EP0925366A1 - Verfahren zur herstellung von carotenoiden und speziellen ölen in pflanzensamen - Google Patents

Verfahren zur herstellung von carotenoiden und speziellen ölen in pflanzensamen

Info

Publication number
EP0925366A1
EP0925366A1 EP97938203A EP97938203A EP0925366A1 EP 0925366 A1 EP0925366 A1 EP 0925366A1 EP 97938203 A EP97938203 A EP 97938203A EP 97938203 A EP97938203 A EP 97938203A EP 0925366 A1 EP0925366 A1 EP 0925366A1
Authority
EP
European Patent Office
Prior art keywords
gene
plant
seed
carotenoid
carotenoid biosynthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938203A
Other languages
English (en)
French (fr)
Inventor
Christine K. Shewmaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Calgene LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calgene LLC filed Critical Calgene LLC
Publication of EP0925366A1 publication Critical patent/EP0925366A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
EP97938203A 1996-08-09 1997-08-08 Verfahren zur herstellung von carotenoiden und speziellen ölen in pflanzensamen Withdrawn EP0925366A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2414596P 1996-08-09 1996-08-09
US24145P 1996-08-09
PCT/US1997/014035 WO1998006862A1 (en) 1996-08-09 1997-08-08 Methods for producing carotenoid compounds and speciality oils in plant seeds

Publications (1)

Publication Number Publication Date
EP0925366A1 true EP0925366A1 (de) 1999-06-30

Family

ID=21819082

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938203A Withdrawn EP0925366A1 (de) 1996-08-09 1997-08-08 Verfahren zur herstellung von carotenoiden und speziellen ölen in pflanzensamen

Country Status (7)

Country Link
EP (1) EP0925366A1 (de)
JP (1) JP2001505409A (de)
CN (1) CN1227609A (de)
AU (1) AU4058497A (de)
BR (1) BR9713462A (de)
CA (1) CA2261577A1 (de)
WO (1) WO1998006862A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642021B2 (en) * 1996-03-29 2003-11-04 University Of Maryland Methods of producing carotenoids by the expression of plant ε-cyclase genes
US6429356B1 (en) * 1996-08-09 2002-08-06 Calgene Llc Methods for producing carotenoid compounds, and specialty oils in plant seeds
US6653530B1 (en) 1998-02-13 2003-11-25 Calgene Llc Methods for producing carotenoid compounds, tocopherol compounds, and specialty oils in plant seeds
US6600089B1 (en) 1998-04-24 2003-07-29 E. I. Du Pont De Nemours And Company Carotenoid biosynthesis enzymes
AU3749199A (en) * 1998-04-24 1999-11-16 E.I. Du Pont De Nemours And Company Carotenoid biosynthesis enzymes
JP2002525034A (ja) * 1998-08-05 2002-08-13 サンジーン ゲーエムベーハー ウント コー．カーゲーアーアー １−デオキシ−ｄ−キシルロース−５−リン酸シンターゼをコードするｄｎａ配列および植物におけるその過剰産生
WO2000011199A1 (en) * 1998-08-20 2000-03-02 Pioneer Hi-Bred International, Inc. COMPOSITIONS AND METHODS FOR ALTERING AN ACETYL-CoA METABOLIC PATHWAY OF A PLANT
IL142041A0 (en) * 1998-10-07 2002-03-10 Syngenta Participations Ag Therapeutically active proteins in plants
US6232530B1 (en) 1998-11-30 2001-05-15 University Of Nevada Marigold DNA encoding beta-cyclase
US6515206B1 (en) 1998-12-23 2003-02-04 Calgene Llc Plastid transformation of Brassica
WO2000049116A1 (en) * 1999-02-18 2000-08-24 Calgene Llc Method for refining a seed oil having micronutrients
DE19909637A1 (de) * 1999-03-05 2000-09-07 Peter Beyer Verfahren zur Verbesserung des agronomischen Wertes und der ernährungsphysiologischen Eigenschaften von Pflanzen
ATE446370T1 (de) 1999-04-12 2009-11-15 Monsanto Technology Llc Öl, das brassicastanol enthält
JP2002541851A (ja) * 1999-04-15 2002-12-10 カルジーン エルエルシー イソプレノイド合成に関与するタンパク質の核酸配列
SE9903336D0 (sv) * 1999-09-17 1999-09-17 Astacarotene Ab DNA construct and its use
CA2401991A1 (en) * 2000-03-17 2001-09-27 Exelixis Plant Sciences, Inc. Melon promoters for expression of transgenes in plants
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
AR028450A1 (es) * 2000-05-12 2003-05-07 Monsanto Technology Llc Mctodos para producir compuestos carotenoides y aceites especiales en semillas de plantas
MXPA02012804A (es) 2000-06-27 2003-05-14 Basf Ag Fragmentos de acido nucleico dianobacterial que codifican las proteinas utiles para controlar las caracteristicas de la planta mediante transformacion nuclear o plastoma.
US7083967B1 (en) 2000-06-27 2006-08-01 Basf Corporation Cyanobacterial nucleic acid fragments encoding proteins useful for controlling plant traits via nuclear or plastome transformation
AU2001290522B2 (en) 2000-08-07 2006-11-30 Monsanto Technology Llc Methyl-D-erythritol phosphate pathway genes
ES2318004T3 (es) 2001-05-09 2009-05-01 Monsanto Technology Llc Genes tyra y usos de los mismos.
WO2003016482A2 (en) 2001-08-17 2003-02-27 Monsanto Technology Llc Methyltransferase genes and uses thereof
DE60235252D1 (de) 2001-10-25 2010-03-18 Monsanto Technology Llc Aromatische methyltransferasen und ihre verwendung
BR0308740A (pt) 2002-03-19 2007-01-09 Monsanto Technology Llc ácidos nucléicos e polipeptìdeos de homogentisado prenil transferase ("hpt"), e empregos destes
AU2003268083A1 (en) 2002-08-05 2004-02-23 Monsanto Technology, Llc Tocopherol biosynthesis related genes and uses thereof
CA2495444A1 (en) * 2002-08-20 2004-03-04 Sungene Gmbh & Co.Kgaa Method for producing ketocarotinoids in plant fruit
PT1589807E (pt) * 2002-12-06 2012-02-02 Del Monte Fresh Produce Company Plantas transgénicas de ananás com níveis modificados de carotenóides e métodos da sua produção
DE602004011035T2 (de) * 2003-03-24 2008-12-18 Syngenta Ltd., Guildford Erhöhte ansammlung von karottenoiden in pflanzen
DE102004007624A1 (de) * 2004-02-17 2005-09-15 Sungene Gmbh & Co. Kgaa Neue Ketolasen und Verfahren zur Herstellung von Ketocarotinoiden
AU2006287233A1 (en) * 2005-09-02 2007-03-08 Cornell University Polynucleotides encoding carotenoid and apocarotenoid biosynthetic pathway
CN100410376C (zh) * 2006-03-06 2008-08-13 中国科学院遗传与发育生物学研究所 与油脂代谢调控相关的转录因子GmDofC及其编码基因与应用
CA2678762A1 (en) * 2007-02-21 2008-08-28 Abdelali Hannoufa Altering carotenoid profiles in plants
ES2339094B1 (es) * 2008-11-13 2011-03-18 Iden Carbohydrate Biotechnology, S.L. Procedimiento para la produccion de plantas transgenicas que presentan alto contenido en compuestos antioxidantes, alta capacidad antioxidante y resistencia al empardecimiento.
CN101514345B (zh) * 2009-02-19 2012-07-04 上海交通大学 生菜植醇激酶蛋白编码序列
US20140123339A1 (en) 2012-10-31 2014-05-01 Pioneer Hi Bred International Inc Transformed Plants Having Increased Beta-Carotene Levels, Increased Half-Life and Bioavailability and Methods of Producing Such
CN104357479B (zh) * 2014-11-18 2017-06-06 西南大学 干扰黄色色素表达同时超量表达番茄红素在制备红色花瓣芸薹属植物中的应用
CN104480128B (zh) * 2014-11-18 2018-02-27 西南大学 抑制黄色色素积累同时积累番茄红素和花青素苷在制备花瓣呈红色芸薹属植物中的应用
CN104404079B (zh) * 2014-12-19 2017-03-15 西南大学 干扰lcyb、lcye表达同时超量表达gl3在制备花瓣呈红色芸薹属植物中的应用
CN104404080B (zh) * 2014-12-19 2017-06-23 西南大学 干扰lcyb、lcye表达同时超量表达egl3在制备花瓣呈红色芸薹属植物中的应用
CN104531755B (zh) * 2014-12-19 2017-06-06 西南大学 干扰lcyb、lcye表达同时异位表达tt8在制备红色花瓣芸薹属植物中的应用
CN104388464B (zh) * 2014-12-19 2017-04-26 西南大学 干扰lcyb、lcye表达并超量表达crtiso在制备红色花瓣芸薹属植物中的应用
CN104531754B (zh) * 2014-12-19 2017-05-31 西南大学 干扰lcyb、lcye表达同时超量表达pap在制备花瓣呈红色芸薹属植物中的应用
CN105695506A (zh) * 2016-04-20 2016-06-22 西南大学 一种改良棉籽营养品质的方法及其用途
EP3792353A1 (de) * 2019-09-13 2021-03-17 CRAG - Centre de Recerca en Agrigenomica CSIC-IRTA-UB-UAB Künstliche chromoplastenbiogenese
CN110656114B (zh) * 2019-10-18 2022-07-01 云南中烟工业有限责任公司 一种烟草色素合成相关的基因及其应用
CN111926036B (zh) * 2020-10-14 2020-12-29 中国农业科学院生物技术研究所 一种联合表达载体及其在玉米籽粒表达虾青素中的应用
CN113549639B (zh) * 2021-07-21 2022-07-29 云南中烟工业有限责任公司 一种降低烟叶总蛋白及烟气苯酚含量的调控基因

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727219A (en) * 1986-11-28 1988-02-23 Agracetus Genic male-sterile maize using a linked marker gene
US5922602A (en) * 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
EP0462231A4 (en) * 1989-08-01 1992-05-13 Pioneer Hi-Bred International, Inc. Transcriptional activators of anthocyanin biosynthesis as visual markers for plant transformation
US7705215B1 (en) * 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
GB8928179D0 (en) * 1989-12-13 1990-02-14 Ici Plc Dna,constructs,cells and plants derived therefrom
US5618988A (en) * 1990-03-02 1997-04-08 Amoco Corporation Enhanced carotenoid accumulation in storage organs of genetically engineered plants
DE69132769T2 (de) * 1990-03-02 2002-04-18 Bp Corp North America Inc Biosynthese von carotinoiden in genetisch hergestellten wirtszellen
RU2005352C1 (ru) * 1991-09-19 1994-01-15 Владимир Савельевич Феденко Способ определения специфичности эндоспермовых мутантов кукурузы к накоплению каротиноидов
GB9204583D0 (en) * 1992-03-03 1992-04-15 Unilever Plc Recombinant plant enzyme
EP0668919B1 (de) * 1992-11-17 2003-06-04 E.I. Du Pont De Nemours And Company Für mikrosom delta 12 fettsäuredesaturase kodierende gene und verwandte enzyme von pflanzen
CA2150133A1 (en) * 1993-02-05 1994-08-18 Vincent Jean-Marie Armel Arondel Altered linolenic and linoleic acid content in plants
WO1996002650A2 (en) * 1994-07-18 1996-02-01 Zeneca Limited Dna, constructs, cells and plants derived therefrom

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9806862A1 *

Also Published As

Publication number Publication date
CN1227609A (zh) 1999-09-01
AU4058497A (en) 1998-03-06
JP2001505409A (ja) 2001-04-24
CA2261577A1 (en) 1998-02-19
BR9713462A (pt) 2000-03-28
WO1998006862A1 (en) 1998-02-19

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