EP0883412A1 - Reservoir destine a la preparation de dialysats - Google Patents

Reservoir destine a la preparation de dialysats

Info

Publication number
EP0883412A1
EP0883412A1 EP97905223A EP97905223A EP0883412A1 EP 0883412 A1 EP0883412 A1 EP 0883412A1 EP 97905223 A EP97905223 A EP 97905223A EP 97905223 A EP97905223 A EP 97905223A EP 0883412 A1 EP0883412 A1 EP 0883412A1
Authority
EP
European Patent Office
Prior art keywords
reservoir
fluid
inner chamber
dialysis
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97905223A
Other languages
German (de)
English (en)
Inventor
Alan Edward Hodge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Helier NHS Trust
Original Assignee
St Helier NHS Trust
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Helier NHS Trust filed Critical St Helier NHS Trust
Publication of EP0883412A1 publication Critical patent/EP0883412A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1666—Apparatus for preparing dialysates by dissolving solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1668—Details of containers

Definitions

  • the present invention relates to a reusable reservoir for use in a haemodialysis. haemofiltration or haemodiafiltration procedure.
  • Haemodialysis is a method of cleansing the blood of patients whose kidney function is impaired.
  • the patient's blood is supplied to one side of a permeable membrane located in a dialysis apparatus.
  • Dialysis membranes are usually formed from polyacrylonitrile or polysulphone.
  • a dialysis fluid containing an electrolyte solution is supplied to the other side of the membrane.
  • the patient's blood is pumped against the membrane, maintaining a controlled low positive blood-to-dialysate pressure gradient.
  • reverse osmosis waste products in the blood diffuse through the membrane into the dialysis fluid.
  • Haemodiafliltration and haemofiltration procedures also take advantage of permeable filter membranes to remove blood waste products. In both procedures, a more permeable filter is used than in haemodialysis and the consequent blood fluid loss is greater than in haemodialysis. Normally, this fluid must be replaced at least in part, for example by one of the methods described above.
  • Haemodialysis, haemodiafiltration and haemofiltration procedures all require the use of an electrolyte-containing fluid either as a dialysis fluid or as a fluid replacement fluid, or both.
  • a major advantage of using sodium acetate was that it became possible to prepare dialysis liquids from single liquid concentrates. Typically, one part of such a concentrate would be diluted 35 times with water before being used in a dialysis procedure. This simple preparative procedure is not available when using bicarbonate buffers because of the immediate precipitation of insoluble carbonates when all the necessary salts, including bicarbonate, are mixed together in one concentrate.
  • the use of sodium acetate as a buffer meant that dialysis liquid could be prepared simply and conveniently at the patient's bedside.
  • sodium bicarbonate was much the better dialysis buffer, in medical terms, than sodium acetate.
  • WO-A-86/03416 teaches a drug delivery apparatus preventing local and systemic toxicity which enables the passive delivery of a drug to the intravenous system of a patient.
  • the apparatus of WO-A-86/03416 comprises a chamber for receiving a beneficial agent such as a drug, the chamber having a fluid pathway therethrough for effecting a regulated supply of the beneficial agent intravenously to a patient.
  • EP-A-0278100 discloses a system for preparing a fluid for a medical procedure by mixing of at least one concentrate in powder form with water.
  • the system contains a cartridge containing a soluble powder material.
  • water is supplied by a first fluid conducting means to the dialysis membrane.
  • An adjustable portion of the fluid thus supplied is diverted through the powder-containing cartridge. If the powder is sodium bicarbonate then the dialysis may be effected using a solution of sodium bicarbonate at a controlled concentration, which solution results after recombination under controlled conditions of the diverted and undiverted portions of the water in the fluid conducting means.
  • EP-A-0278100 and other conventional commercial systems suffer from a number of disadvantages, including the constant need of the user to replace cartridges after a single use thereof.
  • a reservoir for storage and supply of a soluble powder material for use in a haemodialysis, haemofiltration or haemodiafiltration procedure having a fluid inlet means adapted to be releasably connected to a fluid supply line and a fluid outlet means adapted to be releasably connected to a fluid discharge line via which a dialysis solution comprising a solution of the soluble powder material in a fluid supplied in the fluid supply line is supplied to a dialysis apparatus during a haemodialysis, haemofiltration or haemodiafiltration procedure; characterised in that the reservoir has at least one openable and securely reclosable access port through which, when open, the soluble powder material may be supplied to or removed from the reservoir.
  • the reservoir comprises a first inner chamber and an outer chamber, the first inner chamber comprising a first orifice communicating with the fluid inlet means and a second orifice communicating with the outer chamber of the reservoir.
  • the purpose of the inner chamber is to ensure even distribution of the inlet fluid over the inlet end of the outer chamber containing the dialysis powder. This has the advantage of conserving powder by ensu ⁇ ng as much wetting as possible of the powder contained in the outer chamber.
  • a plurality of second orifices are provided in the first inner chamber.
  • This embodiment of the invention is designed to enhance the even distribution of inlet fluid over the powder by providing a "sprinkling" action.
  • the first inner chamber of the reservoir may be a longitudinal chamber communicating with the fluid inlet means and protruding inwardly into the outer chamber of the reservoir.
  • the first inner chamber may be closed at its inwardly protruding end but have a number of lateral second orifices.
  • substantially any number of second orifices may be employed m a cartridge according to the invention.
  • first inner chamber may be of substantially any shape, for example of hexagonal or rectangular cross section, although often a cylindrical shape will be used for ease of construction
  • the purpose of the first inner chamber and second o ⁇ fice or orifices is to enable a fluid supplied to the reservoir via the fluid inlet means to be distributed over the surface of any soluble powder material contained within the outer chamber of the reservoir when the reservoir is in use
  • the use of a plurality of second orifices tends to improve the even distribution of fluid over the inlet end of the reservoir
  • There is no limitation either on the number of second orifices or their location or on the shape and/or size of the first inner chamber provided that the first inner chamber serves the purpose for which it was designed, which is to direct fluid supplied from the fluid inlet means onto a powder located in the outer chamber.
  • One advantage of the sprinkling function of the first inner chamber is that channelling of fluid through the powder in the outer chamber of the reservoir is substantially avoided. The avoidance of channelling improves the reliability of the reservoir.
  • Another advantage of the first inner chamber of a reservoir according to the present invention is that the smoothness of flow of fluid through the reservoir when in use is less susceptible than conventional cartridges to slight changes in pressure of the fluid supplied via the fluid inlet means.
  • the reservoir comprises a second inner chamber comprising a first orifice communicating with the fluid outlet means and a second orifice communicating with the outer chamber of the reservoir.
  • the fluid inlet means comprises a nipple protruding from the reservoir to which nipple a fluid supply line may be connected.
  • the fluid outlet means also comprises a protruding nipple to which a fluid outlet line may be connected. The shape and/or size of such nipples may be chosen to fit a range of commercially available dialysis machines. An openable port is required in the reservoir for supplying or removing a soluble powder material such as sodium bicarbonate therethrough.
  • the reservoir be openable in the region of a fluid inlet end and/or in the region of a fluid outlet end.
  • the reservoir is openable both in the region of its fluid inlet end and in the region of its fluid outlet end.
  • the reservoir is constructed of a hollow tube which is threaded at both its fluid inlet end and its fluid outlet end.
  • two threaded caps, a fluid inlet cap and a fluid outlet cap. are provided. The fluid inlet cap attaches to the fluid inlet end of the reservoir and the fluid outlet cap attaches to the fluid outlet end of the reservoir.
  • the fluid inlet cap in this case is provided on its inner face with the first inner chamber of the reservoir and on its outer face with the fluid inlet means.
  • the fluid outlet cap is provided on its outer face with the fluid outlet means.
  • both caps are fitted with a resilient 'O' ring, for example of natural or synthetic rubber, to ensure sealing efficiency against the hollow tube.
  • the fluid outlet cap may be fitted with a filtration device to prevent egress of undissolved powder material from the reservoir when in use.
  • the fluid outlet end of the reservoir is conveniently constructed with a stepped portion which may be arranged to be seated in a cartridge cradle in a range of commercially available dialysis units. In some cases, it may be necessary to provide an adaptor between the reservoir and the commercial dialysis machine.
  • the invention further provides an adaptor for use with a reservoir of the invention comprising a plug portion for insertion into the corresponding socket of a dialysis machine, the plug portion having two openings and means, optionally in combination with the socket, for ensuring non-communication between said openings, the adaptor further comprising means for supplying via the first of said two openings a fluid for supply to the reservoir and means for recovering via the second of said two openings a solution of powder from the reservoir for use in a dialysis procedure.
  • the reservoir is tapered towards its fluid outlet end. Such tapering ensures smoother flow of the fluid through the powder.
  • the tapering is achieved by means of a tapered sleeve which may be inserted in a close fit arrangement with the reservoir.
  • Figure 1 is a vertical cross-section of a reservoir designed in accordance with a first embodiment of the present invention
  • Figure 2 is a vertical cross-section of a reservoir designed in accordance with a second embodiment of the invention.
  • Figure 3 is a cross-section through an adaptor for use with the reservoir of Figure 2; and Figure 4 is a plan view from above of the adaptor of Figure 3.
  • a soluble powder material such as sodium bicarbonate (not shown) for use in a haemodialysis, haemofiltration or haemodiafiltration procedure.
  • the reservoir (1) comprises an outer chamber (2) which is a hollow cylindrical acrylic tube manufactured by an injection moulding process.
  • Outer chamber (2) has screw-threaded portions (3) at its upper and lower ends respectively.
  • removable cap (4) which is secured to chamber (2) by means of screw-threaded portions (5) on cap (4). Fluid tight engagement of cap (4) and chamber (2) is assisted by a resilient 'O' ring (6) of natural or synthetic rubber.
  • Cap (4) is injection moulded from polycarbonate and has a central orifice (7). Orifice (7) communicates at its upper end with fluid inlet nipple (8) and at its lower end with first inner chamber (9).
  • First inner chamber (9) is provided with four orifices (10) evenly spaced around the circumference of first inner chamber (9).
  • Nipple (8) is shaped to be securable to a fluid inlet line from a commercially available dialysis machine such as the Gambro AK-10 system or the COBE C2RX system.
  • cap ( 11) secured to chamber (2) by a screw-threaded portion generally indicated by reference numeral (12). Fluid tight engagement of cap (11) and chamber (2) is assisted by a resilient 'O' ring (13) of natural or synthetic rubber.
  • Cap (11) is conveniently injection moulded from polycarbonate.
  • Cap (11) has an instepped portion ( 14) in which sits a filter ( 15).
  • the purpose of filter ( 15) is to prevent small particles of undissolved material escaping from reservoir (1) when the reservoir is in use. Any convenient filter material such as a nylon mesh may be used. Conveniently, the mesh size is from about 25 micrometers to about 50 micrometers.
  • Cap ( 1 1) is formed integrally with nipple ( 16) which is shaped to receive a fluid outlet line from any commercial dialysis system.
  • Cap (1 1 ) is also provided with a stepped portion (17) which may serve to seat the reservoir (1) in a corresponding cradle of a commercial dialysis system.
  • tapered sleeve ( 18) Seated within the lower end of chamber (2) is tapered sleeve ( 18) which is a moulded polycarbonate sleeve arranged to fit slidably into chamber (2) and to direct the flow of fluid through chamber (2) towards a central region of the bottom end of chamber (2).
  • chamber (2) is cylindrical with an external diameter of 3.150 inches (8.001cm) and a length of 6.788 inches (17.241cm); threaded portions (3) on chamber (2) extend 5/8 inches ( 1.588cm) from each end of chamber (2); fluid inlet cap (4) and fluid outlet cap (11) each have an external diameter of 4 inches (10.16cm) and an internal diameter (circumferenced by screw threaded portions (5) and (12) respectively) of 3.360 inches (8.534cm); nipples (8) and ( 16) are slightly chamfered at their respective protruding ends; each protrudes from a respective external face of cap (4) or cap (11) by 9/16 inches ( 1.429cm) and each has an external diameter of 3/8 inches (0.953cm) at its respective protruding end, not including any chamfered portion of the end; stepped portion 17 on fluid outlet cap (11) has a diameter of 2.1 inches
  • the reservoir is partially filled with a quantity of sodium bicarbonate, optionally in conjunction with other materials, useful in dialysis.
  • the reservoir is charged with a mass of 500g sodium bicarbonate in readiness for a single dialysis treatment.
  • the reservoir is then connected at its fluid inlet end and at its fluid outlet end to a suitable dialysis apparatus such as the Gambro AK-10 or the COBE C2RX and a dialysis treatment is carried out in accordance with methods which are well known to those skilled in the art.
  • the cartridge is connected to apparatus comprising a first fluid conducting means having a first end for communicating with a source of water to withdraw water into the first fluid conducting means and a second end for delivering a prepared solution: second fluid conducting means having a first end for communicating with a source of water and a second end communicating with the fluid inlet end of the reservoir for introducing water into the reservoir to produce a concentrate fluid containing dissolved powder concentrate in water: third fluid conducting means communicating with the outlet end of the reservoir and with a mixing point in the first fluid conducting means intermediate said first and second ends for conducting the concentrate fluid from the reservoir into the first fluid conducting means to be mixed with fluid being conducted through the first fluid conducting means thereby to produce a prepared solution in the first fluid conducting means for delivery to the second end of the first fluid conducting means.
  • the apparatus will comprise measuring means in the first fluid conducting means downstream of the mixing point for measuring the composition of the prepared solution obtained by the mixing of the concentrate fluid and water in the first fluid conducting means.
  • the apparatus may further comprise flow regulating means in the third fluid conducting means responsive to said measuring means for controlling the flow of the concentrate fluid from the reservoir.
  • the reservoir When a dialysis treatment utilising a reservoir according to the invention has been completed, the reservoir may be detached from the dialysis apparatus and, after appropriate sterilising treatment, may be charged once again with sodium bicarbonate in readiness for a further dialysis treatment. Sterilisation of the reservoir in between treatments may be effected by any of a number of methods which are well known to those skilled in the art.
  • One convenient method of sterilisation is to rinse excess sodium bicarbonate from the reservoir with water before soaking the resevoir in a solution of sodium dichlorisocyanurate (SanichlorTM) at a suitable concentration.
  • Reservoir ( 101) comprises comprises an outer chamber ( 102) which is a hollow cylindrical acrylic tube manufactured by an injection moulding process. Outer chamber (102) has a screw-threaded portion ( 103) at its upper end. At the upper end of reservoir ( 101 ) is shown removable cap ( 104) which is secured to chamber ( 102) by means of screw-threaded portions ( 105) on cap (104). Fluid tight engagement of cap ( 104) and chamber ( 102) is assisted by a resilient 'O' ring ( 106) of natural or synthetic rubber.
  • Cap ( 104) is injection moulded from polycarbonate and has two orifices ( 107 and 107a).
  • Orifice ( 107) communicates at its upper end with fluid inlet nipple ( 108 ) and at its lower end with first inner chamber ( 109).
  • First inner chamber ( 109) is provided with a single orifice ( 1 10) at one end of first inner chamber ( 109).
  • Second inner chamber ( 1 1 1) communicates at its lower end with outer chamber 102 and at its upper end with fluid outlet nipple ( 1 12).
  • reservoir ( 101) In use of reservoir ( 101), the reservoir is filled with a suitable quantity of sodium chloride and lines are taken from each of fluid inlet nipple (108) and fluid outlet nipple ( 1 12) for connection to an adaptor suitable for use with the Fresenius machine referred to above.
  • the adaptor is shown in Figures 3 and 4 and comprises a plug portion ( 113) for insertion into the corresponding socket (not shown) of a Fresenius machine and a receiving portion (1 14) for receiving lines from the fluid inlet nipple ( 108) and the fluid outlet nipple (112).
  • Plug portion ( 113) comprises three concentric cylindrical walls ( 1 15, 1 16 and 1 17) of polyethylene standing up from a base portion (118).
  • a chamber ( 119) which communicates via orifice (120) with the fluid supply line of the dialysis machine (not shown) and via orifice (121 ) with a line (not shown) taken from fluid inlet nipple ( 108).
  • the chamber ( 119) is traversed by a conduit (122) which has an opening (123) at its upper end communicating with the fluid intake line of the dialysis machine (not shown) and an opening (124) at its lower end communicating with a line (not shown) taken from fluid outlet nipple ( 112) of reservoir ( 101).
  • Fluid is supplied to a powder, such as sodium bicarbonate, contained in outer chamber ( 102) and a solution of the powder is drawn into second inner chamber
  • ( 101) may simply be detached from the dialysis machine and prepared for re-use.
  • the reservoir (101) is opened by removing cap (104), excess powder is rinsed from the reservoir and the reservoir is sterilised by a suitable procedure prior to recharging with powder for further use.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention se rapporte à un réservoir conçu pour le stockage et la fourniture de matière pulvérulent soluble utilisée lors des procédures d'hémodialyse, d'hémofiltration ou d'hémodiafiltration, ledit réservoir ayant un moyen d'admission de fluide conçu pour être connecté de manière libérable à un conduit d'alimentation en fluide et un moyen de sortie de fluide conçu pour être relié de manière libérable à un conduit de refoulement du fluide par l'intermédiaire desquels une solution de dialyse, qui comporte une solution de la matière pulvérulent soluble dans un fluide amené par le conduit d'alimentation en fluide, alimente un appareil de dialyse au cours d'une procédure d'hémodialyse, d'hémofiltration ou d'hémodiafiltration. L'invention se caractérise en ce que le réservoir présente au moins un orifice d'accès pouvant être ouvert et refermé de façon sûre à travers lequel, lorsqu'il est ouvert, la matière pulvérulent soluble peut alimenter le réservoir ou en être extraite.
EP97905223A 1996-02-19 1997-02-19 Reservoir destine a la preparation de dialysats Withdrawn EP0883412A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9603468.1A GB9603468D0 (en) 1996-02-19 1996-02-19 Reservoir
GB9603468 1996-02-19
PCT/GB1997/000460 WO1997029796A1 (fr) 1996-02-19 1997-02-19 Reservoir destine a la preparation de dialysats

Publications (1)

Publication Number Publication Date
EP0883412A1 true EP0883412A1 (fr) 1998-12-16

Family

ID=10789018

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97905223A Withdrawn EP0883412A1 (fr) 1996-02-19 1997-02-19 Reservoir destine a la preparation de dialysats

Country Status (10)

Country Link
EP (1) EP0883412A1 (fr)
JP (1) JP2001500748A (fr)
AU (1) AU1884897A (fr)
CA (1) CA2246455A1 (fr)
EE (1) EE9800241A (fr)
GB (1) GB9603468D0 (fr)
HU (1) HUP9900948A2 (fr)
NO (1) NO983773L (fr)
PL (1) PL328498A1 (fr)
WO (1) WO1997029796A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004023377D1 (de) * 2003-04-07 2009-11-12 Gambro Lundia Ab Filter für eine Kartusche für medizinische Dialyse
PL1610843T3 (pl) * 2003-04-07 2009-06-30 Gambro Lundia Ab Zasobnik medyczny z filtrującymi szczelinami
EP1613371B1 (fr) 2003-04-07 2008-08-20 Gambro Lundia AB Dispositif, cartouche et procede de dissolution de poudre dans un liquide, lors de la production d'un fluide de dialyse
DE102011016167A1 (de) * 2011-04-05 2012-12-27 Ritter Gmbh Behälter aus Kunststoff für die Dialyse
CN107537073B (zh) * 2017-08-01 2018-07-31 浙江济民制药股份有限公司 血液透析联机干粉用桶

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0475825B1 (fr) 1990-09-13 1994-12-07 Soludia, S.A. Dispositif pour la préparation extemporanée et en continu de dialysat

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2569560B3 (fr) * 1984-09-06 1987-01-23 Grange Serge Poche de conditionnement de produits pour hemodialyse et dispositif de realisation du concentre pour hemodialyse
JPH07114809B2 (ja) * 1990-07-30 1995-12-13 日機装株式会社 透析液調整用剤の溶解装置
DE4130412C1 (fr) * 1991-09-15 1993-02-25 Zaunbauer, Peter, Dr., 3000 Hannover, De
EP0536645A3 (en) * 1991-10-11 1993-11-03 Saueressig Ulrich Preparation on a dialysis apparatus of the necessary bicarbonate solution for bicarbonate dialysis
ES2137958T3 (es) * 1992-06-26 2000-01-01 Fresenius Medical Care De Gmbh Bolsa para concentrado.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0475825B1 (fr) 1990-09-13 1994-12-07 Soludia, S.A. Dispositif pour la préparation extemporanée et en continu de dialysat

Also Published As

Publication number Publication date
WO1997029796A1 (fr) 1997-08-21
EE9800241A (et) 1998-12-15
AU1884897A (en) 1997-09-02
NO983773D0 (no) 1998-08-18
CA2246455A1 (fr) 1997-08-21
GB9603468D0 (en) 1996-04-17
NO983773L (no) 1998-10-16
PL328498A1 (en) 1999-02-01
HUP9900948A2 (hu) 1999-07-28
JP2001500748A (ja) 2001-01-23

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