EP0859771A4 - Substituierte pyridylpyrrole, solche verbindungen enthaltende zubereitungen und verfahren zu deren nutzung - Google Patents

Substituierte pyridylpyrrole, solche verbindungen enthaltende zubereitungen und verfahren zu deren nutzung

Info

Publication number
EP0859771A4
EP0859771A4 EP96942022A EP96942022A EP0859771A4 EP 0859771 A4 EP0859771 A4 EP 0859771A4 EP 96942022 A EP96942022 A EP 96942022A EP 96942022 A EP96942022 A EP 96942022A EP 0859771 A4 EP0859771 A4 EP 0859771A4
Authority
EP
European Patent Office
Prior art keywords
compounds
methods
compositions containing
substituted pyridyl
pyrroles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96942022A
Other languages
English (en)
French (fr)
Other versions
EP0859771A1 (de
Inventor
Laszlo Stephen E De
Linda L Chang
Dooseop Kim
Nathan B Mantlo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605158.6A external-priority patent/GB9605158D0/en
Priority claimed from GBGB9612062.1A external-priority patent/GB9612062D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0859771A1 publication Critical patent/EP0859771A1/de
Publication of EP0859771A4 publication Critical patent/EP0859771A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
EP96942022A 1995-10-31 1996-10-30 Substituierte pyridylpyrrole, solche verbindungen enthaltende zubereitungen und verfahren zu deren nutzung Withdrawn EP0859771A4 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US15565 1979-02-26
US710095P 1995-10-31 1995-10-31
US7100P 1995-10-31
GB9605158 1996-03-12
GBGB9605158.6A GB9605158D0 (en) 1996-03-12 1996-03-12 Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
US1556596P 1996-04-18 1996-04-18
GB9612062 1996-06-10
GBGB9612062.1A GB9612062D0 (en) 1996-06-10 1996-06-10 Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
PCT/US1996/018539 WO1997016442A1 (en) 1995-10-31 1996-10-30 Substituted pyridyl pyrroles, compositions containing such compounds and methods of use

Publications (2)

Publication Number Publication Date
EP0859771A1 EP0859771A1 (de) 1998-08-26
EP0859771A4 true EP0859771A4 (de) 2000-03-15

Family

ID=27451424

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96942022A Withdrawn EP0859771A4 (de) 1995-10-31 1996-10-30 Substituierte pyridylpyrrole, solche verbindungen enthaltende zubereitungen und verfahren zu deren nutzung

Country Status (4)

Country Link
EP (1) EP0859771A4 (de)
JP (1) JPH11514651A (de)
AU (1) AU702887B2 (de)
WO (1) WO1997016442A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
BR9710352A (pt) 1996-07-11 1999-08-17 Pfizer Compostos piridilpirrole
IL129928A0 (en) 1996-11-19 2000-02-29 Amgen Inc Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents
EP1314731A3 (de) * 1996-12-05 2004-01-02 Amgen Inc. Substituierte Pyrimidinverbindungen und ihre Verwendung
US6096753A (en) 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
WO1998024782A2 (en) * 1996-12-05 1998-06-11 Amgen Inc. Substituted pyrimidine compounds and their use
WO1998024780A2 (en) * 1996-12-05 1998-06-11 Amgen Inc. Substituted pyrimidinone and pyridinone compounds and their use
CA2293436C (en) 1997-06-12 2010-10-26 Rhone-Poulenc Rorer Limited Imidazolyl-cyclic acetals as tnf inhibitors
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
BR9810378A (pt) * 1997-07-01 2000-08-29 Novo Nordisk As Composto,uso do mesmo, composição farmacêutica, e, processos de tratar a diabete do tipo i ou do tipo ii, de tratar a hiperglicemia, e de diminuir a glicose do sangue em um mamìfero
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
EP1473292A1 (de) * 1997-11-03 2004-11-03 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatische heterocyclische Verbindungen als antiinflammatorische Mittel
JP2001521934A (ja) * 1997-11-03 2001-11-13 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 抗炎症薬としての芳香族ヘテロ環式化合物
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
WO1999032121A1 (en) 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
US6174901B1 (en) 1998-12-18 2001-01-16 Amgen Inc. Substituted pyridine and pyridazine compounds and methods of use
KR20010034114A (ko) * 1998-01-14 2001-04-25 니뽄 신야쿠 가부시키가이샤 칼륨 채널 활성화제
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
EP1077967B1 (de) * 1998-05-12 2002-12-04 Wyeth Zur behandlung von insulin-resistenz und hyperglycemie geeignete biphenyl-oxo-essigsäuren
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
WO2000019824A1 (en) 1998-10-07 2000-04-13 Smithkline Beecham Corporation Novel treatment for stroke management
DE19847823A1 (de) * 1998-10-16 2000-04-20 Aventis Pharma Gmbh Substituierte Thiadiazolsulfonamide
JP2002528506A (ja) 1998-11-04 2002-09-03 スミスクライン・ビーチャム・コーポレイション ピリジン−４−イルまたはピリミジン−４−イル置換ピラジン
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
DE60023853T2 (de) 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
AU4315100A (en) * 1999-04-28 2000-11-17 Sankyo Company Limited Preventive or inhibitory agents for hepatopathy
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
KR20010114267A (ko) * 1999-05-14 2001-12-31 오르토-맥네일 파마슈티칼, 인코퍼레이티드 치환된 3-피리딜-4-아릴피롤과 관련 치료방법 및 예방방법
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
JP4162406B2 (ja) 1999-07-09 2008-10-08 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド ヘテロアリール置換ウレア化合物の新規合成方法
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
ES2250182T3 (es) * 1999-09-14 2006-04-16 MERCK FROSST CANADA & CO. Acidos carboxilicos y acilsulfonamidas, composiciones que contienen tales compuestos y procedimientos de tratamiento.
US6900043B1 (en) 1999-09-21 2005-05-31 Amgen Inc. Phosphatases which activate map kinase pathways
WO2001032658A1 (fr) * 1999-11-02 2001-05-10 Ajinomoto Co., Inc. Compose de polyazanaphtalene et utilisation medicinale dudit compose
AU1617901A (en) 1999-11-16 2001-05-30 Boehringer Ingelheim Pharmaceuticals, Inc. Urea derivatives as anti-inflammatory agents
ES2249309T3 (es) 1999-11-23 2006-04-01 Smithkline Beecham Corp Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa.
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
ES2241675T3 (es) 1999-11-23 2005-11-01 Smithkline Beecham Corporation Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa.
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
DE60132723T2 (de) 2000-01-21 2009-01-29 Novartis Pharma Ag Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6821960B2 (en) 2000-11-17 2004-11-23 Noyo Nordisk Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
US6706744B2 (en) 2000-11-17 2004-03-16 Novo Nordisk A/S Glucagon antagonists/inverse agonists
JP2004513935A (ja) 2000-11-17 2004-05-13 ノボ　ノルディスク　アクティーゼルスカブ グルカゴンアンタゴニスト／逆アゴニスト
CN1525968A (zh) * 2001-01-18 2004-09-01 三共株式会社 预防或治疗肝病的组合物
WO2002057255A1 (fr) * 2001-01-22 2002-07-25 Sankyo Company, Limited Derives du pyrrole substitues en 4 ou 5
MY130778A (en) * 2001-02-09 2007-07-31 Vertex Pharma Heterocyclic inhibitiors of erk2 and uses thereof
JP2004530690A (ja) 2001-05-16 2004-10-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 抗炎症性薬剤として有用なジアリールウレア誘導体
MXPA03010724A (es) 2001-05-25 2004-03-02 Boehringer Ingelheim Pharma Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina.
AU2002317377A1 (en) * 2001-07-20 2003-03-03 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
AU2002331310B2 (en) * 2001-08-28 2008-07-17 Leo Pharma A/S Novel aminobenzoephenones
WO2003022832A1 (en) * 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Pyridylfurans and pyrroles as raf kinase inhibitors
US6921762B2 (en) 2001-11-16 2005-07-26 Amgen Inc. Substituted indolizine-like compounds and methods of use
US6881746B2 (en) 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
EP1480973B1 (de) 2002-02-25 2008-02-13 Boehringer Ingelheim Pharmaceuticals Inc. 1,4-disubstituierte benzokondensierte cycloalkyl-harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen
DE60310730T2 (de) 2002-07-09 2007-05-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
CA2500221A1 (en) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. Substituted 3-(2,5 -disubstituted) pyridyl-4-aryl pyrroles for treating inflammatory diseases
US7196106B2 (en) 2002-11-05 2007-03-27 Merck & Co., Inc Cyanothiophene derivatives, compositions containing such compounds and methods of use
WO2004069158A2 (en) 2003-01-27 2004-08-19 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
WO2005065680A1 (en) 2003-12-19 2005-07-21 Merck & Co., Inc. Cyclic guanidines, compositions containing such compounds and methods of use
PL1756064T3 (pl) 2004-06-04 2008-11-28 Merck Sharp & Dohme Pochodne pirazolu, kompozycje zawierające takie związki oraz sposoby ich zastosowania
JP2008507528A (ja) 2004-07-22 2008-03-13 メルク　エンド　カムパニー　インコーポレーテッド 置換ピラゾール、このような化合物を含有する組成物及び使用方法
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US7759337B2 (en) 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
CN101146762A (zh) 2005-03-21 2008-03-19 默克公司 取代的芳基和杂芳基衍生物
JP2008534593A (ja) 2005-03-30 2008-08-28 メルク エンド カムパニー インコーポレーテッド グルカゴン受容体アンタゴニスト化合物、そのような化合物を含む組成物、及びその使用方法
JP2009502923A (ja) 2005-07-26 2009-01-29 メルク エンド カムパニー インコーポレーテッド 置換ピラゾールを合成するための方法
PT1931350E (pt) 2005-09-14 2014-02-12 Takeda Pharmaceutical Administração de inibidores de dipeptidil peptidase
EP1928827B1 (de) 2005-09-27 2012-08-22 Myriad Genetics, Inc. Pyrrolderivate als therapeutische verbindungen
TW200745031A (en) 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
EP2001472A2 (de) 2006-03-23 2008-12-17 Merck and Co., Inc. Glucagon-rezeptor-antagonisten-verbindungen, zusammensetzungen mit solchen verbindungen und verfahren zu ihrer verwendung
AU2007240568A1 (en) 2006-04-21 2007-11-01 Amgen Inc. Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
CA2650619A1 (en) 2006-05-16 2007-11-29 Merck And Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
CA2656507C (en) 2006-07-17 2012-03-20 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
AU2007293065B2 (en) 2006-09-05 2011-08-18 Amgen Inc. Phthalazine, AZA- and diaza-phthalazine compounds and methods of use
EP2069333A1 (de) 2006-09-21 2009-06-17 Novartis Ag Pyrrolderivate für die behandlung zytokin-vermittelter erkrankungen
TW200821284A (en) 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
CA2665195C (en) 2006-10-11 2011-08-09 Amgen Inc. Imidazo- and triazolo-pyridine compounds and methods of use thereof
CA2678735A1 (en) * 2007-02-26 2008-09-04 Santen Pharmaceutical Co., Ltd. Novel pyrrole derivative having ureido group and aminocarbonyl group as substituents
EP1992344A1 (de) 2007-05-18 2008-11-19 Institut Curie P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
WO2009038784A1 (en) 2007-09-21 2009-03-26 Amgen Inc. Triazole fused heteroaryl compounds as p38 kinase inhibitors
WO2010025202A1 (en) 2008-08-29 2010-03-04 Amgen Inc. PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF
EP2334674B1 (de) 2008-08-29 2012-06-06 Amgen, Inc Pyridazinopyridinonverbindungen zur Behandlung von durch Proteinkinase vermittelten Krankheiten
WO2010042646A1 (en) 2008-10-10 2010-04-15 Amgen Inc. Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof
WO2010042649A2 (en) 2008-10-10 2010-04-15 Amgen Inc. PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
US8802695B2 (en) 2010-02-03 2014-08-12 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
NZ611529A (en) 2010-12-23 2015-06-26 Pfizer Glucagon receptor modulators
JP5562495B2 (ja) 2011-02-08 2014-07-30 ファイザー・インク グルカゴン受容体モジュレーター
KR20140023441A (ko) 2011-07-22 2014-02-26 화이자 인코포레이티드 퀴놀린일 글루카곤 수용체 조절제
US9649294B2 (en) 2013-11-04 2017-05-16 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
IT201800003680A1 (it) * 2018-03-16 2019-09-16 Univ Degli Studi Di Siena Composti antivirali e usi di essi

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2113861A1 (de) * 1970-11-16 1972-06-30 Pfizer
EP0034798A2 (de) * 1980-02-19 1981-09-02 E.I. Du Pont De Nemours And Company Entzündungshemmende 4,5-Diaryl-2-(substituierte thio)-Pyrrole und ihre übereinstimmenden Sulfoxyde und Sulfone
WO1993014081A1 (en) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267185A (en) * 1980-04-09 1981-05-12 E. I. Du Pont De Nemours And Company Antidepressant pyrrolylpiperidines, their pharmaceutical compositions and method of use
US4652582A (en) * 1985-01-09 1987-03-24 E. I. Du Pont De Nemours And Company Antiinflammatory-2-halo-4,5-diarylpyrroles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2113861A1 (de) * 1970-11-16 1972-06-30 Pfizer
EP0034798A2 (de) * 1980-02-19 1981-09-02 E.I. Du Pont De Nemours And Company Entzündungshemmende 4,5-Diaryl-2-(substituierte thio)-Pyrrole und ihre übereinstimmenden Sulfoxyde und Sulfone
WO1993014081A1 (en) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KONAKAHARA, TAKEO ET AL: "One-pot synthesis of pyrroles from N-silyl-1-azaallyl anions", HETEROCYCLES ( 1993 ), 35(2), 1171-84, 1993, XP000857214 *
See also references of WO9716442A1 *
SILVESTRI, G. ET AL: "Electrochemical oxidation of 2,4,5-triaryl-substituted pyrroles. II. Oxidative dimerization of 4,5-diphenyl-2-mesitylylpyrrole", J. HETEROCYCL. CHEM. ( 1989 ), 26(2), 489-92, 1989, XP000857212 *
SILVESTRI, G. ET AL: "Electrochemical oxidation of substituted pyrroles. IV. The influence of soluble bases", J. HETEROCYCL. CHEM. ( 1992 ), 29(7), 1847-50, 1992, XP000857213 *

Also Published As

Publication number Publication date
JPH11514651A (ja) 1999-12-14
AU702887B2 (en) 1999-03-11
AU1120897A (en) 1997-05-22
EP0859771A1 (de) 1998-08-26
WO1997016442A1 (en) 1997-05-09

Similar Documents

Publication Publication Date Title
EP0859771A4 (de) Substituierte pyridylpyrrole, solche verbindungen enthaltende zubereitungen und verfahren zu deren nutzung
EP0871444A4 (de) 2,5 substituierte aryl pyrrol, dieses enthaltende zusammensetzungen und dessen verwendung
AU7482396A (en) Substituted aryl pyrroles, compositions containing such compounds and methods of use
SI0807111T1 (en) Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing same
PL323470A1 (en) Application of n-propargil-1-amidoindane (r)-enantionmer, its salts and compositions containing same
HUP9901159A3 (en) Substituted benzylaminopiperidine derivatives and use thereof, pharmaceutical compositions containing these compounds
AU6613996A (en) Heterocyclic compounds and pharmaceutical compositions containing them
EP0811595A4 (de) Hydrochalconderivate, diese enthaltende kosmetische zubereitungen, und verfahren zur herstellung derselben
EP0948257A4 (de) Triaryl-substituierte imidazole, sie enthaltende zusammensetzungen und verfahren zu ihrer verwendung
IL122717A0 (en) Compounds and pharmaceutical compositions containing them
AU7529096A (en) Substituted aryl pyrroles, compositions containing such compounds and methods of use
PL324436A1 (en) Novel derivatives of oxazolydinone, method of obtaining them and therapeutic agents containing such compounds
IL112443A0 (en) Heterocyclic compounds, their preparation and pharmaceutical compositions containing them
IL108800A0 (en) Heterocyclic compounds, their preparation and pharmaceutical compositions containing them
HUP9601680A3 (en) Benzisothiazolyl-substituted aminomethyl-chromanes, pharmaceutical compositions containing the same, process for their preparation and use of the compounds
AU7961498A (en) 9a-azalides, compositions containing such compounds and methods of treatment
AU1841195A (en) 1-beta -methyl-carbapenem, compositions containing same and methods of use
AU7986098A (en) 9a-aza-3-ketolides, compositions containing such compounds and methods of treatment
IL106041A0 (en) Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
HUT76129A (en) Arthropocidal compounds, compositions containing them and process for their preparation
IL107890A0 (en) Substituted n-hydroxycinnamamides, processes for their preparation, compositions containing them and their use
IL123424A0 (en) Heterocyclic compounds their preparation and pharmaceutical compositions containing them
GB9814269D0 (en) 9a-Aza-3-ketolides, compositions containing such compounds and methods of treatment
GB9612062D0 (en) Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
GB9605158D0 (en) Substituted pyridyl pyrroles, compositions containing such compounds and methods of use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980602

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07D 401/04 A, 7A 61K 31/44 B, 7C 07D 403/04 B, 7C 07D 409/14 B, 7C 07D 407/14 B, 7C 07D 401/14 B, 7C 07D 413/14 B, 7C 07D 417/14 B, 7C 07D 401/04 J, 7C 07D 213:00 J, 7C 07D 207:00 J

A4 Supplementary search report drawn up and despatched

Effective date: 20000128

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 20000823

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20030510