservoir (26) wherein slides a piston (34) capable of being perforated. It comprises: a body (16) including means to be fixed on the bottle (14); a member (24) linking the piston (34) capable of being perforated to the body (16); a shuttle (20) relative to the body (16) and said linking member (24), the shuttle bearing a hollow needle (22) whereof one first end (112) is adapted to pierce the piston (34) and whereof the second end (114) is adapted to pierce the cap (44). The shuttle (20) is mobile between a piston wherein the needle ends (112, 114) are spaced apart from the piston (34) capable of being perforated and the cap (44) capable of being perforated and an end-of-stroke transferring position wherein the needle ends (112, 114) are received in the cartridge (12) and the bottle (14).

Description

Dispos itif de trans fert b idirec t ionnel d ' un liquide entre un flacon e t une carpule . B idirec tional transfer device for a liquid between a vial and a cartridge.
La présente invention concerne un dispositif de transfert bidirectionnel d'un liquide entre un flacon muni d un boucnon perforable et une carpule comprenant un réservoir cylindrique dans lequel coulisse un piston perforableThe present invention relates to a device for bidirectional transfer of a liquid between a bottle provided with a perforable cap and a cartridge comprising a cylindrical reservoir in which slides a perforable piston
Il est fréquent que avant de procéder a une injection à l'aide d'une se- ringue, le praticien doive mélanger le liquide contenu initialement dans la seringue avec un lyophilisa contenu initialement dans un flacon muni d'un bouchon perforableIt is frequent that before carrying out an injection using a syringe, the practitioner must mix the liquid initially contained in the syringe with a lyophilisa initially contained in a vial provided with a perforable cap.
Afin de réaliser extemporaπémeπt le mélange, le praticien injecte d'abord dans le flacon la totalité du liquide contenu dans la seringue A cet effet, il per- fore le bouchon du flacon grâce à l'aiguille prévue sur la seringue et destinée à procéder à l'injection proprement diteIn order to achieve extemporaπémeπt the mixture, the practitioner first injects all the liquid contained in the syringe into the vial. For this purpose, he pierces the stopper of the vial using the needle provided on the syringe and intended to carry out the injection itself
Après dissolution du lyophilisa dans le liquide, le mélange obtenu est ré- aspiré dans la seringue au travers de l'aiguille d'injection Après retrait de l'aiguille du flacon, l'injection proprement dite est effectuée sur le patient La réalisation du mélange extemporané avec de tels moyens est relativement malaisée et présente de plus le risque que l'aiguille d'injection soit souillée lors de son introduction dans le flaconAfter the lyophilisa has dissolved in the liquid, the mixture obtained is drawn back into the syringe through the injection needle. After withdrawal of the needle from the vial, the actual injection is carried out on the patient. extemporaneous with such means is relatively awkward and moreover presents the risk that the injection needle becomes soiled when it is introduced into the vial
On connaît par ailleurs des dispositifs de transfert de fluide entre un flacon et une poche souple destinée notamment à une transfusion Toutefois ces dispositifs ne sont pas adaptés pour permettre le transfert bidirectionnel d'un liquide entre un flacon et une seringueFluid transfer devices are also known between a bottle and a flexible bag intended in particular for transfusion. However, these devices are not adapted to allow bidirectional transfer of a liquid between a bottle and a syringe.
L'invention a pour but de fournir une solution au problème du transfert bidirectionnel d'un liquide entre un flacon et une seringue d'injection en fournissant un dispositif qui soit d'un maniement aisé, et garantisse une asepsie satis- faisanteThe object of the invention is to provide a solution to the problem of the bidirectional transfer of a liquid between a vial and an injection syringe by providing a device which is easy to handle, and guarantees satisfactory asepsis.
A cet effet, l'invention a pour objet un dispositif de transfert bidirectionnel d'un liquide entre un flacon muni d'un bouchon perforable et une carpule comprenant un réservoir cylindrique dans lequel coulisse un piston perforable, caractérisé en ce qu'il comporte un corps comportant des moyens d'accrochage du flacon, un organe de liaison du piston perforable au corps et une navette dé- plaçable par rapport au corps et audit organe de liaison, la navette portant une aiguille creuse dont une première extrémité est adaptée pour la perforation du piston et dont la seconde extrémité est adaptée pour la perforation du bouchon O 00/54723 _ PCTtFROO/00671To this end, the subject of the invention is a device for bidirectional transfer of a liquid between a bottle provided with a perforable cap and a cartridge comprising a cylindrical reservoir in which slides a perforable piston, characterized in that it comprises a body comprising means for hooking the bottle, a member for connecting the perforable piston to the body and a shuttle displaceable relative to the body and to said connecting member, the shuttle carrying a hollow needle whose first end is suitable for perforation of the piston and the second end of which is suitable for perforating the plug O 00/54723 _ PCTtFROO / 00671
et en ce que la navette est déplacable entre une position initiale dans laquelle les extrémités de l'aiguille sont espacées du piston perforable et du bouchon perforable et une position finale de transfert dans laquelle les extrémités de l'aiguille sont reçues dans la carpule et le flacon Suivant des modes particuliers de réalisation, le dispositif de transfert comporte l'une ou plusieurs des caractéristiques suivantesand in that the shuttle is movable between an initial position in which the ends of the needle are spaced from the perforable piston and the perforable plug and a final transfer position in which the ends of the needle are received in the cartridge and the bottle According to particular embodiments, the transfer device comprises one or more of the following characteristics
- ledit organe de liaison du piston au corps comporte des moyens d'accrochage sur le corps et est mobile par rapport au corps depuis une position initiale dans laquelle les moyens d'accrochage ne sont pas en prise avec le corps, et une position finale dans laquelle les moyens d'accrochage sont en prise avec le corps, assurant alors la liaison du piston au corps ,- Said member connecting the piston to the body comprises means for hooking on the body and is movable relative to the body from an initial position in which the hooking means are not in engagement with the body, and a final position in which the attachment means are engaged with the body, thus ensuring the connection of the piston to the body,
- ledit organe de liaison du piston au corps comporte une protubérance filetée pour sa fixation dans un évidemeπt taraudé du piston ,said connecting member of the piston to the body comprises a threaded protuberance for fixing it in a threaded recess of the piston,
- ladite navette est montée coulissante dans un conduit dudit organe de liaison du piston au corps- said shuttle is slidably mounted in a conduit of said piston connecting member to the body
- ledit conduit comporte intérieurement une butée limitant la course de déplacement de la navette ,said conduit internally comprises a stop limiting the displacement travel of the shuttle,
- il comporte un capuchon protecteur en forme de coiffe initialement montée sur le corps, lequel capuchon protecteur comporte des moyens d'accrochage sur le réservoir de la carpule ,it includes a protective cap in the form of a cap initially mounted on the body, which protective cap comprises means for hooking onto the reservoir of the cartridge,
- le corps présente un prolongement entourant ladite navette et s'étendant au delà de la première extrémité de l'aiguille ,the body has an extension surrounding said shuttle and extending beyond the first end of the needle,
- il comporte au moins une butée limitant le déplacement axial du réservoir par rapport à l'organe de liaison, interdisant l'extraction du piston hors du réser-- It includes at least one stop limiting the axial displacement of the reservoir with respect to the connecting member, preventing the extraction of the piston from the reservoir -
- il comporte un support de carpule sur lequel prend appui axialement le réservoir de la carpule, et l'un des supports de carpule et de l'organe de liaison comporte au moins une saillie, formant ladite butée, reçue dans une fente longitudinale de l'autre, du support de carpule et de l'organe de liaison pour limiter leur déplacement axial relatif entre le réservoir et l'organe de liaison- It includes a carpule support on which the carpule reservoir bears axially, and one of the carpule supports and of the connecting member comprises at least one projection, forming said stop, received in a longitudinal slot of the other, the cartridge holder and the connecting member to limit their relative axial displacement between the reservoir and the connecting member
L'invention a également pour objet un nécessaire d'injection comportant un dispositif de transfert bidirectionnel tel que défini ci-dessus, ainsi qu'une car- pule et un flacon, dans lequel la carpule est initialement liée a l'orgare de solida- πsation et le flacon est initialement é au corpsThe invention also relates to an injection kit comprising a bidirectional transfer device as defined above, as well as a pule and a vial, in which the carpule is initially linked to the organ of solidarity and the vial is initially e to the body
L'invention sera mieux comprise à la lecture de la description qui va suivre donnée uniquement à titre d'exemple et faite en se référant aux dessins sur lesquelsThe invention will be better understood on reading the description which follows, given solely by way of example and made with reference to the drawings in which
- la figure 1 est une vue en coupe longitudinale du dispositif de transfert selon l'invention dans sa position de stockage- Figure 1 is a longitudinal sectional view of the transfer device according to the invention in its storage position
- les figures 2 et 3 sont des vues respectivement en coupe longitudinale et en perspective avec arrachement partiel du dispositif de transfert dans sa phase initiale d'utilisation ,FIGS. 2 and 3 are views respectively in longitudinal section and in perspective with partial cutaway of the transfer device in its initial phase of use,
- la figure 4 est une vue en coupe longitudinale du dispositif de transfert après pénétration des extrémités de l'aiguille dans le flacon et la carpule- Figure 4 is a longitudinal sectional view of the transfer device after penetration of the ends of the needle into the vial and the cartridge
- la figure 5 est une vue en coupe longitudinale du dispositif αe transfert lors de la phase de transfert du fluide de la carpule vers le flacon , - la figure 6 est une vue en coupe longitudinale du dispositif de transfert alors que tout le liquide a été transféré dans le flacon ,- Figure 5 is a longitudinal sectional view of the transfer device during the transfer phase of the fluid from the cartridge to the bottle, - Figure 6 is a longitudinal sectional view of the transfer device when all the liquid has been transferred to the bottle,
- la figure 7 est une vue en coupe longitudinale du dispositif de transfert lors du recueil du mélange depuis le flacon vers la carpule ,FIG. 7 is a view in longitudinal section of the transfer device during the collection of the mixture from the bottle to the cartridge,
- la figure 8 est une vue en section d'une variante de réalisation du dis- positif de transfert selon l'invention etFIG. 8 is a section view of an alternative embodiment of the transfer device according to the invention and
- la figure 9 est une vue partielle en perspective de l'organe de liaison du dispositif de la figure 8- Figure 9 is a partial perspective view of the connecting member of the device of Figure 8
Le dispositif de transfert 10 représenté sur la figure 1 est adapté au transfert bidirectionnel de fluide entre une carpule 12 et un flacon 14 Ce dispo- sitif est généralement de révolution autour de son axe longitudinal II comporte essentiellement un corps 16, un capuchon protecteur 18, une navette 20 portant une aiguille creuse 22 et un poussoir à vis ou organe de liaison 24 destiné à assurer la so daπsation axiale du piston mobile de la carpule 12 et le corps 16The transfer device 10 shown in FIG. 1 is suitable for the bidirectional transfer of fluid between a cartridge 12 and a bottle 14 This device is generally of revolution around its longitudinal axis II essentially comprises a body 16, a protective cap 18, a shuttle 20 carrying a hollow needle 22 and a screw pusher or connecting member 24 intended to ensure the axial so daπsation of the movable piston of the cartridge 12 and the body 16
Sur la figure 1 , le dispositif de transfert 10, équipe de la carpule 12 et du flacon 14, est représenté en position de stockage avant utilisationIn FIG. 1, the transfer device 10, fitted with the cartridge 12 and the bottle 14, is shown in the storage position before use.
La carpule 12 est destinée à réaliser une injection après avoir été extraite du dispositif de transfert et équipée d'une aiguille d'injection et d'un poussoir d'actionnement Elle comporte un réservoir cylindrique 26 présentant à l'avant un col rétréci 28 obture par un opercule perforaole 30 supporte par une tête 31 L opercule 30 est aαapte pour être perfore car une aiguille d injection montée sur la tête 31 de la carpule en vue αe procéder a une injectionThe cartridge 12 is intended to carry out an injection after having been extracted from the transfer device and equipped with an injection needle and an actuating pusher. It comprises a cylindrical reservoir 26 having at at the front a narrowed neck 28 closed by a perforated cap 30 supported by a head 31 The cap 30 is adapted to be perforated because an injection needle mounted on the head 31 of the cartridge for the purpose of carrying out an injection
L extrémité arrière notée 32 du réservoir 26 qui est opposée à la tête 31 , est obturée par un piston perforable 34 monté coulissant de manière étanche à l'intérieur du réservoir 26 Le piston 34 présente axialement un évidement 36 débouchant à l'extérieur de la carpule Cet évidement est taraudé intérieurement, afin d'assurer ultérieurement le montage par vissage d'un poussoir d'actionnement en vue de réaliser l'injection du liquide contenu dans la carpule Le piston 34 est réalisé dans un matériau polymère de dureté shore donnéeThe rear end denoted 32 of the reservoir 26 which is opposite the head 31, is closed by a perforable piston 34 mounted to slide in leaktight manner inside the reservoir 26 The piston 34 has axially a recess 36 opening out of the carpule This recess is internally threaded, in order to subsequently ensure the mounting by screwing of an actuating pusher in order to inject the liquid contained in the carpule The piston 34 is made of a polymer material of given shore hardness
La carpule 12 est initialement emplie d'un liquide injectable 38 Le flacon 14 comporte un corps en verre 40 présentant un goulot 42 obturé par un opercule perforable 44 Le goulot 42 présente un rebord périphérique 46 définissant un épaulement 48The cartridge 12 is initially filled with an injectable liquid 38 The bottle 14 comprises a glass body 40 having a neck 42 closed by a perforable cap 44 The neck 42 has a peripheral rim 46 defining a shoulder 48
L'opercule perforable 44 est réalisé dans un matériau polymère ayant sensiblement la même dureté shore que celui dans lequel est formé le piston 34 Ainsi, le piston 34 et l'opercule 44 présentent la même résistance à l'enfoncement d'une pointe Avantageusement les matériaux dans lesquels sont réalisés l'opercule 44 et le piston 34 sont les mêmes De plus, leurs épaisseurs mesurées suivant l'axe X-X sont sensiblement identiquesThe perforable cover 44 is made of a polymer material having substantially the same shore hardness as that in which the piston 34 is formed. Thus, the piston 34 and the cover 44 have the same resistance to the penetration of a point. materials in which the cover 44 and the piston 34 are made are the same In addition, their thicknesses measured along the axis XX are substantially identical
Initialement, le flacon 14 est empli d'un lyophilisa 50 constituant une substance médicamenteuse en poudre Le lyophilisa 50 n emplit que partiellement le flacon Comme connu en soi, le flacon est scellé sous vide, de sorte que la pression régnant à l'intérieur du flacon est très inférieure à la pression atmosphériqueInitially, the bottle 14 is filled with a lyophilisa 50 constituting a powdered medicinal substance. The lyophilisa 50 only partially fills the bottle. As known per se, the bottle is sealed under vacuum, so that the pressure prevailing inside the bottle is much lower than atmospheric pressure
Le corps 16 est traversé axialement de part en part par un conduit 60 A une extrémité dite inférieure, le conduit 60 définit un logement 62 de réception du flacon Ce logement présente un lamage 64 de réception du rebord 46 du flacon 14 afin d'assurer l'accrochage de ce dernier En Darticulier le lamage 64 est délimité par des saillies 66 définissant des profils d'accrochage du flacon Elles sont adaptées pour coopérer avec l'épaulement 48 délimité par le goulot du flacon Les saillies 66 présentent des rampes convergentes depuis I extrémité ouverte du logement 62, afin de faciliter l'introduction du flacon dans le corpsThe body 16 is traversed axially right through by a conduit 60 At a so-called lower end, the conduit 60 defines a housing 62 for receiving the bottle This housing has a counterbore 64 for receiving the rim 46 of the bottle 14 in order to ensure the 'hooking of the latter In particular the counterbore 64 is delimited by projections 66 defining hooking profiles of the bottle They are adapted to cooperate with the shoulder 48 delimited by the neck of the bottle The projections 66 have converging ramps from the open end of the housing 62, in order to facilitate the introduction of the bottle into the body
A son autre extrémité αite supérieure le conduit 60 présente une chambre cylindrique 70 dans laquelle sont reçus la navette 20 et l'organe de liaison 24 Les chambres 62 et 70 sont liées par un tronçon intermédiaire 74 de diamètre réduitAt its other upper end, the conduit 60 has a cylindrical chamber 70 in which the shuttle 20 and the connecting member 24 are received. The chambers 62 and 70 are linked by an intermediate section 74 of reduced diameter.
La chamϋre 70 a un diamètre suffisant pour permettre le passage du réservoir 26 La longueur totale de la chambre 70 et du tronçon 74 est avantageusement supérieure à celle αe I aiguille creuse 22 Le tronçon 74 est partiellement obturé à son extrémité s'ouvrant dans la chambre 62 par un diaphragme 75 délimitant une ouverture suffisante pour le passage de l'aiguille 22 Ce diaphragme 75 recouvre partiellement la membrane 44 du flacon 14The chamber 70 has a diameter sufficient to allow the passage of the reservoir 26 The total length of the chamber 70 and of the section 74 is advantageously greater than that of the hollow needle 22 The section 74 is partially closed at its end opening into the chamber 62 by a diaphragm 75 defining a sufficient opening for the passage of the needle 22 This diaphragm 75 partially covers the membrane 44 of the bottle 14
A son extrémité supérieure, le corps 16 présente extérieurement un épaulement 76 réduisant I épaisseur du corps Celui-ci est adapté pour le montage du capuchon protecteur 18At its upper end, the body 16 presents externally a shoulder 76 reducing the thickness of the body. This is suitable for mounting the protective cap 18.
Le capuchon protecteur 18 a généralement la forme d'une coiffe et définit un logement 78 apte à recevoir la carpule 16 et à être engagé depuis son extrémité ouverte partiellement autour du corps 16 II comporte en outre extérieurement, à son extrémité borgne, des moyens 80 d'accrochage sur la tête 31 de la carpule Comme représenté en perspective sur la figure 3 les moyens 80 comportent une fourche 82 délimitée par deux bras définissant une encoche 84 s'étendant radialement, et dont la largeur correspond au diamètre du col rétréci 28 En arrière de la fourche 82, est prévue dans le capuchon protecteur 80, une chambre 86 de réception de la tête 31The protective cap 18 generally has the shape of a cap and defines a housing 78 capable of receiving the cartridge 16 and of being engaged from its open end partially around the body 16 It also comprises externally, at its blind end, means 80 for attachment to the head 31 of the cartridge As shown in perspective in FIG. 3, the means 80 comprise a fork 82 delimited by two arms defining a notch 84 extending radially, and the width of which corresponds to the diameter of the narrowed neck 28 In rear of the fork 82, is provided in the protective cap 80, a chamber 86 for receiving the head 31
L'organe de liaison 24 présente une forme tubulaire II comporte une paroi latérale cylindrique 90 délimitant un conduit 91 II est obturé à une extrémité supérieure par une protubérance filetée 92 faisant saillie vers l'extérieur Cette protubérance 92 est vissée a l'intérieur de I'évidement taraudé 36 et assure ainsi la solidaπsation axiale de l'organe de liaison 24 et du piston 34The connecting member 24 has a tubular shape II has a cylindrical side wall 90 delimiting a conduit 91 II is closed at an upper end by a threaded protuberance 92 projecting outwards This protuberance 92 is screwed inside I 'tapped recess 36 and thus ensures the axial solidaπsation of the connecting member 24 and the piston 34
La protubérance 92 est percée axialement d'un conduit 94 dont le diamètre correspond sensiblement au diamètre extérieur de l'aiguille 22 A son extrémité inférieure, I organe de liaison 24 présente sur la surface extérieure de sa paroi 90 deux gorges successives 96A, 96B espacées axialement Celles-ci sont séparées d'une distance Les gorges 96A et 96B sont adaptées pour coopérer avec un bourrelet périphérique 98 ménagé dans le con- duit 60 du corps Le bourrelet est prévu à l'extrémité du tronçon intermédiaire 74 débouchant dans la chambre 70The protuberance 92 is pierced axially with a conduit 94 whose diameter corresponds substantially to the outside diameter of the needle 22 At its lower end, the connecting member 24 has on the outer surface of its wall 90 two successive grooves 96A, 96B spaced axially These are separated by a distance The grooves 96A and 96B are adapted to cooperate with a peripheral bead 98 formed in the pipe 60 of the body The bead is provided at the end of the intermediate section 74 opening into the chamber 70
La gorge 96 et le bourrelet périphérique 98 sont adaptés pour assurer l'accrochage de l'organe de liaison 24 et du corps 16 Initialement, le bourrelet 98 est engagé dans la gorge inférieure 96A La distance \ι est choisie inférieure à la longueur du tronçon intermédiaire 74 raccourci de l'épaisseur du diaphragme 75The groove 96 and the peripheral bead 98 are adapted to ensure the attachment of the connecting member 24 and the body 16 Initially, the bead 98 is engaged in the lower groove 96A The distance \ ι is chosen to be less than the length of the section intermediate 74 shortened diaphragm thickness 75
La paroi 90 de l'organe de liaison 24 présente intérieurement un bourrelet périphérique 100, délimitant dans l'espace circonscrit par la paroi 90, une chambre 102 de confinement de la navette 20 Ainsi, le bourrelet 100 forme une butée axiale d'arrêt de la navette 20The wall 90 of the connecting member 24 has internally a peripheral bead 100, delimiting in the space circumscribed by the wall 90, a chamber 102 for confining the shuttle 20 Thus, the bead 100 forms an axial stop for stopping shuttle 20
La navette 20 est constituée d'un cou sseau cylindrique 1 10 traversé axialement de part en part par l'aiguille creuse 22 Ainsi, une première extrémité 112 de l'aiguille fait saillie au delà du coulisseau 110 et est reçue initialement dans le passage 94 La seconde extrémité notée 114 de l'aiguille 22 fait saillie en arrière du couhsseau 110 et est initialement disposée en regard de I opercule 44 du flaconThe shuttle 20 consists of a cylindrical neck 1 10 crossed axially right through by the hollow needle 22 Thus, a first end 112 of the needle protrudes beyond the slide 110 and is received initially in the passage 94 The second end noted 114 of the needle 22 protrudes behind the couhsseau 110 and is initially disposed opposite the lid 44 of the bottle.
Les deux extrémités des aiguilles présentent des biseaux analogues, de sorte qu'elles présentent des pointes ayant les mêmes profils en regard du piston 34 et de l'opercule 44 Le diamètre du couhsseau 110 est supérieur au diamètre du passage défini par le diaphragme 75The two ends of the needles have similar bevels, so that they have points having the same profiles opposite the piston 34 and the cover 44 The diameter of the neck 110 is greater than the diameter of the passage defined by the diaphragm 75
Le couhsseau cylindrique 110 présente sur une partie de sa longueur reçue dans la chambre de confinement 102 des nervures longitudinales 1 16 (figure 3) définissant un épaulement 1 18 adapté pour coopérer avec le bourrelet péπ- phéπque 100 formant butée Les nervures longitudinales 1 16 assurent un guidage en translation de la navette 20 à l'intérieur de l'organe de liaison 24 La longueur des nervures 116 est inférieure a la longueur de la chambre de confinement 1 12 définie entre la protubérance 92 et le bourrelet 100 Cette différence de longueur est notée \2 The longitudinal cylinder 110 has, over part of its length received in the confinement chamber 102, longitudinal ribs 1 16 (FIG. 3) defining a shoulder 1 18 adapted to cooperate with the peripheral bead 100 forming a stop The longitudinal ribs 1 16 provide guiding in translation of the shuttle 20 inside the connecting member 24 The length of the ribs 116 is less than the length of the confinement chamber 1 12 defined between the protuberance 92 and the bead 100 This difference in length is noted \ 2
Initialement, comme représenté sur la figure 1 l'organe de liaison 24 est dégagé du corps 16, de sorte que les moyens d'accrochage constitués de la gorge 96A et du bourrelet 98 sont en prise. De même, initialement, la navette 20 est appuyée sur le bourrelet périphérique 100 par l'intermédiaire de I épaulement 118, de sorte que l'extrémité 112 de l'aiguille s étend à l'intérieur de la protubérance 92. Elle est ainsi écartée du piston perforable 34. La navette est alors écartée de la distance l2 de la protubérance 92.Initially, as shown in Figure 1 the connecting member 24 is released from the body 16, so that the hooking means consisting of the groove 96A and the bead 98 are engaged. Likewise, initially, the shuttle 20 is pressed on the peripheral bead 100 by means of the shoulder 118, so that the end 112 of the needle extends inside the protuberance 92. It is thus separated of the perforable piston 34. The shuttle is then moved away from the distance l 2 of the protuberance 92.
De même, l'extrémité 114 de l'aiguille creuse est maintenue écartée de l'opercule 44 par appui de l'extrémité inférieure de l'organe de liaison 24 sur le bourrelet périphérique 98 et appui de la navette 20 sur le bourrelet 100 L'extrémité inférieure du couiisseau 110 est alors séparée d'une distance l3 de l'opercule 44Likewise, the end 114 of the hollow needle is kept apart from the cover 44 by pressing the lower end of the connecting member 24 on the peripheral bead 98 and pressing the shuttle 20 on the bead 100 L the lower end of the couiisseau 110 is then separated by a distance l 3 from the cover 44
Avantageusement, les distances h, l2, l3 sont liées par la relation =l2+l3 L'utilisation du dispositif de transfert 10 s effectue de la manière suivanteAdvantageously, the distances h, l 2 , l 3 are linked by the relation = l 2 + l 3 The use of the transfer device 10 is carried out as follows
Le capuchon protecteur 18 est d'abord retiré et retourné Les moyens d'accrochage 80 sont engagés autour de la tête 31 de la carpule, comme représenté sur les figures 2 et 3The protective cap 18 is first removed and returned. The attachment means 80 are engaged around the head 31 of the cartridge, as shown in FIGS. 2 and 3
Le capuchon protecteur 18 et le corps 16 sont alors rapprochés l'un de l'autre suivant le sens de la flèche F4, comme représenté sur la figure 4 Lors de ce déplacement axial, la navette 20 se déplace par rapport au corps 16 jusqu à une position de transfert dans laquelle l'extrémité 1 12 fait saillie à l'intérieur de la carpule 12 après avoir traversé le piston 34 et l'extrémité 114 fait saillie à l'intérieur du flacon 14 après avoir traversé l'opercule 44The protective cap 18 and the body 16 are then brought towards each other in the direction of the arrow F4, as shown in FIG. 4 During this axial movement, the shuttle 20 moves relative to the body 16 until a transfer position in which the end 1 12 projects inside the cartridge 12 after having crossed the piston 34 and the end 114 projects inside the bottle 14 after having crossed the cover 44
En effet, le déplacement du capuchon protecteur 18 provoque l'enfoncement de la carpule 12 dans la chambre 70 du corps Lors de ce dépla- cernent, l'organe de liaison 24 se trouve déplacé vers le flacon 14 en étant poussé par la carpule La gorge 96A se dégage du bourrelet périphérique 98 et l'extrémité inférieure de l'organe 24 se déplace jusqu à ce que le bourrelet 98 soit reçu dans la gorge périphérique 96B L'enclenchement élastique du bourre- let 98 dans la gorge 96B assure l'accrochage axial définitif de l'organe de liaison 24 et du corps 16In fact, the movement of the protective cap 18 causes the cartridge 12 to sink into the chamber 70 of the body. During this movement, the connecting member 24 is moved towards the bottle 14 by being pushed by the cartridge La groove 96A emerges from the peripheral flange 98 and the lower end of the member 24 moves until the flange 98 is received in the peripheral groove 96B The elastic engagement of the flange let 98 in the groove 96B ensures the final axial attachment of the connecting member 24 and the body 16
Lors du déplacement de l'organe de liaison 24 suivant la course la navette 20, montée coulissante à l'intérieur de l'organe de liaison 24 sur une course de longueur l2, se trouve également déplacée par rapport au corps 16 et à l'organe 24During the movement of the connecting member 24 along the stroke the shuttle 20, slidably mounted inside the connecting member 24 on a stroke of length l 2 , is also moved relative to the body 16 and to the organ 24
En effet, au début du couhssement de l'organe de liaison 24, les extrémités 112 et 114 de l'aiguille viennent en appui respectivement sur le piston 34 et l'opercule 44 Ces derniers perforent alors simultanément le piston 34 et l'opercule 44 lors du rapprochement de la carpule 12 et du flacon 14 Les extrémités de l'aiguille pénètrent ensuite dans la carpule 12 et le flacon 14Indeed, at the start of the connection of the connecting member 24, the ends 112 and 114 of the needle come to bear respectively on the piston 34 and the cover 44 The latter then simultaneously perforate the piston 34 and the cover 44 when the cartridge 12 and the bottle 14 are brought together The ends of the needle then enter the cartridge 12 and the bottle 14
Les duretés Shore du piston 34 et de l'opercule 44 étant identiques, de même que les deux profils des extrémités 112 et 114 de l'aiguille les perforations initiales du piston et de la membrane s'effectuent simultanément, l'aiguille n'étant sollicitée qu'à ces deux extrémitésSince the Shore hardnesses of the piston 34 and of the cover 44 are identical, as are the two profiles of the ends 112 and 114 of the needle, the initial perforations of the piston and of the membrane take place simultaneously, the needle being requested that at these two ends
En fin de déplacement de l'organe de liaison 24, le couhsseau 1 10 vient en appui, d'une part, sur la protubérance d'extrémité 92 de l'organe de liaison et, d'autre part, contre le diaphragme 75 s'étendant au dessus de l'opercule 44 obturant le flacon Dans cette position, représentée sur la figure 4, l'aiguille creuse 22 assure la mise en communication du flacon 14 et de la carpule 12At the end of movement of the connecting member 24, the couch 1 10 comes to bear, on the one hand, on the end protuberance 92 of the connecting member and, on the other hand, against the diaphragm 75 s extending above the cover 44 closing the bottle In this position, shown in FIG. 4, the hollow needle 22 ensures communication between the bottle 14 and the cartridge 12
Comme illustré sur la figure 5, lors de l'enfoncement ultérieur du réservoir 26 dans le corps 16 sous l'action du capuchon protecteur 18 déplacé vers le corps 16 suivant le sens de la flèche F5, le liquide 38 contenu initialement dans la carpule 12 est progressivement transféré dans le flacon 14 Ce transfert résulte de l'enfoncement du piston 34 à l'intérieur du réservoir cylindrique 26, le piston 34 étant maintenu fixe par rapport au corps par l'intermédiaire de l'organe de liaison 24 qui forme ainsi butée alors que le réservoir 26 est déplacé vers le corps 16As illustrated in FIG. 5, during the subsequent insertion of the reservoir 26 into the body 16 under the action of the protective cap 18 moved towards the body 16 in the direction of the arrow F5, the liquid 38 initially contained in the cartridge 12 is gradually transferred to the bottle 14 This transfer results from the depression of the piston 34 inside the cylindrical tank 26, the piston 34 being kept fixed relative to the body by means of the connecting member 24 which thus forms stop while the reservoir 26 is moved towards the body 16
Le remplissage du flacon 14 est rendu possible puisque celui-ci est ini- tialement à une pression inférieure à la pression atmosphériqueThe filling of the bottle 14 is made possible since it is initially at a pressure below atmospheric pressure
Lorsque, comme représenté sur la figure 6, le piston 34 est en appui contre le col 28 de la carpule, l'essentiel du liquide initialement contenu dans celle-ci est transféré dans le flacon 14 Après une agitation suffisante le lyophilisa 50 se dissout dans le liquide 38 à l'intérieur du flacon 14When, as shown in FIG. 6, the piston 34 is in abutment against the neck 28 of the cartridge, most of the liquid initially contained in it is transferred to the bottle 14 After sufficient stirring the lyophilisa 50 dissolves in the liquid 38 inside the bottle 14
Afin de transférer le mélange extemporané ainsi reconstitué à l'intérieur de la carpule 12, le dispositif de transfert 10 est retourné comme représenté sur la figure 7 puis le capuchon protecteur 18 est écarté du corps 16 afin d'aspirer le mélange extemporané dans la carpuleIn order to transfer the extemporaneous mixture thus reconstituted inside the cartridge 12, the transfer device 10 is turned over as shown in FIG. 7 then the protective cap 18 is separated from the body 16 in order to suck the extemporaneous mixture in the cartridge
Lors de la traction opérée sur le réservoir cylindrique 26 de la carpule suivant le sens de la flèche F7, le piston 34 est retenu solidaire du corps 16 par l'intermédiaire de l'organe de liaison 24 accroché au corps par la coopération de la gorge 96B et du bourrelet périphérique 98During the traction operated on the cylindrical reservoir 26 of the cartridge according to the direction of the arrow F7, the piston 34 is retained integral with the body 16 by means of the connecting member 24 attached to the body by the cooperation of the groove 96B and peripheral bead 98
L'aspiration du mélange se produit sous l'action du mouvement du réservoir cylindrique 26 par rapport au piston 34 En effet le mouvement relatif du piston et du réservoir crée une dépression à l'intérieur de celui-ci, qui conduit à l'aspiration du mélange contenu dans le flacon 14 Après un remplissage complet de la carpule 12 avec le mélange extemporané, la carpule 12 est désolidarisée de l'organe de liaison 24 en étant dévissée Celle-ci peut alors être utilisée en vue d'une injection après avoir été munie d'une aiguille d'injection et d'un poussoir d'actionnementThe suction of the mixture occurs under the action of the movement of the cylindrical reservoir 26 relative to the piston 34 In fact the relative movement of the piston and of the reservoir creates a depression inside the latter, which leads to the suction of the mixture contained in the bottle 14 After complete filling of the cartridge 12 with the extemporaneous mixture, the cartridge 12 is separated from the connecting member 24 by being unscrewed. This can then be used for injection after having been fitted with an injection needle and an actuator
Le dispositif de transfert ainsi dépourvu de la carpule est ensuite jeté II convient de noter que dans cette position, l'extrémité 112 de l'aiguille est protégée du fait du prolongement du corps 16, évitant ainsi tout risque de piqûre accidentelle A cet effet, la longueur du corps 16 est choisie suffisante pour se prolonger au delà de l'extrémité 1 12 de l'aiguille creuseThe transfer device thus devoid of the cartridge is then discarded. It should be noted that in this position, the end 112 of the needle is protected due to the extension of the body 16, thus avoiding any risk of accidental puncture For this purpose, the length of the body 16 is chosen to be sufficient to extend beyond the end 12 of the hollow needle
Le dispositif selon l'invention permet un transfert du liquide entre la car- pule et le flacon sans risque de contamination du liquide En effet, les deux extrémités de l'aiguille creuse sont constamment protégées à l'intérieur de l'espace clos délimité par l'organe de liaison 24, le corps 16 et le flacon 14The device according to the invention allows a transfer of the liquid between the cartridge and the bottle without risk of contamination of the liquid. In fact, the two ends of the hollow needle are constantly protected inside the closed space delimited by the connecting member 24, the body 16 and the bottle 14
Cette protection est de plus renforcée par la présence du capuchon protecteur 18 lors des phases de stockage du dispositif De plus la pénétration simultanée des deux extrémités des aiguilles évite tout risque d'entrée d'air ambiant dans la carpule ou le flaconThis protection is further reinforced by the presence of the protective cap 18 during the device storage phases. Furthermore, the simultaneous penetration of the two ends of the needles avoids any risk of entry of ambient air into the cartridge or the vial.
Lorsque le dispositif de transfert est pré-équipé d'un flacon 14 et d'une carpule 12 avant livraison, le transfert peut être effectué sans qu'il soit πéces- saire que la carpule ou le flacon rentre en contact avec la main. Ainsi, tout risque de souillure manuelle est écarté.When the transfer device is pre-equipped with a bottle 14 and a cartridge 12 before delivery, the transfer can be carried out without it being Make sure that the cartridge or the bottle comes into contact with your hand. Thus, any risk of manual soiling is eliminated.
Sur les figures 8 et 9 est représentée une variante de réalisation du dispositif de transfert selon l'invention. Sur cette figure, les éléments analogues ou identiques à ceux du mode de réalisation des figures 1 à 7 sont désignés par les mêmes numéros de référence.In Figures 8 and 9 is shown an alternative embodiment of the transfer device according to the invention. In this figure, elements similar or identical to those of the embodiment of Figures 1 to 7 are designated by the same reference numbers.
On retrouve sur cette figure, un dispositif de transfert 200 associé à une carpule 12 et un flacon 14 contenant un lyophilisa.This figure shows a transfer device 200 associated with a cartridge 12 and a bottle 14 containing a lyophilisa.
Le dispositif de transfert 200 comporte un corps 16 dans lequel est im- mobilisé axialement le flacon 14, un organe de liaison 24 coulissant par rapport au corps et une navette porte-aiguille 20 librement coulissante suivant l'axe de l'organe de liaison 24.The transfer device 200 comprises a body 16 in which the bottle 14 is axially mobilized, a connecting member 24 sliding relative to the body and a needle-holder shuttle 20 freely sliding along the axis of the connecting member 24 .
Le dispositif de transfert 200 comporte en outre un support de carpule 202 comportant des moyens 203 d'accrochage axial du capuchon 18. Dans ce mode de réalisation, l'organe de liaison 24 comporte, en plus de la paroi cylindrique 90, un manchon extérieur 204 coaxial entourant la paroi cylindrique 90 et relié à celle-ci par une paroi annulaire 206. Le manchon 204 est monté coulissant à l'intérieur du corps 16. Il présente des profils en saillie et en creux 208 adaptés pour coopérer avec des profils complémentaires portés par la paroi latérale du corps 16, afin d'assurer leur solidarisatioπ axiale après perforation de l'opercule 44 par l'extrémité 1 14 de l'aiguille creuse.The transfer device 200 further comprises a cartridge support 202 comprising means 203 for axially hooking the cap 18. In this embodiment, the connecting member 24 comprises, in addition to the cylindrical wall 90, an external sleeve 204 coaxial surrounding the cylindrical wall 90 and connected thereto by an annular wall 206. The sleeve 204 is slidably mounted inside the body 16. It has protruding and recessed profiles 208 adapted to cooperate with complementary profiles carried by the side wall of the body 16, in order to ensure their axial solidarisatioπ after perforation of the cover 44 by the end 1 14 of the hollow needle.
Le manchon 204 se prolonge au delà de la protubérance filetée 92 vissée dans le piston 34 de la carpule.The sleeve 204 extends beyond the threaded protuberance 92 screwed into the piston 34 of the cartridge.
Comme représenté sur la figure 9, le manchon 204 présente dans sa pa- roi latérale deux couples de fentes longitudinales 210, 212 décalées angulaire- ment de 90°. Les fentes 210 ont une longueur double des fentes 212. L'extrémité inférieure des deux couples de fentes 210, 212, disposée du côté du flacon 14, s'étendent à un même niveau sur le manchon 204.As shown in FIG. 9, the sleeve 204 has in its side wall two pairs of longitudinal slots 210, 212 offset angularly by 90 °. The slots 210 have a double length of the slots 212. The lower end of the two pairs of slots 210, 212, disposed on the side of the bottle 14, extend at the same level on the sleeve 204.
Le support de carpule 202 comporte un tube intérieur 220 de réception du corps 26 de la carpule. Il est obturé partiellement à son extrémité inférieure par un épaulement 222 sur lequel s'appuie axialement l'extrémité ouverte du réservoir 26 de la carpule. L'épaulement 222 est prolongé par un tronçon tubulaire 224 coulissant le long de la paroi cylindrique 90 de l'organe de liaison. En outre, le tube 220 est entouré dans sa partie inférieure par un manchon coaxiai 230 portant deux saillies diamétralement opposées 232 adaptées pour coulisser à l'intérieur de l'un ou l'autre des couples de fentes 210, 212.The cartridge holder 202 comprises an inner tube 220 for receiving the body 26 of the cartridge. It is partially closed at its lower end by a shoulder 222 on which the open end of the reservoir 26 of the cartridge is supported axially. The shoulder 222 is extended by a tubular section 224 sliding along the cylindrical wall 90 of the connecting member. In addition, the tube 220 is surrounded in its lower part by a coaxial sleeve 230 carrying two diametrically opposite projections 232 adapted to slide inside one or the other of the pairs of slots 210, 212.
Suivant la contenance de la carpule 12 utilisée avec le dispositif de transfert, les saillies 232 sont introduites dans l'un ou l'autre des couples de fentes. Pour une carpule d'une contenance de 1 ,3 mm, c'est-à-dire une carpule ayant un corps de longueur réduite, les saillies 232 sont disposées dans les fentes courtes 212.Depending on the capacity of the cartridge 12 used with the transfer device, the projections 232 are introduced into one or the other of the pairs of slots. For a cartridge with a capacity of 1, 3 mm, that is to say a cartridge having a body of reduced length, the projections 232 are arranged in the short slots 212.
Au contraire, lorsque le dispositif de transfert est utilisé avec une carpule d'une contenance de 2,3 ml, c'est-à-dire une carpule dont la longueur du corps est double d'une carpule de 1 ,3 ml, les saillies 232 sont engagées dans les fentes 210.On the contrary, when the transfer device is used with a cartridge with a capacity of 2.3 ml, that is to say a cartridge whose body length is double that of a cartridge of 1.3 ml, the projections 232 are engaged in slots 210.
On comprend que le support de carpule 202 assure un guidage axial de la carpule 12 lors de son coulissement par rapport à l'organe de liaison 24. La présence des deux couples de fentes sur le manchon 204 de l'organe de liaison permet d'utiliser le même dispositif de transfert avec des carpules de deux contenances différentes.It is understood that the cartridge holder 202 provides axial guidance of the cartridge 12 when it slides relative to the connecting member 24. The presence of the two pairs of slots on the sleeve 204 of the connecting member makes it possible to use the same transfer device with cartridges of two different capacities.
Après transfert du liquide contenu initialement dans la carpule à l'intérieur du flacon, et mélange de celui-ci avec le lyophilisa, le mélange ainsi constitué est réaspiré dans la carpule 12 au travers de l'aiguille. A cet effet, le réservoir de la carpule est tiré grâce au capuchon accroché sur le support d'aiguille 202. Lors du transfert du mélange vers la carpule 12, les saillies 232 coulissent suivant la longueur des fentes 210 ou 212. Lorsque les saillies 232 entrent en contact avec l'extrémité de ces fentes, celles-ci forment butée et s'opposent au déplacement ultérieur de la carpule 12. Ainsi, tout risque de voir le piston 34 extrait du réservoir de la carpule du fait d'un déplacement trop important de celle-ci est évité par la présence des saillies 232 formant butée. Celles-ci limitent en effet la course de déplacement du réservoir de la carpule par rapport à l'organe de liaison 24 solidarisé au piston. After transferring the liquid initially contained in the cartridge inside the bottle, and mixing it with the lyophilisa, the mixture thus formed is drawn back into the cartridge 12 through the needle. To this end, the reservoir of the cartridge is pulled by means of the cap hung on the needle holder 202. During the transfer of the mixture to the cartridge 12, the projections 232 slide along the length of the slots 210 or 212. When the projections 232 come into contact with the end of these slots, they form a stop and oppose the subsequent displacement of the cartridge 12. Thus, any risk of seeing the piston 34 extracted from the reservoir of the cartridge due to a displacement too important of this is avoided by the presence of the projections 232 forming a stop. These in fact limit the displacement stroke of the reservoir of the cartridge relative to the connecting member 24 secured to the piston.

Claims

REVENDICATIONS
1. Dispositif de transfert bidirectionnel d'un liquide (38) entre un flacon (14) muni d'un bouchon perforable (44) et une carpule (12) comprenant un réservoir cylindrique (26) dans lequel coulisse un piston perforable (34), caractérisé en ce qu'il comporte :1. Device for bidirectional transfer of a liquid (38) between a bottle (14) provided with a perforable cap (44) and a cartridge (12) comprising a cylindrical reservoir (26) in which slides a perforable piston (34) , characterized in that it comprises:
- un corps (16) comportant des moyens d'accrochage du flacon (14),a body (16) comprising means for hooking the bottle (14),
- un organe (24) de liaison du piston perforable (34) au corps (16),a member (24) for connecting the perforable piston (34) to the body (16),
- une navette (20) déplacable par rapport au corps (16) et audit organe (24) de liaison, la navette (20) portant une aiguille creuse (22) dont une première extrémité (112) est adaptée pour la perforation du piston (34) et dont la seconde extrémité (1 14) est adaptée pour la perforation du bouchon (44), et en ce que la navette (20) est déplacable entre une position initiale dans laquelle les extrémités de l'aiguille (112, 114) sont espacées du piston perfora- ble (34) et du bouchon perforable (44) et une position finale de transfert dans laquelle les extrémités de l'aiguille (112, 114) sont reçues dans la carpule (12) et le flacon (14).- A shuttle (20) movable relative to the body (16) and to said connecting member (24), the shuttle (20) carrying a hollow needle (22), a first end (112) of which is suitable for perforating the piston ( 34) and whose second end (1 14) is adapted for the perforation of the plug (44), and in that the shuttle (20) is movable between an initial position in which the ends of the needle (112, 114) are spaced from the perforable piston (34) and the perforable plug (44) and a final transfer position in which the ends of the needle (112, 114) are received in the cartridge (12) and the vial (14) .
2. Dispositif selon la revendication 1 , caractérisé en ce que ledit organe (24) de liaison du piston au corps comporte des moyens (96) d'accrochage sur le corps (16) et est mobile par rapport au corps (16) depuis une position initiale dans laquelle les moyens d'accrochage (96) ne sont pas en prise avec le corps (16), et une position finale dans laquelle les moyens d'accrochage (96, 98) sont en prise avec le corps, assurant alors la liaison du piston au corps.2. Device according to claim 1, characterized in that said member (24) connecting the piston to the body comprises means (96) for hooking on the body (16) and is movable relative to the body (16) from a initial position in which the attachment means (96) are not engaged with the body (16), and a final position in which the attachment means (96, 98) are engaged with the body, thereby ensuring connection of the piston to the body.
3. Dispositif selon la revendication 1 ou 2, caractérisé en ce que ledit organe (24) de liaison du piston au corps comporte une protubérance filetée3. Device according to claim 1 or 2, characterized in that said member (24) for connecting the piston to the body comprises a threaded protuberance
(92) pour sa fixation dans un évidement taraudé (36) du piston (34).(92) for fixing it in a threaded recess (36) of the piston (34).
4. Dispositif selon l'une quelconque des revendications précédentes, caractérisé en ce que ladite navette (20) est montée coulissante dans un conduit (91 ) dudit organe (24) de liaison du piston au corps. 4. Device according to any one of the preceding claims, characterized in that said shuttle (20) is slidably mounted in a conduit (91) of said member (24) connecting the piston to the body.
5. Dispositif selon la revendication 4, caractérisé en ce que ledit conduit (91 ) comporte intérieurement une butée (100) limitant la course de déplacement de la navette (20). 6 Dispositif selon l'une quelconque des revendications précédentes, caractérise en ce qu'il comporte un capuchon protecteur (18) en forme de coiffe initialement montée sur le corps (16), lequel capuchon protecteur (18) comporte des moyens (80) d'accrochage sur le réservoir (26) de la carpule 7 Dispositif selon l'une quelconque des revendications précédentes, caractérisé en ce que le corps (16) présente un prolongement entourant ladite navette (20) et s'éteπdant au delà de la première extrémité (112) de l'aiguille5. Device according to claim 4, characterized in that said conduit (91) internally comprises a stop (100) limiting the displacement travel of the shuttle (20). 6 Device according to any one of the preceding claims, characterized in that it comprises a protective cap (18) in the form of a cap initially mounted on the body (16), which protective cap (18) comprises means (80) d hooking onto the reservoir (26) of the cartridge 7 Device according to any one of the preceding claims, characterized in that the body (16) has an extension surrounding said shuttle (20) and extending beyond the first end (112) of the needle
8 Dispositif selon l'une quelconque des revendications précédentes, caractérisé en ce qu'il comporte au moins une butée (232) limitant le déplace- ment axial du réservoir (26) par rapport à l'organe de liaison (24), interdisant l'extraction du piston (34) hors du réservoir (26)8 Device according to any one of the preceding claims, characterized in that it comprises at least one stop (232) limiting the axial movement of the reservoir (26) relative to the connecting member (24), preventing the extraction of the piston (34) from the reservoir (26)
9 Dispositif selon la revendication 8, caractérisé en ce qu'il comporte un support de carpule (202) sur lequel prend appui axialement le réservoir (26) de la carpule (12), et en ce que l'un des supports de carpule (202) et de l'organe de liaison (24) comportant au moins une saillie, formant ladite butée (232), reçue dans une fente longitudinale (210, 212) de l'autre, du support de carpule (202) et de l'organe de liaison (24) pour limiter leur déplacement axial relatif entre le réservoir (26) et l'organe de liaison (24)9 Device according to claim 8, characterized in that it comprises a cartridge support (202) on which the reservoir (26) of the cartridge (12) bears axially, and in that one of the cartridge supports ( 202) and of the connecting member (24) comprising at least one projection, forming said stop (232), received in a longitudinal slot (210, 212) on the other, of the cartridge holder (202) and of the connecting member (24) to limit their relative axial displacement between the reservoir (26) and the connecting member (24)
10 Nécessaire d'injection comportant un dispositif (10) de transfert bidirectionnel selon l'une quelconque des revendications précédentes, ainsi qu'une carpule (12) et un flacon (14), dans lequel la carpule (12) est initialement liée à l'organe de solidansation (24) et le flacon (14) est initialement lié au corps (16) 10 Injection kit comprising a bidirectional transfer device (10) according to any one of the preceding claims, as well as a cartridge (12) and a vial (14), in which the cartridge (12) is initially linked to the solidansation member (24) and the bottle (14) is initially linked to the body (16)
EP00910990A 1999-03-18 2000-03-17 Device for two-way transfer of a liquid between a bottle and a cartridge Expired - Lifetime EP1161217B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9903392A FR2790948B1 (en) 1999-03-18 1999-03-18 DEVICE FOR BIDIRECTIONAL TRANSFER OF A LIQUID BETWEEN A BOTTLE AND A CAPSULE
FR9903392 1999-03-18
PCT/FR2000/000671 WO2000054723A1 (en) 1999-03-18 2000-03-17 Device for two-way transfer of a liquid between a bottle and a cartridge

Publications (2)

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EP1161217A1 true EP1161217A1 (en) 2001-12-12
EP1161217B1 EP1161217B1 (en) 2004-09-08

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EP (1) EP1161217B1 (en)
JP (1) JP4430244B2 (en)
AT (1) ATE275374T1 (en)
AU (1) AU3300300A (en)
DE (1) DE60013565T2 (en)
ES (1) ES2228475T3 (en)
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WO (1) WO2000054723A1 (en)

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FR2790948A1 (en) 2000-09-22
US6746438B1 (en) 2004-06-08
JP4430244B2 (en) 2010-03-10
WO2000054723A1 (en) 2000-09-21
FR2790948B1 (en) 2001-06-22
ATE275374T1 (en) 2004-09-15
JP2002538893A (en) 2002-11-19
AU3300300A (en) 2000-10-04
EP1161217B1 (en) 2004-09-08
DE60013565D1 (en) 2004-10-14
ES2228475T3 (en) 2005-04-16
DE60013565T2 (en) 2005-10-06

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