EP1115422A4 - Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline - Google Patents

Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline

Info

Publication number
EP1115422A4
EP1115422A4 EP99947113A EP99947113A EP1115422A4 EP 1115422 A4 EP1115422 A4 EP 1115422A4 EP 99947113 A EP99947113 A EP 99947113A EP 99947113 A EP99947113 A EP 99947113A EP 1115422 A4 EP1115422 A4 EP 1115422A4
Authority
EP
European Patent Office
Prior art keywords
treatment
insulin related
peptidyl compounds
related ailments
ailments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99947113A
Other languages
German (de)
English (en)
Other versions
EP1115422A1 (fr
Inventor
Erik Helmerhorst
Brian Scott Plewright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curtin University of Technology
Original Assignee
Curtin University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curtin University of Technology filed Critical Curtin University of Technology
Publication of EP1115422A1 publication Critical patent/EP1115422A1/fr
Publication of EP1115422A4 publication Critical patent/EP1115422A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99947113A 1998-09-22 1999-09-17 Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline Withdrawn EP1115422A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP609198 1998-09-22
AUPP6091A AUPP609198A0 (en) 1998-09-22 1998-09-22 Use of non-peptidyl compounds for the treatment of insulin related ailments
PCT/AU1999/000786 WO2000016798A1 (fr) 1998-09-22 1999-09-17 Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline

Publications (2)

Publication Number Publication Date
EP1115422A1 EP1115422A1 (fr) 2001-07-18
EP1115422A4 true EP1115422A4 (fr) 2003-01-29

Family

ID=3810308

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99947113A Withdrawn EP1115422A4 (fr) 1998-09-22 1999-09-17 Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline

Country Status (4)

Country Link
EP (1) EP1115422A4 (fr)
AU (1) AUPP609198A0 (fr)
CA (1) CA2345155A1 (fr)
WO (1) WO2000016798A1 (fr)

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JP2001247459A (ja) 2000-03-03 2001-09-11 Oakland Uniservices Ltd 癌の組み合わせ療法
EP1311262A4 (fr) 2000-07-28 2005-06-01 Cancer Rec Tech Ltd Traitement combine contre le cancer
PE20020453A1 (es) 2000-09-27 2002-06-06 Merck & Co Inc Derivados del acido benzopirancarboxilico para el tratamiento de la diabetes y los trastornos de lipidos
JP4350946B2 (ja) 2000-10-31 2009-10-28 メルク エンド カムパニー インコーポレーテッド 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体
US20110065129A1 (en) 2001-07-27 2011-03-17 Lowe Derek B Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB2386836B (en) 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
US7078423B2 (en) 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
US7087631B2 (en) 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
UA84035C2 (ru) 2003-10-31 2008-09-10 Янссен Фармацевтика Н.В. Производные феноксиуксусных кислот, полезные как двойные агонисты активированных рецепторов пероксисомального пролифератора (ppar)
FR2879458B1 (fr) * 2004-12-21 2007-07-20 Centre Nat Rech Scient Cnrse Sulfamides et sulfinimides fluores
SI2395002T1 (sl) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
JP5497633B2 (ja) 2007-05-09 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒのモジュレーター
SI2225230T1 (sl) 2007-12-07 2017-03-31 Vertex Pharmaceuticals Incorporated Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
PL2639223T3 (pl) 2007-12-07 2017-09-29 Vertex Pharmaceuticals Incorporated Sposób wytwarzania kwasów cykloalkilokarboksyamido-pirydyno-benzoesowych
CA2931134C (fr) 2008-02-28 2019-07-30 Vertex Pharmaceuticals Incorporated Derives heteroaryles convenant comme modulateurs du cftr
JP5394488B2 (ja) 2008-07-15 2014-01-22 エフ．ホフマン−ラ ロシュ アーゲー アミノテトラヒドロインダゾロ酢酸
EP2307382B1 (fr) 2008-07-15 2011-12-21 F. Hoffmann-La Roche AG Acides aminotétrahydroindazoloacétiques
EP2321266A2 (fr) 2008-08-15 2011-05-18 F. Hoffmann-La Roche AG Aminotétralines substituées
EP2321268A2 (fr) 2008-08-15 2011-05-18 F. Hoffmann-La Roche AG Bi-aryle aminotétralines
JP5373104B2 (ja) 2008-11-17 2013-12-18 エフ．ホフマン−ラ ロシュ アーゲー Ｃｒｔｈ２アンタゴニスト又は部分アゴニストとして使用されるナフチル酢酸
CA2740864A1 (fr) 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Acides naphtylacetiques
BRPI0921038A2 (pt) 2008-11-17 2019-09-24 Hoffmann La Roche ácido naftilacéticos
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
JP2013523833A (ja) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
MX342288B (es) 2010-04-22 2016-09-23 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
WO2012127885A1 (fr) 2011-03-18 2012-09-27 小野薬品工業株式会社 Dérivé de tétrahydrocarboline
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
RU2016122882A (ru) 2013-11-12 2017-12-19 Вертекс Фармасьютикалз Инкорпорейтед Способ получения фармацевтических композиций для лечения опосредованных cftr заболеваний
ES2957761T3 (es) 2014-04-15 2024-01-25 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
RU2691136C2 (ru) 2014-11-18 2019-06-11 Вертекс Фармасьютикалз Инкорпорейтед Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2037002A1 (en) * 1969-04-30 1970-12-31 Roques Bernard N-substd biguanide pamoic acid salts prepn
WO1990015816A1 (fr) * 1989-06-16 1990-12-27 The Upjohn Company Composes du type suramine et steroides angiostatiques inhibiteurs de l'angiogenese

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US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
AU612141B2 (en) * 1987-02-25 1991-07-04 Novo Nordisk A/S Novel insulin derivatives
JPH03506023A (ja) * 1988-07-20 1991-12-26 ノボ　ノルデイスク　アクツイエセルスカプ ポリペプチド
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
EP0469084B1 (fr) * 1989-04-20 1995-04-05 Mount Sinai School Of Medicine Of The City University Of New York Analogues d'insuline hepatospecifiques
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2037002A1 (en) * 1969-04-30 1970-12-31 Roques Bernard N-substd biguanide pamoic acid salts prepn
WO1990015816A1 (fr) * 1989-06-16 1990-12-27 The Upjohn Company Composes du type suramine et steroides angiostatiques inhibiteurs de l'angiogenese

Non-Patent Citations (6)

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Title
"[A new salt of metformin proposed in the oral treatment of diabetes: embonate (or pamoate) of metformin]", JOURNEES ANNUELLES DE DIABETOLOGIE DE L'HOTEL-DIEU. FRANCE 1977, 1977, pages 382 - 385, XP000913584, ISSN: 0075-4439 *
AUBERT: "oral antidiabetic...", SCIENCES MEDICALES, vol. 10, no. 47, 1980, pages 31 - 32, XP008010780 *
KLIJN J G ET AL: "Growth factor-receptor pathway interfering treatment by somatostatin analogs and suramin: preclinical and clinical studies.", THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. ENGLAND 20 DEC 1990, vol. 37, no. 6, 20 December 1990 (1990-12-20), pages 1089 - 1095, XP008010776, ISSN: 0960-0760 *
LUNDQUIST I: "Islet lysosomal enzyme activities and plasma insulin levels in obese hyperglycemic mice following injection of the lysosomotropic drug suramin.", DIABETES RESEARCH (EDINBURGH, LOTHIAN) SCOTLAND JUL 1985, vol. 2, no. 4, July 1985 (1985-07-01), pages 207 - 211, XP008010803, ISSN: 0265-5985 *
See also references of WO0016798A1 *
SETYONOHAN B (REPRINT) ET AL: "SURAMIN - PHARMACOKINETIC MONITORING, HEMATOLOGICAL AND ANTITUMOR EFFECTS ON RATS BEARING TRANSPLANTABLE PANCREATIC TUMORS", EUROPEAN JOURNAL OF CANCER, (1990) VOL. 26, NO. 2, PP. 184., DR DANIEL DENHOED CANC CTR, DIV ENDOCRINE ONCOL, ROTTERDAM, NETHERLANDS, XP008010849 *

Also Published As

Publication number Publication date
EP1115422A1 (fr) 2001-07-18
AUPP609198A0 (en) 1998-10-15
WO2000016798A1 (fr) 2000-03-30
CA2345155A1 (fr) 2000-03-30

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