EP1115422A4 - Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline - Google Patents

Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline

Info

Publication number
EP1115422A4
EP1115422A4 EP99947113A EP99947113A EP1115422A4 EP 1115422 A4 EP1115422 A4 EP 1115422A4 EP 99947113 A EP99947113 A EP 99947113A EP 99947113 A EP99947113 A EP 99947113A EP 1115422 A4 EP1115422 A4 EP 1115422A4
Authority
EP
European Patent Office
Prior art keywords
treatment
insulin related
peptidyl compounds
related ailments
ailments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99947113A
Other languages
German (de)
English (en)
Other versions
EP1115422A1 (fr
Inventor
Erik Helmerhorst
Brian Scott Plewright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curtin University of Technology
Original Assignee
Curtin University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curtin University of Technology filed Critical Curtin University of Technology
Publication of EP1115422A1 publication Critical patent/EP1115422A1/fr
Publication of EP1115422A4 publication Critical patent/EP1115422A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99947113A 1998-09-22 1999-09-17 Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline Withdrawn EP1115422A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP609198 1998-09-22
AUPP6091A AUPP609198A0 (en) 1998-09-22 1998-09-22 Use of non-peptidyl compounds for the treatment of insulin related ailments
PCT/AU1999/000786 WO2000016798A1 (fr) 1998-09-22 1999-09-17 Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline

Publications (2)

Publication Number Publication Date
EP1115422A1 EP1115422A1 (fr) 2001-07-18
EP1115422A4 true EP1115422A4 (fr) 2003-01-29

Family

ID=3810308

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99947113A Withdrawn EP1115422A4 (fr) 1998-09-22 1999-09-17 Utilisation de composes non-peptidyliques pour le traitement d'affections liees a l'insuline

Country Status (4)

Country Link
EP (1) EP1115422A4 (fr)
AU (1) AUPP609198A0 (fr)
CA (1) CA2345155A1 (fr)
WO (1) WO2000016798A1 (fr)

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JP2001247459A (ja) 2000-03-03 2001-09-11 Oakland Uniservices Ltd 癌の組み合わせ療法
WO2002009700A1 (fr) 2000-07-28 2002-02-07 Cancer Research Technology Limited Traitement combine contre le cancer
EP1324995A2 (fr) 2000-09-27 2003-07-09 Merck & Co., Inc. Derives d'acide benzopyrancarboxylique utilises pour le traitement du diabete et des troubles lipidiques
EP1347755A2 (fr) * 2000-10-31 2003-10-01 Merck & Co., Inc. Derives d'acide benzopyranocarboxylique pour traiter le diabete et d'autres troubles lipidiques
US20110065129A1 (en) 2001-07-27 2011-03-17 Lowe Derek B Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB2386836B (en) 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
US7087631B2 (en) 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
US7078423B2 (en) 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
UA84035C2 (ru) 2003-10-31 2008-09-10 Янссен Фармацевтика Н.В. Производные феноксиуксусных кислот, полезные как двойные агонисты активированных рецепторов пероксисомального пролифератора (ppar)
FR2879458B1 (fr) * 2004-12-21 2007-07-20 Centre Nat Rech Scient Cnrse Sulfamides et sulfinimides fluores
SI1945632T1 (sl) 2005-11-08 2014-03-31 Vertex Pharmaceuticals Incorporated Heterocikliäśni modulatorji za prenaĺ alce z atp-vezavno kaseto
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
JP5497633B2 (ja) 2007-05-09 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド Cftrのモジュレーター
WO2009073757A1 (fr) 2007-12-07 2009-06-11 Vertex Pharmaceuticals Incorporated Formes solides d'acide 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-méthylpyridin-2-yl)benzoïque
WO2009076142A2 (fr) 2007-12-07 2009-06-18 Vertex Pharmaceuticals Incorporated Procédés de fabrication d'acides cycloalkylcarboxamido-pyridine benzoïques
CA3039943C (fr) 2008-02-28 2021-07-13 Vertex Pharmaceuticals Incorporated Derives heteroaryles convenant comme modulateurs du cftr
US8138208B2 (en) 2008-07-15 2012-03-20 Hoffmann-La Roche Inc. Aminotetrahydroindazoloacetic acids
US8124641B2 (en) 2008-07-15 2012-02-28 Hoffmann-La Roche Inc. Aminotetrahydroindazoloacetic acids
JP2012500189A (ja) 2008-08-15 2012-01-05 エフ.ホフマン−ラ ロシュ アーゲー ビアリールアミノテトラリン
JP5302398B2 (ja) 2008-08-15 2013-10-02 エフ.ホフマン−ラ ロシュ アーゲー 置換アミノテトラリン
US8188090B2 (en) 2008-11-17 2012-05-29 Hoffman-La Roche Inc. Naphthylacetic acids
CN102216249A (zh) 2008-11-17 2011-10-12 霍夫曼-拉罗奇有限公司 萘乙酸
SG171734A1 (en) 2008-11-17 2011-07-28 Hoffmann La Roche Naphthylacetic acids
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CA2795804C (fr) 2010-04-07 2021-10-26 Vertex Pharmaceuticals Incorporated Compositions pharmaceutiques de l'acide 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yle) cyclopropanecarboxamido)-3-methylpyridin-2-yle)benzoique et leur administration
KR20130056244A (ko) 2010-04-22 2013-05-29 버텍스 파마슈티칼스 인코포레이티드 시클로알킬카르복스아미도-인돌 화합물의 제조 방법
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
CA2930199C (fr) 2013-11-12 2022-10-25 Vertex Pharmaceuticals Incorporated Procede de preparation de compositions pharmaceutiques pour le traitement de maladies a mediation assuree par le cftr
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
PT3221692T (pt) 2014-11-18 2021-09-10 Vertex Pharma Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2037002A1 (en) * 1969-04-30 1970-12-31 Roques Bernard N-substd biguanide pamoic acid salts prepn
WO1990015816A1 (fr) * 1989-06-16 1990-12-27 The Upjohn Company Composes du type suramine et steroides angiostatiques inhibiteurs de l'angiogenese

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US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
CA1339416C (fr) * 1987-02-25 1997-09-02 Liselotte Langkjaer Derives de l'insuline
ATE93238T1 (de) * 1988-07-20 1993-09-15 Novo Nordisk As Menschliche insulinanalage und zubereitungen daraus.
JPH04502465A (ja) * 1988-12-23 1992-05-07 ノボ ノルディスク アクティーゼルスカブ ヒトインシュリン類似物質
ATE120762T1 (de) * 1989-04-20 1995-04-15 Sinai School Medicine Hepatospezifische insulin-analoga.
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2037002A1 (en) * 1969-04-30 1970-12-31 Roques Bernard N-substd biguanide pamoic acid salts prepn
WO1990015816A1 (fr) * 1989-06-16 1990-12-27 The Upjohn Company Composes du type suramine et steroides angiostatiques inhibiteurs de l'angiogenese

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"[A new salt of metformin proposed in the oral treatment of diabetes: embonate (or pamoate) of metformin]", JOURNEES ANNUELLES DE DIABETOLOGIE DE L'HOTEL-DIEU. FRANCE 1977, 1977, pages 382 - 385, XP000913584, ISSN: 0075-4439 *
AUBERT: "oral antidiabetic...", SCIENCES MEDICALES, vol. 10, no. 47, 1980, pages 31 - 32, XP008010780 *
KLIJN J G ET AL: "Growth factor-receptor pathway interfering treatment by somatostatin analogs and suramin: preclinical and clinical studies.", THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. ENGLAND 20 DEC 1990, vol. 37, no. 6, 20 December 1990 (1990-12-20), pages 1089 - 1095, XP008010776, ISSN: 0960-0760 *
LUNDQUIST I: "Islet lysosomal enzyme activities and plasma insulin levels in obese hyperglycemic mice following injection of the lysosomotropic drug suramin.", DIABETES RESEARCH (EDINBURGH, LOTHIAN) SCOTLAND JUL 1985, vol. 2, no. 4, July 1985 (1985-07-01), pages 207 - 211, XP008010803, ISSN: 0265-5985 *
See also references of WO0016798A1 *
SETYONOHAN B (REPRINT) ET AL: "SURAMIN - PHARMACOKINETIC MONITORING, HEMATOLOGICAL AND ANTITUMOR EFFECTS ON RATS BEARING TRANSPLANTABLE PANCREATIC TUMORS", EUROPEAN JOURNAL OF CANCER, (1990) VOL. 26, NO. 2, PP. 184., DR DANIEL DENHOED CANC CTR, DIV ENDOCRINE ONCOL, ROTTERDAM, NETHERLANDS, XP008010849 *

Also Published As

Publication number Publication date
WO2000016798A1 (fr) 2000-03-30
CA2345155A1 (fr) 2000-03-30
EP1115422A1 (fr) 2001-07-18
AUPP609198A0 (en) 1998-10-15

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