EP0736007A4 - Antagonistes non peptidiques des recepteurs des tachykinines - Google Patents
Antagonistes non peptidiques des recepteurs des tachykininesInfo
- Publication number
- EP0736007A4 EP0736007A4 EP95904891A EP95904891A EP0736007A4 EP 0736007 A4 EP0736007 A4 EP 0736007A4 EP 95904891 A EP95904891 A EP 95904891A EP 95904891 A EP95904891 A EP 95904891A EP 0736007 A4 EP0736007 A4 EP 0736007A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- tachykinin receptor
- peptide tachykinin
- peptide
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17113493A | 1993-12-21 | 1993-12-21 | |
US171134 | 1993-12-21 | ||
PCT/US1994/014312 WO1995017382A1 (fr) | 1993-12-21 | 1994-12-14 | Antagonistes non peptidiques des recepteurs des tachykinines |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0736007A1 EP0736007A1 (fr) | 1996-10-09 |
EP0736007A4 true EP0736007A4 (fr) | 1997-03-19 |
Family
ID=22622667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95904891A Withdrawn EP0736007A4 (fr) | 1993-12-21 | 1994-12-14 | Antagonistes non peptidiques des recepteurs des tachykinines |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0736007A4 (fr) |
JP (1) | JPH09506898A (fr) |
AU (1) | AU1339795A (fr) |
CA (1) | CA2176130A1 (fr) |
MX (1) | MXPA99001870A (fr) |
WO (1) | WO1995017382A1 (fr) |
ZA (1) | ZA9410040B (fr) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5492927A (en) * | 1993-12-21 | 1996-02-20 | Eli Lilly And Company | Non-peptide tachykinin receptor antagonists to treat allergy |
JPH09507071A (ja) * | 1993-12-21 | 1997-07-15 | イーライ・リリー・アンド・カンパニー | アミロイド原性ペプチドに関連した状態を治療又は予防する方法 |
IL115582A0 (en) * | 1994-10-14 | 1996-01-19 | Lilly Co Eli | Methods for treating resistant tumors |
AU3953695A (en) * | 1994-10-20 | 1996-05-15 | Eli Lilly And Company | Bicyclic bradykinin receptor antagonists |
EP0895781A3 (fr) * | 1994-10-20 | 1999-07-07 | Eli Lilly And Company | Utilisation de benzofuranes, benzothiophénes ou d'indoles pour la fabrication d'un médicament pour le tratement de consitions provoquèes par un excés de tachykinines |
EP0910369B1 (fr) * | 1996-03-26 | 2010-04-21 | Eli Lilly And Company | Benzothiofenes, formulations dans lesquelles ils entrent et techniques |
US6458811B1 (en) | 1996-03-26 | 2002-10-01 | Eli Lilly And Company | Benzothiophenes formulations containing same and methods |
CA2206752A1 (fr) * | 1996-07-02 | 1998-01-02 | George Joseph Cullinan | Composes de benzothiophene,intermediaires, procedes et methodes d'utilisation |
US6288105B1 (en) | 1997-04-30 | 2001-09-11 | Eli Lilly And Company | Antithrombotic agents |
EP1027051B1 (fr) | 1997-04-30 | 2005-01-05 | Eli Lilly And Company | Agents antithrombotiques |
JP2001522373A (ja) | 1997-04-30 | 2001-11-13 | イーライ・リリー・アンド・カンパニー | 抗血栓剤 |
AU7274098A (en) | 1997-04-30 | 1998-11-24 | Eli Lilly And Company | Antithrombotic agents |
US6284756B1 (en) | 1998-04-30 | 2001-09-04 | Eli Lilly And Company | Antithrombotic agents |
ATE229520T1 (de) * | 1998-10-28 | 2002-12-15 | Lilly Co Eli | Benzothiophenderivate als antithrombotische mitteln und zwischenprodukte |
JP2004531559A (ja) | 2001-05-22 | 2004-10-14 | イーライ・リリー・アンド・カンパニー | エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体 |
ATE321754T1 (de) | 2001-05-22 | 2006-04-15 | Lilly Co Eli | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren |
GB0130305D0 (en) * | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
MX2007000428A (es) | 2004-07-15 | 2008-03-05 | Amr Technology Inc | Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina. |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
CA2615403C (fr) | 2005-07-15 | 2015-06-16 | Amr Technology, Inc. | Tetrahydrobenzazepines substituees par aryle et heteroaryle, et leur utilisation pour bloquer la reabsorption de la noradrenaline, de la dopamine, et de la serotonine |
AU2006297443B2 (en) | 2005-09-29 | 2010-08-12 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
CA2664113C (fr) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Utilisation de la platencine et de la platensimycine en tant qu'inhibiteurs de la synthese des acides gras pour traiter l'obesite, lediabete et le cancer |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP2109608B1 (fr) | 2007-01-10 | 2011-03-23 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Indazoles à substitution amide utilisés comme inhibiteurs de la poly(adp-ribose)polymérase (parp) |
US8106086B2 (en) | 2007-04-02 | 2012-01-31 | Msd K.K. | Indoledione derivative |
JP5501227B2 (ja) | 2007-06-27 | 2014-05-21 | メルク・シャープ・アンド・ドーム・コーポレーション | ヒストンデアセチラーゼ阻害剤としての4−カルボキシベンジルアミノ誘導体 |
AU2009222122A1 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
EP2413932A4 (fr) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | Inhibiteurs de l'activité akt |
EP2429293B1 (fr) | 2009-05-12 | 2014-10-29 | Bristol-Myers Squibb Company | FORMES CRISTALLINES DE (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN -6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE ET LEURS UTILISATIONS |
KR20120034644A (ko) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
ES2662072T3 (es) | 2009-05-12 | 2018-04-05 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma |
KR101485645B1 (ko) | 2009-10-14 | 2015-01-22 | 머크 샤프 앤드 돔 코포레이션 | p53 활성을 증가시키는 치환된 피페리딘 및 그의 용도 |
WO2011163330A1 (fr) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk |
CN107090456B (zh) | 2010-08-02 | 2022-01-18 | 瑟纳治疗公司 | 使用短干扰核酸的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1基因表达的抑制 |
HUE044815T2 (hu) | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (fr) | 2010-09-01 | 2012-03-08 | Schering Corporation | Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
WO2012058210A1 (fr) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | INHIBITION FACILITÉE PAR L'INTERFÉRENCE D'ARN DE L'EXPRESSION D'UN GÈNE AU MOYEN D'ACIDES NUCLÉIQUES INTERFÉRENTS COURTS (siNA) |
US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
CN103732592A (zh) | 2011-04-21 | 2014-04-16 | 默沙东公司 | 胰岛素样生长因子-1受体抑制剂 |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
EP3919620A1 (fr) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Compositions d'acide nucléique interférent court (sina) |
CA2882950A1 (fr) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Nouveaux composes inhibiteurs de erk |
LT2925888T (lt) | 2012-11-28 | 2018-01-10 | Merck Sharp & Dohme Corp. | Vėžio gydymo kompozicijos ir būdai |
BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
WO2014120748A1 (fr) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2 |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
US20210309688A1 (en) | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US20210277009A1 (en) | 2018-08-07 | 2021-09-09 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4024273A (en) * | 1974-06-20 | 1977-05-17 | Smithkline Corporation | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138163A (en) * | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
US3975537A (en) * | 1973-09-21 | 1976-08-17 | Smith Kline | Pharmaceutical compositions and methods of producing coronary vasodilation |
US3880891A (en) * | 1973-09-21 | 1975-04-29 | Smithkline Corp | Substituted benzofurans |
US3947470A (en) * | 1974-06-20 | 1976-03-30 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
-
1994
- 1994-12-14 AU AU13397/95A patent/AU1339795A/en not_active Abandoned
- 1994-12-14 CA CA002176130A patent/CA2176130A1/fr not_active Abandoned
- 1994-12-14 WO PCT/US1994/014312 patent/WO1995017382A1/fr not_active Application Discontinuation
- 1994-12-14 EP EP95904891A patent/EP0736007A4/fr not_active Withdrawn
- 1994-12-14 JP JP7517478A patent/JPH09506898A/ja active Pending
- 1994-12-15 ZA ZA9410040A patent/ZA9410040B/xx unknown
-
1999
- 1999-02-25 MX MXPA99001870A patent/MXPA99001870A/es unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4024273A (en) * | 1974-06-20 | 1977-05-17 | Smithkline Corporation | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity |
Non-Patent Citations (11)
Title |
---|
CHEMICAL ABSTRACTS, vol. 105, no. 5, 4 August 1986, Columbus, Ohio, US; abstract no. 42591k, HUANG, WENLONG ET AL: "Synthesis of ..." XP002023027 * |
CHEMICAL ABSTRACTS, vol. 106, no. 9, 2 March 1987, Columbus, Ohio, US; abstract no. 60767x, DAI,DEZAI ET AL.: "Anticonvulsant and analgesic activities of ..." XP002023026 * |
CHEMICAL ABSTRACTS, vol. 111, no. 7, 14 August 1989, Columbus, Ohio, US; abstract no. 57444n, DUNARI, NEELAM ET AL: "Structure-activity relationship of antiestrogens. ..." XP002023025 * |
CHEMICAL ABSTRACTS, vol. 88, no. 3, 16 January 1978, Columbus, Ohio, US; abstract no. 22527w, INION, HENRI ET AL: "Study of the indole series. IV. ..." XP002023028 * |
CHEMICAL ABSTRACTS, vol. 99, no. 19, 7 November 1983, Columbus, Ohio, US; abstract no. 158165m, DURANI, N. ET AL: "A convenient synthesis of ..." XP002023029 * |
EUR. J. MED. CHEM. - CHIM. THER., vol. 12, no. 5, - 1977, pages 483 - 487 * |
INDIAN J. CHEM., SECT. B, vol. 22b, no. 5, - 1983, pages 489 - 490 * |
J. MED. CHEM., vol. 32, no. 8, - 1989, pages 1700 - 1707 * |
NANJING YAOXUEYUAN XUEBAO, vol. 17, no. 3, - 1986, pages 225 - 228 * |
See also references of WO9517382A1 * |
YAOXUE XUEBAO, vol. 20, no. 10, - 1985, pages 737 - 746 * |
Also Published As
Publication number | Publication date |
---|---|
CA2176130A1 (fr) | 1995-06-29 |
WO1995017382A1 (fr) | 1995-06-29 |
JPH09506898A (ja) | 1997-07-08 |
MXPA99001870A (es) | 2004-09-06 |
AU1339795A (en) | 1995-07-10 |
ZA9410040B (en) | 1996-06-18 |
EP0736007A1 (fr) | 1996-10-09 |
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