EP0948590A1 - Compositions de nettoyage - Google Patents

Compositions de nettoyage

Info

Publication number
EP0948590A1
EP0948590A1 EP97946468A EP97946468A EP0948590A1 EP 0948590 A1 EP0948590 A1 EP 0948590A1 EP 97946468 A EP97946468 A EP 97946468A EP 97946468 A EP97946468 A EP 97946468A EP 0948590 A1 EP0948590 A1 EP 0948590A1
Authority
EP
European Patent Office
Prior art keywords
surfactant
foam
composition according
cleansing composition
denture cleansing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97946468A
Other languages
German (de)
English (en)
Other versions
EP0948590A4 (fr
Inventor
Owen Thurlby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP0948590A1 publication Critical patent/EP0948590A1/fr
Publication of EP0948590A4 publication Critical patent/EP0948590A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
    • C11D3/3738—Alkoxylated silicones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/28—Sulfonation products derived from fatty acids or their derivatives, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C11D17/0065—Solid detergents containing builders
    • C11D17/0073—Tablets
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3942—Inorganic per-compounds

Definitions

  • the present invention relates to granular denture cleansing compositions.
  • the invention relates to granular, cleansing compositions, suitable for cleaning teeth or dentures which can be incorporated into compressed form, such as denture cleanser tablets and the like, to deliver enhanced plaque prevention benefits together with excellent cleansing performance and in-use performance characteristics.
  • Tablets and powders for cleansing dentures and the like are well known in the art.
  • the aim of a denture cleanser product is to clean the denture as fully and as quickly as possible and especially to remove the accumulation of plaque, mucilaginous and bacterial deposits which collect while the denture is being worn.
  • To wear a denture which has not been completely cleaned of plaque and bacterial deposits is not only unhygienic but can also within a short space of time result in a detrimental effect on the mucous membrane.
  • bacterial deposits can lead to so-called bacterial corrosion of the plastics material used to produce the denture with consequent colour change and malodour formation.
  • Denture cleansers are usually used by being dissolved in a glass of warm water. To be effective, it is first necessary for the tablet or powder to dissolve rapidly. This is particularly true of the compressed tablet form. Effervescence, which can be generated as the tablet dissolves, assists in tablet break-up and the foam generated also helps signal efficacy to the consumer. Surfactants in the formulation enhance foam generation and cleaning. It is further desirable to deposit an agent on the teeth or dentures which prevents further plaque build-up. Many silicones are suitable for this purpose as described, for example, in WO 96/19563 and WO 96/19191. However the silicones can also act as foam suppressors. Moreover, the presence of a surfactant can also inhibit the silicone deposition and make compressed tablets slow to dissolve.
  • the invention provides granular, denture cleansing composition
  • granular, denture cleansing composition comprising an inorganic persalt bleaching agent, a silicone oil and from 0.55 to 3.8% of a foam-forming surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants and mixtures thereof, wherein the silicone oil and the foam- orming surfactant are in discrete, separate granules.
  • the granular compositions have high foaming activity and help prevent plaque build-up on dentures or teeth.
  • the granules are free-flowing and dissolve rapidly, even when processed into compressed tablet form.
  • the granular, denture cleansing composi tions of the invention can be in tablet, granular or powder form, although tablet-form compositions are highly preferred herein. Compositions in tablet form can be single or multiple layered tablets.
  • compositions comprise an inorganic persalt bleaching agent, a silicone oil and from 0.55 to 3.8% of a foam-forming surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants and mixtures thereof, as essential components and can additionally comprise several optional components.
  • a foam-forming surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants and mixtures thereof, as essential components and can additionally comprise several optional components.
  • a first essential ingredient of the compositions of the present invention is a persalt bleaching agent.
  • the bleaching agent can be selected from any of the well-known bleaching agents known for use in denture cleansers such as the alkali metal and ammonium persulfates, perborates, percarbonates and perphosphates and the alkali metal and alkaline earth metal peroxides.
  • suitable bleaching agents include potassium, ammonium, sodium and lithium persulfates and perborate mono- and tetrahydrates, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides.
  • the alkali metal persulfates, perborates and mixtures thereof are preferred for use herein, highly preferred being the alkali metal perborates.
  • the tablet compositions herein will provide excellent antimicrobial activity even in the absence of alkali metal persulfates.
  • the amount of bleaching agent in the total composition is generally from about 5% to about 70%, preferably from about 20% to about 60%.
  • Preferred compositions comprise both a persulphate salt and a perborate salt.
  • the persulphate salt and perborate salt can be in any ratio but it has been found that better foaming is achieved with a weight ratio of from about 0.8:1 to about 5:1, preferably from about 1.5:1 to about 4:1, more preferably from about 2: 1 to about 3.5:1. Both of these ingredients are effective bleaches which contribute to the stain removal activity of the cleansing compositions.
  • Suitable sources of the persulphate salt are the alkali metal and ammonium persulphates.
  • Preferred is potassium monopersulphate or a mixed salt thereof.
  • Particularly preferred are the commercially available mixed salts such as Caroat®, marketed by Degussa, and Oxone®, marketed by E I du Pont de Nemours Co. and which are a 2:1 :1 mixture of potassium monopersulphate, potassium sulphate and potassium bisulphate and which have an active oxygen content of about 4.5%.
  • the level of persulphate salt is suitably from about 5% to about 60%, preferably from about 20% to about 50%, more preferably from about 35% to about 45% by weight of the composition.
  • Suitable perborate salts are the alkali metal perborates, particularly sodium perborate.
  • Sodium perborate is preferably used as the monohydrate or anhydrous form, although the tetrahydrate can also be used.
  • the monohydrate or mixtures of the monohydrate and anhydrous forms of sodium perborate is from 0:100 to about 30:70.
  • the total level of perborate salt is generally from about 6% to about 30%, preferably from about 10% to about 25%, more preferably from about 12% to about 18% by weight of the composition.
  • silicone oil herein is meant a polymer with a silicon or siloxane backbone that is insoluble in or immiscible with water at 25°C and is liquid at 25°C; or mixtures therof.
  • Suitable classes of silicone oils include, but are not limited to, dimethicones, dimethiconols, dimethicone copolyols and aminoalkylsilicones.
  • a highly preferred si licone oi l is a dimethicone copolyol or aminoalkylsilicone antiplaque agent such as those described in WO 96/19563 and WO 96/19554.
  • Suitable aminoalkylsilicones are selected from noncyclic, hydrophobic aminoalkylsilicones having a formula comprising two basic units:
  • R.1 and R.2 are independently selected from H ,alkyl and alkenyl of about 1 to about 10 carbons optionally substituted with fluoro or cyano groups, hydroxy, alkoxy, and acetoxy, for example, wherein R.1 and R.2 are independently selected from methyl, ethyl, phenyl, vinyl, trifluoropropyl and cyanopropyl, and R is — R 3 N ⁇ R 5 or — R 3 - N R 5 x "
  • R 6 wherein R- is a divalent alkylene of about 1-20, preferably about 3-5 carbon atoms optionally substituted or interrupted by O atoms, R ⁇ , R5 and R ⁇ which may be the same or different are selected from H, alkyl of about 1-20, preferably about 1-10, more preferably about 1-4 carbons optionally substituted or interrupted by N and/or O atoms, and X" is a monovalent anion such as halide, hydroxide, and tosylate, said amino- alkylsilicone including from about 0.1-2%, preferably from about 0.5-2% of unit (1) on a repeating unit basis.
  • Preferred aminoalkylsilicones comprise amodimethicones.
  • Amodimethicones are poly- dimethylsiloxane polymers containing aminoalkyl groups.
  • the aminoalkyl groups may be present either pendant or at one or more ends of the polydimethylsiloxane chain.
  • Preferred are aminoalkylsilicones in which aminoalkyl moiety R is selected from (CH 2 ) 3 NH 2 , (CH 2 )3NHCH2CH 2 NH2, (CH2)3N(CH 2 CH 2 OH)2, (CH 2 )3NH 3 + X-, and (CH 2 )3N(CH 3 ) 2 (Ci 8 H37) + X-, and especially from (CH 2 )3NH 2 and (CH 2 )3NH- CH2CH2NH2.
  • aminoalkyl silicones having an average molecular weight of about 5,000 and above, preferably from about 5000 to about 100,000, more preferably from about 5000 to about 30,000.
  • Aminoalkyl silicone compounds suitable for use herein are well known. Methods of preparing aminoalkylsilicones are given in, for example, US-A-2,930,809.
  • Examples of amodimethicones include OSI's Magnasoft fluid. These polymers comprise aminoalkyl groups affixed to a predominantly polydimethylsiloxane structure.
  • the typical structure of Magnasoft's aminoalkyl group-containing units is OSi(Me)C3H 6 NHCH 2 CH 2 NH2.
  • alkyl or alkoxy dimethicone copolyols having the formula (I): wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is from 0 to about 200, m is from about 1 to about 40, q is from about 1 to about 100, the molecular weight of the residue (C2H4 ⁇ -) x (C3H6 ⁇ -)yX is from about 50 to about 2000, preferably from about 250 to about 1000 and x and y are such that the weight ratio of oxyethylene:oxypropylene is from 100:0 to 0:100, preferably from 100:0 to about 20:80.
  • X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms
  • Y is selected from alkyl and alkoxy groups having from about 8 to about
  • the dimethicone copolyol is selected from C12 to C20 alkyl dimethicone copolyols and mixtures thereof. Highly preferred is cetyl dimethicone copolyol marketed under the Trade Name Abil EM90.
  • the silicone antiplaque agent is generally present in a level of from about 0.1% to about 5%, preferably from about 0.2% to about 3%, more preferably from about 0.3% to about 1.5% by weight.
  • a desirable additional ingredient of the denture cleansing compositions of the invention is a silicone surfactant having the general formula (I)
  • X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is CH3, q is 0, n is from about 1 to about 100, m is from about 1 to about 40, the molecular weight of the residue (C2H4 ⁇ -) x (C3H6 ⁇ -)yX is from about 50 to about 2000, and x and y are such that the weight ratio of oxyethylene:oxy- propylene is from about 100:0 to about 0:100.
  • the silicone surfactant itself a dimethicone copolyol, assists in subsequent re-dispersion of the silicone antiplaque agent in aqueous media whilst still allowing the antiplaque agent to deposit onto surfaces such as teeth, gums or artificial dentures.
  • the silicone surfactant is selected from dimethicone copolyols having a HLB value in the range from about 8 to about 14, more preferably from about 9 to about 12, and mixtures thereof.
  • a suitable example of such a material is that marketed under the Trade Name Silwet L7230.
  • the silicone surfactant is generally present in a level of from about 0.1%) to about 5%, preferably from about 0.2% to about 3%, more preferably from about 0.3% to about 1.5% by weight of the composition.
  • the level of the silicone surfactant should be chosen such that the ratio of silicone surfactant to the silicone antiplaque agent is from about 0.5:1 to about 5:1, more preferably from about 0.8:1 to about 3:1, most preferably from about 0.9:1 to about 2:1 by weight.
  • a preferred method of incorporating the silicone antiplaque agent and/or the silicone surfactant is via a spray-dried powder as will be described further below.
  • the powder includes a water-soluble carrier.
  • water-soluble carrier herein is meant any material which is has a solid at 25°C, is capable of being processed into granular form, is capable of being made into a clear or translucent aqueous solution at 25°C at a level of about 1% by weight of the solution, and is safe for use on human skin or mucosa.
  • Suitable carriers include, but are not limited to, polyethylene glycols, starches, gum arabic, gum tragacanth, gum acacia, carrageenans, cellulose derivatives and mixtures thereof.
  • the carrier is capable of being spray-dried into a free-flowing powder.
  • the water-soluble carrier is a food-grade carrier selected from starches, gum arabic, gum tragacanth, gum acacia and mixtures thereof.
  • a particularly preferred carrier is a modified starch available under the tradename Capsul E from National Starch & Chemical of Manchester, UK.
  • the carrier can comprise a sugar alcohol or saccharide, such as sorbitol, mannitol or maltodextrin. Without being limited by theory, it is believed that the sugar alcohol or saccharide helps to form a film on the surface of the particle which improves the encapsulation of the oil by the powder particle.
  • a preferred carrier consists of a mixture of starch and sorbitol, preferably from about 2.5:1 to about 4:1, more especially about 3 : 1 by weight of the carrier.
  • a mixture of gum acacia and maltodextrin in the ratio of from about 1 :2 to about 2:1 can also suitably be used.
  • the water-soluble carrier is generally present in a level of from about 50% to about 99%, preferably from about 60% to about 90%, more preferably from about 65% to about 90% by weight of the spray-dried powder.
  • the powders are generally in granular form, wherein the powder has a volume average particle size in the range from about 20 ⁇ m to about 500 ⁇ m, preferably from about 50 ⁇ m to about 250 ⁇ m, more preferably from about 80 ⁇ m to about 150 ⁇ m.
  • the average particle size can be measured using standard sieve techniques well known in the art. Alternatively, the average particle size can be measured using a commercial instrument such as the Malvern Mastersizer X available from Malvern Instruments Ltd. of Malvern, Worcs., UK,.
  • the Mastersizer is preferably fitted with a MSX64 Dry Powder Feeder and a a 300 mm lens for measuring particles in the range 1.2 to 600 microns.
  • the powders can be prepared by dispersing the silicone antiplaque agent and/or the silicone surfactant in a aqueous solution of the water-soluble carrier and spray-drying the resultant dispersion.
  • the strength of the carrier solution is not critical, it will be understood that very dilute solutions will require considerable input of energy to dry.
  • the aqueous solution of the carrier will comprise from about 25% to about 50%, more preferably from about 30%) to about 45%, more especially from about 35% to about 40%) of the carrier by weight of the solution.
  • the silicone should be present in the dispersion in the form of discrete droplets having a volume average droplet size in the range from about 0.5 ⁇ m to about 20 ⁇ m.
  • the ratio of the average spray-dried particle size to the average droplet size should be at least about 2.5:1.
  • the ratio of the average spray-dried particle size to the average droplet size is at least about 4: 1, preferably at least about 6: 1, more preferably at least about 10:1. Smaller droplets, in relation to the final spray-dried powder particle size, serve to improve the flow characteristics and further processability of the powder.
  • the desired droplet size can be achieved by using shear mixing to form the dispersion and measured by using phase contrast photomicroscopy.
  • a suitable procedure is to use, for example, a Nikon Labophot 2 at 400x magnification with fixed focal length and fitted with a graticule. It will be appreciated that a suitable number of observations need to be made to reduce the sampling error. The precise number to be made will depend, for example, upon the droplet size distribution achieved.
  • the dispersion is mixed, with adjustment of the shear rate if necessary, until the desired droplet size is attained.
  • the spray-dried silicone powders preferably also include a flavour or perfume oil.
  • a flavour or perfume oil As used herein, the term 'flavour or perfume oil' means those flavour or perfume essences v d equivalent synthetic ingredients which are added to the powder for the principal purpose of modifying the taste and / or odour or other organoleptic sensations of the powder or the final product into which the powder is incorporated. It excludes silicone antiplaque agents and silicone surfactants as described above but includes lipophilic physiological cooling agents.
  • Lipophilic flavorants suitable for use herein comprise one or more flavor components selected from wintergreen oil, oregano oil, bay leaf oil, peppermint oil, spearmint oil, clove oil, sage oil, sassafras oil, lemon oil, orange oil, anise oil, benzaldehyde, bitter almond oil, camphor, cedar leaf oil, marjoram oil, citronella oil, lavendar oil, mustard oil, pine oil, pine needle oil, rosemary oil, thyme oil, cinnamon leaf oil, and mixtures thereof.
  • Physiological cooling agents suitable for use herein include carboxamides, menthane esters and menthane ethers, and mixtures thereof.
  • preferred cooling agents suitable for use herein include Takasago 10 [3-1-menthoxy propan-l,2-diol (MPD)], from Takasago International Corporation, and carboxamides such as those described in US-A- 4,136,163, January 23, 1979 to Watson et al., and US-A-4,230, 688, October 28, 1980 to Rawsell et al.
  • the amount of flavour or perfume oil employed is normally a matter of preference subject to such factors as flavour type, base type and strength desired.
  • the level of flavour or perfume oil in the compositions of the invention is generally in the range from about 1% to about 15% by weight of the spray-dried powder.
  • the flavour or perfume oil is incorporated by making an intimate premix of the silicone antiplaque agent and the flavour or perfume oil, along with the silicone surfactant, where used, and then forming a dispersion of the premix in the carrier solution as described above.
  • flavour or perfume oil being in intimate admixture with the silicone antiplaque agent acts to enhance the substantivity of the flavour or perfume oil to teeth and/or dentures, thereby providing enhanced and/or sustained organoleptic impact.
  • lipophilic antimicrobial compounds can advantageously be included along in the same manner as the flavour or perfume oil, to provide enhanced and/or sustained antimicrobial efficacy.
  • Suitable lipophilic antimicrobial compounds for use herein include thymol, menthol, triclosan, 4-hexylresorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butyl paraben, methyl paraben, propyl paraben, salicylamides, and mixtures thereof.
  • a third essential feature of the present invention is a foam-forming surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants and mixtures thereof.
  • ⁇ foam- forming surfactant' as used herein excludes silicone surfactants as described hereinbefore.
  • the foam- forming surfactant used in the denture cleansing compositions of the invention can be selected from the many available that are compatible with the other ingredients of the composition, both in the dry state and in solution.
  • Suitable anionic surfactants include alkyl sulphates, such as sodium lauryl sulphate, alkyl ether sulphates, alkyl aryl sulphonates such as sodium doddecyl benzene sulphonate (SDBS), alkyl sarcosinates, and alkyl sulphosuccinates.
  • a highly preferred anionic surface active agent is sodium lauryl sulphoacetate, commercially available as Lathanol® powder. It has also been found that the use of a surfactant mixture, comprising a primary surfactant and an additional co-surfactant, can boost foaming and reduce the total surfactant level.
  • the total amount of foam- forming surfactant comprises from about 0.55% to about 3.8%, preferably from about 0.7% to about 3%, more preferably from about
  • suitable levels of co-surfactant are from about o. ⁇ % to about 1%, preferably from about 0.2% to about about 0.5% by weight of the composition. If the total level of foam- forming surfactant is too high then the compositions, especially tabletted compositions, can become slow to dissolve. If the level is too low then foaming is impaired.
  • Suitable non-ionic and ampholytic surface active agents include, for example, condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or fatty acid alkanolamides, the fatty acid alkanolamides themselves, esters of long-chained (C -C22) fatty acids with polyalcohols or sugars, for example glycerylmonostearate or saccharose monolaurate or sorbitolpolyoxyethylene- mono-or di-stearate, betaines, sulphobetaines or long-chain alkylaminocarboxylic acids.
  • alkylene oxides such as ethylene or propylene oxide
  • fatty alcohols phenols, fatty amines or fatty acid alkanolamides
  • esters of long-chained (C -C22) fatty acids with polyalcohols or sugars, for example glycerylmonostearate or saccharose monol
  • compositions of the present invention are in discrete, separate granules.
  • foam- orming surfactant is incorporated into a distinctly separate granule from the silicone oil. It has been found that keeping foam-forming surfactant physically separate from the silicone oil helps prevent the surfactant interfering with the silicone deposition process.
  • One method of achieving this is to form a spray-dried powder comprising the silicone oil, as described above and to either prepare a separate granular premix comprising the foam- forming surfactant, or to include the foam- forming surfactant with the excipients in the final mixing process prior to tabletting. It has been found that when the foam- forming surfactant is included with the excipients it can have a binding effect and eliminate or substantially reduce the need for additional binders such as polyethylene glycols which can have the effect of slowing down tablet disintegration.
  • Denture cleansing compositions of the invention can be supplemented by other usual components of such formulations, especially additional effervescence generators, bleach actiavtors, desiccants, chelating agents, enzymes, flavours, physiological cooling agents, antimicrobial compounds, dyestuffs, sweeteners, tablet binders and fillers, foam stabilisers such as the fatty acid sugar esters, preservatives, lubricants such as talc, magnesium stearate, finely divided amorphous pyrogenic silicas, etc.
  • the free moisture content of the final composition is desirably less than about 1% and especially less than about 0.5%.
  • the perborate salt / persulphate salt combinations described above give rise to oxygen effervescence.
  • an additional, carbon dioxide effervescence generator comprising a bicarbonate salt and an acid is included.
  • the carbon dioxide effervescence generator is useful for providing rapid, initial effervescence when the composition is first added to water which will usually be about neutral pH but may be slightly acidic. The initial effervescence is valuable for dispersing the solid composition in water and assisting its dissolution by providing turbulence.
  • Preferred bicarbonate salts are the rapidly soluble alkali metal bicarbonates, such as sodium bicarbonate, potassium bicarbonate and mixtures thereof, especially sodium bicarbonate.
  • the bicarbonate salt is provided in admixture with at least one non-toxic, physiologically-acceptable organic or inorganic acid, such as tartaric, fumaric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic acid, sodium fumarate, sodium or potassium acid phosphates, betaine hydrochloride or mixtures thereof.
  • non-toxic, physiologically-acceptable organic or inorganic acid such as tartaric, fumaric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic acid, sodium fumarate, sodium or potassium acid phosphates, betaine hydrochloride or mixtures thereof.
  • sulphamic acid is preferred.
  • the carbon dioxide effervescence generator takes the form of a solid premix comprising sodium bicarbonate and sulphamic acid, which in the presence of water releases carbon dioxide with effervescence.
  • the premix can comprise further additives and excipients such as sodium carbonate and dye. Whilst sodium carbonate can itself can provide carbon dioxide effervescence, since it is not as soluble as the bicarbonate it is less valuable in this respect.
  • the weight ratio of the perborate salt to the bicarbonate salt, where both are used is suitably in the range of from about 2:1 to about 20:1, preferably from about 2.5:1 to about 10:1, more preferably from about 3 : 1 to about 5:1.
  • the bicarbonate salt generally comprises from about 1% to about 20%, preferably from about 3% to about 10%, more preferably from about 4% to about 6% of the total composition.
  • the acid component generally comprises from about 2% to about 15%, preferably from about 3% to about 10% of the total composition.
  • An especially preferred additional component of the present invention is a bleach activator.
  • a preferred bleach activator is an organic peroxyacid precursor, which in general terms can be defined as a compound having a titre of at least 1.5ml of 0.1 N sodium thiosulphate in the following peracid formation test.
  • test solution is prepared by dissolving the following materials in 1000 mis distilled water:
  • the mixture obtained by addition of the activator is vigorously stirred and maintained at 60°C. After 5 minutes from addition, a 100 ml portion of the solution is withdrawn and immediately pipetted onto a mixture of 250 g cracked ice and 15 ml glacial acetic acid. Potassium iodide (0.4 g) is then added and the liberated iodine is immediately titrated with 0.1 N sodium thiosulphate with starch as indicator until the first disappearance of the blue colour. The amount of sodium thiosulphate solution used in ml is the titre of the denture cleansing activator.
  • the organic peracid precursors are typically compounds containing one or more acyl groups, which are susceptible to perhydrolysis.
  • the preferred activators are those of the N-acyl or O-acyl compound type containing a acyl radical R-CO wherein R is a hydrocarbon or substituted hydrocarbon group having preferably from about 1 to about 20 carbon atoms.
  • suitable peracid precursors include: 1) Acyl organoamides of the formula RCONRjR2, where RCO is carboxylic acyl radical, R ⁇ is an acyl radical and R2 is an organic radical, as disclosed in US-A- 3,117,148.
  • Examples of compounds falling under this group include: a) N,N - diacetylaniline and N-acetylphthalimide; b) N-acylhydantoins, such as N,N' -diacetyl-5,5-dimethylhydantoin; c) Polyacylated alkylene diamines, such as
  • N,N,N'N' -tetraacetylethylenediamine (TAED) and the corresponding hexamethylenediamine (TAHD) derivatives, as disclosed in GB-A-907,356, GB-A-907,357 and GB-A-907,358; d) Acylated glycolurils, such as tetraacetylglycoluril, as disclosed in GB-A-
  • Examples of compounds of this type include phenyl acetate, sodium acetoxy benzene sulphonate, trichloroethylacetate, sorbitol hexaacetate, fructose pentaacetate, p-nitrobenzaldehyde diacetate, isopropenyl acetate, acetyl aceto hydroxamic acid, and acetyl salicylic acid.
  • esters of a phenol or substituted phenol with an alpha-chlorinated lower aliphatic carboxylic acid such as chloroacetylphenol and chloroacetylsalicylic acid, as disclosed in US-A- 3,130,165.
  • Preferred compounds of this type are those wherein: a) Ac is R3-CO and R3 is a linear or branched alkyl group containing from 6 to 20, preferably 6 to 12, more preferably 7 to 9 carbon atoms and wherein the longest linear alkyl chain extending from and including the carbonyl carbon contains from 5 to 18, preferably 5 to 10 carbon atoms, R3 optionally being substituted (preferably alpha to the carbonyl moiety) by Cl, Br, OCH3 or OC2H5.
  • R3 optionally being substituted (preferably alpha to the carbonyl moiety) by Cl, Br, OCH3 or OC2H5.
  • this class of material include sodium
  • Ac has the formula R3(AO) m XA wherein R3 is a linear or branched alkyl or alkylaryl group containing from 6 to 20, preferably from 6 to 15 carbon atoms in the alkyl moiety, R5 being optionally substituted by Cl, Br, OCH3, or OC2H5, AO is oxyethylene or oxypropylene, m is from 0 to 100, X is O, NR4 or CO-NR4, and A is CO, CO-CO, R ⁇ -CO, CO-R
  • Denture cleansing activator compounds of this type include carbonic acid derivatives of the formula R3(AO) m OCOL, succinic acid derivatives of the formula
  • m is preferably from 0 to 10
  • R3 is preferably C6-C12, more preferably Cg-Cjo alkyl when m is zero and C9-C15 when m is non-zero.
  • the leaving group L is as defined above.
  • Optionally substituted anhydrides of benzoic or phthalic acid for example, benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride.
  • benzoic anhydride m-chlorobenzoic anhydride
  • phthalic anhydride preferred are organic peracid precursors of types 1(c) and 4(a).
  • TAED is particularly preferred.
  • the level of bleach activator by weight of the total composition is preferably from about 0.1% to about 10%, more preferably from about 0.5% to about 5%.
  • Denture cleansing compositions according to the invention can additionally include one or more additional bleaching agents.
  • suitable additional bleaching agents include sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides.
  • Tablet binders and fillers suitable for use herein include polyvinyl-pyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethyleneglycols of molecular weight of from about 1000 to about 50,000, Carbowax having a molecular weight of from 4000 to 20,000, fatty acids, sodium carboxymethyl cellulose, gelatin, fatty alcohols, clays, polymeric polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, magnesium hydroxide carbonate, sodium sulphate, proteins, cellulose ethers, cellulose esters, polyvinyl alcohol, alginic acid esters, and triglycerides.
  • polyethyleneglycols especially those having molecular weight of from about 1,000 to about 30,000, preferably from about 12,000 to about 30,000, and triglycerides are highly preferred.
  • Chelating agents beneficially aid cleaning and denture cleansing stability by keeping metal ions, such as calcium, magnesium, and heavy metal cations in solution.
  • suitable chelating agents include sodium tripolyphosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, aminopoly-carboxylates such as nitrilotriacetic acid and ethylenediamine tetracetic acid (EDTA) and salts thereof, and polyphosphonates and aminopolyphosphonates such as hydroxyethanediphosphonic acid, ethylenediamine tetramethylenephosphonic acid, diethylenetriaminepentamethylene- phosphonic acid and salts thereof.
  • EDTA ethylenediamine tetracetic acid
  • the chelating agent selected is not critical except that it must be compatible with the other ingredients of the denture cleanser when in the dry state and in aqueous solution.
  • EDTA and its salts, especially the tetrasodium salt, are preferred.
  • the chelating agent comprises between 0.1 and 20 percent by weight of the composition and preferably between 0.5 and 5 percent.
  • Phosphonic acid chelating agents preferably comprise from about 0.1 to about 1 percent, preferably from about 0.1 % to about 0.5% by weight of composition.
  • Enzymes suitable for use herein are exemplified by proteases, alkalases, amylases, lipases, dextranases, mutanases, glucanases etc. The following examples further describe and demonstrate the preferred embodiments within the scope of the present invention.
  • the percentages are by weight of the denture cleanser tablet.
  • the blue and white granulates are made separately by roller compaction.
  • the silicone-containing spray-dried powder is made as described hereinbefore.
  • the two granulates, the spray-dried powder and the excipients are then mixed together in a planetary mixer and the tablets are made by compressing the mixture of components in a punch and dye rotary tabletting press at a pressure of about 2 xlO ⁇ kPa.
  • the overall tablet weight is 3 g; diameter 25 mm.
  • the denture cleansing tablets of Examples IV to VII display improved antiplaque, cleansing and anti-bacterial activity together with excellent cohesion and other physical and in-use performance characteristics.

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Abstract

L'invention concerne des compositions granulaires de nettoyage de prothèses dentaires, lesquelles comprennent un agent de blanchiment inorganique du type persel, une huile silicone et un tensioactif formateur de mousse choisi parmi des tensioactifs anioniques et amphotères et des mélanges de ceux-ci, et sont caractérisées en ce que l'huile silicone et le tensioactif formateur de mousse sont en granules séparés. Ces compositions possèdent une excellente activité détachante ainsi qu'une meilleure effervescence et/ou désintégration du comprimé, et elles se présentent de manière tout à fait appropriée sous forme de comprimés, en tant que nettoyants de prothèses dentaires.
EP97946468A 1996-11-01 1997-10-30 Compositions de nettoyage Withdrawn EP0948590A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9622844.0A GB9622844D0 (en) 1996-11-01 1996-11-01 Cleansing compositions
GB9622844 1996-11-01
PCT/US1997/019952 WO1998020091A1 (fr) 1996-11-01 1997-10-30 Compositions de nettoyage

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EP0948590A1 true EP0948590A1 (fr) 1999-10-13
EP0948590A4 EP0948590A4 (fr) 2000-07-26

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EP (1) EP0948590A4 (fr)
JP (1) JP2001505195A (fr)
CA (1) CA2270474A1 (fr)
GB (1) GB9622844D0 (fr)
HU (1) HUP9904675A3 (fr)
TR (1) TR199900934T2 (fr)
WO (1) WO1998020091A1 (fr)

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EP1245667B1 (fr) * 2001-03-26 2005-10-26 The Procter & Gamble Company Procédé de nettoyage de surfaces dures avec un produit liquide comprenant un agent de blanchiment
US7166235B2 (en) * 2002-05-09 2007-01-23 The Procter & Gamble Company Compositions comprising anionic functionalized polyorganosiloxanes for hydrophobically modifying surfaces and enhancing delivery of active agents to surfaces treated therewith
JP5339672B2 (ja) * 2006-07-03 2013-11-13 小林製薬株式会社 漂白洗浄剤組成物
CN110050031B (zh) 2016-12-07 2021-07-20 株式会社钟化 液态树脂组合物
JP7130471B2 (ja) * 2018-06-29 2022-09-05 小林製薬株式会社 洗浄セット及びその利用
EP4051772A1 (fr) * 2019-10-31 2022-09-07 The Procter & Gamble Company Particules antimicrobiennes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492939A (en) * 1974-03-11 1977-11-23 Procter & Gamble Ltd Controlled-sudsing detergent compositions
GB2120293A (en) * 1982-04-08 1983-11-30 Colgate Palmolive Co Laundry softening detergent
WO1996019563A1 (fr) * 1994-12-22 1996-06-27 The Procter & Gamble Company Compositions detergentes comprenant du copolyol de dimethicone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962107A (en) * 1974-06-24 1976-06-08 Johnson & Johnson Enzyme-containing denture cleanser tablet
AU510235B2 (en) * 1975-12-22 1980-06-19 Johnson & Johnson Denture cleanser tablet
US4647451A (en) * 1984-05-11 1987-03-03 Colgate-Palmolive Company Anhydrous dentifrice

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492939A (en) * 1974-03-11 1977-11-23 Procter & Gamble Ltd Controlled-sudsing detergent compositions
GB2120293A (en) * 1982-04-08 1983-11-30 Colgate Palmolive Co Laundry softening detergent
WO1996019563A1 (fr) * 1994-12-22 1996-06-27 The Procter & Gamble Company Compositions detergentes comprenant du copolyol de dimethicone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9820091A1 *

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CA2270474A1 (fr) 1998-05-14
WO1998020091A1 (fr) 1998-05-14
TR199900934T2 (xx) 1999-07-21
HUP9904675A2 (hu) 2000-05-28
EP0948590A4 (fr) 2000-07-26
JP2001505195A (ja) 2001-04-17
GB9622844D0 (en) 1997-01-08
HUP9904675A3 (en) 2000-12-28

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