MX9805289A - Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina. - Google Patents
Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina.Info
- Publication number
- MX9805289A MX9805289A MX9805289A MX9805289A MX9805289A MX 9805289 A MX9805289 A MX 9805289A MX 9805289 A MX9805289 A MX 9805289A MX 9805289 A MX9805289 A MX 9805289A MX 9805289 A MX9805289 A MX 9805289A
- Authority
- MX
- Mexico
- Prior art keywords
- arylsulphonyl
- novel
- amino acid
- acid derivatives
- receptor affinity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invencion se refiere a compuestos de formula (I) en la que R1 a R9, R16 y R17 son tal como se define en la reivindicacion (1). Estos compuestos son farmacologicamente activos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9600269A FR2743562B1 (fr) | 1996-01-11 | 1996-01-11 | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9805289A true MX9805289A (es) | 1998-10-31 |
Family
ID=9488041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9805289A MX9805289A (es) | 1996-01-11 | 1998-06-29 | Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina. |
Country Status (12)
Country | Link |
---|---|
US (3) | US6015812A (es) |
EP (1) | EP0877737B1 (es) |
JP (1) | JP4086316B2 (es) |
AT (1) | ATE203745T1 (es) |
AU (1) | AU1383297A (es) |
BR (1) | BR9707120B1 (es) |
DE (1) | DE69705930T2 (es) |
ES (1) | ES2162231T3 (es) |
FR (1) | FR2743562B1 (es) |
MX (1) | MX9805289A (es) |
NO (1) | NO310975B1 (es) |
WO (1) | WO1997025315A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837815A (en) * | 1994-12-15 | 1998-11-17 | Sugen, Inc. | PYK2 related polypeptide products |
ATE226193T1 (de) * | 1996-08-28 | 2002-11-15 | Procter & Gamble | Substituierte zyklische amine als metalloproteaseinhibitoren |
GB9621814D0 (en) * | 1996-10-19 | 1996-12-11 | British Biotech Pharm | Metalloproteinase inhibitors |
FR2765222B1 (fr) * | 1997-06-27 | 1999-12-31 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
WO1999006340A2 (en) | 1997-07-31 | 1999-02-11 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
US6861442B1 (en) * | 1998-12-30 | 2005-03-01 | Sugen, Inc. | PYK2 and inflammation |
SK12462001A3 (sk) | 1999-03-03 | 2002-04-04 | The Procter & Gamble Company | Inhibítory metaloproteáz |
BR0008716A (pt) | 1999-03-03 | 2002-09-24 | Procter & Gamble | Inibidores de metaloprotease contendo alquenil ou alquinil |
GB9913079D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
FR2822827B1 (fr) * | 2001-03-28 | 2003-05-16 | Sanofi Synthelabo | Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant |
BR0209386A (pt) * | 2001-05-14 | 2004-07-06 | Novartis Ag | Derivados de sulfonamida |
AR038377A1 (es) * | 2002-02-08 | 2005-01-12 | Merck & Co Inc | Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo) |
ES2256727T3 (es) * | 2002-02-08 | 2006-07-16 | MERCK & CO., INC. | Derivados de n-bifenilmetil aminocicloalcanocarboxamida. |
AU2003217764A1 (en) | 2002-03-01 | 2003-09-16 | Merck & Co., Inc. | Aminoalkylphosphonates and related compounds as edg receptor agonists |
FR2840897B1 (fr) | 2002-06-14 | 2004-09-10 | Fournier Lab Sa | Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique |
JP4413863B2 (ja) * | 2002-11-07 | 2010-02-10 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体 |
DE602004021358D1 (de) | 2003-03-25 | 2009-07-16 | Fournier Lab Sa | Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen |
FR2852958B1 (fr) * | 2003-03-25 | 2005-06-24 | Fournier Lab Sa | Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique |
CA2423876C (en) | 2003-04-01 | 2013-05-28 | Universite De Sherbrooke | Novel selective bradykinin (bk) b1 peptidic receptor antagonists and uses thereof |
JP2006522835A (ja) | 2003-04-10 | 2006-10-05 | アムジェン インコーポレイテッド | 環状アミン誘導体およびブラジキニンによって媒介される炎症関連障害の処置におけるそれらの使用 |
CA2521937A1 (en) | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof |
US7414134B2 (en) * | 2004-10-12 | 2008-08-19 | Amgen Inc. | B1 bradykinin receptor antagonists |
JP2008515976A (ja) | 2004-10-13 | 2008-05-15 | アムジエン・インコーポレーテツド | トリアゾール及びブラジキニンb1受容体拮抗物質としてのその使用 |
EP2240458B1 (de) * | 2008-02-06 | 2011-08-03 | Boehringer Ingelheim International GmbH | Arylsulfonamide wirksam als schmerzmittel |
AU2009235634B8 (en) * | 2008-04-08 | 2013-05-23 | Grunenthal Gmbh | Substituted sulfonamide derivatives |
CA2752190A1 (en) | 2009-02-13 | 2010-08-19 | Jerini Ag | Small molecule bradykinin b1 receptor antagonists |
WO2011000863A1 (en) * | 2009-07-01 | 2011-01-06 | Dsm Ip Assets B.V. | Sulfonamide derivatives for use in the treatment of skin conditions |
EP2316820A1 (en) | 2009-10-28 | 2011-05-04 | Dompe S.p.A. | 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them |
SI2813502T1 (sl) | 2013-06-14 | 2017-05-31 | Dompe Farmaceutici S.P.A. | Antagonisti receptorja za bradikinin in farmacevtski sestavki, ki jih vsebujejo |
EP3740482A1 (en) | 2018-01-17 | 2020-11-25 | Migal Galilee Research Institute Ltd. | New methionine metabolic pathway inhibitors |
BR112020014561A2 (pt) | 2018-01-17 | 2020-12-08 | Migal - Galilee Research Institute Ltd. | Nibidores inovadores da via metabólica da metionina |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2701480B1 (fr) * | 1993-02-15 | 1995-05-24 | Sanofi Elf | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
-
1996
- 1996-01-11 FR FR9600269A patent/FR2743562B1/fr not_active Expired - Fee Related
-
1997
- 1997-01-07 US US09/101,214 patent/US6015812A/en not_active Expired - Lifetime
- 1997-01-07 AU AU13832/97A patent/AU1383297A/en not_active Abandoned
- 1997-01-07 AT AT97900243T patent/ATE203745T1/de not_active IP Right Cessation
- 1997-01-07 BR BRPI9707120-0A patent/BR9707120B1/pt not_active IP Right Cessation
- 1997-01-07 WO PCT/FR1997/000026 patent/WO1997025315A1/fr active IP Right Grant
- 1997-01-07 DE DE69705930T patent/DE69705930T2/de not_active Expired - Lifetime
- 1997-01-07 JP JP52491697A patent/JP4086316B2/ja not_active Expired - Fee Related
- 1997-01-07 ES ES97900243T patent/ES2162231T3/es not_active Expired - Lifetime
- 1997-01-07 EP EP97900243A patent/EP0877737B1/fr not_active Expired - Lifetime
-
1998
- 1998-06-29 MX MX9805289A patent/MX9805289A/es not_active IP Right Cessation
- 1998-07-10 NO NO19983190A patent/NO310975B1/no not_active IP Right Cessation
-
1999
- 1999-11-04 US US09/434,333 patent/US6100278A/en not_active Expired - Lifetime
-
2000
- 2000-06-13 US US09/593,067 patent/US6313120B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2743562A1 (fr) | 1997-07-18 |
DE69705930T2 (de) | 2002-04-11 |
AU1383297A (en) | 1997-08-01 |
EP0877737B1 (fr) | 2001-08-01 |
JP4086316B2 (ja) | 2008-05-14 |
EP0877737A1 (fr) | 1998-11-18 |
FR2743562B1 (fr) | 1998-04-03 |
NO310975B1 (no) | 2001-09-24 |
WO1997025315A1 (fr) | 1997-07-17 |
US6015812A (en) | 2000-01-18 |
JP2000504315A (ja) | 2000-04-11 |
US6100278A (en) | 2000-08-08 |
BR9707120A (pt) | 1999-07-20 |
DE69705930D1 (de) | 2001-09-06 |
ES2162231T3 (es) | 2001-12-16 |
BR9707120B1 (pt) | 2010-10-05 |
NO983190L (no) | 1998-07-10 |
ATE203745T1 (de) | 2001-08-15 |
US6313120B1 (en) | 2001-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
HC | Change of company name or juridical status |
Owner name: SANOFI-AVENTIS |
|
PD | Change of proprietorship |
Owner name: SANOFI-AVENTIS |
|
HC | Change of company name or juridical status |
Owner name: SANOFI-AVENTIS |
|
MM | Annulment or lapse due to non-payment of fees |