EP0958780A1 - Système à capteur avec accès permanemment implanté - Google Patents

Système à capteur avec accès permanemment implanté Download PDF

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Publication number
EP0958780A1
EP0958780A1 EP99810408A EP99810408A EP0958780A1 EP 0958780 A1 EP0958780 A1 EP 0958780A1 EP 99810408 A EP99810408 A EP 99810408A EP 99810408 A EP99810408 A EP 99810408A EP 0958780 A1 EP0958780 A1 EP 0958780A1
Authority
EP
European Patent Office
Prior art keywords
access
substances
fluids
implanted
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99810408A
Other languages
German (de)
English (en)
Other versions
EP0958780B1 (fr
Inventor
Michel Willi
Ulrich Haueter
Thomas Frei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
Disetronic Licensing AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disetronic Licensing AG filed Critical Disetronic Licensing AG
Publication of EP0958780A1 publication Critical patent/EP0958780A1/fr
Application granted granted Critical
Publication of EP0958780B1 publication Critical patent/EP0958780B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6864—Burr holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Definitions

  • the invention relates to a method and a device for detecting the concentration or the presence of substances in body fluids and their use an access implanted in the body to the inside of the body as part of a such capture.
  • Needle sensors also fail because they can be used in a very short time (about half a day) are attacked or rejected by the body.
  • Non-invasive techniques such as determining concentration via Fluoroscopy techniques are not yet technically mature enough, to get enough exact values.
  • Port body that is subcutaneous or percutaneous be implanted and the administration of drugs via tube channels are known for example from US-A-5,306,255 and EP-B-0 302 076.
  • the method according to the invention for determining the concentration or the presence of substances in body fluids solves this problem in that Analysis of the fluids via a permanently implanted access to the body Inside the body, the available liquid is accessed.
  • the method according to the invention now aims to be permanent accesses implanted in the body for access to body fluids use.
  • the quick-change units May include, for example, a bordered sealing membrane, open mostly on those parts of the body where the mouth is blocked for a long time does not occur or they are designed so that attacks or rejection reactions through the body cell its function at least in the predetermined period of use cannot interfere.
  • This advantage can now also be used according to the invention Access to the body fluids can be used by means of such accesses. This means that such permanent accesses also allow for analysis purposes to be able to access liquids for a long time.
  • Access is therefore advantageously via a permanently implanted device for the administration of drugs and in a particularly preferred Embodiment of the method according to the invention via an implanted in the skin Port body with a hose arrangement extending into the interior of the body.
  • Port bodies are particularly suitable for permanent insulin administration Access, preferably to the umbilical vein implanted in the abdominal cavity in the body.
  • the abdominal cavity, the peritoneum and also the umbilical vein have proven to be beneficial Locations for the administration of insulin have been shown, since the insulin reabsorbs there more quickly is considered, for example, with a subcutaneous delivery. Because insulin consumption in takes place in the body cells themselves, the cell fluid also appears very suitable place to measure the blood sugar level, because here practically directly at the place of consumption a central average is measured. Accordingly, are suitable Port body for insulin administration into the abdominal cavity is particularly good as the invention Access points to the body fluid to be analyzed.
  • port bodies are indeed invasive devices, but one is sufficient here single implantation, so that the patient can access his Body fluid no longer feels any inconvenience through such port bodies.
  • One embodiment of a method according to the invention is characterized in that that a test sensor has access to the detection of concentration or presence the substances are introduced into the inside of the body and recorded there becomes. This opens up the possibility of continuous or intermittent Measurement with the test sensor remaining inside the body at the measurement location and in particular when using a port body with a hose arrangement is introduced via a separate hose.
  • an inventive detection method with a To carry out the remaining test sensor inside the body is to use the Access body fluid taken from inside the body and analyzed at one point that is away from the point of withdrawal.
  • the body fluid still in the body preferably at an intermediate point in the hose arrangement of a sensor is analyzed and for this purpose sucked in at this point.
  • an intermediate point as a measuring point is in particular in the fact that possible deposits on the mouth of the hose over which the Access occurs, can arise, then no negative influence on the measuring accuracy if the test sensor is at a distance from the hose mouth Intermediate position.
  • the inner part of the hose therefore protects you test sensor permanently attached to an intermediate point of the hose in front of direct Pollution. Temperature constancy is also ensured. When changing the The abdomen remains unaffected by the sensor.
  • a microdialysis probe used to remove the substances in the body fluid.
  • the device according to the invention for detecting the concentration or the presence of substances in body fluids has one permanently implanted in the body Access to the inside of the body, which is used to analyze the liquids is adapted that the liquids can be accessed via this body.
  • the access is preferably a permanently implanted device for administration of medicines, especially a port body implanted in the skin a tube arrangement extending into the interior of the body.
  • the access of the device according to the invention or the port body preferably has Passages by means of which a test sensor is inserted into the interior of the body.
  • the access or the port body preferably has a separate hose for insertion of such a test sensor.
  • a particularly preferred embodiment of the device according to the invention is characterized in that a microdialysis probe is assigned to the access via which the substances in the body fluid are taken from.
  • the invention further relates to the use of a device permanently implanted in the body Access to the inside of the body to record concentration or presence of substances in body fluids. With such use, all of the above advantageous embodiments of the method according to the invention and the device can be realized.
  • the port body which is denoted in its entirety by 10 in the figure, is in one shown implanted in the skin 15. It consists of a shaft part 11 to which an approximately disc-shaped anchoring part 13 is fastened on the outside, which serves to fix the port body 10 in the skin.
  • the shaft part 11 forms a hollow housing in which an elastic self-closing Membrane 12 is added.
  • each the tubes 23 and 21 each have a catheter inserted, namely the present one Example of the delivery catheter 24 and the suction catheter 22.
  • a drug such as insulin
  • the suction catheter 22 there is a point at the mouth of the tube 23 a drug, such as insulin, while being supplied by the suction catheter 22 from a point at the end at the mouth of the tube 21 body fluid can be removed.
  • Fastening sections 14 are also shown schematically on the upper side of the shaft 11 provided for connecting upper sealing or end caps, not shown are provided on the catheters 24 and 22.
  • the supply hose 23 is preferably standardized lengths of 150 or 180 mm have, while the suction hose 21 is approximately a length of at least 30, preferably from 60 to 120 mm, possibly up to 180 mm. Based on The arrangement shown here can now be seen that this port body both for delivering medication via the delivery catheter 24 as well as for accessing Body fluid can be used via the suction catheter 22. Preferably extend the tubes 23 and 21 into the patient's abdomen, where the cell fluid is located, to which either a drug must be added or the should be analyzed to test certain concentrations.
  • test sensor can also be permanently attached to the location be indicated by the dashed arrow 26.
  • the advantage of this registration procedure lies in the fact that suction is no longer necessary and the detection is made possible directly at a designated measuring point.
  • test sensor in Hose remains permanently at 25 or at the end 26 of the hose, becomes an electronic one Test sensor used, the lead wires with the catheter 22 from the body can be brought out.
  • such electrical test sensors mostly a working electrode, a counter electrode and a currentless reference electrode exhibit.
  • the shaft 11 of the port body (as is usually the case is) made of a metallic material, can advantageously according to the invention the shaft 11 can also be used as a reference electrode or counter electrode, so that, according to the invention, such measurements also simplify the electrical sensor can be reached.
  • Another way to use the arrangement shown in the figure consists of the hose 21 for a single measurement or for each individual measurement just insert a probe once, the one at its front end Has test strips for concentration detection.
  • the measurement determination and - Evaluation can be done in the inserted state or after removal according to known Procedure.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP99810408A 1998-05-20 1999-05-07 Système à capteur avec accès permanemment implanté Expired - Lifetime EP0958780B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19822711A DE19822711B4 (de) 1998-05-20 1998-05-20 Sensorsystem mit Portkörper
DE19822711 1998-05-20

Publications (2)

Publication Number Publication Date
EP0958780A1 true EP0958780A1 (fr) 1999-11-24
EP0958780B1 EP0958780B1 (fr) 2009-10-07

Family

ID=7868460

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99810408A Expired - Lifetime EP0958780B1 (fr) 1998-05-20 1999-05-07 Système à capteur avec accès permanemment implanté

Country Status (5)

Country Link
US (2) US6986755B2 (fr)
EP (1) EP0958780B1 (fr)
JP (1) JP2000105212A (fr)
AT (1) ATE444705T1 (fr)
DE (2) DE19822711B4 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007003431A1 (fr) 2005-07-06 2007-01-11 Medizinische Universität Graz Dispositif et procédé de distribution et d'élimination de substances provenant et à destination d'un tissu ou d'un vaisseau

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19942898B4 (de) * 1999-09-08 2007-07-05 Disetronic Licensing Ag Dialysesonde
US7900632B2 (en) * 2006-08-18 2011-03-08 Cookgas, L.L.C. Laryngeal mask with esophageal blocker and bite block
US20090069743A1 (en) * 2007-09-11 2009-03-12 Baxter International Inc. Infusion therapy sensor system
FR3017771B1 (fr) 2014-02-24 2023-03-17 Centre Nat Rech Scient Plantes a rendement accru et methode d'obtention de telles plantes
US20170319108A1 (en) * 2016-05-09 2017-11-09 Jill Renee Donohoo Implantable device for locating drug users

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302076A1 (fr) 1986-04-18 1989-02-08 Dan Lundgren Passage pour implant.
US4805624A (en) * 1985-09-09 1989-02-21 The Montefiore Hospital Association Of Western Pa Low-potential electrochemical redox sensors
EP0534074A1 (fr) * 1991-09-16 1993-03-31 Institut für Diabetestechnologie gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH Procédé et dispositif pour la mesure de la concentration des éléments constituants dans le fluide du corps
US5306255A (en) 1991-09-07 1994-04-26 Hans Haindl Portcatheter
US5441481A (en) * 1994-05-27 1995-08-15 Mishra; Pravin Microdialysis probes and methods of use
WO1995028878A1 (fr) * 1994-04-25 1995-11-02 Minimed Inc. Pompe de perfusion et ensemble capteur de glucose
US5474552A (en) * 1994-06-27 1995-12-12 Cb-Carmel Biotechnology Ltd. Implantable drug delivery pump

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US4622974A (en) * 1984-03-07 1986-11-18 University Of Tennessee Research Corporation Apparatus and method for in-vivo measurements of chemical concentrations
US4799494A (en) * 1986-10-22 1989-01-24 Wang Ko P Percutaneous aspiration lung biopsy needle assembly
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US4824434A (en) * 1987-01-14 1989-04-25 Seitz Jr H Michael Apparatus used in a method for removing tissue and living organisms from human body cavities
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4805624A (en) * 1985-09-09 1989-02-21 The Montefiore Hospital Association Of Western Pa Low-potential electrochemical redox sensors
EP0302076A1 (fr) 1986-04-18 1989-02-08 Dan Lundgren Passage pour implant.
US5306255A (en) 1991-09-07 1994-04-26 Hans Haindl Portcatheter
EP0534074A1 (fr) * 1991-09-16 1993-03-31 Institut für Diabetestechnologie gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH Procédé et dispositif pour la mesure de la concentration des éléments constituants dans le fluide du corps
WO1995028878A1 (fr) * 1994-04-25 1995-11-02 Minimed Inc. Pompe de perfusion et ensemble capteur de glucose
US5441481A (en) * 1994-05-27 1995-08-15 Mishra; Pravin Microdialysis probes and methods of use
US5474552A (en) * 1994-06-27 1995-12-12 Cb-Carmel Biotechnology Ltd. Implantable drug delivery pump

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007003431A1 (fr) 2005-07-06 2007-01-11 Medizinische Universität Graz Dispositif et procédé de distribution et d'élimination de substances provenant et à destination d'un tissu ou d'un vaisseau

Also Published As

Publication number Publication date
DE19822711B4 (de) 2006-11-23
EP0958780B1 (fr) 2009-10-07
DE59915093D1 (de) 2009-11-19
US20020026143A1 (en) 2002-02-28
US7670312B2 (en) 2010-03-02
DE19822711A1 (de) 1999-12-09
ATE444705T1 (de) 2009-10-15
JP2000105212A (ja) 2000-04-11
US6986755B2 (en) 2006-01-17
US20060100573A1 (en) 2006-05-11

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