EP0898900B1 - Utilisation d'une composition nutritive pour la préparation d'une composition liquide pour diabétiques - Google Patents

Utilisation d'une composition nutritive pour la préparation d'une composition liquide pour diabétiques Download PDF

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Publication number
EP0898900B1
EP0898900B1 EP98201018A EP98201018A EP0898900B1 EP 0898900 B1 EP0898900 B1 EP 0898900B1 EP 98201018 A EP98201018 A EP 98201018A EP 98201018 A EP98201018 A EP 98201018A EP 0898900 B1 EP0898900 B1 EP 0898900B1
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EP
European Patent Office
Prior art keywords
fibre
composition
inulin
source
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
EP98201018A
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German (de)
English (en)
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EP0898900A3 (fr
EP0898900A2 (fr
Inventor
Véronique Jaussan
Claudia Roessle
Thomas Schweizer
Michel Bourguignon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Nestle SA
Original Assignee
Societe des Produits Nestle SA
Nestle SA
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Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA
Priority to EP98201018A priority Critical patent/EP0898900B1/fr
Priority to EP03003009.2A priority patent/EP1310173B2/fr
Publication of EP0898900A2 publication Critical patent/EP0898900A2/fr
Publication of EP0898900A3 publication Critical patent/EP0898900A3/fr
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/231—Pectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/238—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
    • A23L29/27—Xanthan not combined with other microbial gums
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
    • A23L29/271—Curdlan; beta-1-3 glucan; Polysaccharides produced by agrobacterium or alcaligenes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • This invention relates to the use of a nutritional composition for the preparation of a liquid composition for the nutritional management of diabetic symptoms in patients.
  • Diabetes is a general term for a group of metabolic disorders which are characterised by the inability to properly metabolise glucose. This inability is due either to a deficiency of the hormone insulin or to a resistance to the action of insulin. In either case, if untreated, the inability leads to hyperglycaemia and its complications of morbidity and mortality.
  • Diabetes is usually classified into three clinical classes; diabetes mellitus, gestational diabetes, and impaired glucose tolerance or glucose intolerance. Diabetes mellitus is generally broken down into two types; type I diabetes mellitus and type II diabetes mellitus. Type I diabetes mellitus occurs in individuals who produce little or no insulin and constitutes less than about 10% of the diabetic population. The onset of type I diabetes mellitus usually manifests itself during youth. Type II diabetes mellitus, or non-insulin dependent diabetes mellitus, usually develops after the age of about 30 years and constitutes more than about 90% of the diabetic population. Impaired glucose tolerance, in the clinical setting, often occurs as stress-induced hyperglycaemia.
  • diabetes is treated by the administration of exogenous insulin or antihyperglycaemic agents.
  • exogenous insulin or antihyperglycaemic agents are used for the nutritional therapy of diabetes. These guidelines suggest that diabetic patients should consume about 20 to 25 g of dietary fibre daily.
  • Dietary fibres may be classified as soluble and insoluble. Insoluble fibres appear to have little influence on glycemic levels. However, the incorporation of soluble fibres into foods is known reduce postprandial glycaemia in diabetics (Anderson, J.W. and Akanji, A.O.; 1993; "Treatment of Diabetes with High Fiber Diets", CRC Handbook of Dietary Fiber in Human Nutrition , CRC Press Inc, 2nd Edition, pages 443 to 470). Examples of soluble fibres which are believed to have this property are guar gum, pectin, xanthan gum, and ⁇ -glucan. This property makes soluble fibres ideal candidates for incorporation into foods for diabetics.
  • EP 0 768 043 discloses a nutritional composition for use by diabetics containing a controlled absorbed carbohadrate component, which consists of a rapidly, moderately and a slowly absorbed fraction.
  • the composition also comprises fibre, which may be selected from any combination of fibre and which is not distiguished functionally.
  • EP 0 756 828 discloses a fibre composition for consumption by healthy people in Western societies, which is suitable to produce short chain fatty acids.
  • the fibre composition comprises soluble and insoluble non-starch polysaccharides, oligosaccharides and/or resistant starch.
  • One nutritional composition which offers a solution to the problem is described in US patent 5,292,723.
  • the nutritional composition described in this patent has a carbohydrate component made up of glucose polymers, modified starch, and soluble fibre.
  • Pectin is suggested as a suitable soluble fibre.
  • the nutritional composition has a viscosity of less than 0.05 kg/ms when measured at about 20°C. Further the nutrition composition, when consumed, results in lower glycemic response in patients as compared to glucose of the same energy content.
  • this invention relates to the use of a nutritional composition for the preparation of a liquid composition for the nutritional management of diabetes, the composition containing a protein source, a lipid source, and a carbohydrate source, the carbohydrate source including a fibre mixture comprising a viscous soluble fibre selected from the group comprising guar gum, xanthan gum, gum arabic, pectin, ⁇ -glucan and mixtures of these, and inulin or a hydrolysate of inulin, or both.
  • the use of a fibre mixture of a viscous soluble fibre and inulin, a hydrolysate of inulin, or both results in an adequately reduced glycemic response while retaining reasonably low viscosity. Therefore, due to the excellent flow properties, the nutritional composition is ideally suited to be tube-fed to patients. Further, the use of inulin or its hydrolysates provides a substrate for lactic acid bacteria in the gastro-intestinal tract; leading to beneficial effects in the general health of the patient.
  • the nutritional composition may be in liquid form or in the form of a soluble powder which is reconstituteable in an aqueous liquid to provide a liquid nutritional composition.
  • the protein source provides about 10% to about 20% of energy
  • the lipid source provides about 30% to about 50% of energy
  • the carbohydrate source provides about 35% to about 55% of energy.
  • the composition contains a protein source, a lipid source, and a carbohydrate source.
  • the carbohydrate source includes a fibre mixture comprising a viscous soluble fibre and inulin.
  • soluble fibre means those dietary fibres which are characterised as soluble using the method of Prosky et al; 1988; J. Assoc. Off. Anal. Chem , 70 , 5, 1017. This is the official method of the Association of Official Analytical Chemists.
  • viscous soluble fibre means a soluble fibre which is able to increase the viscosity of the contents of the stomach and the small intestine and slow gastric emptying rates.
  • the viscous soluble fibre is selected from the group comprising guar gum, xanthan gum, and gum arabic, pectin, and ⁇ -glucan, or mixtures of these. Pectin and gum arabic are particularly preferred.
  • the inulin may be provided in the form of a natural extract which is suitable for human consumption. Extracts from chicory are particularly suitable.
  • the extract preferably contains at least 80% by weight of inulin or a hydrolysate of inulin; more preferably at least 90% by weight of inulin or a hydrolysate of inulin.
  • the inulin preferably has a degree of polymerisation of at least about 8; for example about 10 to about 25.
  • Suitable inulin extracts may be obtained from Orafti SA of Tirlemont 3300, Belgium under the trade mark "Raftiline".
  • the inulin may be provided in the form of Raftiline®ST which is a fine white powder which contains about 90 to about 94% by weight of inulin, up to about 4% by weight of glucose and fructose, and about 4 to 9% by weight of sucrose.
  • the average degree of polymerisation of the inulin is about 10 to about 12.
  • the inulin may also be in the form of inulin hydrolysates or mixtures of inulin and inulin hydrolysates. Inulin hydrolysates are commonly known as fructooligosaccahrides or FOS.
  • Inulin and its hydrolysates are reported to promote the growth of bifidobacteria in the gastro-intestinal tract and, in certain circumstances prevent or decrease the growth of pathogens such as Clostridiae . Further, promoting the growth of bifidobacteria is reported to have various other beneficial effects. Moreover, inulin and its hydrolysates may reduce blood glucose levels.
  • the fibre mixture may also contain a source of insoluble dietary fibre.
  • Suitable sources of insoluble dietary fibres are hull fibres from legumes and grains; for example pea hull fibre, oat hull fibre, barley hull fibre, and soy hull fibre. Pea hull fibre is especially preferred. However any suitable source of insoluble dietary fibre may be used. These sources may also contain some soluble fibre.
  • the ratio of soluble fibre, including inulin, to insoluble fibre is preferably about 1:3 to about 3:1; more preferably about 1:1 to about 2:1.
  • ratio of soluble fibre, including inulin, to insoluble fibre is preferably about 2:1.
  • the fibre mixture may be present in an amount of about 1.0 g/100ml to about 2.0 g/100ml; for example about 1.3 g/100ml to about 1.7 g/100ml; for example about 1.5 g/100 ml.
  • the fibre mixture comprises about 0.5 g/100 ml inulin, about 0.5 g/100 ml pectin or gum arabic, and about 0.5 g/100 ml outer pea fibre.
  • the protein source is preferably a high quality protein source; for example milk protein, whey protein, casein protein, or soy protein, or mixtures of these proteins.
  • the protein source may be in the form of intact protein or may be hydrolyzed.
  • Other protein sources such as rice, pea and oat protein, or mixtures thereof, may also be used.
  • the protein source may include free amino acids.
  • the protein source preferably provides about 10% to about 20% of the energy of the composition.
  • the protein source may provide about 12% to about 18% of the energy of the composition; preferably about 15% of the energy of the composition.
  • the carbohydrate source may be any suitable carbohydrate or carbohydrate mixtures.
  • the carbohydrate source may be maltodextrin, modified starch, amylose starch, topioca starch, corn starch, or fructose, or mixtures thereof. Modified starch is preferred; especially modified topioca and corn starches.
  • the carbohydrate source includes maltodextrin, maltodextrin with a low DE is preferred; for example maltodextrin with a DE of 3 or less.
  • the composition is low in or free from mono- and di-saccharides such as fructose and other exchange sugars, and lactose.
  • the composition contains less than about 3 g/l of lactose.
  • the carbohydrate source including the viscous soluble fibre and inulin, provides about 35% to about 55% of the energy of the composition; preferably about 40% to about 50% of the energy.
  • the carbohydrate source may provide about 45% of the energy of the composition.
  • the amount of energy provided to the patient by the viscous soluble fibre and inulin is very small.
  • the lipid source is preferably rich in monounsaturated fatty acids; for example monounsaturated fatty acids may provide at least 50% of energy of the lipid source. Preferably, monounsaturated fat acids provide about 25% to about 35% of the energy of the composition; for example about 29 to 30%.
  • the lipid source may contain polyunsaturated fatty acids (omega-3 and omega-6 fatty acids); preferably these polyunsaturated fatty acids provide up to about 10% of the energy of the composition. For example these polyunsaturated fatty acids may provide about 3% to about 10% of the energy of the composition.
  • the lipid profile of the enteral composition is preferably designed to have a polyunsaturated fatty acid omega-6 (n-6) to omega-3 (n-3) ratio of about 4:1 to about 10:1. Saturated fatty acids preferably provide less than 10% of the energy of the composition; for example less than about 7%.
  • the lipid source may provide about 30% to about 50% of the energy of the composition; preferably about 35% to about 45%.
  • the lipid source may provide about 40% of the energy of the composition.
  • the lipid source may include medium chain triglycerides.
  • medium chain triglycerides may make up about 10% to about 50% by weight of the lipid source.
  • Suitable sources of monounsaturated fatty acids are olive oil, sunflower oil rich in oleic acid, rapeseed oil rich in oleic acid, hazelnut oil, safflower oil, and the like. If medium chain triglycerides are included in the lipid source, fractionated coconut oils are a suitable source of medium chain triglycerides. A mixture of sunflower oil, rapeseed oil and olive oil is preferred.
  • the enteral composition preferably includes a complete vitamin and mineral profile.
  • sufficient vitamins and minerals may be provided to supply about 75% to about 250% of the recommended daily allowance of the vitamins and minerals per 1000 calories of the nutritional composition.
  • the nutritional composition conveniently has an osmolarity of about 180 mOsm/l to about 300 mOsm/l; for example about 190 mOsm/l to about 210 mOsm/l.
  • the viscosity of the nutritional composition when measured at room temperature, is preferably less than about 0.04 kg/ms; especially less than about 0.035 kg/ms.
  • the viscosity of the nutritional composition when measured at room temperature, may be about 0.015 to about 0.03 kg/ms.
  • the flow rate of the nutritional composition through a standard feeding tube is preferably less than about 150 minutes/l; for example less than about 100 minutes/l.
  • the energy density of the nutritional composition is preferably about 700 kcal/l to about 1500 kcal/l; for example about 1000 kcal/l.
  • the nutritional composition is preferably in the form of a ready-to-use formulation.
  • the composition may be fed to a patient via a nasogastric tube, jejunum tube or by having the patient drink it.
  • the nutritional composition may be in a variety of forms; for example as a fruit juice-type beverage, a milk shake-type beverage and the like.
  • the nutritional composition may be in soluble powder form to be reconstituted prior to use.
  • flavours sweeteners and other additives may be present.
  • Artificial sweeteners such as acetosulfame and L-aspartyl based sweeteners may be used; for example aspartame.
  • the nutritional composition may be produced as is conventional; for example, by blending together the protein source, the carbohydrate source, and the lipid source. If used, the emulsifiers may be included in the blend. The vitamins and minerals may be added at this point but are usually added later to avoid thermal degradation. Any lipophilic vitamins, emulsifiers and the like may be dissolved into the lipid source prior to blending. Water, preferably water which has been subjected to reverse osmosis, may then be mixed in to form a liquid mixture. The temperature of the water is conveniently about 50°C to about 80°C to aid dispersal of the ingredients. Commercially available liquefiers may be used to form the liquid mixture.
  • the liquid mixture may then be thermally treated to reduce bacterial loads.
  • the liquid mixture may be rapidly heated to a temperature in the range of about 80°C to about 110°C for about 5 seconds to about 5 minutes. This may be carried out by steam injection or by heat exchanger; for example a plate heat exchanger.
  • the liquid mixture may then be cooled to about 60°C to about 85°C; for example by flash cooling.
  • the liquid mixture is then homogenised; for example in two stages at about 7 MPa to about 40 MPa in the first stage and about 2 MPa to about 14 MPa in the second stage.
  • the homogenised mixture may then be further cooled to add any heat sensitive components; such as vitamins and minerals.
  • the pH and solids content of the homogenised mixture is conveniently standardised at this point.
  • the homogenised mixture is preferably aseptically filled into suitable containers.
  • Aseptic filling of the containers may be carried out by pre-heating the homogenised mixture (for example to about 75 to 85°C) and then injecting steam into the homogenised mixture to raise the temperature to about 140 to 160°C; for example at about 150°C.
  • the homogenised mixture may then be cooled, for example by flash cooling, to a temperature of about 75 to 85°C.
  • the homogenised mixture may then be further homogenised, cooled to about room temperature and filled into containers. Suitable apparatus for carrying out aseptic filling of this nature is commercially available.
  • the homogenised mixture is dried to powder; for example by spray drying. Conventional procedures may be used.
  • the nutritional composition may be used as a nutritional support for patients suffering from metabolic anomalies which make them susceptible to hypo- or hyperglycaemia.
  • the nutritional composition may be used as a nutritional support for patients suffering from type I diabetes mellitus, type II diabetes mellitus, or intolerance to glucose.
  • the nutritional composition may be used as a nutritional support for patients who are at risk of a recurrence of hypo- or hyperglycaemia.
  • the nutritional composition may also be used as nutritional support for post operative patients.
  • the nutritional composition is particularly useful for the nutritional management of diabetic symptoms of diabetic patients.
  • the amount of the nutritional composition required to be fed to a patient will vary depending upon factors such as the patient's condition, the patient's body weight, the age of the patient, and whether the nutritional composition is the sole source of nutrition. However the required amount may be readily set by a medical practitioner. In general, sufficient of the nutritional composition is administered to provide the patient with about 1 g protein to about 4.0 g protein per kg of body weight per day. For example, an adult patient may be administered about 1.5 g protein to about 2.0 g protein per kg of body weight per day. Further, sufficient of the nutritional composition is administered to provide the patient with up to about 40 g of dietary fibre (insoluble and soluble) per day; for example about 25 g to about 35 g of dietary fibre per day. If the nutritional formula is used as a supplement to other foods, the amount of the nutritional composition that is administered daily may be decreased accordingly.
  • the nutritional composition may be taken in multiple doses, for example 2 to 5 times, to make up the required daily amount or may taken in a single dose.
  • the nutritional composition may also be fed continuously over a desired period.
  • a ready-to-use nutritional composition is prepared.
  • the nutritional composition includes the following components: Component Conc. (/100ml) Energy (%) Protein 3.8 g 15 Casein/Soy Protein (1:1) Carbohydrate 11.2 g 45 Maltodextrin (low DE) 1.0 g Modified Starch 10.2 g Soluble fibre including Inulin 1.0 g Insoluble fibre 0.5 g Lipids 4.4 g 40 Rapeseed oil, Sunflower oil, Olive oil, Glyceryl stearate, Soya lecithin Vitamins Vitamin A 150 IU Vitamin C 10 mg Vitamin D 10 IU Vitamin E 1.0 mg Vitamin K 3.0 ⁇ g Thiamin 0.1 mg Riboflavine 0.12 mg Pantothenic acid 0.50 mg Vitamin B6 0.14 mg Vitamin B12 0.30 ⁇ g Niacin 1.2 mg Folic acid 18 ⁇ g Biotin 10 ⁇ g Minerals Zinc, Iron, Copper, Magnesium, Manganese, Selenium, Iodine, Potassium, Calcium,
  • the composition has an osmolarity of 210 mOsm/l and an osmolality of 240 mOsm/kg.
  • the viscosity is 0.023 kg/ms and the free flow rate is less than 70 minutes per 500 ml through standard enteral tubing.
  • the volunteers are between 20 and 45 years of age and have fasting blood glucose levels of about 70 to about 110 mg/dl. Any volunteer exhibiting the symptoms of diabetes mellitus type I or II or fructose intolerance are excluded.
  • the study is carried out in two stages, each stage comprising two study days separated by a wash out period of at least 7 days. The stages are also separated by a wash out period of at least 7 days.
  • each volunteer Prior to each study day, each volunteer consumes an evening meal of pizza, salad and an apple. No alcohol is taken. Then, from 10 pm, each volunteer undergoes an overnight fast. In the morning of the study day, an indwelling catheter is placed on each volunteer. A blood sample is then taken. A meal is then consumed within 10 minutes of the taking of the sample. Further blood samples are taken at 15, 30, 45, 60, 90, 120 and 180 minutes after meal intake.
  • the blood glucose for each sample is analysed by the glucose oxidase method using a COBAS analyser (Hoffmann-La Roche). The insulin level for each sample is measured by radioimmune assay (Pharmacia).
  • AUC integrated area under the curve
  • the product of example 1 the Sondalis® Fiber product of Nestlé Clinical Nutrition, and the Fresubin Diabetes product of Fresenius GmbH.
  • the product of example 1 the Sondalis® Fiber product of Nestlé Clinical Nutrition
  • the Fresubin Diabetes product of Fresenius GmbH Four hundred 400 ml of the product of example 1, 400 ml of the Sondalis® Fiber product, and 444 ml of the Fresubin Diabetes product are consumed in each case to provide a standard energy intake of 400 kcal. All meals contain comparable amounts of minerals and micronutrients.
  • the glycemic responses of the product of example 1 and the Fresubin Diabetes product are significantly lower than that of the Sondalis® Fiber; about 30 mmol/l and 50 mmol/l respectively after 120 minutes compared to about 80 mmol/l after 120 minutes. Further, for the product of example 1, blood glucose response is much flatter than that of the Sondalis® Fiber product. The peak change of the product of example 1 is also less than that of the other products. While the glycemic response of the product of example 1 is lower than that of the Fresubin Diabetes product, the differences are not significant. Therefore the product of example 1 is suitable for use with diabetic patients.
  • each composition is determined at 25°C using a Contraves Rheomat according to manufacturer's instructions.
  • the composition of example 1 is filled into a sealed, flexible bag and connected to a stand at a standard height.
  • the Fresubin DFN Plus product which is in a glass container (its original packing) is connected to a separate stand at the same height.
  • An enteral feeding tube is connected to each container and the time required to deliver 500 ml through the enteral feeding tube is determined.
  • An open reservoir is then connected to each stand and the composition of example 1 poured into one reservoir and the Fresubin DFN Plus product poured into the other.
  • An enteral feeding tube is connected to each reservoir and the time required to deliver 500 ml through the enteral feeding tube is determined.
  • Property Composition of example 1 Fresubin DFN Plus product Viscosity (kg/ms) 0.023 0.035 Free Flow Rate (min/500ml) - Original Container 66 158 - Open reservoir 60 129
  • a ready-to-use nutritional composition is prepared.
  • the nutritional composition includes the following components: Component Conc. (/100ml) Energy (%) Protein 3.8 g 15 Casein/Soy Protein (1:1) Carbohydrate 11.2 g 45 Maltodextrin (low DE) 1.0 g Modified topioca and corn starch 10.2 g Soluble fibre including Inulin 1.0 g Insoluble fibre 0.5 g Lipids 4.4 g 40 Rapeseed oil, Sunflower oil, Olive oil, Mono- and di-glycerides (E471) Vitamins and minerals as in example 1
  • the composition has an osmolarity of 190 mOsm/l.
  • the viscosity is about 0.023 kg/ms and the free flow rate is less than about 70 minutes per 500 ml through standard enteral tubing.
  • Monounsaturated fatty acids provide about 29% of energy, polyunsaturated fatty acids provide about 6% of energy, and saturated fatty acids provide about 5% of energy.

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Claims (8)

  1. Utilisation d'une source de protéines, d'une source de lipides, d'une source de glucides et d'un mélange de fibres comprenant
    une fibre soluble visqueuse choisie dans le groupe comprenant la gomme guar, la gomme xanthane, la gomme arabique, la pectine, le β-glucane et leurs mélanges, et
    l'inuline, un hydrolysat d'inuline ou leur mélange,
       pour la préparation d'une composition liquide destinée à assurer les besoins nutritionnels dans le cas du diabète.
  2. Utilisation suivant la revendication 1, dans laquelle la composition nutritionnelle liquide a une viscosité, lorsqu'elle est mesurée à température ambiante, de 0,015 à 0,03 kg/ms.
  3. Utilisation suivant la revendication 1 ou 2, dans laquelle le mélange de fibres comprend en outre une source de fibres diététiques insolubles.
  4. Utilisation suivant la revendication 3, dans laquelle la source de fibres diététiques insolubles consiste en fibres de cosses de pois.
  5. Utilisation suivant la revendication 3 ou 4, dans laquelle le rapport des fibres solubles, comprenant l'inuline, aux fibres insolubles est compris dans l'intervalle de 1:3 à 3:1.
  6. Utilisation suivant l'une quelconque des revendications 1 à 5, dans laquelle le mélange de fibres comprend 0,5 g/100 ml d'inuline, 0,5 g/100 ml de pectine ou de gomme arabique et 0,5 g/100 ml de fibres de cosses de pois.
  7. Utilisation suivant l'une quelconque des revendications 1 à 6, dans laquelle la source de lipides comprend des acides gras mono-insaturés qui fournissent 25% à 35% de l'énergie de la composition.
  8. Utilisation suivant l'une quelconque des revendications 1 à 7, dans laquelle la source de lipides comprend des acides gras saturés fournissant moins de 10% de l'énergie de la composition.
EP98201018A 1997-06-23 1998-03-31 Utilisation d'une composition nutritive pour la préparation d'une composition liquide pour diabétiques Revoked EP0898900B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98201018A EP0898900B1 (fr) 1997-06-23 1998-03-31 Utilisation d'une composition nutritive pour la préparation d'une composition liquide pour diabétiques
EP03003009.2A EP1310173B2 (fr) 1997-06-23 1998-03-31 Composition pour la nutrition des diabétiques

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97201915 1997-06-23
EP97201915 1997-06-23
EP98201018A EP0898900B1 (fr) 1997-06-23 1998-03-31 Utilisation d'une composition nutritive pour la préparation d'une composition liquide pour diabétiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP03003009.2A Division EP1310173B2 (fr) 1997-06-23 1998-03-31 Composition pour la nutrition des diabétiques

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EP0898900A2 EP0898900A2 (fr) 1999-03-03
EP0898900A3 EP0898900A3 (fr) 2000-04-26
EP0898900B1 true EP0898900B1 (fr) 2003-10-01

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EP03003009.2A Expired - Lifetime EP1310173B2 (fr) 1997-06-23 1998-03-31 Composition pour la nutrition des diabétiques
EP98201018A Revoked EP0898900B1 (fr) 1997-06-23 1998-03-31 Utilisation d'une composition nutritive pour la préparation d'une composition liquide pour diabétiques

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JP (1) JPH1118725A (fr)
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AT (2) ATE362715T1 (fr)
AU (1) AU746103B2 (fr)
BR (1) BR9802204B1 (fr)
CA (1) CA2234398C (fr)
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HU (1) HUP9801422A3 (fr)
ID (1) ID20470A (fr)
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ZA (1) ZA985426B (fr)

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DE69818594D1 (de) 2003-11-06
EP1310173B1 (fr) 2007-05-23
ATE362715T1 (de) 2007-06-15
EP1310173A2 (fr) 2003-05-14
BR9802204A (pt) 1999-07-20
AU7311898A (en) 1998-12-24
ES2206821T3 (es) 2004-05-16
HUP9801422A3 (en) 2001-02-28
EP1310173A3 (fr) 2003-12-17
ID20470A (id) 1998-12-24
CA2234398C (fr) 2009-12-08
HU9801422D0 (en) 1998-08-28
AU746103B2 (en) 2002-04-18
CN1203037A (zh) 1998-12-30
EP0898900A3 (fr) 2000-04-26
DE69837821T3 (de) 2015-05-28
JPH1118725A (ja) 1999-01-26
DE69837821D1 (de) 2007-07-05
EP0898900A2 (fr) 1999-03-03
ZA985426B (en) 1999-12-22
MY128100A (en) 2007-01-31
CA2234398A1 (fr) 1998-12-23
DE69837821T2 (de) 2008-01-31
EP1310173B2 (fr) 2014-12-31
DE69818594T2 (de) 2004-09-23
CN1122457C (zh) 2003-10-01
HUP9801422A2 (hu) 1999-05-28
ES2286339T5 (es) 2015-02-26
ES2286339T3 (es) 2007-12-01
ATE250867T1 (de) 2003-10-15
BR9802204B1 (pt) 2013-10-29

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