EP1045711A1 - Vorrichtung zum inhalieren pulverförmiger substanzen - Google Patents

Vorrichtung zum inhalieren pulverförmiger substanzen

Info

Publication number
EP1045711A1
EP1045711A1 EP98965867A EP98965867A EP1045711A1 EP 1045711 A1 EP1045711 A1 EP 1045711A1 EP 98965867 A EP98965867 A EP 98965867A EP 98965867 A EP98965867 A EP 98965867A EP 1045711 A1 EP1045711 A1 EP 1045711A1
Authority
EP
European Patent Office
Prior art keywords
blister pack
plate
particular according
adapter
groove
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98965867A
Other languages
German (de)
English (en)
French (fr)
Inventor
Alfred Von Schuckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of EP1045711A1 publication Critical patent/EP1045711A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0035Piercing means
    • A61M15/0036Piercing means hollow piercing means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Definitions

  • the invention relates to a device for
  • the intake manifold is for the
  • the object of the invention is to provide a generic Iha-
  • 00037 provides a spatially favorable assignment. moreover
  • Such tongues can be
  • 00055 blister pack can be assigned.
  • 00070 of the flexible boom looks further in detail 00071 so that the boom has a thickened end
  • 00075 length of the boom at least about half the width
  • 00080 plate including the adapter from a hinged cover
  • 00089 corresponding hinge suitably lies in the back
  • 00095 plus suction tube includes protective. It is also a
  • 00104 strap extends like a visor in front of the sensitive one
  • 00120 is that the adapter by means of a push button
  • the procedure is such that
  • 00126 blister pack is molded. It is about
  • the groove is formed in the wall forming the cavities
  • 00140 is provided. This and the further measure that the 00141 blister pack back wall closes the receptacle for 00142 pieces, leads to closed rooms, in 00143 in which the inserts are accommodated. Finally 00144 a measure is proposed to the effect that 00145 are assigned to the front end of the suction pipe locking fingers 00146, which, resilient in the radial direction, move into fitting niches 00147 of the guide holes in the plate and engage in the locking holes assigned to 00148 guide holes. In 00149 this way, a use-safe assignment of the 00150 suction pipe is achieved. The locking is noticeable, so that 00151 the user can be sure that he has reached the correct 00152 suction standby position.
  • the locking 00154 niches ensure that the locking heads of the locking 00155 fingers are included in the fitting function.
  • the corresponding structure can be formed simply by 00157 that the latching niches are formed by bridges which 00158 extend parallel to the edge of the guide hole and are less thick than the height of the guide hole be00160.
  • the top of the bridges is recessed to the top 00162 side of the plate.
  • 00163 00164 The subject matter of the invention is explained in more detail below with reference to 00165 of a graphically illustrated embodiment example. It shows: 00167 00168 FIG.
  • FIG. 1 the device according to the invention for inhalation 00169 in perspective view, namely 00170 in a ready-to-use position and 00171 accordingly exposed plate, that is 00172 open housing, 00173 00174
  • FIG. 2 the front view of the closed housing
  • 00176 Fig. 3 is a side view of this
  • 00177 00178 Fig. 4 the housing in plan view
  • 00179 00180 Fig. 5 the bottom view of the housing
  • 00181 00182 Fig. 6 is a front view of the device with the 00183 tem hinged lid open
  • 00184 00185 Fig. 7 is a side view of this
  • 00186 00187 Big. 8 a representation corresponding to FIG.
  • FIG. 9 a side view of this
  • 00192 00193 FIG. 10 the suction pipe in side view
  • 00194 00195 FIG. 11 the same in front view
  • 00196 00197 FIG. 12 the boom in side view
  • 00198 00199 FIG. 13 the same in front view
  • 00200 00201 FIG. 14 the adapter in top view
  • 00202 00203 FIG. 15 a side view of this
  • 00204 00205 FIG. 16 the blister pack in top view
  • 00206 00207 FIG. 17 a side view of this
  • 00208 00209 FIG. 18 the adapter in perspective individual representation 00210, enlarged, 00211 Fig. 19 the associated docking end of the blister
  • Fig. 20 shows a cross section through the connection point
  • FIG. 21 shows a longitudinal section through this connecting point
  • FIG. 22 shows an offset longitudinal section through the contents
  • FIG. 23 an offset cross section through the contents
  • Fig. 27 the bottom view of the intake manifold, namely
  • FIG. 29 shows a longitudinal section through FIG. 28,
  • FIG. 30 shows a longitudinal section through FIG. 25, 00246 Fig. 31 in perspective the cutting end 00247 side of the suction tube, 00248 00249 Fig. 32 a cross section through a modified 00250 embodiment of a blister pack, in exploded view, 00252 00253 Fig. 33 the top view of this, clearly assigned 00254 nete moisture-absorbing inserts, 00255 and reproduced only in an enlarged excerpt, 00257 00258 Fig. 34 this blister pack in the assembled 00259 form, namely towards one end, 00260 00261 Fig. 35 the top view of this blister pack in 00262 entirety, 00263 00264 Fig.
  • the device V shown for inhaling powder-like substances comprises an essentially flat plate 1. This is perforated like a sieve. It is a matter of guide holes 2 arranged in a row for 00276 for the targeted attachment or plugging in of a 00277 suction pipe 3. 00278 00279 The suction pipe 3 has a cutting edge 4 at its front, insertable 00280 end.
  • the latter pierces you 00281 free-stretched section 5 'of a cover film 5 covering a cavity 6.
  • 00283 00284 With regard to the cavity 6, it is a bowl-shaped depression 00285 7 of a blister pack 8.
  • the bowl 00286 depth is approximately 4 mm and bowl diameter in Entrance 00287 area approx.7.5 mm.
  • 00288 00289 the latter (8) contains 6 pulverulent substance in a large number of such cavities.
  • 00292 is, for example, medicament powder 9. This is indicated in the 00293 drawings by dot matrix.
  • 00294 00295 The cover film 5 consists of an aluminum film.
  • the circular edges 6 'of the cavities 6 here are 00300 when the blister pack 8 is assigned in an operational manner 00301 to the plate 1 which functions as a mask 00302 congruent to the guide holes 2 of the plate 1.
  • 00303 00304 This can be gradually inserted and removed 00305 pull and move the suction tube 3 into the next 00306 guide hole 2, apply the medication powder 9 in precisely measured doses.
  • the corresponding supply 00308 to the destination is done by suction on the suction pipe 3.
  • the 00309 suction pipe 3 has a mouth 00310 piece opening 10 at its other end.
  • the mouthpiece opening 10 is flow-connected to the pipe-open area of the cutting edge 4 via a suction channel 11 00314. In this way, the cavity 6 is emptied completely 00315. 00316 The suction channel 11 is flowed with cross ventilation holes 12
  • A is the corresponding connecting bridge
  • tube 3 is in a half-shell-like version 16
  • brackets 16 ', 16' ' are spatially
  • Mouthpiece heel is an axial limit stop for
  • 00374 17 takes a U-shaped cross section
  • the locking projection 28 is one
  • 00439 can be lifted using an appropriate pulling force. 00440
  • 00443 is about 2: 1.
  • 00455 according to its radial opening 32 on a waist 00456 33 of the suction pipe 3 on the catch.
  • the waist circumference 00457 is circular, as is the interior of the ring 31.
  • 00458 So there remains a rotational ability between the ring designated 00459 as the swivel ring 31 and 00460 the waist 33.
  • 00461 00462 diametrically the opening 32 of the swivel ring 31 sets 00463 the cord-like Extension arm 30.
  • the other end merges into 00464 a thickened end 34. It is a 00465 shaped ball there.
  • the boom 30 is centered to 00466 (see Figures 12 and 13).
  • the thickened end 34 holds the extension 30 on the 00469 blister pack 8 or plate 1.
  • the corresponding 00470 coupling position is obtained when 00471 the blister pack 8 is pushed under the plate 1 00472 (see FIGS. 8.9).
  • the latter forms a shaft 35 which corresponds to the cross-sectional profile of the blister pack 8 00474 corresponding to 00473 (cf. FIG. 22).
  • the counterstop is the one there
  • the boom 30 is like
  • 00537 profile is semi-spherical and dimensioned so that at least
  • the slot 48 which extends in the longitudinal center plane of the housing 40 er00560, provides an accessible, fully 00561 movable housing-side fixing point for the bracket 30.
  • the radius of action for inserting the suction pipe 3 00564 into the guide holes 2 is covered, and also the space 00565 may be in the lateral direction, for which the length of the Ausle00566 device 30 corresponds to at least approximately half the width of the plate 1 00567.
  • 00568 00569 The top exit of slot 48 is chamfered.
  • 00588 extends in the plane essentially also the longitudinal center axis of the suction pipe 3 clipped into the 00589 socket 16. The radially extending boom 30 can thus be inserted into the channel 43 correspondingly running 00591 without transverse loads. 00592 00593 loads on the hinged lid 41 also occur
  • ge 51 and the edge wall 52 are level with each other. 00619
  • the shell-like blister structure is on that of the plate
  • 00627 1 side provided with a rear wall 53.
  • the 00628 provides a tight seal to the outside. Also
  • 00648 is a support by the sealed, for example
  • the associated die part is located in
  • 00676 is mushroom-like, cross-slotted or cross-slotted
  • the cutting edge 4 has a bow-shaped or frame-shaped one
  • the tappet blades 61 act as displacers. she
  • the tappet blades 61 can, as shown, also be sharpened 00736, which is any 00737 if their displacement function is not detrimental.
  • 00738 00739 The clear distance between the ram blades 61 and 00740, the width 00741 of the cutting blade frame cavity 60 measured in the larger cutting edge are the same. From the 00742 root of both elements 60, 61, the clearly narrower 00743 clear cross section of the suction pipe 3 merges into a larger 00744 clear inner diameter, forming the suction channel 00745 11.
  • plug-in limiting protrusions 66 for 00750 are the head end of 00751 suction pipe 3, which can be inserted into the guide holes 2.
  • the undersides of corresponding, quadruple 00752 and essentially equally spaced 00753 plug-in limiting protrusions 66 meet the outer edge zones of the plate 1 in this Position 00755 has reached the optimal immersion depth of the cutting edge 4 towards the Kavi00756 action 6.
  • the suction pipe 3 has provisions for 00760 locking with the plate 1.
  • 3 locking fingers 67 are formed on the front end of the suction tube. 00762 They run freestanding in the head area and parallel 00763 to the cutting edge 4 and end in outward-facing locking heads 00764 68. The locking is noticeable. 00765 00766 The locking fingers 47 move when the intake pipe
  • the latching niches 70 are special, as from FIG. 22
  • Rest area 70 00801 reduces the vertical height of bridge 72.
  • 00803 bar is the top of the bridge 72 recessed
  • the joining projection 78 can also

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Medicinal Preparation (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
EP98965867A 1997-12-22 1998-12-22 Vorrichtung zum inhalieren pulverförmiger substanzen Withdrawn EP1045711A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19757208 1997-12-22
DE19757208A DE19757208A1 (de) 1997-12-22 1997-12-22 Vorrichtung zum Inhalieren pulverförmiger Substanzen
PCT/EP1998/008420 WO1999032179A1 (de) 1997-12-22 1998-12-22 Vorrichtung zum inhalieren pulverförmiger substanzen

Publications (1)

Publication Number Publication Date
EP1045711A1 true EP1045711A1 (de) 2000-10-25

Family

ID=7852975

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98965867A Withdrawn EP1045711A1 (de) 1997-12-22 1998-12-22 Vorrichtung zum inhalieren pulverförmiger substanzen

Country Status (17)

Country Link
EP (1) EP1045711A1 (xx)
JP (1) JP2001526096A (xx)
KR (1) KR20010033411A (xx)
CN (1) CN1284891A (xx)
AU (1) AU751738B2 (xx)
BR (1) BR9814371A (xx)
CA (1) CA2316345A1 (xx)
DE (1) DE19757208A1 (xx)
EE (1) EE200000399A (xx)
HU (1) HUP0100589A3 (xx)
IL (1) IL136878A0 (xx)
NO (1) NO20003182L (xx)
NZ (1) NZ505272A (xx)
PL (1) PL341319A1 (xx)
SK (1) SK9542000A3 (xx)
TR (1) TR200001862T2 (xx)
WO (1) WO1999032179A1 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6679256B2 (en) * 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
DE19961300A1 (de) 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator
SE9904705D0 (sv) 1999-12-21 1999-12-21 Astra Ab An inhalation device
US7258118B2 (en) 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
DE102007005724A1 (de) * 2007-01-31 2008-08-07 Behr Gmbh & Co. Kg Luftausströmer
FR2918352B1 (fr) * 2007-07-03 2009-10-09 Valois Sas Dispositif d'ouverture de reservoir pour dispositif de distribution de produit fluide
EP2082763A1 (en) 2008-01-24 2009-07-29 Boehringer Ingelheim International Gmbh Inhaler
DE102017106500A1 (de) * 2017-03-27 2018-09-27 Aixtron Se Pulverdosierer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5133454A (en) * 1990-12-06 1992-07-28 Hammer Steven G Intravenous catheter biohazard prevention packaging device
US5533502A (en) * 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
US5642727A (en) * 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
DE19619536A1 (de) 1996-04-25 1997-10-30 Alfred Von Schuckmann Inhalier-Vorrichtung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9932179A1 *

Also Published As

Publication number Publication date
PL341319A1 (en) 2001-04-09
AU751738B2 (en) 2002-08-29
BR9814371A (pt) 2003-01-28
NO20003182L (no) 2000-08-21
CA2316345A1 (en) 1999-07-01
JP2001526096A (ja) 2001-12-18
CN1284891A (zh) 2001-02-21
WO1999032179A1 (de) 1999-07-01
NZ505272A (en) 2002-05-31
HUP0100589A3 (en) 2001-07-30
IL136878A0 (en) 2001-06-14
HUP0100589A1 (hu) 2001-06-28
NO20003182D0 (no) 2000-06-19
TR200001862T2 (tr) 2001-01-22
DE19757208A1 (de) 1999-06-24
KR20010033411A (ko) 2001-04-25
AU2163299A (en) 1999-07-12
EE200000399A (et) 2002-02-15
SK9542000A3 (en) 2000-11-07

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