EP0957928A1 - Pflanzenextrakte zubereitungen, verfahren zu deren herstellung und diese extrakte enthaltende pharmazeutische zusammensetzung - Google Patents
Pflanzenextrakte zubereitungen, verfahren zu deren herstellung und diese extrakte enthaltende pharmazeutische zusammensetzungInfo
- Publication number
- EP0957928A1 EP0957928A1 EP97907160A EP97907160A EP0957928A1 EP 0957928 A1 EP0957928 A1 EP 0957928A1 EP 97907160 A EP97907160 A EP 97907160A EP 97907160 A EP97907160 A EP 97907160A EP 0957928 A1 EP0957928 A1 EP 0957928A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- extract
- plant
- treatment
- migraine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000000419 plant extract Substances 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 10
- 239000000284 extract Substances 0.000 claims abstract description 27
- 241000196324 Embryophyta Species 0.000 claims abstract description 22
- 238000011282 treatment Methods 0.000 claims abstract description 20
- 208000019695 Migraine disease Diseases 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 13
- 206010027599 migraine Diseases 0.000 claims abstract description 13
- 241001465754 Metazoa Species 0.000 claims abstract description 10
- 241000282414 Homo sapiens Species 0.000 claims abstract description 6
- 239000010949 copper Substances 0.000 claims description 14
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 10
- 229910052802 copper Inorganic materials 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
- 241000124033 Salix Species 0.000 claims description 5
- 241000404542 Tanacetum Species 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000002151 riboflavin Substances 0.000 claims description 3
- 229960002477 riboflavin Drugs 0.000 claims description 3
- 235000019192 riboflavin Nutrition 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 239000011573 trace mineral Substances 0.000 claims description 3
- 235000013619 trace mineral Nutrition 0.000 claims description 3
- 241001278097 Salix alba Species 0.000 abstract description 25
- 229940001448 feverfew extract Drugs 0.000 abstract description 3
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 17
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- 230000000202 analgesic effect Effects 0.000 description 9
- 102000005962 receptors Human genes 0.000 description 9
- 108020003175 receptors Proteins 0.000 description 9
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- 244000042664 Matricaria chamomilla Species 0.000 description 7
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- RLQZIECDMISZHS-UHFFFAOYSA-N 2-phenylcyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C=CC(=O)C(C=2C=CC=CC=2)=C1 RLQZIECDMISZHS-UHFFFAOYSA-N 0.000 description 6
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 6
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 6
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- 230000002460 anti-migrenic effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
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- 241000700159 Rattus Species 0.000 description 5
- 229940108925 copper gluconate Drugs 0.000 description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 239000000679 carrageenan Substances 0.000 description 4
- 235000010418 carrageenan Nutrition 0.000 description 4
- 229920001525 carrageenan Polymers 0.000 description 4
- 229940113118 carrageenan Drugs 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 3
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- 239000002775 capsule Substances 0.000 description 3
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- 229940091250 magnesium supplement Drugs 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 239000002287 radioligand Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 208000002881 Colic Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 229960002274 atenolol Drugs 0.000 description 2
- -1 copper sulphate Chemical class 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
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- 230000000144 pharmacologic effect Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012453 sprague-dawley rat model Methods 0.000 description 2
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- VFIDUCMKNJIJTO-CJNGLKHVSA-N (2r,3r)-1-[(7-methyl-2,3-dihydro-1h-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol Chemical compound CC(C)N[C@H](C)[C@@H](O)COC1=CC=C(C)C2=C1CCC2 VFIDUCMKNJIJTO-CJNGLKHVSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000011980 Anacyclus pyrethrum Nutrition 0.000 description 1
- 240000008276 Anacyclus pyrethrum Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 description 1
- XKMLYUALXHKNFT-UUOKFMHZSA-N Guanosine-5'-triphosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XKMLYUALXHKNFT-UUOKFMHZSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241001495454 Parthenium Species 0.000 description 1
- AVFIYMSJDDGDBQ-UHFFFAOYSA-N Parthenium Chemical compound C1C=C(CCC(C)=O)C(C)CC2OC(=O)C(=C)C21 AVFIYMSJDDGDBQ-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241001470487 Salix cinerea Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 208000000491 Tendinopathy Diseases 0.000 description 1
- 206010043255 Tendonitis Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 206010047163 Vasospasm Diseases 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 229960002213 alprenolol Drugs 0.000 description 1
- PAZJSJFMUHDSTF-UHFFFAOYSA-N alprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1CC=C PAZJSJFMUHDSTF-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940124433 antimigraine drug Drugs 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
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- 210000000170 cell membrane Anatomy 0.000 description 1
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- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
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- 229960004704 dihydroergotamine Drugs 0.000 description 1
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
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- 229960003638 dopamine Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002884 effect on inflammation Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 231100000334 hepatotoxic Toxicity 0.000 description 1
- 230000003082 hepatotoxic effect Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000001755 magnesium gluconate Substances 0.000 description 1
- 229960003035 magnesium gluconate Drugs 0.000 description 1
- 235000015778 magnesium gluconate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000030247 mild fever Diseases 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000002474 noradrenergic effect Effects 0.000 description 1
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- 230000007310 pathophysiology Effects 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002089 prostaglandin antagonist Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940084038 salix alba bark extract Drugs 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
- 229960003708 sumatriptan Drugs 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
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- 230000006794 tachycardia Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
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- 201000004415 tendinitis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Definitions
- compositions of salicoids and parthenoids, or of plants or plant extracts containing these two active principles, in particular associated with a metal preferably chosen from copper, zinc or magnesium to the trace element, or riboflavin, were endowed with remarkable anti-inflammatory, analgesic and anti-migraine properties.
- plant extract is understood in the broad sense both plants and parts of plants, for example and preferably dried or dehydrated, and ground, or alternatively extracts of such plants or parts of plants obtained using at least one aqueous and / or organic solvent and which are in a form conventionally used in pharmacy or dietetics, liquid or in particular solid.
- a preferred composition above is characterized in that it additionally contains riboflavin, zinc, magnesium or preferably copper in the state of a trace element, that is to say that the metal is used in low or very low proportions, for example less than 1 part per 100, preferably less than 1 part per 300, particularly less than 1 part per 1000 relative to the weight of the other components.
- the copper used can be in particular in the form of copper salts, particularly cupric salts (Cu ++ ), for example in the form of mineral salts such as copper sulphate, and very particularly salified in the form of organic salts, preferably in form of gluconates.
- the same is true for zinc or magnesium. More particularly, the above compositions are retained in which the plant of the genus Tanacetum is Tanacetum parthenium and the plant of the genus Salix is Salix alba.
- compositions which are the subject of the present invention have very advantageous pharmacological properties. They are endowed in particular with remarkable anti-inflammatory, analgesic and antimigraine properties.
- the usual dose which varies depending on the subject treated and the condition in question, can be, for example, from 100 mg to 1000 mg per day orally in humans of aerial parts, dried and ground, of Tanacetum parthenium with 300 mg to 1000 mg of bark, dried and crushed, of Salix alba and with 0.05 mg to 2.50 mg of copper as cupric ions, for 7 to 30 days for curative treatment or preventive of migraines.
- the active principle is advantageously present at physiologically effective doses; the aforementioned compositions contain in particular an effective anti-migraine dose of at least one active ingredient above.
- the above compositions can be incorporated into pharmaceutical compositions intended for the digestive tract.
- compositions can be, for example, solid or liquid and can be presented in the pharmaceutical forms commonly used in human medicine, such as for example simple or coated tablets, capsules, granules, caramels, suppositories; they are prepared according to the usual methods.
- the active ingredient (s) can be incorporated therein into excipients usually used in these pharmaceutical compositions, such as talc, gum arabic, lactose, starch, magnesium stearate, cocoa butter, aqueous vehicles or not , fatty substances of animal or vegetable origin, paraffinic derivatives, glycols, various wetting agents, dispersants or emulsifiers, preservatives.
- a composition described above can also be in the form of a food supplement or a dietetic or phytotherapeutic product. In these forms, it can be in the common forms of pharmaceutical compositions, in particular those intended for “general public” use.
- compositions can advantageously be combined with another active ingredient chosen from the group consisting of analgesics, antipyretics, antibiotics, anti-inflammatories, corticoids, antivirals and drugs for cardiovascular pathologies.
- the products were tested on male and female Ico rats (Sprague Dawley) weighing approximately 250 g supplied by the company IFFA-CREDO.
- the products tested were suspended in hydroxypropyl methyl cellulose (HPMC).
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/FR1997/000370 WO1998039018A1 (fr) | 1997-03-03 | 1997-03-03 | Compositions d'extraits de plantes, leur procede de preparation, et compositions pharmaceutiques les renfermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0957928A1 true EP0957928A1 (de) | 1999-11-24 |
Family
ID=9502635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97907160A Withdrawn EP0957928A1 (de) | 1997-03-03 | 1997-03-03 | Pflanzenextrakte zubereitungen, verfahren zu deren herstellung und diese extrakte enthaltende pharmazeutische zusammensetzung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6254899B1 (de) |
| EP (1) | EP0957928A1 (de) |
| JP (1) | JP2001513803A (de) |
| AU (1) | AU1930897A (de) |
| CA (1) | CA2283122A1 (de) |
| WO (1) | WO1998039018A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2775600B1 (fr) * | 1998-03-05 | 2000-10-06 | Ravi Shrivastava | Nouvelle composition pharmaceutique pour le traitement des troubles d'origine neurologique |
| US6068999A (en) * | 1998-06-25 | 2000-05-30 | Hendrix; Curt | Dietary supplement for supporting cerebrovascular tone and treating migraine headaches |
| DE19844836A1 (de) | 1998-09-30 | 2000-04-20 | Hexal Ag | Pharmazeutisch, wirksames, pflanzliches Präparat zur Behandlung von Migräne |
| US6312736B1 (en) * | 1999-12-09 | 2001-11-06 | Biotech Corporation | Herbal composition to relieve pain |
| FR2805158B1 (fr) * | 2000-02-18 | 2004-12-03 | L M D | Composition cosmetique ou medicamenteuse contenant une lactone sesquiterpenique ou un analogue pour traiter les desordres lies a la croissance pilaire, et son procede de preparation. |
| DE10015617A1 (de) * | 2000-03-29 | 2001-10-04 | Peter Laetzsch | Migränemittel |
| FR2807319B1 (fr) * | 2000-04-07 | 2004-10-22 | L M D | Composition cosmetique ou en tant que medicament contenant une lactone sesquiterpenique pour traiter les hematomes, et procede de traitement |
| JP2005518439A (ja) * | 2002-02-26 | 2005-06-23 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 抗痙攣性誘導体と抗片頭痛薬を含んで成る片頭痛治療用共治療薬 |
| WO2004037165A2 (en) * | 2002-08-23 | 2004-05-06 | The Research Foundation Of State University Of New York | Nitric oxide and its biomedical significance |
| US7192614B2 (en) | 2002-11-05 | 2007-03-20 | Gelstat Corporation | Compositions and methods of treatment to alleviate or prevent migrainous headaches and their associated symptoms |
| US20040219229A1 (en) * | 2003-04-30 | 2004-11-04 | Tim Clarot | Migraine relief composition and methods of using and forming same |
| FR2882255B1 (fr) * | 2005-02-24 | 2008-05-16 | Apis Spheromont | Spheroides prepares a partir d'un principe actif isole d'origine vegetale et d'une solution d'origine vegetale contenant le principe actif ou un precurseur de celui-ci |
| US8409637B2 (en) | 2007-06-21 | 2013-04-02 | Puramed Bioscience Inc. | Compositions and methods for treating and preventing migrainous headaches and associated symptoms |
| IT201700085185A1 (it) * | 2017-07-26 | 2019-01-26 | Cristalfarma S R L | Integratore alimentare per uso come coadiuvante nel trattamento e profilassi dell’emicrania |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2221150A1 (en) * | 1973-03-13 | 1974-10-11 | Neukirch Jacques | Infusions of Tanacetum balsamita - for treatment of psoriasis, eczema and cutaneous allergies |
| HU184575B (en) * | 1982-07-16 | 1984-09-28 | Otto Mallasz | Method for producing preparations fixable on skin generating locally electrolytic and bio currents |
| SE8701662L (sv) * | 1987-04-22 | 1988-10-23 | Gelder Nico M Van | Saett och medel foer att behandla neurologiska sjukdomar, exempelvis migraen genom paaverkan av nervcellerna |
| WO1995008318A2 (fr) * | 1993-09-15 | 1995-03-30 | Valentina Nikolaevna Peidus | Substance medicinale a proprietes anti-infecteuses destinee a etre utilisee dans le traitement de la sterilite et dans la protection de la grossesse |
| CA2141126A1 (en) * | 1995-01-26 | 1996-07-27 | Natalie J. Lazarowych | Combinational drug for treating migraine and other illnesses |
| US5538959A (en) * | 1995-01-26 | 1996-07-23 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
-
1997
- 1997-03-03 JP JP53821398A patent/JP2001513803A/ja active Pending
- 1997-03-03 AU AU19308/97A patent/AU1930897A/en not_active Abandoned
- 1997-03-03 EP EP97907160A patent/EP0957928A1/de not_active Withdrawn
- 1997-03-03 US US09/380,371 patent/US6254899B1/en not_active Expired - Fee Related
- 1997-03-03 CA CA002283122A patent/CA2283122A1/fr not_active Abandoned
- 1997-03-03 WO PCT/FR1997/000370 patent/WO1998039018A1/fr not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9839018A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2283122A1 (fr) | 1998-09-11 |
| JP2001513803A (ja) | 2001-09-04 |
| WO1998039018A1 (fr) | 1998-09-11 |
| AU1930897A (en) | 1998-09-22 |
| US6254899B1 (en) | 2001-07-03 |
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