EP1115409A4 - COMPOSITION FOR PROLONGING DISASTER AFTER A MEAL - Google Patents
COMPOSITION FOR PROLONGING DISASTER AFTER A MEALInfo
- Publication number
- EP1115409A4 EP1115409A4 EP00950624A EP00950624A EP1115409A4 EP 1115409 A4 EP1115409 A4 EP 1115409A4 EP 00950624 A EP00950624 A EP 00950624A EP 00950624 A EP00950624 A EP 00950624A EP 1115409 A4 EP1115409 A4 EP 1115409A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- weight
- nutritional composition
- meal
- satiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 235000012054 meals Nutrition 0.000 title claims abstract description 23
- 235000019627 satiety Nutrition 0.000 title claims abstract description 23
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- 244000298697 Actinidia deliciosa Species 0.000 claims 1
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- 235000008733 Citrus aurantifolia Nutrition 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 241000675108 Citrus tangerina Species 0.000 claims 1
- 235000015001 Cucumis melo var inodorus Nutrition 0.000 claims 1
- 240000002495 Cucumis melo var. inodorus Species 0.000 claims 1
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- 235000019693 cherries Nutrition 0.000 claims 1
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- 235000012907 honey Nutrition 0.000 claims 1
- 239000004571 lime Substances 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 claims 1
- 150000004668 long chain fatty acids Chemical class 0.000 abstract description 3
- 101800001982 Cholecystokinin Proteins 0.000 description 16
- 102100025841 Cholecystokinin Human genes 0.000 description 16
- 229940107137 cholecystokinin Drugs 0.000 description 16
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 16
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 8
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- 230000037406 food intake Effects 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 229940068196 placebo Drugs 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 229960005069 calcium Drugs 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 230000004580 weight loss Effects 0.000 description 5
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- 230000037213 diet Effects 0.000 description 4
- 235000019525 fullness Nutrition 0.000 description 4
- 229920001592 potato starch Polymers 0.000 description 4
- 229940122618 Trypsin inhibitor Drugs 0.000 description 3
- 101710162629 Trypsin inhibitor Proteins 0.000 description 3
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- 238000002474 experimental method Methods 0.000 description 3
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- 239000002753 trypsin inhibitor Substances 0.000 description 3
- 101100298225 Caenorhabditis elegans pot-2 gene Proteins 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- 108010046377 Whey Proteins Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
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- 239000000047 product Substances 0.000 description 2
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- 230000028327 secretion Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 101150092509 Actn gene Proteins 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 101710150887 Cholecystokinin A Proteins 0.000 description 1
- 206010016338 Feeling jittery Diseases 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
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- 230000036506 anxiety Effects 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
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- 239000003797 essential amino acid Substances 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
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- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
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- 235000021119 whey protein Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/56—Protease inhibitors from plants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a nutritional composition for extending satiety following a meal More particularly the nutritional composition includes protein, medium and/or long chain fatty acids and calcium to stimulate the secretion of cholecystokinin a gastric peptide, and a source of proteinase inhibitor extracted from potatoes that prevents the breakdown of cholecystokinin By increasing and sustaining the levels of cholecystokinin, the present invention extends satiety
- a second approach has focused on slowing gastric emptying thereby creating a feeling of fullness
- This approach utilizes insoluble fibers, which slow the movement of food through the gastrointestinal tract
- the disadvantage with the use of fiber is that the quantities needed to produce an effect create an unpalatable diet as well as numerous gastrointestinal effects including bloating, gas and dian iea
- a third approach investigates stimulating the body's satiety mechanism. When food is consumed a peptide is released called Cholecystokinin Releasing Protein (CCK-RP). Cholecystokinin Releasing Protein then stimulates the release of cholecystokinin in the gut. Cholecystokinin has been shown to increase satiety.
- CCK-RP When cholecystokinin is released it also stimulates the release of enzymes which inactivate CCK-RP. When CCK-RP is inactivated, CCK levels drop and the feeling of satiation is diminished. Studies have shown that cholecystokinin is extremely effective in extending satiety following ingestion of a meal. Although CCK has been shown to extend satiety and reduce food intake, a major disadvantage is that it must be given intravenously. When administered orally, CCK is inactivated by gastric enzymes. This has severely limited its use as a potential weight loss agent.
- a number of nutritive agents can stimulate the release of cholecystokinin.
- proteins, fat (particularly medium chain fatty acids), and calcium stimulate the release of CCK.
- United States Patent No. 4,491 ,578 discloses the oral administration of a trypsin inhibitor to stimulate satiety by stimulating the release of cholecystokinin.
- the trypsin inhibitor was postulated to act by inhibiting the negative feedback signal for cholecystokinin secretion. In this fashion, the trypsin inhibitor sustained levels of cholecystokinin thereby extending satiety.
- the present invention provides for nutritional composition in a dry powder form for extending satiety following ingestion of a meal
- the dry nutritional composition includes proteins in the range of 10% to 80%
- the protein can be in the form of soy, whey, casein or a specific amino acid mixture containing essential amino acids or of the amino acid phenylalanine
- the dry nutritional composition also includes the mineral calcium in the range of 2% to 6%
- the calcium can be in the form of a salt including calcium chloride, calcium carbonate, calcium lactate etc
- the dry nutritional composition also includes medium and/or long chain fatty acids (C ⁇ 2 - C 22 ) in the range of 10%-40%
- the dry nutritional composition also includes a source of proteinase inhibitor extracted from potatoes wherein the protease inhibitor is present in the range of 0.02%-5%
- Fig 1 is a graphical representation of the responses of test subjects as to their feeling of satiety taken in fifteen minute intervals over a three and one-half hour period following a meal, showing both subjects who were administered a placebo and subjects who were administered a nutritional supplement according to the present invention
- Fig 2 is a graphical representation of the responses of test subjects as to their feeling of hunger taken in fifteen minute intervals over a three and one-half hour period following a meal, showing both subjects who were administered a placebo and subjects who were administered a nutritional supplement according to the present invention
- the nutritional composition for nutritional intervention for extending satiety includes nutritional agents being protein, medium and/or chain fatty acids, calcium, an extract of potatoes containing proteinase inhibitor, and, in a preferred form, flavoring agents and coloring agents
- the proteinase inhibitor is a heat stable protein present in potatoes and in extracts from potatoes and has a molecular weight of approximately 21 ,000 It is both a trypsin and chymotrypsm inhibitor, with its critical functionality being that it stimulates the release of cholecystokinin
- the protease inhibitor with the desired activity is present m potatoes and m more concentrated form in commercially available extracts or fractions of potatoes, such as coarse potato flour and potato fibei Specifically, coarse potato flour available from Nonpa ⁇ el Company contains approximately 0 49 mg of potato protease inhibitor two per gram, and Paselh PPC potato flour av ailable fiom Avebe Company, The Netherlands, contains about 1 35
- an advantage of the present invention is that it provides for a nutritional intervention composition for extending satiety and reducing hunger following the termination of a meal
- an advantage of the present invention is that it provides continual effectiveness over a 30-day period and by extending satiety results in significant weight loss
- the source of the protease inhibitor may vary depending on the particular application for the satiety extending product of the present invention
- coarse potato flour contains a significant amount of the protease inhibitor, it is difficult to disperse in water
- teachings of the invention set out above can readily accomplish determining an appropriate source of protease inhibitor as well as other components that may be added to the composition to improve characteristics such as mouth feel, taste, and the like
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14589299P | 1999-07-27 | 1999-07-27 | |
| US145892P | 1999-07-27 | ||
| PCT/US2000/020157 WO2001017541A1 (en) | 1999-07-27 | 2000-07-25 | Composition for extending post meal satiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1115409A1 EP1115409A1 (en) | 2001-07-18 |
| EP1115409A4 true EP1115409A4 (en) | 2005-04-13 |
Family
ID=22515008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP00950624A Withdrawn EP1115409A4 (en) | 1999-07-27 | 2000-07-25 | COMPOSITION FOR PROLONGING DISASTER AFTER A MEAL |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1115409A4 (pt) |
| JP (2) | JP2003508490A (pt) |
| KR (1) | KR20010075394A (pt) |
| AU (1) | AU779377C (pt) |
| BR (1) | BR0006959A (pt) |
| CA (1) | CA2348067A1 (pt) |
| MX (1) | MXPA01003054A (pt) |
| WO (1) | WO2001017541A1 (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334875A (zh) * | 2017-08-30 | 2017-11-10 | 南宁学院 | 一种治疗腹泻的药酒及其制备方法 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686456B2 (en) | 2001-07-06 | 2004-02-03 | Kemin Foods, L.C. | Method for the elimination of Kunitz and Bowman-Birk trypsin inhibitors and carboxypeptidase inhibitor from potato proteins |
| JP2005015358A (ja) * | 2003-06-25 | 2005-01-20 | Pharma Design Inc | 摂食障害の治療に供される医薬組成物 |
| WO2006110731A2 (en) * | 2005-04-11 | 2006-10-19 | University Of Tennessee Research Foundation | Stable dairy components effective for fat loss |
| JP2010094085A (ja) * | 2008-10-17 | 2010-04-30 | Pola Chem Ind Inc | ダイエット用の食品組成物 |
| JP5691105B2 (ja) * | 2009-01-30 | 2015-04-01 | 株式会社東洋新薬 | ジャガイモ抽出物を含有する食品の呈味改善方法 |
| EP2227966B1 (en) * | 2009-02-25 | 2016-07-27 | Coöperatie Avebe U.A. | Condiment |
| JP5672588B2 (ja) * | 2009-05-26 | 2015-02-18 | 株式会社東洋新薬 | ダイエット用組成物 |
| WO2011068150A1 (ja) * | 2009-12-04 | 2011-06-09 | 株式会社東洋新薬 | グルカゴン様ペプチド－１分泌促進剤 |
| CN111493254A (zh) * | 2020-04-10 | 2020-08-07 | 苏州绿叶日用品有限公司 | 一种含有马铃薯提取物的固体饮料及其制备方法 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491578A (en) * | 1982-06-14 | 1985-01-01 | Peikin Steven R | Method of stimulating satiety in mammals |
| US4833128A (en) * | 1984-12-28 | 1989-05-23 | Neil Solomon | Dietary supplement |
| EP0648495A2 (en) * | 1993-07-16 | 1995-04-19 | Hercules Incorporated | Cation-complexed polysaccharides |
| US5468727A (en) * | 1990-12-13 | 1995-11-21 | Board Of Regents, The University Of Texas System | Methods of normalizing metabolic parameters in diabetics |
| US5595772A (en) * | 1995-06-07 | 1997-01-21 | Massachusetts Institute Of Technology | Composition and methods for losing weight |
| US5674896A (en) * | 1990-01-22 | 1997-10-07 | Fuji Oil Company, Limited | Appetite suppressing agent and use thereof |
| EP0898900A2 (en) * | 1997-06-23 | 1999-03-03 | Societe Des Produits Nestle S.A. | Composition and method for providing nutrition to diabetics |
| WO1999056563A2 (en) * | 1998-05-07 | 1999-11-11 | Abbott Laboratories | NUTRITIONALLY COMPLETE LOW pH ENTERAL FORMULA |
| US5989584A (en) * | 1994-08-05 | 1999-11-23 | Wisconsin Alumni Research Foundation | CCK antibodies used to improve feed efficiency |
| US6025363A (en) * | 1998-11-17 | 2000-02-15 | Giles, Jr.; James A. | Composition for suppressing appetite |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5221668A (en) * | 1992-02-26 | 1993-06-22 | Abbott Laboratories | Nutritional product for trauma and surgery patients |
| US5340603A (en) * | 1993-08-30 | 1994-08-23 | Abbott Laboratories | Nutritional product for human infants having chronic lung disease |
-
2000
- 2000-07-25 WO PCT/US2000/020157 patent/WO2001017541A1/en not_active Application Discontinuation
- 2000-07-25 MX MXPA01003054A patent/MXPA01003054A/es active IP Right Grant
- 2000-07-25 BR BR0006959-0A patent/BR0006959A/pt not_active IP Right Cessation
- 2000-07-25 JP JP2001521331A patent/JP2003508490A/ja active Pending
- 2000-07-25 EP EP00950624A patent/EP1115409A4/en not_active Withdrawn
- 2000-07-25 AU AU63704/00A patent/AU779377C/en not_active Ceased
- 2000-07-25 KR KR1020017003896A patent/KR20010075394A/ko not_active Application Discontinuation
- 2000-07-25 CA CA002348067A patent/CA2348067A1/en not_active Abandoned
-
2005
- 2005-08-15 JP JP2005235268A patent/JP2005336208A/ja active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491578A (en) * | 1982-06-14 | 1985-01-01 | Peikin Steven R | Method of stimulating satiety in mammals |
| US4833128A (en) * | 1984-12-28 | 1989-05-23 | Neil Solomon | Dietary supplement |
| US5674896A (en) * | 1990-01-22 | 1997-10-07 | Fuji Oil Company, Limited | Appetite suppressing agent and use thereof |
| US5468727A (en) * | 1990-12-13 | 1995-11-21 | Board Of Regents, The University Of Texas System | Methods of normalizing metabolic parameters in diabetics |
| EP0648495A2 (en) * | 1993-07-16 | 1995-04-19 | Hercules Incorporated | Cation-complexed polysaccharides |
| US5989584A (en) * | 1994-08-05 | 1999-11-23 | Wisconsin Alumni Research Foundation | CCK antibodies used to improve feed efficiency |
| US5595772A (en) * | 1995-06-07 | 1997-01-21 | Massachusetts Institute Of Technology | Composition and methods for losing weight |
| EP0898900A2 (en) * | 1997-06-23 | 1999-03-03 | Societe Des Produits Nestle S.A. | Composition and method for providing nutrition to diabetics |
| WO1999056563A2 (en) * | 1998-05-07 | 1999-11-11 | Abbott Laboratories | NUTRITIONALLY COMPLETE LOW pH ENTERAL FORMULA |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| US6025363A (en) * | 1998-11-17 | 2000-02-15 | Giles, Jr.; James A. | Composition for suppressing appetite |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO0117541A1 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334875A (zh) * | 2017-08-30 | 2017-11-10 | 南宁学院 | 一种治疗腹泻的药酒及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU779377B2 (en) | 2005-01-20 |
| JP2003508490A (ja) | 2003-03-04 |
| WO2001017541A1 (en) | 2001-03-15 |
| KR20010075394A (ko) | 2001-08-09 |
| CA2348067A1 (en) | 2001-03-15 |
| AU6370400A (en) | 2001-04-10 |
| MXPA01003054A (es) | 2003-07-14 |
| EP1115409A1 (en) | 2001-07-18 |
| JP2005336208A (ja) | 2005-12-08 |
| BR0006959A (pt) | 2001-06-26 |
| AU779377C (en) | 2005-06-30 |
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