MX9801322A - Bioconjugados de complejos de manganeso de ligandos macrociclicos que contienen nitrogeno, efectivos como catalizadores para dismutar superoxido. - Google Patents

Bioconjugados de complejos de manganeso de ligandos macrociclicos que contienen nitrogeno, efectivos como catalizadores para dismutar superoxido.

Info

Publication number
MX9801322A
MX9801322A MX9801322A MX9801322A MX9801322A MX 9801322 A MX9801322 A MX 9801322A MX 9801322 A MX9801322 A MX 9801322A MX 9801322 A MX9801322 A MX 9801322A MX 9801322 A MX9801322 A MX 9801322A
Authority
MX
Mexico
Prior art keywords
bioconjugates
catalysts
application
manganese complexes
injury
Prior art date
Application number
MX9801322A
Other languages
English (en)
Other versions
MXPA98001322A (es
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of MX9801322A publication Critical patent/MX9801322A/es
Publication of MXPA98001322A publication Critical patent/MXPA98001322A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Bioconjugados de imitadores de la superoxido dismutasa (SOD) de bajo peso molecular representados por la formula (I): caracterizados porque R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z y n son como se define en la presente invencion, utiles como agentes terapéuticos para estados y trastornos por enfermedad inflamatoria, tales como lesion isquémica por reperfusion, crisis fulminante, aterosclerosis, y todas las demás condiciones de daño o lesion de tejidos inducidas por oxidantes.
MXPA/A/1998/001322A 1995-08-17 1998-02-17 Bioconjugados de complejos de manganeso de ligandos macrociclicos que contienen nitrogeno, efectivos como catalizadores para dismutar superoxido MXPA98001322A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US242195P 1995-08-17 1995-08-17
US002421 1995-08-17
PCT/US1996/012767 WO1997006824A2 (en) 1995-08-17 1996-08-14 Bioconjugates of manganese complexes and their application as catalysts

Publications (2)

Publication Number Publication Date
MX9801322A true MX9801322A (es) 1998-05-31
MXPA98001322A MXPA98001322A (es) 1998-10-23

Family

ID=

Also Published As

Publication number Publication date
AU700958B2 (en) 1999-01-14
NO980649D0 (no) 1998-02-16
CA2229799A1 (en) 1997-02-27
AU6765596A (en) 1997-03-12
JP2000513322A (ja) 2000-10-10
CZ39898A3 (cs) 1998-07-15
IL123040A0 (en) 1998-09-24
WO1997006824A3 (en) 1997-07-03
KR19990037647A (ko) 1999-05-25
CN1200039A (zh) 1998-11-25
NO980649L (no) 1998-04-02
PL324993A1 (en) 1998-07-06
BR9610347A (pt) 1999-06-01
EP0844886A2 (en) 1998-06-03
WO1997006824A2 (en) 1997-02-27

Similar Documents

Publication Publication Date Title
CA2072934A1 (en) Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
AU5964894A (en) Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CA2224060A1 (en) Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
IL102408A0 (en) Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
KR950701911A (ko) 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제(peripheral vaso-dilating agent containing piperidine derivative as active ingredient)
MA28010A1 (fr) Derives de piperazine et leur utilisation comme agents therapeutiques
ES2191076T3 (es) Nuevos derivados de 1-aril-pirazol y su empleo como plaguicidas.
IL140554A0 (en) Oxamyl derivatives and pharmaceutical compositions containing the same
ATE107499T1 (de) Haarkräftigungsmittel.
MX9805289A (es) Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina.
WO1997006824A3 (en) Bioconjugates of manganese complexes and their application as catalysts
DE69418243D1 (de) N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
PT928788E (pt) Compostos farmaceuticamente activos
NO972726D0 (no) Tricykliske forbindelser
GEP20022654B (en) Indazole Amide Compounds As Serotoninergic Agents
CA2114727A1 (en) Quinoline Derivatives as Immunostimulants
NO984164L (no) Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid
DE69530988D1 (de) Benzimidazolderivate mit dopaminerger wirkung
DK0420121T3 (da) Antitumormiddel
NO984165L (no) Jernkomplekser av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismuterende superoksider
DE69504272D1 (de) N-Arylthiohydrazon-Derivate als insektizide und akarazide Mittel
ES2108298T3 (es) 4-estrenos puenteados en 19,11, activos como gestagenos.
NZ332029A (en) Sulfonamide substituted chromans, process for their preparation, their use as a medicament and pharmaceutical preparations comprising them
CA2133186A1 (en) 3- or 4-glycosyloxybenzopyran derivative and antiallergic agent containing the derivative as active ingredient
CA2267376A1 (en) Process for producing depsipeptide derivatives and novel intermediates therefor