EP0892788A1 - Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation - Google Patents

Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation

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Publication number
EP0892788A1
EP0892788A1 EP97918109A EP97918109A EP0892788A1 EP 0892788 A1 EP0892788 A1 EP 0892788A1 EP 97918109 A EP97918109 A EP 97918109A EP 97918109 A EP97918109 A EP 97918109A EP 0892788 A1 EP0892788 A1 EP 0892788A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
phenyl
alkoxy
alkylthio
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97918109A
Other languages
German (de)
English (en)
Inventor
Wilhelm Amberg
Andreas Kling
Dagmar Klinge
Hartmut Riechers
Ernst Baumann
Liliane Unger
Manfred Raschack
Stefan Hergenröder
Sabine Schult
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
BASF SE
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Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of EP0892788A1 publication Critical patent/EP0892788A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Definitions

  • the present invention relates to new carboxylic acid derivatives, their preparation and use.
  • Endothelin is a 21 amino acid peptide that is synthesized and released by vascular endothelium. Endothelin exists in three isoforms, ET-1, ET-2 and ET-3.
  • endothelin or "ET” means one or all isoforms of endothelin.
  • Endothelin is a potent vasoconstrictor and has a strong effect on vascular tone. This vasoconstriction is known to be caused by the binding of endothelin to its receptor (Nature, 332, 411-415, 1988; FEBS
  • the invention relates to carboxylic acid derivatives of the formula I.
  • R 2 is hydrogen, hydroxyl, NH 2 , NH (C 1 -C 4 -alkyl), N (C 1 - C 4 alkyl) 2 , halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy,
  • C 1 -C 4 haloalkoxy or C 1 -C 4 alkylthio, or CR 2 is linked to CR 12 to give a 5- or 6-membered ring as indicated below;
  • X is nitrogen or CR 12 , wherein R 12 is hydrogen or C 1-5 alkyl or CR 12 together with CR 2 or CR 3 forms a 5- or 6-membered alkylene or alkenylene ring which is replaced by one or two C 1-4 -Alkyl groups can be substituted and in which in each case one methylene group can be replaced by oxygen, sulfur, -NH or -NC 1-4 -alkyl;
  • R 3 is hydrogen, hydroxy, NH 2 , NH (C 1 -C 4 alkyl), N (C 1 -C 4 alkyl) 2 , halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy,
  • C 1 -C 4 haloalkoxy, -NH-OC 1-4 alkyl, C 1 -C 4 alkylthio; or CR 3 is with CR 12 as stated above to a 5- or
  • R 4 and R 5 (which may be the same or different):
  • Phenyl or naphthyl which can be substituted by one or more of the following radicals: halogen, nitro, cyano, hydroxy, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy,
  • R 6 is hydrogen, C 1 -C 8 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl or
  • C 3 -C 8 cycloalkyl where these radicals can each be mono- or polysubstituted by: halogen, hydroxy, mercapto, carboxy, nitro, cyano, C 1 -C 4 alkoxy, C 3 -C 6 alkenyloxy,
  • Phenyl or naphthyl each of which can be substituted by one or more of the following radicals: halogen, nitro, cyano, hydroxy, amino, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl,
  • the compounds and also the intermediates for their preparation, e.g. II and IV, can have one or more asymmetric substituted carbon atoms.
  • Such compounds can exist as pure enantiomers or pure diastereomers or as a mixture thereof.
  • the use of an enantiomerically pure compound as the active ingredient is preferred.
  • the invention further relates to the use of the abovementioned carboxylic acid derivatives for the production of medicaments, in particular for the production of inhibitors for endothelin receptors.
  • R 13 is halogen or R 14 is -SO 2 -, where R 14 can be C 1 -C 4 alkyl, C 1 -C 4 haloalkyl or phenyl.
  • the reaction preferably takes place in an inert solvent or diluent with the addition of a suitable base, ie a base which brings about a deprotonation of the intermediate IV, in a temperature range from room temperature to the boiling point de
  • solvents or diluents are aliphatic, alicyclic and aromatic hydrocarbons, each of which may optionally be chlorinated, such as, for example, hexane, cyclohexane, petroleum ether, ligroin, benzene, toluene, xylene, methylene chloride, chloroform, carbon tetrachloride, ethyl chloride and trichlorethylene, ether, such as, for example, diisopropyl ether, dibutyl ether, methyl tert-butyl ether, propylene oxide, dioxane and tetrahydrofuran, nitriles, such as, for example, acetonitrile and propionitrile, acid amides, such as, for example
  • Sulfoxides and sulfones such as dimethyl sulfoxide and sulfolane.
  • An alkali or alkaline earth metal hydride such as sodium hydride, potassium hydride or calcium hydride, a carbonate such as alkali metal carbonate, for example sodium or potassium carbonate, an alkali or alkaline earth metal hydroxide such as sodium or potassium hydroxide, an organometallic compound such as butyllithium or an alkali amide such as lithium diisopropylamide can serve as the base.
  • Compounds of the formula I can also be prepared by starting from the corresponding carboxylic acids, ie compounds of the formula I in which R is COOH, and converting them first in the usual manner into an activated form such as an acid halide, an anhydride or imidazolide and this is then reacted with a corresponding hydroxyl compound H ⁇ R 8 .
  • This reaction can be carried out in the customary solvents and often requires the addition of a base, the above-mentioned being possible.
  • These two steps can also be simplified, for example, by adding the carboxylic acid in
  • compounds of the formula I can also be prepared by starting from the salts of the corresponding carboxylic acids, ie from compounds of the formula I in which R is a group COR 1 and R 1 is OM, where M is an alkali metal cation or can be the equivalent of an alkaline earth metal cation.
  • salts can be reacted with many compounds of the formula R 1 -A, where A is a conventional nucleofugic leaving group, for example halogen such as chlorine, bromine, iodine or aryl or alkylsulfonyl optionally substituted by halogen, alkyl or haloalkyl, such as toluenesulfonyl and Methylsulfonyl or other equivalent leaving group.
  • A is a conventional nucleofugic leaving group, for example halogen such as chlorine, bromine, iodine or aryl or alkylsulfonyl optionally substituted by halogen, alkyl or haloalkyl, such as toluenesulfonyl and Methylsulfonyl or other equivalent leaving group.
  • Substituents A are known or are easy to obtain with general technical knowledge. This reaction can be carried out in the customary solvents and is advantageously carried out with the addition of a base, the abovementioned being possible.
  • R in Formula I is widely variable.
  • R stands for a group
  • R 1 has the following meaning: a) hydrogen; b) a succinylimidoxy group; c) a 5-membered heteroaromatic linked via a nitrogen atom, such as pyrrolyl, pyrazolyl, imidazolyl and triazolyl, which has one or two halogen atoms, or one or two
  • R 1 also a group
  • R 7 is C 1 -C 4 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl or optionally substituted phenyl, which can be substituted by one or more, for example one to three, of the following radicals:
  • Halogen nitro, cyano, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl,
  • R 1 is also a radical OR 8 , in which R 8 is hydrogen, the cation of an alkali metal such as lithium,
  • an alkaline earth metal such as calcium, magnesium and barium or a physiologically compatible organic ammonium ion such as tertiary C 1 -C 4 alkylammonium or the ammonium ion;
  • C 3 -C 8 cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl, cyclooctyl,
  • C 1 -C 8 alkyl in particular C 1 -C 4 alkyl such as methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, tert-butyl;
  • CH 2 phenyl which can be substituted by one or more of the following radicals: halogen, nitro, cyano, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, hydroxy, C 1 -C 4 alkoxy, mercapto ,
  • R 8 can furthermore be a phenyl radical which can carry one to five halogen atoms and / or one to three of the following radicals: nitro, cyano, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, hydroxy, C 1 - C 4 alkoxy, mercapto, C 1 -C 4 alkylthio, amino,
  • the following may be mentioned in particular: 1-pyrazolyl,
  • R 9 means:
  • R 1 is a residue
  • R 9 has the meaning given above; h) furthermore R 1 can mean
  • R 10 and R 11 may be the same or different and have the following meaning:
  • R 10 and R 11 together form an optionally substituted, for example by, closed to form a ring
  • C 1 -C 4 alkyl substituted C 4 -C 7 alkylene chain which may contain a heteroatom, for example oxygen, sulfur or nitrogen, such as - (CH 2 ) 4 -, - (CH 2 ) 5 -, - (CH 2 ) 6 -, - (CH 2 ) 7 -,
  • carboxylic acid derivatives of the general formula I are - both as pure enantiomers or
  • R 2 is hydrogen, hydroxy, N (C 1 -C 4 alkyl) 2, those mentioned for R 1 in each C 1 -C 4 alkyl , C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio groups and halogen atoms, in particular chlorine, methyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy , or CR 2 is linked to CR 12 to a 5- or 6-membered ring as indicated below;
  • X is nitrogen or CR 12 , wherein R 12 is hydrogen or alkyl or CR 12 together with CR 2 or CR 3 forms a 5- to 6-membered alkylene or alkenylene ring, in each of which one methylene group can be replaced by oxygen or sulfur, such as
  • R 3 is hydrogen, hydroxy, N (C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl,
  • C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio groups and halogen atoms, in particular chlorine, methyl, methoxy, ethoxy, difluoromethoxy, Trifluoromethoxy or CR 3 is with CR 12 as mentioned above to a 5- or
  • R 4 and R 5 which may be the same or different, phenyl or naphthyl, which may be substituted by one or more, for example one to three, of the following radicals: halogen, nitro, cyano, hydroxy, mercapto, amino, C 1 -C 4 -Alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -alkylamino, di-C 1 -C 4 alkylamino, C 1 -C 4 alkylcarbonyl, C 1 -C 4 alkoxycarbonyl;
  • Phenyl or naphthyl which are ortho-linked via a direct bond, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO 2 , NH or N-alkyl group or C 3 -C 7 cycloalkyl;
  • R 5 is C 1 -C 8 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl or C 3 -C 8 cycloalkyl as mentioned above in particular, where these radicals can each be substituted one or more times by: halogen ,
  • Phenyl or naphthyl which can be substituted by one or more of the following radicals: halogen, nitro, cyano, hydroxy, amino, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, phenoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylamino or C 1 -C 4 dialkylamino; a five- or six-membered heteroaromatic containing one to three nitrogen atoms and / or a sulfur or oxygen atom which can carry one to four halogen atoms and / or one or two of the following radicals: C 1 -C 4 -alkyl,
  • C 1 -C 4 alkylthio phenyl, phenoxy or phenylcarbonyl, where the phenyl radicals can in turn carry one to five halogen atoms and / or one to three of the following radicals: C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy and / or C 1 -C 4 alkylthio, as mentioned in particular for R 4 ; Z sulfur or oxygen.
  • R 2 C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, trifluoromethyl
  • X is nitrogen or CR 12 , wherein
  • R 12 represents hydrogen or alkyl or CR 12 together with CR 2
  • R 3 is the C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkyl-thio groups mentioned in R 1 or C -R 3 is with C -R 12 as mentioned above to a 5 - or 6-membered ring linked;
  • R 4 and R 5 are phenyl (identical or different) which can be substituted by one or more, for example one to three, of the following radicals: halogen, nitro, hydroxy, C 1 -C 4 -alkyl,
  • C 1 -C 4 alkoxy, C 1 -C 4 alkylthio or R 4 and R 5 are phenyl groups which are linked to one another via a direct bond, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO 2 , NH or N-alkyl group; or
  • R 4 and R 5 are C 3 -C 7 cycloalkyl
  • R 6 is C 1 -C 8 alkyl, C 3 -C 6 alkenyl or C 3 -C 8 cycloalkyl, where these radicals can each be mono- or polysubstituted by: halogen, mercapto, caboxy, hydroxy, nitro, cyano ,
  • Phenyl or naphthyl which can be substituted by one or more of the following radicals: halogen, nitro, cyano, hydroxy, amino, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, phenoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylamino or C 1 -C 4 dialkylamino; a five- or six-membered heteroaromatic containing a nitrogen atom and / or a sulfur or oxygen atom which can carry one to four halogen atoms and / or one or two of the following radicals: C 1 -C 4 alkyl, C 1 -C 4 -Halogenalkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, phenyl, phenoxy or phenylcarbonyl, the phenyl radical
  • the compounds of the present invention offer new therapeutic potential for the treatment of hypertension, pulmonary hypertension, myocardial infarction, angina pectoris, acute renal failure, renal insufficiency, cerebral vasospasm, cerebral ischemia, subarachnoid hemorrhage, migraine, asthma, atherosclerosis, endotoxic organ shock, endageninin , intravascular coagulation, restenosis after angioplasty, benign prostatic hyperplasia, ischemic and intoxication-related kidney failure or hypertension, as well as cancer, especially prostate cancer and skin cancer.
  • Another object of the invention is the combination of compounds of formula I with inhibitors of the renin-angiotensin system (RAS).
  • RAS renin-angiotensin system
  • RAS inhibitors are known for example from EP 634 175.
  • the combinations according to the invention are suitable for the treatment of diseases for which the compounds of the formula I alone are effective, in particular for the treatment of hypertension and chronic heart failure.
  • the ET A receptor-expressing CHO cells were grown in F 12 medium with 10% fetal calf serum, 1% glutamine, 100 U / ml penicillin and 0.2% streptomycin (Gibco BRL, Gaithersburg, MD, USA). After 48 h the cells were washed with PBS and incubated with 0.05% trypsin-containing PBS for 5 min. The mixture was then neutralized with F 12 medium and the cells were collected by centrifugation at 300 ⁇ g. To lyse the cells, the pellet was briefly washed with lysis buffer (5 mM Tris-HCl, pH 7.4 with 10% glycerol) and then incubated in a concentration of 10 7 cells / ml lysis buffer at 4 ° C.
  • lysis buffer 5 mM Tris-HCl, pH 7.4 with 10% glycerol
  • Guinea pig cerebellas were homogenized in the Potter-Elvejhem homogenizer and obtained by differential centrifugation at 1,000 xg for 10 min and repeated supernatant centrifugation at 20,000 xg for 10 min.
  • the membranes were incubated in incubation buffer (50 mM Tris-HCl, pH 7.4 with 5 mM MnCl 2 , 40 ⁇ g / ml bacitracin and 0.2% BSA) in a concentration of 50 ⁇ g Protein suspended per test batch and incubated at 25 ° C. with 25 pM [125J] -ET 1 (ET A receptor test) or 25 pM [125J] -RZ 3 (ET B receptor test) in the presence and absence of test substance. The non-specific binding was determined with 10 -7 M ET 1 .
  • buffer A 120 mM NaCl, 5 mM KCl, 1, 5 mM MgCl 2 , 1 mM CaCl 2 , 25 mM HEP
  • the fluorescence signal of 2 x 10 5 cells per ml at Ex / Em 380/510 was continuously recorded at 30 ° C.
  • the test substances were added to the cells and after an incubation time of 3 min ETI the maximum change in fluorescence was determined.
  • the answer of the Cells on ET1 without the addition of a test substance served as a control and were set to 100%.
  • the principle of the test is to inhibit the sudden cardiac death of the mouse caused by endothelin, which is probably caused by narrowing of the coronary arteries, by pretreatment with endothelin receptor antagonists. After intravenous injection of 10 nmol / kg endothelin in a volume of 5 ml / kg body weight, the animals die within a few minutes.
  • the lethal endothelin-1 dose is checked in each case in a small animal collective. If the test substance is administered intravenously, the endothelin-1 injection, which is lethal in the reference group, is usually given 5 minutes afterwards. For other types of application, the default times are extended, possibly up to several hours. The survival rate is documented and effective doses that protect 50% of the animals against endothelin cardiac death for 24 hours or longer (ED 50) are determined.
  • a K + contracture is first triggered on aortic segments of the rabbit. After washing out, an endothelin dose-response curve is drawn up to the maximum. Potential endothelin antagonists are applied to other preparations in the same vessel 15 minutes before the endothelin dose-response curve begins. The effects of endothelin are calculated in% of the K + contracture. Effective endothelin antagonists shift the endothelin dose-response curve to the right.
  • the compounds according to the invention can be administered in the usual way orally or parenterally (subcutaneously, intravenously, intramuscularly, intraperotoneally).
  • the application can also be done with steam or sprays through the nasopharynx.
  • the dosage depends on the age, condition and weight of the patient and on the type of application.
  • the daily dose of active ingredient is between approximately 0.5 and 50 mg / kg body weight when administered orally and between approximately 0.1 and 10 mg / kg body weight when administered parenterally.
  • the new compounds can be used in the customary pharmaceutical application forms, solid or liquid, e.g. as tablets, film-coated tablets, capsules, powders, granules, dragees, suppositories, solutions, ointments, creams or sprays. These are manufactured in the usual way.
  • the active ingredients can be processed with the usual pharmaceutical auxiliaries such as tablet binders, fillers, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, retardants, antioxidants and / or propellants (see H. Sucker et al .: Pharmaceuticals Technology, Thieme-Verlag, Stuttgart, 1991).
  • the application forms thus obtained contain the active ingredient
  • Methyl 2- (2,6-dimethoxy-pyrimidin-4-yloxy) -3-methoxy-3,3-diphenyl-propionate 1.15 g (4 mmol) methyl 2-hydroxy-3-methoxy-3,3-diphenyl-propionate were dissolved in 10 ml of dimethylformamide and 276 mg (2 mmol) of potassium carbonate were added. Then you gave
  • 3,3-diphenyl-propionic acid 2.0 g (5.5 mmol) of 2- (2-tert-butyl-6-trifluoromethyl-pyrimidin-4-yloxy) -3-methoxy-3,3-diphenyl-propionic acid benzyl ester were dissolved in 250 ml of methanol , with 120 mg palladium on activated carbon (5%) and stirred under hydrogen at room temperature for 2 hours. After the hydrogen uptake had ended, the catalyst was filtered off through Celite and the solvent was removed on a rotary evaporator.

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Abstract

L'invention concerne des dérivés d'acide carboxylique de la formule (I) dans laquelle les restes correspondant à la définition donnée dans la description. L'invention concerne en outre la préparation de ces composés et leur utilisation comme médicaments.
EP97918109A 1996-04-12 1997-04-04 Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation Withdrawn EP0892788A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19614542 1996-04-12
DE19614542A DE19614542A1 (de) 1996-04-12 1996-04-12 Neue Carbonsäurederivate, ihre Herstellung und Verwendung
PCT/EP1997/001687 WO1997038982A1 (fr) 1996-04-12 1997-04-04 Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation

Publications (1)

Publication Number Publication Date
EP0892788A1 true EP0892788A1 (fr) 1999-01-27

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EP97918109A Withdrawn EP0892788A1 (fr) 1996-04-12 1997-04-04 Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation

Country Status (23)

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US (1) US6103732A (fr)
EP (1) EP0892788A1 (fr)
JP (1) JP2000508325A (fr)
KR (1) KR20000005366A (fr)
CN (1) CN1216042A (fr)
AR (1) AR006593A1 (fr)
AU (1) AU711293B2 (fr)
BG (1) BG63202B1 (fr)
BR (1) BR9708614A (fr)
CA (1) CA2250764A1 (fr)
CO (1) CO4900038A1 (fr)
DE (1) DE19614542A1 (fr)
HR (1) HRP970200A2 (fr)
ID (1) ID19050A (fr)
IL (1) IL126026A0 (fr)
NO (1) NO311802B1 (fr)
NZ (1) NZ331704A (fr)
PL (1) PL329240A1 (fr)
SK (1) SK127698A3 (fr)
TR (1) TR199802042T2 (fr)
TW (1) TW419465B (fr)
WO (1) WO1997038982A1 (fr)
ZA (1) ZA973096B (fr)

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US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
ID25620A (id) * 1997-09-04 2000-10-19 Basf Ag Turunan-turunan asam karboksilat baru, pembuatannya dan penggunaannya sebagai campuran reseptor antagonis et a/et b
EP1498124B1 (fr) * 1997-10-17 2007-07-04 Ark Therapeutics Limited Utilisation d'inhibiteurs du système rénine-angiotensine
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
EP1243262B1 (fr) * 2001-03-20 2006-05-31 Schwarz Pharma Ag Nouvelle utilisation d'un composé peptidique pour le traitement de la douleur inflammatoire non-neuropathique
DK1243263T3 (da) * 2001-03-21 2003-03-17 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte
MXPA06011937A (es) 2004-04-16 2007-01-26 Sanol Arznei Schwarz Gmbh Uso de compuestos peptidicos para la profilaxis y el tratamiento de dolor de cabeza cronico.
BRPI0514721A (pt) * 2004-08-27 2008-06-24 Sanol Arznei Schwarz Gmbh uso de compostos de peptìdeos para tratar dor de cáncer ósseo, dor induzida por quimioterapia e nucleosìdeo
EP1754476A1 (fr) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) pour le traitement de la myalgie, par exemple de la fibromyalgie
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
KR20150003925A (ko) * 2006-06-15 2015-01-09 유씨비 파르마 게엠베하 상승적 항경련 효과를 갖는 약제학적 조성물

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NO984713L (no) 1998-10-09
BG102770A (en) 1999-11-30
IL126026A0 (en) 1999-05-09
NO984713D0 (no) 1998-10-09
CA2250764A1 (fr) 1997-10-23
AR006593A1 (es) 1999-09-08
CN1216042A (zh) 1999-05-05
KR20000005366A (ko) 2000-01-25
NO311802B1 (no) 2002-01-28
TW419465B (en) 2001-01-21
AU711293B2 (en) 1999-10-07
NZ331704A (en) 2000-06-23
BR9708614A (pt) 1999-08-03
JP2000508325A (ja) 2000-07-04
PL329240A1 (en) 1999-03-15
AU2636497A (en) 1997-11-07
BG63202B1 (bg) 2001-06-29
ID19050A (id) 1998-06-04
ZA973096B (en) 1998-10-12
SK127698A3 (en) 2000-03-13
CO4900038A1 (es) 2000-03-27
DE19614542A1 (de) 1997-10-16
TR199802042T2 (xx) 2000-09-21
HRP970200A2 (en) 1998-04-30
WO1997038982A1 (fr) 1997-10-23
US6103732A (en) 2000-08-15

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