EP0695161B1 - Preparations topiques cosmetiques et medicales - Google Patents

Preparations topiques cosmetiques et medicales Download PDF

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Publication number
EP0695161B1
EP0695161B1 EP94913592A EP94913592A EP0695161B1 EP 0695161 B1 EP0695161 B1 EP 0695161B1 EP 94913592 A EP94913592 A EP 94913592A EP 94913592 A EP94913592 A EP 94913592A EP 0695161 B1 EP0695161 B1 EP 0695161B1
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EP
European Patent Office
Prior art keywords
parts
xylitol
substances
sodium
pyrrolidone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP94913592A
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German (de)
English (en)
Other versions
EP0695161A1 (fr
Inventor
Sven Gohla
Friedrich Heinze
Jens Nielsen
Carl Thamssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
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Filing date
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Publication of EP0695161A1 publication Critical patent/EP0695161A1/fr
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Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/002—Aftershave preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to cosmetic care products and medical topical preparations, in particular those that, applied to the skin or mucous membranes, have a moisturizing and cooling effect.
  • compositions are known per se.
  • ionic compounds especially ammonium salts, described as cooling agents.
  • cooling preparations isopropanolic gels with camphor and menthol additives applied.
  • essential oils are common, especially Camphor and menthol, but also their derivatives, e.g. Menthyl lactate or menthyl 3-hydroxybutyrate, in cooling Compositions incorporated.
  • the object of the present invention was therefore caring cosmetic and medical preparations available to face the disadvantages of the prior art have, especially those which, on the skin or Mucous membranes applied, moisturizing and / or cooling Act.
  • this object is achieved through the use cosmetically or pharmaceutically harmless Substances with positive enthalpy of solution for the production of cosmetic or medicinally topical preparations for skin care, the substance or substances in the Preparations in a largely anhydrous medium are present and / or through a material barrier of be shielded from a water-containing medium.
  • the object is achieved by cosmetic and dermatological compositions containing one or more sugar alcohols of the general formula the sugar alcohol (s) being present in the preparations in a largely anhydrous medium and / or being shielded from a water-containing medium by a material barrier.
  • Xylitol has the structural formula in Fischer's notation
  • Xylitol can be technically hydrogenated from xylose and is e.g. as a sugar substitute used for diabetics. It serves occasionally in cosmetic preparations as humectants.
  • uronic acids of the general formula (or their cyclic forms) and their salts are uronic acids of the general formula (or their cyclic forms) and their salts, provided that these uronic acids or uronic acid salts are distinguished by a positive enthalpy of solution and by cosmetic or pharmaceutical safety.
  • An advantageous uronic acid salt according to the invention is sodium mannuronate, which is characterized by the following structure:
  • cooling effect of xylitol according to the invention in combinations with substances, selected from the group mannitol, sorbitol, propylene glycol, Glycerin, urea, 2-pyrrolidone-5-carboxylic acid and their Sodium salt and sodium mannuronate can be increased.
  • the increase in cooling effect is in relation to the cooling effect of the individual substances superadditive and is therefore based on a synergism.
  • Mixtures of xylitol and at least one of the substances selected from the group consisting of mannitol, sorbitol, glycerol, propylene glycol, urea, 2-pyrrolidone-5-carboxylic acid, sodium (2-pyrrolidone-5) carboxylate, sodium mannuronate, NH 4 are particularly advantageous Cl and tartaric acid and / or their salts.
  • the advantageous xylitol content 0.5 - 99.5 wt .-%, based on the total weight of these compositions.
  • the material barrier according to the invention can, for example consist of having the substance or substances positive enthalpy of solution microencapsulated.
  • Typical is the shell material in a solvent - colloidal or as a real solution - to solve and the core material, thus the later content of the microcapsules, in the resulting one Solution as a solid or as a fine droplet to disperse.
  • the said dispersion is divided into the finest droplets, in a heated medium, e.g. hot air, sprayed.
  • the solvent evaporates.
  • the wrapping material falls out again as a solid and forms a shell the core material. So there are already raw microcapsules before, which is still subjected to the usual preparation steps and incorporated into the final preparations can. This method uses the well-known phenomenon of coacervation.
  • Another option is to cover the microcapsules by interfacial polymerization of the shell material to create. This means that not the final one Shell material is used as such, but preliminary stages, For example, monomers that are on the core material attach and polymerize there to the final wrapping film.
  • Fat coating processes are also advantageous embodiments of the method according to the invention.
  • the materials for the microencapsulation can be advantageous from the usual hydrophilic or hydrophobic substances or mixtures thereof can be selected. Solids, in particular natural polymeric materials, e.g. Strength and other polysaccharides are preferred. But also synthetic Polymers can be used advantageously.
  • casing materials are fats and / or waxes, preferably those with a solidification temperature of approx. 35 - 80 ° C. Mixtures are particularly advantageous from cetyl palmitate and cetyl alcohol.
  • polysaccharides and their derivatives natural and partially synthetic origin in particular Cellulose derivatives, including in particular those Derivatives of chitin are to be understood.
  • the polymers the ⁇ - and / or ⁇ -hydroxycarboxylic acids, in particular the polymers of glycolic acid (polyglycolide), the Lactic acid (polylactide), ⁇ -hydroxybutyric acid (polyhydroxybutyrate), ⁇ -hydroxyvaleric acid (polyhydroxyvalerate) and / or their copolymers or mixtures from such polymers and / or copolymers.
  • the working temperature is not should be more than 90 ° C.
  • microcapsules can, as is known to those skilled in the art can be opened in many ways. So they can go through mechanical force broken or by chemical, e.g. enzymatic, processes are opened and release the active ingredient (s) from the core of the capsule.
  • the core material is in the solvent is as little soluble as possible.
  • the cosmetic and / or dermatological invention Preparations can be composed as usual and to treat the skin and / or hair in the sense a dermatological treatment or a treatment in the Serving the senses of nourishing cosmetics. But you can too used in make-up products in decorative cosmetics will. They preferably contain 0.01% by weight to 30% by weight, but in particular 0.1 wt .-% to 10 wt .-%, cosmetic or pharmaceutically acceptable substances with positive Enthalpy of solution, especially sugar alcohols, especially prefers xylitol, as long as it is guaranteed that the Substance or the substances in the preparations in one largely anhydrous medium are present and / or through a material barrier from a water-containing medium be shielded.
  • preparations according to the invention are used sufficient in the usual manner for cosmetics and dermatics Amount applied to the skin.
  • the preparations according to the invention can be prepared in various Shapes are available. So you can e.g. a solution, a water-in-oil (W / O) or type emulsion Oil-in-water (O / W), or multiple emulsions, for example of the type water-in-oil-in-water (W / O / W), one gel, one Hydrodispersion, a solid stick or an aerosol represent.
  • the cosmetic preparations according to the invention can cosmetic auxiliaries, as they usually contain used in such preparations, e.g. Preservatives, Bactericides, perfumes, preventive agents of foaming, dyes, pigments, which is a coloring
  • Preservatives Bactericides, perfumes, preventive agents of foaming, dyes, pigments, which is a coloring
  • mixtures of the above Solvent used. With alcoholic solvents water can be another ingredient.
  • Gels according to the invention usually contain alcohols low C number, e.g. Ethanol, isopropanol, 1,2-propanediol, Glycerin and water or an oil mentioned above in the presence of a thickener that is used in oily alcoholic
  • a thickener that is used in oily alcoholic
  • gels silicon dioxide or an aluminum silicate, for aqueous-alcoholic or alcoholic Gel is preferably a polyacrylate.
  • aluminum silicates such as Bentonite, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
  • the Thickener is in the gel e.g. in a lot between 0.1 and 30% by weight, preferably between 0.5 and 15 % By weight.
  • Fixed pins according to the invention contain e.g. natural or synthetic waxes, fatty alcohols, metal soaps or Fatty acid esters.
  • sprayable cosmetic or dermatological preparations are the usual known volatile, liquefied Blowing agents, for example hydrocarbons (Propane, butane, isobutane) suitable alone or in Mixture can be used together. Compressed air too is advantageous to use.
  • hydrocarbons Propane, butane, isobutane
  • the preparations according to the invention can advantageously be used in Form of deodorant cosmetics.
  • They contain one or more substances from the trap Group of substances commonly called deodorant or antiperspirant substances use Find.
  • Aluminum chlorohydrate, but also mixtures, are advantageous as described for example in DE-OS 37 40 186 will.
  • the preparations according to the invention can preferably also contain substances that contain UV radiation in the UVB range absorb, the total amount of filter substances e.g. 0.1% to 30% by weight, preferably 0.5 is up to 10% by weight, in particular 1 to 6% by weight on the total weight of the preparation to make cosmetic To provide preparations that cover the skin protect the entire range of ultraviolet radiation. They can also serve as sunscreens.
  • Emulsions according to the invention e.g. in the form of a sunscreen cream, a sunscreen lotion or sunscreen milk are advantageous and contain e.g. the above Fats, oils, waxes and other fat bodies, as well Water and an emulsifier, as is usually the case for one such type of formulation is used.
  • UVB filters should go without saying not be limiting.
  • UVA filter which is used advantageously according to the invention are, for example, derivatives of dibenzoylmethane, especially 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. It can be used for the UVB combination used amounts are used.
  • UVA filters should go without saying also not to be limiting.
  • the preparations according to the invention can also be inorganic Contain pigments commonly found in cosmetics to protect the skin from UV rays. These are oxides of titanium, zinc, iron, Zirconium, silicon, manganese, aluminum, cerium and Mixtures of these, as well as modifications in which the oxides are the active agents. It is particularly preferred are pigments based on titanium dioxide.
  • Such cosmetic and dermatological ones are also advantageous Preparations in the form of a sunscreen, of a pre-soleil or consortium-soleil product. These additionally advantageously contain at least a UVA filter and / or at least one UVB filter and / or at least one inorganic pigment.
  • Xylitol is presented in micronized form. Over a The nozzle becomes a mixture of polylactide and methyl cellulose in a ratio of 1:10, which is dissolved in chloroform, and which is heated to a temperature of 60 ° C was in the fluidized bed process on the xylitol particles upset.
  • microcapsules containing solid Xylitol present obtained in high yield.
  • Micronized xylitol is added to a kneader mixer suitable for mixing powder.
  • a triglyceride mixture (Witepsol R , high-melting variants, Dynamit Nobel) is combined with the micronized xylitol at 40 ° C. The resulting mixture is cooled to room temperature with constant vigorous agitation.
  • microcapsules containing solid Xylitol present obtained in high yield.
  • a mixture according to Example 1 is in micronized form submitted.
  • a mixture of polylactide is passed through a nozzle and 1:10 methyl cellulose in chloroform is present in solution, and which to a temperature was heated from 60 ° C, in a fluidized bed process on the Solid particles applied.
  • microcapsules containing one in solid Form present mixture according to Example 1 in high yield receive.
  • Body lotion % By weight Arlatone 985 4.00 Brij 78 2.00 Miglyol 812 5.00 Paraffin oil DAB 9 5.00 Microcapsules according to example 13 5.00 Perfume, colors and preservatives q.s. H 2 O ad 100.00
  • Body splash % By weight Ethanol 40.00 Carbopol 940 0.40 Diisopropanolamine 0.40 Uvinul D50 0.05 Polyethylene glycol 2000 monooleate 5.00 Microcapsules according to example 12 10.00 Perfume, colors and preservatives q.s. H 2 O ad 100.00
  • Deodorant spray % By weight Irgasan DP 300 0.10 n-octyldodecanol 0.50 Microcapsules according to Example 11 5.00 Ethanol 33.40 Propane / Butane 2.7 (propellant) ad 100.00
  • Deodorant pen % By weight Irgasan DP 300 0.20 Sodium stearate 7.00 1,2-propylene glycol 30.30 Microcapsules according to Example 11 20.00 Triton X 100 4.00 Ethanol 31.00 H 2 O VES 6.00
  • Deodorant pump spray % By weight Irgasan DP 300 0.20 Triton X 100 0.50 Ethanol 65.00 Microcapsules according to example 13 12.00 Perfume, dyes q.s. H 2 O ad 100.00
  • Deodorant gel % By weight Chlorhexidine diacetate 0.10 Triton X 100 3.00 Hydroxyethyl cellulose 0.50 Ethanol 40.00 Microcapsules according to example 13 20.00 Perfume, dyes q.s. H 2 O ad 100.00
  • Deodorant emulsion % By weight Irgasan DP 300 0.10 Glyceryl stearate 4.00 PEG-40 cetylstearyl alcohol 3.00 2-octyldodecanol 5.00 Ethanol 10.00 Polyacrylate / methacrylate copolymer (Lubragel, Sederma) 0.70 Glycerin 2.00 Microcapsules according to example 13 15.00 Perfume, dyes q.s. H 2 O ad 100.00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (7)

  1. Utilisation de substances cosmétiquement ou pharmaceutiquement acceptables, à enthalpie positive de dissolution, pour la production de préparations topiques cosmétiques ou médicales rafraíchissantes pour le soin de la peau, la substance ou les substances dans les préparations étant présente(s) dans un milieu essentiellement anhydre et/ou étant protégée(s) d'un milieu aqueux par une barrière matérielle.
  2. Utilisation selon la revendication 1, caractérisée en ce que l'on choisit comme substance ou substances à enthalpie positive de dissolution un ou plusieurs alcools glucidiques de formule générale
    Figure 00320001
  3. Utilisation selon la revendication 2, caractérisée en ce que l'alcool glucidique est le xylitol.
  4. Utilisation selon la revendication 1, caractérisée en ce que la barrière matérielle consiste en ce que la substance ou les substances à enthalpie positive de dissolution sont microencapsulées.
  5. Utilisation selon la revendication 3, caractérisée en ce que le xylitol est présent en association avec au moins l'une des substances choisies dans l'ensemble constitué par le mannitol, le sorbitol, le propylèneglycol, le glycérol, l'urée, l'acide 2-pyrrolidone-5-carboxylique et son sel de sodium, ainsi que le mannuronate de sodium.
  6. Utilisation selon la revendication 5, caractérisée en ce que sont contenues des associations de:
    0,5 - 10,0 parties de xylitol
    0,0 - 5,0 parties de mannitol
    0,0 - 5,0 parties de sorbitol
    0,0 - 5,0 parties de glycérol
    0,0 - 5,0 parties de propylèneglycol
    0,0 - 5,0 parties d'urée
    0,0 - 5,0 parties de (2-pyrrolidone-5-)carboxylate de sodium
    0,0 - 5,0 parties de mannuronate de sodium
    par rapport à la composition totale de la préparation, à la condition qu'au moins l'un des composants à l'exception du xylitol se trouve à une concentration d'au moins 0,1% en poids.
  7. Utilisation selon la revendication 6, caractérisée en ce que sont contenues des associations de:
    0,5 - 10,0 parties de xylitol
    0,0 - 5,0 parties de mannitol
    0,0 - 5,0 parties de sorbitol
    0,0 - 5,0 parties de glycérol
    0,0 - 5,0 parties de propylèneglycol
    0,0 - 5,0 parties d'urée
    0,0 - 5,0 parties d'acide 2-pyrrolidone-5-carboxylique
    0,0 - 5,0 parties de (2-pyrrolidone-5-)carboxylate de sodium
    0,0 - 5,0 parties de mannuronate de sodium
    par rapport à la composition totale de la préparation, à la condition qu'au moins l'un des composants à l'exception du xylitol se trouve à une concentration d'au moins 1,0% en poids.
EP94913592A 1993-04-19 1994-04-13 Preparations topiques cosmetiques et medicales Expired - Lifetime EP0695161B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4312656A DE4312656C2 (de) 1993-04-19 1993-04-19 Kühlend wirkende kosmetische oder dermatologische Zusammensetzungen
DE4312656 1993-04-19
PCT/EP1994/001145 WO1994023688A2 (fr) 1993-04-19 1994-04-13 Preparations topiques cosmetiques et medicales

Publications (2)

Publication Number Publication Date
EP0695161A1 EP0695161A1 (fr) 1996-02-07
EP0695161B1 true EP0695161B1 (fr) 1998-04-01

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EP94913592A Expired - Lifetime EP0695161B1 (fr) 1993-04-19 1994-04-13 Preparations topiques cosmetiques et medicales

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US (1) US5861440A (fr)
EP (1) EP0695161B1 (fr)
JP (1) JPH08508745A (fr)
AT (1) ATE164512T1 (fr)
DE (2) DE4312656C2 (fr)
ES (1) ES2115945T3 (fr)
WO (1) WO1994023688A2 (fr)

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ES2115945T3 (es) 1998-07-01
DE4312656C2 (de) 1996-01-25
JPH08508745A (ja) 1996-09-17
DE59405590D1 (de) 1998-05-07
ATE164512T1 (de) 1998-04-15
WO1994023688A3 (fr) 1995-01-19
US5861440A (en) 1999-01-19
EP0695161A1 (fr) 1996-02-07
WO1994023688A2 (fr) 1994-10-27
DE4312656A1 (de) 1994-10-20

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