EP0844886A2 - Bioconjugues de complexes de manganese et leur application comme catalyseurs - Google Patents

Bioconjugues de complexes de manganese et leur application comme catalyseurs

Info

Publication number
EP0844886A2
EP0844886A2 EP96928057A EP96928057A EP0844886A2 EP 0844886 A2 EP0844886 A2 EP 0844886A2 EP 96928057 A EP96928057 A EP 96928057A EP 96928057 A EP96928057 A EP 96928057A EP 0844886 A2 EP0844886 A2 EP 0844886A2
Authority
EP
European Patent Office
Prior art keywords
alkyl
aryl
groups
attached
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96928057A
Other languages
German (de)
English (en)
Inventor
William L. Neumann
Dennis P. Riley
Randy H. Weiss
Susan L. Henke
Patrick J. Lennon
Karl W. Aston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of EP0844886A2 publication Critical patent/EP0844886A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

Bioconjugués d'imitateurs de mimétiques à faible poids moléculaire de superoxyde-dismutase (S.O.D.) représentés par la formule (I) dans laquelle R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z et n sont tels que définis dans la description. Ces substances s'avèrent bénéfiques comme agents thérapeutiques dans le traitement de pathologies inflammatoires et des troubles tels que les lésions ischémiques/de perfusion répétée, les accidents cérébrovasculaires, l'athérosclérose, et dans toutes les autres formes de destructions ou de lésions tissulaires induites par oxydation.
EP96928057A 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs Withdrawn EP0844886A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US242195P 1995-08-17 1995-08-17
US2421 1995-08-17
PCT/US1996/012767 WO1997006824A2 (fr) 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs

Publications (1)

Publication Number Publication Date
EP0844886A2 true EP0844886A2 (fr) 1998-06-03

Family

ID=21700675

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96928057A Withdrawn EP0844886A2 (fr) 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs

Country Status (12)

Country Link
EP (1) EP0844886A2 (fr)
JP (1) JP2000513322A (fr)
KR (1) KR19990037647A (fr)
CN (1) CN1200039A (fr)
AU (1) AU700958B2 (fr)
BR (1) BR9610347A (fr)
CA (1) CA2229799A1 (fr)
CZ (1) CZ39898A3 (fr)
IL (1) IL123040A0 (fr)
NO (1) NO980649L (fr)
PL (1) PL324993A1 (fr)
WO (1) WO1997006824A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2254142T3 (es) 1999-01-25 2006-06-16 National Jewish Medical And Research Center Porfirinas sustituidas y su uso terapeutico.
US6749832B2 (en) 1999-12-23 2004-06-15 Amersham Plc Labelled ascorbic acid derivatives
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
EP1439842A4 (fr) 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
KR20140001257A (ko) 2008-05-13 2014-01-06 유니버시티 오브 캔사스 금속 추출 펩타이드(ｍａｐ) 태그 및 관련된 방법
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
CN103906756B (zh) * 2011-09-26 2020-03-03 加莱拉实验室有限责任公司 用于治疗疾病的方法
WO2013181461A2 (fr) 2012-06-01 2013-12-05 University Of Kansas Peptide de capture de métal avec une activité superoxyde dismutase
AU2018221043A1 (en) * 2017-02-15 2019-09-12 Galera Labs, Llc Pentaaza macrocyclic ring complexes for local intestinal delivery
CN108752383B (zh) * 2018-05-02 2020-10-30 江苏理工学院 一种具有sod活性的吡唑羧酸酯锰配合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281463A3 (fr) * 1987-03-06 1989-01-25 Sumitomo Pharmaceuticals Company, Limited Complexe de platine, son procédé de préparation et composition pharmaceutique comportant ce complexe
ATE164164T1 (de) * 1991-07-19 1998-04-15 Monsanto Co Mangan-komplexe mit stickstoff enthaltenden makrozyklischen liganden, wirksam als superoxiddismutasekatalysatoren.
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CN1152880A (zh) * 1994-04-22 1997-06-25 孟山都公司 使用含氮大环配拉体的金属络合物的诊断图像分析的方法
US6525041B1 (en) * 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
AU5928396A (en) * 1995-06-07 1996-12-30 Monsanto Company Process for preparing substituted polyazamacrocycles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9706824A2 *

Also Published As

Publication number Publication date
WO1997006824A2 (fr) 1997-02-27
IL123040A0 (en) 1998-09-24
CA2229799A1 (fr) 1997-02-27
AU700958B2 (en) 1999-01-14
MX9801322A (es) 1998-05-31
JP2000513322A (ja) 2000-10-10
BR9610347A (pt) 1999-06-01
AU6765596A (en) 1997-03-12
NO980649L (no) 1998-04-02
NO980649D0 (no) 1998-02-16
WO1997006824A3 (fr) 1997-07-03
CN1200039A (zh) 1998-11-25
CZ39898A3 (cs) 1998-07-15
PL324993A1 (en) 1998-07-06
KR19990037647A (ko) 1999-05-25

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Legal Events

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