WO1998002138A1 - Composition dessicante emulsive pour la peau - Google Patents

Composition dessicante emulsive pour la peau Download PDF

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Publication number
WO1998002138A1
WO1998002138A1 PCT/BR1997/000027 BR9700027W WO9802138A1 WO 1998002138 A1 WO1998002138 A1 WO 1998002138A1 BR 9700027 W BR9700027 W BR 9700027W WO 9802138 A1 WO9802138 A1 WO 9802138A1
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WO
WIPO (PCT)
Prior art keywords
skin
agent
weight
composition
desiccant
Prior art date
Application number
PCT/BR1997/000027
Other languages
English (en)
Inventor
Simoni Chitarra Souza
Luiz Gustavo Martins Matheus
Original Assignee
Indústria e Comércio de Cosméticos Natura Ltda.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indústria e Comércio de Cosméticos Natura Ltda. filed Critical Indústria e Comércio de Cosméticos Natura Ltda.
Publication of WO1998002138A1 publication Critical patent/WO1998002138A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • the present invention refers to a desiccant composition for the skin, to collaborate in skin reconstitution in event of lesions, for example, produced by acne, reducing the local inflammatory process, regulating vascularization, fighting against harmful microorganisms and accelerating the cicatrization with no antiaesthetic marks.
  • This composition for skin treatment is presented in form of an oil-in- water emulsion, which acts as vehicle to the dissolution, respectively, dispersion of the composition's active principles, and also of complementary agents, which are adjuvants or additives, usually, of conventional use in these type of cosmetic compositions.
  • the active principles of the present composition are the ones which are going to actuate over the skin, respectively with desiccation, renovating, moisturizing, anti-inflammatory, and antiseptic functions, and as permeability regulating agent of the capillary system responsible for permeability regulation.
  • these agents and active principles comprise:
  • Desiccant agents generally applied through the association of two mineral desiccants, chosen, by one side, among the absorbing clays group, specially kaolin, and, by the other side, an activated titanium dioxide (TiO 2 ) of fine granularity, which can be derived either from the rutile form or from the anatase form, which are crystallographic varieties of the Ti0 2 .
  • These desiccants act through adsorption and absorption, removing the oiliness excess of the skin's sebaceous glands secretions in the affected area and, consequently, accelerating skin reconstitution in this same area.
  • the added ratio corresponds to 5,000 to 20,000% of kaolin and 1 ,000 to 15,000%, by weight, of Ti0 2 .
  • a renovating or restoring agent for the skin tissues, favoring cellular proliferation which is allantoin, a glyoxylic acid diureide. This specific agent also calms down irritations and equalizes skin's roughness and is added in a 0,050 to 0,500%, by weight, ratio.
  • An agent with simultaneous moisturizing and anti-inflammatory actions which, by choice, is panthenol, or better, D-panthenol, which exerts a moisturizing action and stimulates epithelium restoration, acting as superficial skin cicatrizant. Its ratio is of 0,100 to 5,000, by weight, in relation to the global composition.
  • a cooperative cicatrization agent natural, namely a calendula extract, which, besides being cicatrizant, has an invigorating and cellular stimulation action, acting specifically as protective and restoring agent for the tissues.
  • the added ratio corresponds to 0,100 to 5,000%, by weight, in relation to the composition.
  • a specific antiseptic agent which is benzalconial chloride, a well know quaternary ammonium compound, with local anti-microbial and antiseptic action and skin's surface preserver. Is added in a 0,050 to 0,300%, by weight, ratio.
  • a cooperative anti-inflammatory agent constituted of bisabolol, which has an anti-phlogistic action, reducing dermal tumefactions and irritations, and is added in a 0,500 to 5,000%, by weight, ratio
  • a capillary permeability regulation agent which is rutin, a vitamin P derivative. Rutin normalizes capillary permeability through vasoconstrictive action, inhibits the abnormal liquid accumulation in the derma and protects against skin lesions, produced due to allergic reactions. Is added in a 0,001 to 0,050%, by weight, ratio.
  • the above mentioned active substances are formulated in form of an oil-in-water type formulation, which maintains the insoluble solids in suspension, particularly the desiccant agents, usually with the help of usual additives, conventional in this type of cosmetic compositions. These additives comprise:
  • a vehicle whose base is water, in which lipophile components of the composition itself will be emulsified, eventually with the addition of a compatible oil, conventional in liquid cosmetic preparations.
  • This vehicle constitutes composition's 30,00 to 60,00%, by weight, serving as dispersion and/or suspension medium for the other components.
  • An usual preservative chosen among the group comprising parabens, thiazolidines, imidazolidinyl urea, diazolidinyl urea, formaldehyde and formaldehyde derivatives, benzoic acid and derivatives, specially the lower alkyl esters of para-oxybenzoic acids, quatemium 15, phenoxyethanol, 2-bromo-2-nitropropane, 1 ,3-diol, added in ratio varying between 0,10 and 1 ,00%, by weight, in relation to the global composition.
  • An emollient chosen among the group comprising the fatty esters, specially isopropyl isostearate, isobutyl palmitate, isocetyl stearate, octyl palmitate, isopropyl laurate, cetyl lactate, isopropyl linoleate, the palmitic acid itself, oleic acid, octadecanol, behenyl alcohol, cetyl palmitate, octyl isostearate, isopropyl stearate, glyceryl stearates, ethylene glycol stearate, alkyl benzoates and oxybenzoates, white pure mineral oil, lanolin alcohols and their derivatives, either esterified or etherified, waxes and refined vegetable oils, silicones and their derivatives, as well as a mixture of the above mentioned substances, in a 1 ,00 to 20,00%, by weight, ratio.
  • An emulgator with the function of helping the formation of an oil-in-water type emulsion, in which the solid insoluble components will remain dispersed, either as discrete particles or as droplets, in the event of hydrophobic substances, usually oily.
  • the emulgators are added in a 0,10 to 5,00%, by weight, ratio, and are(is) chosen among the sorbitan, glycerol, waxes and phosphated fatty amines derivatives, acrylic polymers and their salts, polyoxiethylenes, polyethylene glycols and their derivatives, ethoxylated fatty alcohols, ethoxylated fatty acids, with or without neutralization with mineral or organic bases.
  • a thickener is added in a 0,10 to 15,00%, by weight, ratio.
  • the thickeners are, by themselves, well known, and can be organic, as gums, usually vegetable, starches and modified starches, cellulose derivatives, as cellulose esters or ethers, hydrophilic fatty alcohols, polyethylene glycol stearates, alkyl aryl ammonium compounds, and hydrophilic, vinyl and acrylic polymers, or be mineral, as modified aluminium and magnesium silicates, esmectites, hydrated aluminum silicates, and mixtures of two or more of the above mentioned substances.
  • the pigments used in the present invention are inorganic, as iron oxides, titanium dioxide, or compatible organic pigments, according to the state of technique, being added in a 0,10 to 5,00%, by weight, ratio. Their use aims to provide a pleasant color to the composition, without interfering in the desiccant agents action, which do also cooperate with the pigments to promote the final cosmetic color.
  • sequestering agents are added with the objective of substance fixation, which, in free state, could interfere in the active components and/or certain adjuvants actuation, or even in the components that can be found in the water used to prepare the formulation.
  • the sequestering agents are added in a 0,05 to 0,50%, by weight, ratio in relation to the composition and, usually, comprise ethylene diamino tetraacetic acid (EDTA) and its salts, ethydronic acid, deferrioxamine, lactoferrine.
  • EDTA ethylene diamino tetraacetic acid
  • the composition can also comprise humectant agents, added to diminish the interfacial tension of the solid or hydrophobic components in contact with water or other aqueous medium. These can be glycerol, glycol, sorbitol derivatives, hydrosoluble silicones and other humectants having surfactant properties, in a ratio varying between 5,00 and 20,00%, by weight, in relation to the global composition. Manufacturing Process
  • the present desiccant emulsion, pigmented is manufactures through usual cosmetic processing techniques. Some special care should be taken to obtain a good disposition of the components insoluble in water or in the aqueous medium.
  • the solid desiccant components and the pigments should be previously wetted and very well disposed in an adequate liquid, compatible with the emulsion, prepared separately.
  • the dispersion of these insoluble components is done in an adequate equipment, in other words, in a micronizer, colloid mills and others, already conventional.
  • the emulsion constituted of an aqueous phase, dispersant, and an oily phase, dispersed, should be previously homogenized and heated at 80°C. After that, it is possible to perform the final emulsification, and stabilization, through the action of the emulsifying additive. Then, the dispersion containing the solid components and, eventually, the other thermostable components, are added. The product is then cooled down to 45°C, or room temperature, for the incorporation of the thermosensitive components, followed by final mechanical homogenization. Examples
  • the first step is the solids wetting, comprising 10,50% of kaolin, 7,50% of titanium dioxide and 0,5% of micronized basic iron oxide, in an adequate water quantity, containing 3,00% of usual emulsifying agent, as ethoxylated cetyl alcohol with 10-15 EO/mol.
  • aqueous vehicle which totalizes 60,00%
  • the other components are dissolved/dispersed, namely, 0,28% of allantoin, 1 ,00% of panthenol, 1 ,00% of calendula extract, 0,10% of benzalconial chloride, 0,60% of bisabolol and 0,02% of rutin, as well as 0,30% of methyl/isopropyl paraben, as preservative, 3,20% of an emollient, isopropyl linoleate, and 12,00% of an humectant, hydrosoluble silicone.
  • the last mentioned components can only be added to a fraction of the aqueous vehicle, first adding the humectant and then the other complements through stirring and, at last, the remaining quantity of vehicle, performing, at last, the incorporation of the solids dispersion, previously prepared, through homogenization.
  • Example 3 The example 1 is repeated, but half of the quantity of humectant is added in the previous solids dispersion and the other half quantity of humectant is added in the remaining aqueous vehicle and complements.
  • Example 3 The example 1 is repeated, but half of the quantity of humectant is added in the previous solids dispersion and the other half quantity of humectant is added in the remaining aqueous vehicle and complements.
  • the example 1 is repeated, adding the complete quantity, 12,00%, of humectant agent in the previous solids dispersion and using the total quantity of emulsifying agent, 3,00%, to emulsify the non-solid portion of the complementary components in the remaining vehicle.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

La présente invention concerne une composition dessicante, sous forme d'émulsion, comprenant un nouvel ensemble d'agents actifs aux capacités coopérantes reconnues dans la reconstitution d'une peau affectée par des sécrétions dermiques excessives, s'employant à assécher ladite peau jusqu'à ce qu'elle récupère les propriétés d'une peau normale et y associant une réduction des incidences des irritations et des inflammations locales, observées particulièrement dans les cas d'acné. Ledit ensemble d'agents actifs comporte une association de deux agents dessicants inorganiques, le kaolin et le dioxyde de titane, auxquels s'ajoutent plusieurs composés organiques, à savoir : un agent régénérant, l'allantoïne, un agent humectant, le penthénol, un agent cicatrisant extrait du souci officinal, un agent antiseptique, le chlorure de benzalkonium, un agent anti-inflammatoire, le bisbolol et, à titre d'agent régulateur de la perméabilité capillaire, de la rutine. On prépare ces composants actifs par émulsion respective et dispersion dans un excipient aqueux, avec l'aide d'agents spécifiques, tels les agents émulsifs habituels et des agents humectants. On peut aussi y ajouter d'autres éléments coopérants, conservateurs, émollients, épaississants, pigments, ainsi que d'éventuels agents chélateurs pour former l'émulsion définitive présentant les caractéristiques voulues en termes de stabilité, consistance et durabilité physico-chimiques de son action spécifique, de sa couleur et de sa sensation agréable sur la peau.
PCT/BR1997/000027 1996-07-12 1997-07-10 Composition dessicante emulsive pour la peau WO1998002138A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI9603084-4 1996-07-12
BR9603084A BR9603084A (pt) 1996-07-12 1996-07-12 Composição secativa em forma de emulsão para a pele

Publications (1)

Publication Number Publication Date
WO1998002138A1 true WO1998002138A1 (fr) 1998-01-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR1997/000027 WO1998002138A1 (fr) 1996-07-12 1997-07-10 Composition dessicante emulsive pour la peau

Country Status (4)

Country Link
BR (1) BR9603084A (fr)
CO (1) CO5261511A1 (fr)
PE (1) PE89598A1 (fr)
WO (1) WO1998002138A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000010513A1 (fr) * 1998-08-18 2000-03-02 The Procter & Gamble Company Compositions cosmetiques contenant de l'oxyde de titane de rutile et d'anatase et des emollients
DE10050155A1 (de) * 2000-10-11 2002-04-18 Beiersdorf Ag Kosemtische und dermatologische Zubereitungen mit einem Gehalt an Desferrioxamin
EP1284601A2 (fr) * 2000-05-12 2003-02-26 Alwyn Company, Inc. Creme pour la peau contenant de l'allantoine
FR2844716A1 (fr) * 2002-09-23 2004-03-26 Marcel Jacques Chicouri Nouvelles compositions pharmaceutiques destinees notamment a l'hygiene des pieds des diabetiques
WO2004032963A2 (fr) * 2002-10-04 2004-04-22 Photokinetix Inc. Delivrance photocinetique de substances biologiquement actives au moyen d'une lumiere incoherente pulsee
EP2172106A1 (fr) * 2000-05-12 2010-04-07 Alwyn Company, Inc. Crème pour la peau contienant d'allantoin
ITMI20091075A1 (it) * 2009-06-17 2010-12-17 Valetudo Srl Composizioni farmaceutiche e cosmetiche comprendenti lactoferrina ciclopirox acido etidronico
US7897144B2 (en) 2001-02-28 2011-03-01 Johnson & Johnson Comsumer Companies, Inc. Compositions containing legume products
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US8877790B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US9095574B2 (en) 2010-02-02 2015-08-04 Scioderm, Inc. Methods of treating psoriasis using allantoin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330628A1 (de) * 1983-08-25 1985-03-07 Schülke & Mayr GmbH, 2000 Norderstedt Hautschutz- und -pflegelotion
US4749563A (en) * 1986-12-08 1988-06-07 Charles Of The Ritz Group Ltd. Moisture-resistant skin treatment compositions
WO1993008793A1 (fr) * 1991-10-30 1993-05-13 The Boots Company Plc Composition pour les soins de toilette
WO1996017588A1 (fr) * 1994-12-07 1996-06-13 Lancaster Group Gmbh Preparation cosmetique contenant du kaolin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330628A1 (de) * 1983-08-25 1985-03-07 Schülke & Mayr GmbH, 2000 Norderstedt Hautschutz- und -pflegelotion
US4749563A (en) * 1986-12-08 1988-06-07 Charles Of The Ritz Group Ltd. Moisture-resistant skin treatment compositions
WO1993008793A1 (fr) * 1991-10-30 1993-05-13 The Boots Company Plc Composition pour les soins de toilette
WO1996017588A1 (fr) * 1994-12-07 1996-06-13 Lancaster Group Gmbh Preparation cosmetique contenant du kaolin

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
WO2000010513A1 (fr) * 1998-08-18 2000-03-02 The Procter & Gamble Company Compositions cosmetiques contenant de l'oxyde de titane de rutile et d'anatase et des emollients
US9084780B2 (en) 1999-07-23 2015-07-21 Scioderm, Inc. Allantoin-containing skin cream
US8877788B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US8877790B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US8877789B2 (en) 1999-07-23 2014-11-04 Scioderm, Inc. Allantoin-containing skin cream
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
EP1284601A4 (fr) * 2000-05-12 2005-02-09 Alwyn Co Inc Creme pour la peau contenant de l'allantoine
EP2172106A1 (fr) * 2000-05-12 2010-04-07 Alwyn Company, Inc. Crème pour la peau contienant d'allantoin
EP1284601A2 (fr) * 2000-05-12 2003-02-26 Alwyn Company, Inc. Creme pour la peau contenant de l'allantoine
DE10050155A1 (de) * 2000-10-11 2002-04-18 Beiersdorf Ag Kosemtische und dermatologische Zubereitungen mit einem Gehalt an Desferrioxamin
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7897144B2 (en) 2001-02-28 2011-03-01 Johnson & Johnson Comsumer Companies, Inc. Compositions containing legume products
FR2844716A1 (fr) * 2002-09-23 2004-03-26 Marcel Jacques Chicouri Nouvelles compositions pharmaceutiques destinees notamment a l'hygiene des pieds des diabetiques
WO2004032963A3 (fr) * 2002-10-04 2004-12-16 Photokinetix Inc Delivrance photocinetique de substances biologiquement actives au moyen d'une lumiere incoherente pulsee
WO2004032963A2 (fr) * 2002-10-04 2004-04-22 Photokinetix Inc. Delivrance photocinetique de substances biologiquement actives au moyen d'une lumiere incoherente pulsee
EP2275104A3 (fr) * 2009-06-17 2011-12-21 Valetudo S.r.l. Composition pharmaceutique et cosmétique comprenant de la lactoferrine, du ciclopirox et de l'acide étidronique
ITMI20091075A1 (it) * 2009-06-17 2010-12-17 Valetudo Srl Composizioni farmaceutiche e cosmetiche comprendenti lactoferrina ciclopirox acido etidronico
US9095574B2 (en) 2010-02-02 2015-08-04 Scioderm, Inc. Methods of treating psoriasis using allantoin
US9339492B1 (en) 2010-02-02 2016-05-17 Scioderm, Inc. Methods of treating psoriasis using allantoin

Also Published As

Publication number Publication date
BR9603084A (pt) 1998-05-05
PE89598A1 (es) 1998-12-16
CO5261511A1 (es) 2003-03-31

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