AU700174B2 - Detergent composition comprising a dimethicone copolyol - Google Patents
Detergent composition comprising a dimethicone copolyol Download PDFInfo
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- AU700174B2 AU700174B2 AU46871/96A AU4687196A AU700174B2 AU 700174 B2 AU700174 B2 AU 700174B2 AU 46871/96 A AU46871/96 A AU 46871/96A AU 4687196 A AU4687196 A AU 4687196A AU 700174 B2 AU700174 B2 AU 700174B2
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
- C11D3/3738—Alkoxylated silicones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0052—Gas evolving or heat producing compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/10—Carbonates ; Bicarbonates
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/39—Organic or inorganic per-compounds
- C11D3/3942—Inorganic per-compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
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Description
r WO 96/19563 PCT/US95/16673 1 DETERGENT COMPOSITION COMPRISING A DIMETHICONE
COPOLYOL
TECHNICAL
FIELD
The present invention relates to cleansing compositions and especially to compositions for use in cleansing dentures and the like. In particular, the invention relates to denture cleansing compositions having enhanced antiplaque activity together with excellent denture cleansing performance, appearance, physical and dissolution characteristics, anti-bacterial efficacy and in-use performance characteristics.
BACKGROUND
Effervescent tablets and powders for cleansing dentures and the like are well known in the art. The aim of a denture cleanser product is to clean the denture as fully and as quickly as possible and especially to remove the accumulation of plaque, mucilaginous and bacterial deposits which collect while the denture is being worn. To wear a denture which has not been completely cleaned of plaque and bacterial deposits is not only unhygenic but can also within a short space of time result in a detrimental effect on the mucous membrane. Moreover bacterial deposits can lead to so-called bacterial corrosion of the plastics material used to produce the denture with consequent colorchange and malodor-formation.
It is known to include silicones in dentifrice compositions, allegedly to coat the teeth and prevent cavities and staining. For instance, GB-A- 689,679 discloses a mouthwash containing an organopolysiloxane for preventing adhesion of, or for removing tars, stains, tartar and food particles from the teeth.
US-A-2,806,814 discloses dental preparations including, in combination, a higher aliphatic acyl amide of an amino carboxylic acid compound as an active and a silicone compound. The patent notes that silicone compounds have been proposed for prevention of adhesion or to facilitate the removal of tars, stains, tartar and the like from teeth.
The silicone compound is said to act as a synergist in improving the antibacterial and acid inhibiting activity of the active ingredient.
Dimethyl polysiloxanes are said to be particularly effective.
US-A-3624120 discloses quaternary ammonium salts of cyclic siloxane polymers for use as cationic surfactants, bactericides and as anticariogenic agents.
Dentures of course are generally made of a plastics material such as acrylic and the problem of preventing plaque accumulation or of removing plaque from dentures is therefore fundamentally different from the problem of plaque prevention and removal from dental enamal.
Accordingly, the present invention provides a denture cleanser having improved efficacy on plaque, mucilaginous and bacterial deposits and which at the same time provides excellent denture cleansing performance, appearance, physical characteristics, dissolution and inuse performance characteristics.
SUMMARY OF THE INVENTION According to a first aspect of the invention, there is provided a denture S. cleansing composition including an inorganic persalt bleaching agent, an effervescence generator and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having the formula I
I
CH
3 SiO -SiO-- SiO SiO-i-CH 3 n
I
0 (C 2 H40-)(C 3 H60-)yX q WO 96/19563 PCT/US95/16673 3 wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is from about 0 to about 200, m is from about 1 to about q is from about 1 to about 100, the molecular weight of the residue (C2H40-)x(C3H60-)yX is from about 50 to about 2000, preferably from about 250 to about 1000 and x and y are such that the weight ratio of oxyethylene:oxypropylene is from about 100:0 to about 0:100, preferably from about 100:0 to about 20:80. The present invention also relates to the use of the defined dimethicone copolyol as antiplaque agent in denture cleansing compositions All percentages and ratios herein are by weight of total composition, unless otherwise indicated.
The cleansing compositions of the invention thus comprise three essential components, a bleaching agent, a dimethicone copolyol and an effervescent base composition. Each of these will be discussed in turn.
The bleaching agent takes the form of an inorganic persalt and can be selected from any of the well-known bleaching agents known for use in denture cleansers such as the alkali metal and ammonium persulfates, perborates, percarbonates and perphosphates and the alkali metal and alkaline earth metal peroxides. Examples of suitable bleaching agents include potassium, ammonium, sodium and lithium persulfates and perborate mono- and tetrahydrates, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides.
Of these, however, the alkali metal persulfates, perborates and mixtures thereof are prefered for use herein, highly preferred being the alkali metal perborates. Indeed, it is a feature of the invention that the tablet compositions herein will provide excellent antimicrobial activity even in the absence of alkali metal persulfates.
WO 96/19563 PCT/US95/16673 4 The amount of bleaching agent in the total composition is generally from about 5 to about 70% preferably from about 10% to about In compositions comprising a mixture of alkali metal persulfates and perborates, the overall persulfate:perborate ratio is suitably from about 5:1 to about 1:5, more especially from about 2:1 to about 1:2.
The compositions herein also contain a dimethicone copolyol antiplaque agent. In general terms, the dimethicone copolyol is selected from alkyl- and alkoxy-dimethicone copolyols having the formula
CH
3
CH
3
CH
3 CH3 H3 Ci3- SiO--SiO-SiO iO--SiCH 3 I I I I I
CH
3
CH
3
(CH
2 3 Y CH 3 nI 0 (C 2
H
4 0-)x(C 3
H
6 0-)yX q -m wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is from about 0 to about 200, m is from about 1 to about q is from about 1 to about 100, the molecular weight of the residue (C2H40-)x(C3H60-)yX is from about 50 to about 2000, preferably from about 250 to about 1000 and x and y are such that the weight ratio of oxyethylene:oxypropylene is from about 100:0 to about 0:100, preferably from about 100:0 to about 20:80.
In preferred embodiments, the dimethicone copolyol is selected from
C
1 2 to C20 alkyl dimethicone copolyols and mixtures thereof. Highly preferred is cetyl dimethicone copolyol marketed under the Trade Name Abil EM90. The dimethicone copolyol is generally present in a WO 96/19563 PCT/US95/16673 level of from about 0.01 to about 25 preferably from about 0.1 to about more preferably from about 0.5% to about 1.5% by weight.
The denture cleansing compositions also incorporate an effervescence generator which in preferred embodiments takes the form of a solid base material which in the presence of water releases carbon dioxide or oxygen with effervescence. The effervescence generator utilized in the compositions herein can be selected from generators which are effective under acid, neutral or alkaline pH conditions, but preferably it consists of a combination of a generator which is effective or most effective under acid or neutral pH conditions and a generator which is effective or most effective under alkaline pH conditions.
Effervescence generators which are effective under acid or neutral pH conditions include a combination of at least one alkali metal carbonate or bicarbonate, such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium carbonate, potassium bicarbonate, or mixtures thereof, in admixture with at least one non-toxic, physiologically-acceptable organic acid, such as tartaric, fumaric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic acid, sodium fumarate, sodium or potassium acid phosphates, betaine hydrochloride or mixtures thereof. Of these, malic acid is preferred.
Effervescence generators which are effective under alkaline pH conditions include persalts such as alkali and alkaline earth metal peroxoborates as well as perborates, persulphates, percarbonates, perphosphates and mixtures thereof as previously described, for example, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a monopersulphate such as Caroat R marketed by E I du Point de Nemours Co. and which is a 2:1:1 mixture of monopersulphate, potassium sulphate and potassium bisulphate and which has an active oxygen content of about In highly preferred compositions, the solid base material incorporates a (bi)carbonate/acid effervescent couple optionally in combination with a perborate/persulphate oxygen effervescence generator. The combination of generators is valuable for achieving optimum dissolution characteristics and pH conditions for achieving optimum WO 96/19563 PCT/US95/16673 6 cleaning and antimicrobial activity. The (bi)carbonate components generally comprise from about 5% to about 65%, preferably from about 25% to 55 of the total composition; the acid components generally comprise from about 5% to about 50%, preferably from about 10% to about 30% of the total composition.
The compositions of the invention can be supplemented by other known components of denture cleansing formulations. An especially preferred additional component is an organic peroxyacid precursor, which in general terms can be defined as a compound having a titre of at least 1.5ml of 0.1N sodium thiosulfate in the following peracid formation test.
A test solution is prepared by dissolving the following materials in 1000 mls distilled water: sodium pyrophosphate (Na4P20 7 .10H20) sodium perborate (NaBO2.H202.3H 2 0) having 10.4% available oxygen 0.615g sodium dodecylbenzene sulphonate To this solution at 60 0 C an amount of activator is added such that for each atom of available oxygen present one molecular equivalent of activator is introduced.
The mixture obtained by addition of the activator is vigorously stirred and maintained at 60 0 C. After 5 minutes from addition, a 100 ml portion of the solution is withdrawn and immediately pipetted onto a mixture of 250 g cracked ice and 15 ml glacial acetic acid. Potassium iodide (0.4 g) is then added and the liberated iodine is immediately titrated with 0.1 N sodium thiosulphate with starch as indicator until the first disappearance of the blue colour. The amount of sodium thiosulphate solution used in ml is the titre of the bleach activator.
WO 96/19563 PCT/US95/16673 7 The organic peracid precursors are typically compounds containing one or more acyl groups, which are susceptible to perhydrolysis. The preferred activators are those of the N-acyl or O-acyl compound type containing a acyl radical R-CO wherein R is a hydrocarbon or substituted hydrocarbon group having preferably from about 1 to about carbon atoms. Examples of suitable peracid precursors include: 1) Acyl organoamides of the formula RCONR 1
R
2 where RCO is carboxylic acyl radical, R 1 is an acyl radical and R2 is an organic radical, as disclosed in US-A-3,117,148. Examples of compounds falling under this group include: a) N,N diacetylaniline and N-acetylphthalimide; b) N-acylhydantoins, such as N,N' c) Polyacylated alkylene diamines, such as N,N,N'N' -tetraacetylethylenediamine (TAED) and the corresponding hexamethylenediamine (TAHD) derivatives, as disclosed in GB-A-907,356, GB-A-907,357 and GB-A- 907,358; d) Acylated glycolurils, such as tetraacetylglycoluril, as disclosed in GB-A-1,246,338, GB-A-1,246,339 and GB-A- 1,247,429.
2) Acylated sulphonamides, such as N-methyl-N-benzoyl-menthane sulphonamide and N-phenyl-N-acetyl menthane sulphonamide, as disclosed in GB-A-3,183,266.
3) Carboxylic esters as disclosed in GB-A-836,988, GB-A-963,135 and GB-A-1,147,871. Examples of compounds of this type include phenyl acetate, sodium acetoxy benzene sulphonate, trichloroethylacetate, sorbitol hexaacetate, fructose pentaacetate, p-nitrobenzaldehyde diacetate, isopropeneyl acetate, acetyl aceto hydroxamic acid, and acetyl salicylic acid. Other examples are esters of a phenol or substituted phenol with an alpha-chlorinated lower aliphatic carboxylic acid, such as chloroacetylphenol and chloroacetylsalicylic acid, as disclosed in US-A-3,130,165.
WO 96/19563 PCT/US95/16673 8 4) Carboxylic esters having the gernal formal Ac L wherein Ac is the acyl moiety of an organic carboxylic acid comprising an optionally substituted, linear or branched C6-C 2 0 alkyl or alkenyl moiety or a C6-C 2 0 alkyl-substituted aryl moiety and L is a leaving group, the conjugate acid of which has a pKa in the range from 4 to 13, for example oxybenzenesulfonate or oxybenzoate. Preferred compounds of this type are those wherein: a) Ac is R3-CO and R3 is a linear or branched alkyl group containing from 6 to 20, preferably 6 to 12, more preferably 7 to 9 carbon atoms and wherein the longest linear alkyl chain extending from and including the carbonyl carbon contains from 5 to 18, preferably 5 to carbon atoms, R3 optionally being substituted (preferably alpha to the carbonyl moiety) by Cl, Br, OCH3 or Examples of this class of material include sodium 3,5,5trimethylhexanoyloxybenzene sulfonate, sodium 3,5,5trimethylhexanoyloxybenzoate, sodium 2-ethylhexanoyl oxybenzenesulfonate, sodium nonanoyl oxybenzene sulfonate and sodium octanoyl oxybenezenesulfonate, the acyloxy group in each instance preferably being psubstituted; b) Ac has the formula R3(AO)mXA wherein R3 is a linear or branched alkyl or alkylaryl group containing from 6 to preferably from 6 to 15 carbon atoms in the alkyl moiety, being optionally substituted by Cl, Br, OCH 3 or AO is oxyethylene or oxypropylene, m is from 0 to 100, X is O, NR4 or CO-NR 4 and A is CO, CO-CO, R6-CO, CO-R 6 -CO, or CO-NR 4
-R
6 -CO wherein R4 is C 1
C
4 alkyl and R6 is alkylene, alkenylene, arylene or alkarylene containing from 1 to 8 carbon atoms in the alkylene or alkenylene moiety. Bleach activator compounds of this type include carbonic acid derivatives of the formula R3(AO)mOCOL, succinic acid derivatives of the formula R30CO(CH2) 2 COL, glycollic acid derivatives of the WO 96/19563 PCT/US95/16673 9 formula R30CH2COL, hydroxypropionic acid derivatives of the formula R30CH2CH 2 COL, oxalic acid derivatives of the formula R30COCOL, maleic and fumaric acid derivatives of the formula R3OCOCH =CHCOL, acyl aminocaproic acid derivatives of the formula R3CONRI(CH2)6COL, acyl glycine derivatives of the formula R3CONR 1 CH2COL, and amino-6-oxocaproic acid derivatives of the formula R3N(RI)CO(CH 2 4 COL. In the above, m is preferably from 0 to 10, and R3 is preferably C6-C12, more preferably C6-C10 alkyl when m is zero and C9-C15 when m is non-zero. The leaving group L is as defined above.
Acyl-cyanurates, such as triacetyl- or tribenzoylcyanurates, as disclosed in US patent specification No. 3,332,882.
6) Optionally substituted anhydrides of benzoic or phthalic acid, for example, benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride.
Of all the above, preferred are organic peracid precursors of types l(c) and 4(a).
Where present, the level of peroxyacid bleach precursor by weight of the total composition is preferably from about 0.1% to about more preferably from about 0.5% to about 5% and is generally added in the form of a bleach precursor agglomerate.
The bleach precursor agglomerates preferred for use herein generally comprise a binder or agglomerating agent in a level of from about 5 to about 40%, more especially from about 10% to about 30% by weight thereof. Suitable agglomerating agents include polyvinylpyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethyleneglycols of molecular weight of from about 1000 to about 50,000, Carbowax having a molecular weight of from 4000 to 20,000, nonionic surfactants, fatty acids, sodium carboxymethyl cellulose, gelatin, fatty alcohols, phosphates and WO 96/19563 PCTIUS95/16673 polyphosphates, clays, aluminosilicates and polymeric polycarboxylates. Of the above, polyethyleneglycols are highly preferred, especially those having molecular weight of from about 1,000 to about 30,000, preferably 2000 to about 10,000.
Preferred from the viewpoint of optimum dissolution and pH characteristics are bleach precursor agglomerates which comprise from about 10% to about 75 preferably from about 20% to about 60 by weight thereof of peroxyacid bleach precursor, from about 5 to about 60% preferably from about 5% to about 50%, more preferably from about 10% to about 40% of a (bi) carbonate/acid effervescent couple, from about 0% to about 20% of a peroxoboroate, and from about 5% to about 40%, preferably from about 10% to about 30% of an agglomerating agent.
The final bleach precursor granules desirably have an average particle size of from about 500 to about 1500, preferably from about 500 to about 1,000 um, this being valuable from the viewpoint of optimum dissolution performance and aesthetics. The level of bleach precursor agglomerates, moreover, is preferably from about 1% to about more preferably from about 5% to about 15% by weight of composition.
The compositions of the invention can be in paste, liquid, tablet, granular or powder form, although tablet-form compositions are highly preferred herein. Compositions in tablet form can be single or multiple layered tablets.
The compositions of the invention can be supplemented by other usual components of denture cleansing formulations, especially surfactants, chelating agents, enzymes, flavorants, physiological cooling agents, antimicrobial compounds, dyestuffs, sweeteners, tablet binders and fillers, foam depressants such as dimethylpolysiloxanes, foam stabilizers such as the fatty acid sugar esters, preservatives, lubricants such as talc, magnesium stearate, finely divided amorphous pyrogenic silicas, etc. The free moisture content of the final composition is desirably less than about 1% and especially less than about 0.5 WO 96/19563 PCT/US95/16673 11 Tablet binders and fillers suitable for use herein include polyvinylpyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethyleneglycols of molecular weight of from about 1000 to about 50,000, Carbowax having a molecular weight of from 4000 to 20,000, nonionic surfactants, fatty acids, sodium carboxymethyl cellulose, gelatin, fatty alcohols, clays, polymeric polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, magnesium hydroxide carbonate, sodium sulfate, proteins, cellulose ethers, cellulose esters, polyvinyl alcohol, alginic acid esters, vegetable fatty materials of a pseudocolloidal character. Of the above, polyethyleneglycols are highly preferred, especially those having molecular weight of from about 1,000 to about 30,000, preferably from about 12,000 to about 30,000.
The surface active agent used in the compositions of the invention can be selected from the many available that are compatible with the other ingredients of the denture cleanser, both in the dry state and in solution. Such materials are believed to improve the effectiveness of the other ingredients of the composition by aiding their penetration into the interdental surfaces. Also, these materials aid in the removal of food debris attached to the teeth. Between 0.1 and 5 percent by weight of the dry composition of a dry powder or granular anionic surface active agent, such as sodium lauryl sulfate, sodium Nlauroylsarcosinate, sodium lauryl sulfoacetate or dioctyl sodium sulfosuccinate or ricinoleyl sodium sulfosuccinate, may, for example, be included in the composition and preferably the surface active agent comprises between 0.5 and 4 percent of the composition.
Suitable cationic, non-ionic and ampholytic surface active agents include, for example, quaternary ammonium compounds such as cetyltrimethylammonium bromide, condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or fatty acid alkanolamides, the fatty acid alkanolamides themselves, esters of long-chained (C 8
-C
22 fatty acids with polyalcohols or sugars, for example glycerylmonostearate or WO 96/19563 PCT/US95/16673 12 saccharosemonolaurate or sorbitolpolyoxyethylenemono-or di-stearate, betaines, sulphobetaines or long-chain alkylaminocarboxylic acids.
Chelating agents beneficially aid cleaning and bleach stability by keeping metal ions, such as calcium, magnesium, and heavy metal cations in solution. Examples of suitable chelating agents include sodium tripolyphosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, aminopolycarboxylates such as nitrilotriacetic acid and ethylenediamine tetracetic acid and salts thereof, and polyphosphonates and aminopolyphosphonates such as hydroxyethanediphosphonic acid, ethylenediamine tetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid and salts thereof.
The chelating agent selected is not critical except that it must be compatible with the other ingredients of the denture cleanser when in the dry state and in aqueous solution. Advantageously, the chelating agent comprises between 0.1 and 60 percent by weight of the composition and preferably between 0.5 and 30 percent. Phosphonic acid chelating agents, however, preferably comprise from about 0.1 to about 1 percent, preferably from about 0.1% to about 0.5 by weight of composition.
Enzymes suitable for use herein are exemplified by proteases, alkalases, amylases, lipases, dextranases, mutanases, glucanases etc.
Flavorants suitable for use in the compositions of the invention include wintergreen oil, oregano oil, bay leaf oil, peppermint oil, spearmint oil, clove oil, sage oil, sassafras oil, lemon oil, orange oil, anise oil, benzaldehyde, bitter almond oil, camphor, cedar leaf oil, marjoram oil, citronella oil, lavendar oil, mustard oil, pine oil, pine needle oil, rosemary oil, thyme oil, cinnamon leaf oil, and mixtures thereof.
Suitable antimicrobial compounds include thymol, menthol, triclosan, 4-hexylresorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butyl paraben, methyl paraben, propyl paraben, salicylamides, and mixtures thereof.
WO 96/19563 PCT/US95/16673 13 The following Examples further describe and demonstrate the preferred embodiments within the scope of the present invention.
WO 96/19563 PCTIUS95/16673 14 EXAMPLES I TO V The following are representative denture cleansing tablets according to the invention. The percentages are by weight of the total tablet. The tablets are made by compressing a mixture of the granulated components in a punch and dye 105 kPa.
tabletting press at a pressure of about Malic Acid Citric Acid Sodium Carbonate Sulphamic Acid PEG 20,000 PVP 40,000 Sodium Bicarbonate Sodium Perborate Monohydrate Potassium Monopersulphate Pyrogenic Silica Talc
EDTA
EDTMP
1 Flavor 5 Abil EM90 4 Bleach Precursor Agglomerate I II 12 10 10 10 8 III IV 15 10 6 3 7 8 24.5 16 13 1 1 2 Bleach Precursor Agglomerate I II
TAED
2 2
TMHOS
3 2 3 Sulphamic Acid 2 2 Sodium Bicarbonate 0.5 0.2 PEG 6000 2.5 2 Dye 0.8 1. Ethylenediaminetetramethylenephosphonic 2. Tetraacetylethylene diamine III IV V 4 5 2 0.2 2.4 1.4 acid 2 0.5 2.5 2 2 Sodium 3,5,5-trimethylhexanoyloxybenzene sulfonate Cetyl dimethicone copolyol Peppermint-based flavor In Examples I to V above, the overall tablet weight is 3 g; diameter mm.
The denture cleansing tablets of Examples I to V display improved antiplaque efficacy together with excellent cleansing and anti-bacterial activity, cohesion and other physical and in-use performance characteristics.
"Comprises/comprising" when used in this specification is taken to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.
o• et** *t o
Claims (10)
1. A denture cleansing composition including an inorganic persalt bleaching agent, an effervescence generator and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having the formula(l): CH 3 CH 3 CH 3 CH3 QH3 I II I__ CH 3 SiO--SiO---SiO -iO----Si-CH 3 CH- I I i-CH 3 CH 3 CH 3 (CH 2 3 Y CH 3 n1 0 (C 2 H 4 0-)x(C 3 H60-)yX q J wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from 1 to 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from 8 to 22 carbon atoms, n is from 0 to 200, m is from 1 to 40, q is from 1 to 100, the molecular weight of the residue (C 2 H 4 0-)x(C 3 H60-)yX is from 50 to 2000, and x and y are such that the weight ratio of oxyethylene:oxypropylene is from 100:0 to 0:100.
2. The composition according to Claim 1 wherein the dimethicone copolyol is selected from C 1 2 to C 2 0 alkyl dimethicone copolyols and mixtures thereof.
3. The composition according to Claim 1 or 2 wherein the dimethicone copolyol is cetyl dimethicone copolyol.
4. The composition according to any one of Claims 1 to 3 including from 0.01% to 25% by weight of the dimethicone copolyol.
The composition according to Claim 4 including from 0.1% to 5% by weight of the dimethicone copolyol. 17
6. The composition according to any one of Claims 1 to 5 wherein the inorganic persalt bleaching agent includes one or more bleaching agents selected from alkali metal persulfates, alkali metal perborates and mixtures thereof.
7. The composition according to any one of the Claims 1 to 6 wherein the effervescence generator includes a (bi)carbonate/acid effervescent couple.
8. The composition according to any one of Claims 1 to 7 additionally including an organic peroxyacid bleach precursor.
9. The composition according to Claim 8 wherein the organic peroxyacid ::bleach precursor is selected from acylated polyalkyldiamines and carboxylic esters having the general formula AcL wherein Ac is the acyl moiety or an organic carboxylic acid including an optionally substituted, linear or branched C 6 -C 20 alkyl or alkenyl moiety or a C 6 -C 20 alkyl-substituted aryl moiety and L is a leaving group, the conjugate acid of which has a pKa in the range from 4 to 13.
10. The composition according to Claim 9 wherein the organic peroxyacid bleach precursor is tetraacetylethylenediamine. DATED this 16th day of October, 1998. THE PROCTER GAMBLE COMPANY WATERMARK PATENT TRADEMARK ATTORNEYS 290 BURWOOD ROAD HAWTHORN VICTORIA 3122 AUSTRALIA LCG/JGC:BA VAX DOC 023 AU4687196.WPC
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425931.4A GB9425931D0 (en) | 1994-12-22 | 1994-12-22 | Cleansing compositions |
GB9425931 | 1994-12-22 | ||
PCT/US1995/016673 WO1996019563A1 (en) | 1994-12-22 | 1995-12-13 | Detergent composition comprising a dimethicone copolyol |
Publications (2)
Publication Number | Publication Date |
---|---|
AU4687196A AU4687196A (en) | 1996-07-10 |
AU700174B2 true AU700174B2 (en) | 1998-12-24 |
Family
ID=10766386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU46871/96A Ceased AU700174B2 (en) | 1994-12-22 | 1995-12-13 | Detergent composition comprising a dimethicone copolyol |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0799301A4 (en) |
CN (1) | CN1170432A (en) |
AU (1) | AU700174B2 (en) |
BR (1) | BR9510470A (en) |
CA (1) | CA2206489C (en) |
CZ (1) | CZ190497A3 (en) |
GB (1) | GB9425931D0 (en) |
HU (1) | HUT77707A (en) |
PL (1) | PL320862A1 (en) |
RU (1) | RU2163479C2 (en) |
SK (1) | SK82697A3 (en) |
TR (1) | TR199501665A2 (en) |
WO (1) | WO1996019563A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294154B1 (en) | 1994-12-22 | 2001-09-25 | Procter And Gamble Company | Oral compositions containing dimethicone copolyols |
GB9622845D0 (en) * | 1996-11-01 | 1997-01-08 | Procter & Gamble | Effervescent bleaching compositions |
GB9622844D0 (en) * | 1996-11-01 | 1997-01-08 | Procter & Gamble | Cleansing compositions |
DK0991371T3 (en) * | 1997-01-16 | 2008-10-27 | Procter & Gamble | A method of treating dentures |
EP1059069A1 (en) | 1999-06-07 | 2000-12-13 | The Procter & Gamble Company | A denture cleaning apparatus |
US6685921B2 (en) | 2000-10-25 | 2004-02-03 | The Procter & Gamble Company | Dental care compositions |
US20040166068A1 (en) * | 2003-02-20 | 2004-08-26 | The Procter & Gamble Company | Antiplaque denture adhesive compositions |
EP2762882B1 (en) | 2013-01-31 | 2020-11-25 | Sensirion AG | Portable electronic device with ketone sensor |
EP2762864B1 (en) | 2013-01-31 | 2018-08-08 | Sensirion AG | Membrane-based sensor device and method for manufacturing the same |
EP2762868B1 (en) | 2013-01-31 | 2017-03-15 | Sensirion AG | Diffusion based metal oxide gas sensor |
EP2801819A1 (en) | 2013-05-08 | 2014-11-12 | Sensirion AG | Metal oxide chemical sensor for portable device |
EP2808675A1 (en) | 2013-05-31 | 2014-12-03 | Sensirion AG | Integrated metal oxide chemical sensor |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3607759A (en) * | 1969-04-17 | 1971-09-21 | Colgate Palmolive Co | Denture soak tablet |
US4155868A (en) * | 1975-12-22 | 1979-05-22 | Johnson & Johnson | Enzyme and active oxygen containing denture cleanser tablet |
US5055305A (en) * | 1988-12-02 | 1991-10-08 | Richardson-Vicks, Inc. | Cleansing compositions |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2158943A1 (en) * | 1970-12-03 | 1972-06-29 | Scherico Ltd., Luzern (Schweiz) | Moussing preparations |
US4115293A (en) * | 1975-10-06 | 1978-09-19 | E. I. Du Pont De Nemours And Company | Denture cleanser |
JPS5756434A (en) * | 1980-09-22 | 1982-04-05 | Kao Corp | Stabilized foamable composition |
US4409118A (en) * | 1981-04-03 | 1983-10-11 | Warner-Lambert Company | Tablet forming cleanser composition and method of preparation |
US4518520A (en) * | 1983-04-22 | 1985-05-21 | Warner-Lambert Company | Cleaner having improved dissolution time and clarity and improved of preparation |
US5290555A (en) * | 1989-09-14 | 1994-03-01 | Revlon Consumer Products Corporation | Cosmetic compositions with structural color |
US5310563A (en) * | 1991-10-25 | 1994-05-10 | Colgate-Palmolive Company | Dental material and method for applying preventative and therapeutic agents |
US5403578A (en) * | 1994-02-08 | 1995-04-04 | Gordon; Norman | Stable tooth and gum dentifrice with microencapsulation and method for making same |
-
1994
- 1994-12-22 GB GBGB9425931.4A patent/GB9425931D0/en active Pending
-
1995
- 1995-12-13 HU HU9800684A patent/HUT77707A/en unknown
- 1995-12-13 EP EP95944509A patent/EP0799301A4/en not_active Withdrawn
- 1995-12-13 AU AU46871/96A patent/AU700174B2/en not_active Ceased
- 1995-12-13 SK SK826-97A patent/SK82697A3/en unknown
- 1995-12-13 CN CN95196929A patent/CN1170432A/en active Pending
- 1995-12-13 BR BR9510470A patent/BR9510470A/en not_active Application Discontinuation
- 1995-12-13 RU RU97112392/14A patent/RU2163479C2/en active
- 1995-12-13 PL PL95320862A patent/PL320862A1/en unknown
- 1995-12-13 CZ CZ971904A patent/CZ190497A3/en unknown
- 1995-12-13 WO PCT/US1995/016673 patent/WO1996019563A1/en not_active Application Discontinuation
- 1995-12-13 CA CA002206489A patent/CA2206489C/en not_active Expired - Fee Related
- 1995-12-22 TR TR95/01665A patent/TR199501665A2/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3607759A (en) * | 1969-04-17 | 1971-09-21 | Colgate Palmolive Co | Denture soak tablet |
US4155868A (en) * | 1975-12-22 | 1979-05-22 | Johnson & Johnson | Enzyme and active oxygen containing denture cleanser tablet |
US5055305A (en) * | 1988-12-02 | 1991-10-08 | Richardson-Vicks, Inc. | Cleansing compositions |
Also Published As
Publication number | Publication date |
---|---|
SK82697A3 (en) | 1998-02-04 |
MX9704665A (en) | 1997-09-30 |
EP0799301A1 (en) | 1997-10-08 |
RU2163479C2 (en) | 2001-02-27 |
WO1996019563A1 (en) | 1996-06-27 |
GB9425931D0 (en) | 1995-02-22 |
EP0799301A4 (en) | 1999-08-18 |
TR199501665A3 (en) | 1996-07-21 |
CZ190497A3 (en) | 1997-11-12 |
CN1170432A (en) | 1998-01-14 |
CA2206489A1 (en) | 1996-06-27 |
HUT77707A (en) | 1998-07-28 |
AU4687196A (en) | 1996-07-10 |
TR199501665A2 (en) | 1996-07-21 |
PL320862A1 (en) | 1997-11-10 |
BR9510470A (en) | 1998-05-26 |
CA2206489C (en) | 2001-03-27 |
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Legal Events
Date | Code | Title | Description |
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MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |