EP1140872B1 - An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine - Google Patents

An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine Download PDF

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Publication number
EP1140872B1
EP1140872B1 EP99956293A EP99956293A EP1140872B1 EP 1140872 B1 EP1140872 B1 EP 1140872B1 EP 99956293 A EP99956293 A EP 99956293A EP 99956293 A EP99956293 A EP 99956293A EP 1140872 B1 EP1140872 B1 EP 1140872B1
Authority
EP
European Patent Office
Prior art keywords
cosolvent
dichlorophenyl
diamino
triazine
cyanide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99956293A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1140872A1 (en
Inventor
Sharad Kumar Vyas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torrent Pharmaceuticals Ltd
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Publication of EP1140872A1 publication Critical patent/EP1140872A1/en
Application granted granted Critical
Publication of EP1140872B1 publication Critical patent/EP1140872B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
EP99956293A 1998-12-14 1999-12-07 An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine Expired - Lifetime EP1140872B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
INCA217198 1998-12-14
IN2171KO1998 1998-12-14
PCT/IB1999/001955 WO2000035888A1 (en) 1998-12-14 1999-12-07 An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

Publications (2)

Publication Number Publication Date
EP1140872A1 EP1140872A1 (en) 2001-10-10
EP1140872B1 true EP1140872B1 (en) 2003-09-17

Family

ID=11092821

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99956293A Expired - Lifetime EP1140872B1 (en) 1998-12-14 1999-12-07 An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

Country Status (7)

Country Link
US (1) US6111101A (cs)
EP (1) EP1140872B1 (cs)
AU (1) AU1292400A (cs)
CA (1) CA2334937C (cs)
CZ (1) CZ20011949A3 (cs)
PL (1) PL348865A1 (cs)
WO (1) WO2000035888A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1390355A4 (en) * 2001-02-27 2005-02-23 Teva Pharma NEW CRYSTALLINE FORMS OF LAMOTRIGIN AND METHOD FOR THE PRODUCTION THEREOF
DE10134980C2 (de) 2001-07-17 2003-05-28 Helm Ag Verfahren zur Herstellung von Lamotrigin
CA2366521C (en) 2001-12-24 2007-03-06 Brantford Chemicals Inc. A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines
ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
WO2007069265A1 (en) * 2005-12-12 2007-06-21 Unichem Laboratories Limited A novel process for the synthesis of lamotrigine and its intermediate
WO2007138075A1 (en) * 2006-05-31 2007-12-06 Calaire Chimie Sas Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride
US20120142919A1 (en) 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
CN101506178A (zh) * 2006-08-14 2009-08-12 隆沙有限公司 制备拉莫三嗪的方法
WO2009061513A1 (en) * 2007-11-09 2009-05-14 Thar Pharmaceuticals Crystalline forms of lamotrigine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2708183C3 (de) * 1977-02-25 1979-08-09 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Verfahren zur Herstellung von Acylcyaniden
DK153787C (da) * 1979-06-01 1989-01-16 Wellcome Found Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament

Also Published As

Publication number Publication date
WO2000035888A1 (en) 2000-06-22
PL348865A1 (en) 2002-06-17
CA2334937C (en) 2004-09-21
US6111101A (en) 2000-08-29
AU1292400A (en) 2000-07-03
EP1140872A1 (en) 2001-10-10
CZ20011949A3 (cs) 2001-09-12
CA2334937A1 (en) 2000-06-22

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