MXPA97004665A - Detergent composition comprising a dimetic copoliolde - Google Patents

Abstract

The present invention relates to a denture cleaning composition, characterized in that it comprises an inorganic persal bleaching agent, an effervescence generator and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having the formula (I) : wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, and is selected from alkyl and alkoxy groups having about 8 to 22 carbon atoms, n is from about 0 to about 200, m is from 1 to about 40, q is from 1 to about 100, the molecular weight of the residue (C2H4O-) x (C3H6O-) and X is from about 50 to about 2000, andxyy are such that the proportion by weight of oxyethylene: oxypropylene is from about 100: 0 to about 0: 1

Description

COMPOSITION DETERGENT COMPRISING A COPOLY OF DIMETICONR TECHNICAL FIELD The present invention relates to cleaning compositions and especially to compositions that are used in dental cleaning and the like. In particular, the invention relates to dental cleaning compositions having improved antiplaque activity together with excellent physical and dissolution characteristics, appearance and performance for dental cleaning, antibacterial efficacy characteristics and performance characteristics in use.

BACKGROUND OF THE INVENTION Tablets and effervescent powders for dental cleaning and the like are well known in the art. The purpose of a denture cleansing product is to clean the denture as quickly and as best as possible and especially to remove the accumulation of plaque, ilaginous and bacterial deposits which accumulate while the denture is wearing out. Showing a denture which has not been completely released from plaque and bacterial deposits is not only unhygienic, but can also, within a short space of time, result in a detrimental effect on the mucous membrane. In addition, bacterial deposits can lead to the so-called bacterial corrosion of the plastic materials that are used to produce the denture with consequent color changes and malodour formation. It is known to include silicones in dentifrice compositions, supposedly to cover the teeth and prevent cavities and discolorations. For example, the patent GB-fi-689,679 discloses a mouthwash containing an organopolysiloxane to prevent adhesion of, or to remove, tars, stains, tartar and food particles from the teeth. U.S. Patent R-2,806.81 discloses dental preparations including, in combination, a higher aliphatic acylamide of an aminocarboxylic acid compound as an active compound and a silicone compound. The patent notes that silicone compounds have been proposed for the prevention of adhesion, or to facilitate the removal, of tars, spots, tartar and the like of teeth. It is said that the silicone compound acts as a synergist by improving the antibacterial and acid inhibiting activity of the active ingredient. It is said that dimethyl polysiloxanes are particularly effective. The US Patent No. 3624120 describes quaternary ammonium salts of cyclic siloxane polymers which are used as cationic surfactants, bactericides and as anticariogenic agents. Dentures, in fact, are generally made of a plastic material such as acrylic, and the problem of preventing plaque build-up or removing plaque from dentures is, therefore, fundamentally different from the problem of prevention and removal. of the plate from the dental scan. Accordingly, the present invention provides a dental cleaner that has improved efficacy on plate and bacterial and bacterial deposits and which, at the same time, provides excellent physical, appearance and performance characteristics for tooth cleaning and dissolution and performance characteristics. In use.

BRIEF DESCRIPTION OF THE INVENTION According to a first aspect of the invention, there is provided a dental cleaning composition comprising an inorganic persal bleaching agent, an effervescence generator and a di ethicone copolyol selected from alkyl- and alkoxy-diriethylene copolyols having the formula (I) wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, and is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is about 0 to about 200, m is about 1 to about 40, q is about 1 to about 100, the molecular weight of the residue (C2H4O-) n (C3H6O-) and X is about 50 to about 2000, preferably about 250 to about 1000 and x and y are such that the weight ratio of oxyethylene: oxypropylene is about 100: 0 to about 0: 100, preferably about 100: 0 to about 20:80. The present invention also relates to the use of the di-ethicone copolyol as an antiplaque agent in dental cleaning compositions. All percentages and proportions herein are by weight of the total composition, unless otherwise indicated. The cleaning compositions of the invention thus comprise three essential components, a bleaching agent, a dimethicone copolyol and an effervescent base composition. Each of these will be discussed in turn. The bleaching agent to the form of an inorganic persalt and can be selected from any of the well-known bleaching agents known to be used in dental cleansers such as ammonium and alkali metal persulfates, perborates, percarbonates and perfosphates and the peroxides of alkali metal and alkaline earth metal. Examples of suitable bleaching agents include persulfates of potassium, ammonium, sodium and lithium and rnonono- and tetrahydrated perborate, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides. Of these, however, alkali metal persulfates, perborates and mixtures thereof are preferred for use herein, with alkali metal perborates being highly preferred. Furthermore, it is a feature of the invention that the tablet compositions herein will provide excellent antimicrobial activity even in the absence of alkali metal persulfates. The amount of bleaching agent in the total composition is generally about 5 to about 70%, preferably about 10% to about 50%. In compositions comprising a mixture of alkali metal persulfates and perborates, the total ratio of persulfate: perborate is conveniently about 5: 1 about 1: 5, more especially about 2: 1 to about 1: 2. The compositions herein also contain a dimethicone copolyol anti-plaque agent. In general terms, the dimethicone copolyol is selected from alkyl- and alkoxy-dimethicone copolyols having the formula (I): CH3- wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups groups having from about 1 to about 16 carbon atoms, and is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, is about 0 to about 200, m is about 1 to about 40, q is about 1 to about 100, the molecular weight of the residue (C2H4O-) n (C3HβO-) and is about 50 to about 2000, preferably about 250 to about 1000 andxyy are such that the weight ratio of oxyethylene: oxypropylene is about 100: 0 to about 0: 100, preferably about 100: 0 to about 20:80. In preferred embodiments, the dimethicone copolyol is selected from alkyl diketonicone copolyols of C12 to C20 and mixtures thereof. Highly preferred is the copolyol of cetyldimethicone marketed under the trade name flbil EM90. The dimethicone copolyol is generally present at a level of about 0.01% to about 25%, preferably about 0.1% to about 5%, more preferably about 0.5% to about 1.5% by weight. The dental cleaning compositions also incorporate an effervescence generator which in preferred embodiments takes the form of a solid base material which in the presence of water releases carbon dioxide or oxygen with effervescence. The effervescence generator used in the compositions herein can be selected from generators which are effective under acid, neutral or alkaline pH conditions, but preferably consists of a combination of a generator which is effective or more effective under the conditions of Acidic or neutral pH and a generator which is effective or more effective under alkaline pH conditions. Effervescence generators which are effective under acidic or neutral pH conditions include a combination of at least one alkali metal carbonate or bicarbonate, such as sodium bicarbonate, sodium carbonate, sodium seekicarbonate, potassium carbonate, sodium bicarbonate. potassium or mixtures thereof, in admixture with at least one physiologically acceptable non-toxic organic acid, such as tartaric acid, aric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic, sodium fumarate, phosphates sodium or potassium acids, betaine hydrochloride or mixtures thereof. Of these, the rnálico acid is preferred. Effervescence generators which are effective under alkaline pH conditions include persalts such as alkali metal or alkaline earth metal peroxoborate, as well as perborates, persulfates, percarbonates, perfosphates and mixtures thereof as described above, for example, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a monopersulfate such as Caroat * marketed by EI du Point de Nemours Co. and which is a mixture of 2: 2: 1 monopersulfate, potassium sulfate and potassium bisulfate and which has an active oxygen content of almost 4.5%. In highly preferred compositions, the solid base material incorporates an effervescent couple of (bi) carbonate / acid optionally in combination with a perborate / persulfate oxygen effervescence generator. The combination of generators is valuable to achieve optimal dissolution characteristics and pH conditions to achieve optimal cleaning and antimicrobial activity. The (bi) carbonate components generally comprise about 5% to about 65%, preferably about 25% to 55% of the total composition; the acid components generally comprise about 5% to about 50%, preferably about 10% to about 30% of the total composition. The compositions of the invention can be complemented by other known components of dental cleaning formulations. An especially preferred additional component is an organic peroxyacid precursor, which in general terms can be defined as a compound having a titer of at least 1.5 rnl of 0.1N sodium thiosulfate in the following permeation test. A test solution is prepared by dissolving the following materials in 1000 ml of distilled water: sodium pyrophosphate (Na «P2? 7.10H2?) 2.5 g sodium perborate (NaBO2.H2O2.3H2O) having 10.4% available oxygen 0.615 g sodium dodecylbenzenesulfonate 0.5g To this solution at 60 ° C is added an amount of activator such that for each available oxygen atom present a molecular equivalent of the activator is introduced. The mixture obtained by the addition of the activator is stirred vigorously and maintained at 60 ° C. After 5 minutes from the addition, a 100 ml portion of the solution is separated and pipetted immediately onto a mixture of 250 g of crushed ice and 15 ml of glacial acetic acid. Potassium iodide (0.4 g) is then added and the released iodine is immediately titrated with 0.1 N sodium thiosulfate with starch as indicator until the first disappearance of the blue color. The amount of sodium thiosulfate solution used in rnl is the title of the bleach activator. Organic peracid precursors are typically compounds that contain one or more acyl groups, which are susceptible to perhydrolysis. Preferred activators are those of the N-acyl and O-acyl compound type containing an acyl radical R-CO wherein R is a hydrocarbon or substituted hydrocarbon group preferably having about 1 to about 20 carbon atoms. Examples of suitable peracid precursors include: 1) Acyl organoamides of the formula RCONRi R2, where RCO is an acyl carboxylic radical, Ri is an acyl radical and R2 is an organic radical, as described in the US patent. A-3,117,148. Examples of compounds that fall within this group include: a) N, N-diacetylaniline and N-acetylphthalimide; b) N-acylhydantoins, such as N, N'-diacetyl-5,5-dimethylhydantoin; c) Polyacylated alkylenediamines, such as N, N, N'N'-tetraacetylethylenediamine (TAED) and the corresponding derivatives of hexa ethylenediamine (TAHD), as described in patents GB-A-907, 356, GB-A- 907,357 and GB-A-907,358; d) Acylated glycolurils, such as tetraacetylglycoluril, as described in GB-A-1, 245,338, GB-A-1, 246, 339 and GB-A-1,247,429. 2) Acylated sulfonamides, such as N-rnethyl-N-benzoylmethanesulfonamide and N-phenyl-N-acetylmethane sulfonamide, as described in the patent 6B-A-3, 183,266. 3) Carboxylic esters as described in GB-A-836, 988, GB-A-963, 135 and GB-A-1, 147, 871. Examples of compounds of this type include phenylacetate, sodium acetoxybenzenesulfonate, trichloroethylacetate , sorbitol hexaacetate, fructose pentaacetate, p-nitrobenzaldehyde diacetate, isopropeneyl acetate, acetylacetohydroxamic acid, and acetylsalicylic acid. Other examples are esters of a phenol or phenol substituted with an alpha-chlorinated lower aliphatic carboxylic acid, such as chloroacetyl phenol and chloroacetylisalicylic acid, as described in US Pat. No. A-3,130,165. 4) Carboxylic esters having the general formula Ac L, wherein Ac is the acyl portion of an organic carboxylic acid comprising an optionally substituted straight or branched C6-C20 alkyl or alkenyl portion or an aryl portion substituted with C6-C20 alkyl and L is a residual group, the conjugated acid of which has a pKa on a scale of 4 to 13, for example, oxybenzenesulfonate or oxybenzoate. Preferred compounds of this type are those wherein: a) Ac is R3-CO and R3 is a linear or branched alkyl group containing from 6 to 20, preferably from 12, more preferably from 7 to 9 carbon atoms and wherein the longer linear alkyl chain extending from and including the carbonyl carbon contains from 5 to 18, preferably 5 to 10 carbon atoms, with R3 being optionally substituted (preferably alpha to the carbonyl portion) by Cl, Br, 0CH3 or OC2H5. Examples of this class of material include 3, 5, 5-trimethylhexanoyloxy-benzene sulfonate, sodium 3,5,5-trirnethylhexanoyloxybenzoate, sodium 2-ethylhexanoyloxybenzene sulfonate., sodium nonanoyl oxybenzenesulfonate and sodium octanoyl oxybenzenesulfonate, the acyloxy group in each case being preferably p-substituted. b) Ac has the formula R3IA0) mXA where R3 is a linear or branched alkyl or alkylaryl group containing from 6 to 20, preferably from 6 to 15 carbon atoms in the alkyl portion, Rs being optionally substituted by Cl, Br, OCH3, u OC2H5, AO is oxyethylene or oxypropylene, m is from 0 to 100, X is 0, NR4 or CO-NR4 and A is CO, CO-CO, Rβ-CO, CO-Rβ-CO or CO-NR4-R6- CO, wherein R "is Ci-C4 alkyl and 6 is alkylene, alkenylene, arylene or alkarylene containing from 1 to 8 carbon atoms in the alkylene or alkenylene portion. Bleach activating compounds of this type include carbonic acid derivatives of the formula R3 (AO) mOCOL, succinic acid derivatives of the formula R3? CO (CH2) 2C0L, glycolic acid derivatives of the formula R3OCH2COL, hydroxypropionic acid derivatives of the formula the formula R3 OCH2 CH2COL, oxalic acid derivatives of the formula R3OCOCOL, maleic and aric acid derivatives of the formula R3? COCH = CHCOL, acyl-naproic acid derivatives of the formula R3CONR1 (CH2) ßCOL, acylglycine derivatives of the formula R3 CONRi CH2 COL, and ami or -6-oxocaproic acid derivatives of the formula R3 (R?) C0 (CH2 COL.) In the above, m is preferably from 0 to 10, and R3 is preferably C6-C1, more preferably C 1 -C 0 alkyl when m is zero, and C 9 -C 15 when m is not zero The residual group L is as defined above 5) Acyl cyanurates, such as triacetyl- or tribenzoylcyanurates, as described in US patent specification No. 3,332,882. 6) Optionally substituted anhydrides of benzoic or phthalic acid, for example, benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride. Of all of the above, organic peracid precursors of the types I (c) and 4 (a) are preferred. Where present, the level of peroxyacid bleach precursor by weight of the total composition is preferably about 0.1% to about 10%, more preferably about 0.5% to about 5% and is generally added in the form of an agglomerate of bleach precursor. Preferred bleach precursor agglomerates for use herein generally comprise a binder or binder at the level of from about 5% to about 40%, more especially about 10% to about 30% by weight thereof. Suitable binder agents include polyvinylpyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethylene glycols of molecular weight about 1,000 to about 50,000, Carbowax having a molecular weight of 4,000 to 20,000, nonionic surfactants, fatty acids, sodium carboxymethylcellulose, gelatin, fatty alcohols, phosphates and polyphosphates, clays, alu inosilicates and polymeric polycarboxylates. Of the above, polyethylene glycols are highly preferred, especially those having a molecular weight of from about 1,000 to about 30,000, preferably from 2,000 to about 10,000. Preferred from the standpoint of optimum dissolution and pH characteristics are agglomerates of bleach precursor which comprise from about 10% to about 75%, preferably from about 20% to about 60% by weight thereof of bleach precursor. of peroxyacid, about 5% to about 60%, preferably about 5% to about 50%, more preferably about 10% to about 40% of an effervescent couple of (bi) carbonate / acid, about 0% a about 20% of a peroxoborate, and about 5% to about 40%, preferably about 10% to about 30% of a binder. The granules of the final bleach precursor desirably have an average particle size of from about 500 to about 1,500, preferably about 500 to about, 000um, being this valuable from the aesthetic point of view and optimal dissolution performance. The level of agglomerates of the bleach precursor, in addition, is preferably about 1% to about 20%, more preferably about 5% to about 15% by weight of the composition. The compositions of the invention can be in the form of paste, liquid, tablet, granular or powder, although the compositions in tablet form are highly preferred herein. The compositions in tablet form can be individual or multiple coated tablets. The compositions of the invention can be complemented by other customary components of dental cleaning formulations, especially surfactants, chelating agents, enzymes, flavors, refreshing physiological agents, antimicrobial compounds, colorants, sweeteners, binders and tablet fillers, foam suppressants such such as dimethyl polysiloxanes, foam stabilizers such as sugar esters of fatty acids, preservatives, lubricants such as talc, magnesium stearate, amorphous pyrogenic silicas finely ld divided, etc. The moisture-free content of the final composition is desirably less than about 1% and especially less than about 0.5%. Suitable binders and tablet fillers for use herein include polyvinyl pyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 50,000, polyethylene glycols of molecular weight from about 1,000 to about 50,000, Carbowax having a molecular weight of 4,000 to 20,000, surfactants. nonionics, fatty acids, sodium carboxymethylcellulose, gelatin, fatty alcohols, clays, polymeric polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, magnesium hydroxide carbonate, sodium sulfate, proteins, ethers of cellulose, cellulose esters, polyvinyl alcohol, esters of alginic acid, vegetable fatty materials of a pseudocolloidal character. Of the above, polyethylene glycols are highly preferred, especially those having a molecular weight of from about 1,000 to about 30,000, preferably about 12,000 to about 30,000. The surfactant used in the compositions of the invention can be selected from the many available which are compatible with the other ingredients of the dental cleanser, both in the dry state and in solution. It is believed that such materials improve the effectiveness of the other ingredients of the composition by facilitating their penetration into the interdental surfaces. Also, these materials facilitate the removal of fixed food debris to the teeth. Between 0.1 and 5% by weight of the dry composition of a dry powder or granular anionic surfactant agent, such as sodium lauryl sulfate, sodium N-lauroyl sarcosinate, sodium lauryl sulphoacetate or sodium dioctyl s-lfosuccinate or sodium pcinoleyl sulfosuccinate can, for example, it is included in the composition and preferably the surfactant comprises between 0.5 and 4% of the composition. Suitable cationic, nonionic and ampholytic surfactants include, for example, ammonium quaternary compounds such as cetyltriyl ethylammonium bromide, condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or alkanolamides. of fatty acid, the fatty acid alkanolamides themselves, esters of long-chain fatty acids (C8-C22) with polyalcohols or sugars, for example glycerylmonostearate or saccharosamonolaurate or sorbitolpolyoxyethylene-nono-or di-stearate, betaines, sulfobetaines or long-chain alkylaminocarboxylic acids . Chelating agents beneficially improve the cleaning and bleaching stability by keeping in solution metal ions, such as calcium, magnesium and heavy metal cations. Examples of suitable chelating agents include sodium tripoli phosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, aminopolycarboxylates such as nitrophoteacetic acid and acetic acid lactone and salts thereof, and polyphosphonates and aminopolyphosphonates such as hydroxyethanediphosphonic acid, ethylenediamine acid. tetramethienophosphonate, ethylene phosphonic diethiienotriaminoponta acid and salts thereof. The selected chelating agent is not critical except that it must be compatible with the other ingredients of the dental cleanser when it is in the dry state and in aqueous solution. Advantageously, the chelating agent comprises between 0.1 and 60% by weight of the composition and preferably between 0.5 and 30%. However, the phosphomonic acid chelating agents preferably comprise about 0.1 to about 1%, preferably about 0.1% to about 0.5% by weight of the composition. Suitable enzymes for use herein are exemplified by proteases, alkases, slabs, lipases, dextranases, mutanases, glucanases, etc. Suitable flavors for use in the compositions of the invention include wintergreen oil, oregano oil, bay leaf oil, peppermint oil, spearmint oil, clove oil, sage oil, sassafras oil, lemon oil, orange oil, anise oil, benzaldehyde, bitter almond oil , camphor, cedar leaf oil, marjoram oil, citronella oil, lavender oil, mustard oil, pine oil, pine needles oil, rosemary oil, screw oil, cinnamon leaf oil, and mixtures thereof. Suitable antimicrobial compounds include thymol, rnentol, triclosan, 4-hexylresorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butylparaben, i.1paraben, propylparaben, salicylamides, and mixtures thereof. The following examples further describe and demonstrate the preferred embodiments within the scope of the present invention.

EXAMPLES I TO V The following are representative tablets for dental cleaning according to the invention. The percentages are by weight of the total tablet. The tablets are obtained by compressing a mixture of the granulated components in a punch press and given at a pressure of almost 105 kPa.

II III ?? Y.

Malic acid 12 10 15 14 Citric acid - - 10 15 Sodium carbonate 10 8 10 6 10 Sulfamic acid 5 - 3 3 PEG 20,000 - - 3 8 5 PVP 40,000 6 3 Sodium bicarbonate 22 19 24..5 13 23 Sodium perborate monohydrated 15 12 16 30 15 Sodium monopersulfate 15 18 13 - 14 Pyrrogenic silica - 3 1 1 - Talc 2 - - - - EDTA - - 1 __ 3 EDTMP1 1 - - 1 - Taste5 2 1 2 1 2 Abil EM904 1 5 0., 5 10 1 Agglomerate of bleach precursor 10 12 10 Agglomerate of bleach precursor I 11 III IV V TAED2 2 - 4 5 2.5 TMH0S3 2 3 - __ - Sulphamic acid 2 2 2 2 3.5 Sodium bicarbonate 0.5 0.2 0.2 0.5 2 PEG 6000 2.5 2 2.4 2.5 1.5 Colorant - 0.8 1.4 2 0.5 1. - Ethylene diamine tetramethylene phosphonic acid 2.- Tetraacetylene diamine 3. sodium 3.- 3,5,5-trimethylhexanoyloxybenzenesulfonate 4.- Copolyol of cetyldimethicone 5.- Peppermint flavor In examples I to V, the Total weight of the tablet is 3 g; diameter of 25 rnrn. The dental cleaning tablets of examples I to V exhibit improved antiplaque efficacy together with excellent cleansing and antibacterial activity, cohesion characteristics and other physical and performance characteristics in use.

Claims (8)

NOVELTY OF THE INVENTION CLAIMS

1. - A dental cleaning composition comprising an inorganic persal bleaching agent, an effervescence generator and a copolyol of dirneticone selected from alkyl- and alkoxy-dimethicone copolyols having the formula (I): wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, and is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is about 0 to about 200, rn is about 1 to about 40, q is about 1 to about 100, the molecular weight of the residue (C2H * 0) x (C3HβO-) and X is about 50 to about 2000, yxyy are such that the weight ratio of oxyethylene: oxypyrolene is from 100: 0 to 0: 100.

2. A composition according to claim 1, wherein the dichketone copolyol is selected from C12 to C20 alkyldimethicone copolyols and mixtures thereof.

3. A composition according to claim 2, wherein the copolyol of dimethicone is copolyol of cetildi ethicone.

4. A composition according to claim 1, comprising from about 0.01% to about 25% by weight of the dimethicone copolyol.

5. A composition according to claim 1, wherein the inorganic persal bleaching agent comprises one or more bleaching agents selected from alkali metal persulfates, alkali metal perborates and mixtures thereof.

6. A composition according to claim 1, wherein the effervescence generator comprises an effervescent couple of (bi) carbonate / acid.

7. A composition according to claim 1, further comprising an organic peroxyacid bleach precursor.

8. A composition according to claim 7, wherein the organic peroxyacid bleach precursor is selected from acylated polyalkyldiammas, especially tetraacetylethylenediamine, and carboxylic esters having the general formula AcL wherein Ac is the acyl portion of an acid organic carboxylic comprising an optionally substituted straight or branched C6-C20 alkyl or alkenyl portion or an aryl portion substituted by C6-C20 alkyl and L is a residual group, the conjugate acid of which has pKa on the scale of 4 to 13 SUMMARY OF THE INVENTION A dental cleaning composition comprising an inorganic persal bleaching agent, an effervescence generator and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having formula (I) wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, and is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is about 0 to about 200, rn is about 1 to about 40, q is about 1 to about 100, the molecular weight of the residue (C2H4O-) N (C3HβO- and X is about 50 to about 2000, andxyy are such that the oxyethylene: oxypropylene weight ratio is about 100: 0 to about 0: 100. The composition provides improved antiplaque activity, cleansing activity and antibacterial activity along with excellent physical and performance characteristics in use. MG / ycl / lss / aprn. P97-545F.