MX9805289A - Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina. - Google Patents

Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina.

Info

Publication number
MX9805289A
MX9805289A MX9805289A MX9805289A MX9805289A MX 9805289 A MX9805289 A MX 9805289A MX 9805289 A MX9805289 A MX 9805289A MX 9805289 A MX9805289 A MX 9805289A MX 9805289 A MX9805289 A MX 9805289A
Authority
MX
Mexico
Prior art keywords
arylsulphonyl
novel
amino acid
acid derivatives
receptor affinity
Prior art date
Application number
MX9805289A
Other languages
English (en)
Inventor
Bernard Ferrari
Jean Gougat
Claude Muneaux
Yvette Muneaux
Pierre Perreaut
Claudine Planchenault
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9488041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9805289(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX9805289A publication Critical patent/MX9805289A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invencion se refiere a compuestos de formula (I) en la que R1 a R9, R16 y R17 son tal como se define en la reivindicacion (1). Estos compuestos son farmacologicamente activos.
MX9805289A 1996-01-11 1998-06-29 Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina. MX9805289A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9600269A FR2743562B1 (fr) 1996-01-11 1996-01-11 Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
MX9805289A true MX9805289A (es) 1998-10-31

Family

ID=9488041

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805289A MX9805289A (es) 1996-01-11 1998-06-29 Nuevos derivados de n-(arilsulfonil)aminoacidos que tienen una afinidad por los receptores de la bradicinina.

Country Status (12)

Country Link
US (3) US6015812A (es)
EP (1) EP0877737B1 (es)
JP (1) JP4086316B2 (es)
AT (1) ATE203745T1 (es)
AU (1) AU1383297A (es)
BR (1) BR9707120B1 (es)
DE (1) DE69705930T2 (es)
ES (1) ES2162231T3 (es)
FR (1) FR2743562B1 (es)
MX (1) MX9805289A (es)
NO (1) NO310975B1 (es)
WO (1) WO1997025315A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
ATE226193T1 (de) * 1996-08-28 2002-11-15 Procter & Gamble Substituierte zyklische amine als metalloproteaseinhibitoren
GB9621814D0 (en) * 1996-10-19 1996-12-11 British Biotech Pharm Metalloproteinase inhibitors
FR2765222B1 (fr) * 1997-06-27 1999-12-31 Fournier Ind & Sante Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
WO1999006340A2 (en) 1997-07-31 1999-02-11 The Procter & Gamble Company Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
SK12462001A3 (sk) 1999-03-03 2002-04-04 The Procter & Gamble Company Inhibítory metaloproteáz
BR0008716A (pt) 1999-03-03 2002-09-24 Procter & Gamble Inibidores de metaloprotease contendo alquenil ou alquinil
GB9913079D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
FR2819254B1 (fr) * 2001-01-08 2003-04-18 Fournier Lab Sa Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
BR0209386A (pt) * 2001-05-14 2004-07-06 Novartis Ag Derivados de sulfonamida
AR038377A1 (es) * 2002-02-08 2005-01-12 Merck & Co Inc Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)
ES2256727T3 (es) * 2002-02-08 2006-07-16 MERCK & CO., INC. Derivados de n-bifenilmetil aminocicloalcanocarboxamida.
AU2003217764A1 (en) 2002-03-01 2003-09-16 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
FR2840897B1 (fr) 2002-06-14 2004-09-10 Fournier Lab Sa Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
JP4413863B2 (ja) * 2002-11-07 2010-02-10 メルク エンド カムパニー インコーポレーテッド 糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
DE602004021358D1 (de) 2003-03-25 2009-07-16 Fournier Lab Sa Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen
FR2852958B1 (fr) * 2003-03-25 2005-06-24 Fournier Lab Sa Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique
CA2423876C (en) 2003-04-01 2013-05-28 Universite De Sherbrooke Novel selective bradykinin (bk) b1 peptidic receptor antagonists and uses thereof
JP2006522835A (ja) 2003-04-10 2006-10-05 アムジェン インコーポレイテッド 環状アミン誘導体およびブラジキニンによって媒介される炎症関連障害の処置におけるそれらの使用
CA2521937A1 (en) 2003-04-10 2004-10-28 Amgen, Inc. Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof
US7414134B2 (en) * 2004-10-12 2008-08-19 Amgen Inc. B1 bradykinin receptor antagonists
JP2008515976A (ja) 2004-10-13 2008-05-15 アムジエン・インコーポレーテツド トリアゾール及びブラジキニンｂ１受容体拮抗物質としてのその使用
EP2240458B1 (de) * 2008-02-06 2011-08-03 Boehringer Ingelheim International GmbH Arylsulfonamide wirksam als schmerzmittel
AU2009235634B8 (en) * 2008-04-08 2013-05-23 Grunenthal Gmbh Substituted sulfonamide derivatives
CA2752190A1 (en) 2009-02-13 2010-08-19 Jerini Ag Small molecule bradykinin b1 receptor antagonists
WO2011000863A1 (en) * 2009-07-01 2011-01-06 Dsm Ip Assets B.V. Sulfonamide derivatives for use in the treatment of skin conditions
EP2316820A1 (en) 2009-10-28 2011-05-04 Dompe S.p.A. 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them
SI2813502T1 (sl) 2013-06-14 2017-05-31 Dompe Farmaceutici S.P.A. Antagonisti receptorja za bradikinin in farmacevtski sestavki, ki jih vsebujejo
EP3740482A1 (en) 2018-01-17 2020-11-25 Migal Galilee Research Institute Ltd. New methionine metabolic pathway inhibitors
BR112020014561A2 (pt) 2018-01-17 2020-12-08 Migal - Galilee Research Institute Ltd. Nibidores inovadores da via metabólica da metionina

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701480B1 (fr) * 1993-02-15 1995-05-24 Sanofi Elf Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
FR2743562A1 (fr) 1997-07-18
DE69705930T2 (de) 2002-04-11
AU1383297A (en) 1997-08-01
EP0877737B1 (fr) 2001-08-01
JP4086316B2 (ja) 2008-05-14
EP0877737A1 (fr) 1998-11-18
FR2743562B1 (fr) 1998-04-03
NO310975B1 (no) 2001-09-24
WO1997025315A1 (fr) 1997-07-17
US6015812A (en) 2000-01-18
JP2000504315A (ja) 2000-04-11
US6100278A (en) 2000-08-08
BR9707120A (pt) 1999-07-20
DE69705930D1 (de) 2001-09-06
ES2162231T3 (es) 2001-12-16
BR9707120B1 (pt) 2010-10-05
NO983190L (no) 1998-07-10
ATE203745T1 (de) 2001-08-15
US6313120B1 (en) 2001-11-06

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: SANOFI-AVENTIS

PD Change of proprietorship

Owner name: SANOFI-AVENTIS

HC Change of company name or juridical status

Owner name: SANOFI-AVENTIS

MM Annulment or lapse due to non-payment of fees