EP0685237B1 - Vorgefüllte Spritze - Google Patents

Vorgefüllte Spritze Download PDF

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Publication number
EP0685237B1
EP0685237B1 EP95107993A EP95107993A EP0685237B1 EP 0685237 B1 EP0685237 B1 EP 0685237B1 EP 95107993 A EP95107993 A EP 95107993A EP 95107993 A EP95107993 A EP 95107993A EP 0685237 B1 EP0685237 B1 EP 0685237B1
Authority
EP
European Patent Office
Prior art keywords
projection
top wall
tip member
syringe body
tip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95107993A
Other languages
English (en)
French (fr)
Other versions
EP0685237A3 (de
EP0685237A2 (de
Inventor
Hitoshi Futagawa
Masafumi Aramata
Yoji Arifuku
Kenji Himeshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissho Corp
Original Assignee
Nissho Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissho Corp filed Critical Nissho Corp
Publication of EP0685237A2 publication Critical patent/EP0685237A2/de
Publication of EP0685237A3 publication Critical patent/EP0685237A3/de
Application granted granted Critical
Publication of EP0685237B1 publication Critical patent/EP0685237B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/348—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub snap lock, i.e. upon axial displacement of needle assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle

Definitions

  • the present invention relates to a prefilled syringe, i.e., a syringe previously filled with a medical solution and, more particularly, a prefilled syringe of glass which is easy to manufacture, simple in assemble, and affords a sterile environment for a medical solution before injection.
  • a tip for attachment of a needle is formed into so-called lure (luer) tip, i.e., a reduced hollow tube having a tapering outer wall.
  • lure (luer) tip i.e., a reduced hollow tube having a tapering outer wall.
  • a lure tip has so far been produced as an integral part of a syringe body as shown in Fig. 10 or as a separate member as shown in Figs. 11 and 12.
  • the separate lure tip member L1 shown in Fig. 11 is molded out of a synthetic resin, fitted in a narrow mouth of a syringe body through a packing P, and then fixed thereto with an aluminum fitting member F.
  • the separate lure member L2 with a skirt portion as shown in Fig. 12 is molded out of a hard plastic material, and press-fitted on a narrow mouth of a syringe body with a rubber stopper R fitted therein.
  • the syringe with the lure tip L1 as shown in Fig. 10 is low in productivity but high in production cost. Since the lure tip L1 is produced by thermally softening a glass tube and then shaping it into a certain form, the accuracy thereof is not satisfactory. Thus, the tapering outer wall portion of the lure tip mating with a needle hub or female lure connector has to be polished with whetstones to improve the accuracy. This causes lowering of productivity and an increase in production cost since it is difficult to automate the polishing process of the glass syringes and since it is required to perform a functional test for all the produced glass syringes.
  • the lure tip for the syringe shown in Fig. 11 must be fixed by the fitting member of metal aluminum, which produces fine powder of aluminum during fixing process.
  • the syringe has such disadvantages that there is a fear of contamination of an aseptic room or entering pollution by foreign substances, that foreign matter may enter into the medical solution, and that it requires segregated disposal.
  • EP-A-0 528 120 relates to a syringe for medical use wherein the needle mounting member is fixed on the top of the outer flange of the syringe cylinder by a safety ring while a tip cap mounted on the needle mounting member is held in place by the top wall of a safety cap.
  • a prefilled syringe comprising a syringe body of glass having at one end a reduced mouth portion and at the opposite end an opening, said syringe body being filled with a medical solution; a tip member liquid-tightly attached to said mouth portion of the syringe body; a sealing member arranged between said tip member and mouth portion to provide a liquid tight seal between them; a cap-shaped member for fixing said sealing member to the mouth portion; a covering means removably fitted on said tip member for covering the externally extending projection of said tip member; and a plunger means for liquid-tight fitting in said opening of the syringe body at a position close to the proximal end.
  • the syringe body has at one end a mouth portion reduced in diameter and at the opposite end an opening for attachment of plunger means.
  • the plunger means is fitted in the opening of the syringe body at a position close to the proximal end of the syringe body.
  • a prefilled syringe of the present invention comprises a syringe body 1 of glass, a tip member 2 liquid-tightly fixed to a distal end or mouth portion of the syringe body 1, a sealing member or packing 4 for making a liquid tight seal between the tip member 2 and a mouth portion 11 of the syringe body 1, a covering member or a rubber cap 5 for closing an externally extending projection 23 of the tip member 2, and a holding member 3 for holding the tip member 2 in place on the mouth portion 11 of the syringe body 1 and for holding and fixing the rubber cap 5 to the tip member 2.
  • the syringe body 1 is filled up with a medical solution (not illustrated in the drawings) and is closed at its proximal end by a plunger 6.
  • the syringe body 1 is a hollow glass tube having at one end the mouth portion 11 reduced in diameter and at the opposite end an opening for attachment of plunger means 6.
  • the upper part 11 of the syringe body is formed like a mouth portion of a vial so as to have an annular projection which swells out and then continues straight up to the upper end.
  • the syringe body 1 is provided with a flange 12 at the proximal end and closed by the plunger 6 fitted in the opening to close liquid-tightly.
  • the plunger 6 consists of a plunger rod 62 and a gasket 61 fitted on the top of the plunger rod 62 so as to move smoothly along the lumen of the syringe body 1.
  • This gasket 61 is generally made of an elastic material such as natural rubber and synthetic rubber including butyl rubber, isoprene rubber and elastomers.
  • the gasket 61 is formed into a short round body tapered toward the distal end, with a recess 64 for attachment of a head 63 of the plunger rod 62.
  • the packing 4 attached to the mouth portion 11 of the syringe body 1 includes a tubular body with a through-hole 43 and an upper flange 41 for making a liquid tight seal at contacting surfaces on the top surface of the mouth portion 11 and the packing 4, and a limb or leg portion 42 extending downward therefrom and close contact with the inner wall of the mouth portion 11 for sealing up the mouth portion 11.
  • An external diameter of the leg portion 42 is almost equal to an internal diameter of mouth portion 11, while the diameter of the through-hole 43 is slightly smaller than the external diameter of the outlet portion 26 of the tip member 2.
  • the packing 4 is usually made of the same elastic material as that used for the gasket 61.
  • a ring-shaped packing P with the same internal diameter as that of the mouth portion 11, as shown in Fig. 11, may be used as a sealing member instead of the packing 4.
  • the tip member 2 is, usually of a flexible material such as polypropylene, polyethylene, polycarbonate, ABS resin and the like, attached to the mouth portion 11 through the packing 4.
  • the tip member 2 is slidable along the outer wall of the mouth portion 11 of the syringe body 1 when constructing the prefilled syringe.
  • the tip member 2 is molded into a cap-like member including a top wall 21, a tubular projection 23 passing through the top wall 21, and a skirt portion 22 slightly swelling out to the bottom.
  • the tubular projection 23 is divided, by the top wall 21, into two portions, i.e., an outwardly extending portion 26a which extends upward from the top wall 21, and an inwardly extending portion 26b which extends downward from the top wall 21.
  • the outwardly extending portion 26a is used for attachment of a needle in use, while inwardly extending portion 26b is fitted in the packing 4 for leading a medical solution in the syringe body 1 to the outwardly extending portion 26a.
  • the tubular projection 23 is provided with a passage 25 passing through the lower and upper portions 26a and 26b.
  • a medical solution in the syringe can be pushed out therefrom through the needle attached to the upper portion 26a of the tip member 2.
  • the skirt portion 22 is provided at a lower part of the inner wall with engaging projections 24 (four projections in the figures of the drawings) and at a lower part of the outer wall with engaging means 222 which engages with engaging projection or hooked portion 35 of the holding member 3.
  • the skirt portion 22 is provided with one or more slits 28 extending axially from the bottom end of the skirt so as to be expandable at its lower part. Preferably, three or four slits 28 are made in the skirt portion.
  • the upper part of the tubular projection i.e., outwardly extending portion 26a for needle attachment has an outer wall usually reduced in diameter toward the top, which is closed by the sealing member or rubber cap 5. If the syringe has a large capacity, as shown in Fig. 9, the tubular projection 23 may be formed in an eccentric position with respect to the axis of the tip member 2 to facilitate insertion of a needle into patient's skin.
  • the engaging projections 24 on lower part of the interior wall of the skirt 22 are engaged with an annular lip formed on the neck portion of the syringe body 1 when the tip member 2 has snapped over the annular lip after being moved smoothly along the outer wall of the annular lip of the syringe 1.
  • the engaging means 222 on the lower part of the outer wall of the skirt 22 is constructed to engage with the engaging projection 35 of the holding member 3.
  • the top wall 21 may be provided with bores 27 for removal of the tip member 2 from a mold after molding.
  • the tip member 2 may be provided at an upper part of the skirt 22 with an annular groove 221 which engages with engaging projection 35 of the holding member 3 mentioned later. In case of the tip member 2 with the annular groove 221, it is possible to keep the holding member 3 on the tip member 2. Thus, it is possible to attach the tip member 2, holding member 3 and packing 4 to the mouth portion 11 of the syringe body 1 at a time, provided that tip member 2, holding member 3, packing 4 and rubber cap 5 are assembled into one piece.
  • the holding member 3 is fitted on the needle attachment portion 23 of the tip member 2 provided with the sealing means or rubber cap 5, thereby the tip member 2 is fixed to the mouth portion 11 of the syringe body 1 and the rubber cap 5 is fixed to the tip member 2.
  • the rubber cap 5 is one example of the sealing member to be attached to needle attachment portion 23 of the tip member 2.
  • the rubber cap 5 usually of the same elastic material as that of the sealing member or packing, is composed of a top wall 51 and a downwardly enlarged skirt 52. At the bottom of the skirt 52 there is an annular projection 53 adapted to be pressed against the tip member 2 by the holding member.
  • the annular projection 53 may be rounded off an upper corner R portion 54 so as to facilitate removal of the rubber cap 5.
  • the holding member 3 is of a synthetic resin similar to that of the tip member 2 and composed of a top wall 31 and a skirt 32.
  • the top wall 31 is provided with an opening 34 having an inwardly facing annular rim 33 which contacts with the annular projection 53 of the rubber cap 5 and presses it against the top wall 21 of the tip member 2.
  • the engaging projection 35 of the holding member 3 is engaged with the engaging means 222, e.g., an undercut, formed in the lower part of the outer wall of the tip member 2 at the time that the inner surface of the top wall 31 of the holding member 3 comes into contact with the upper surface of the top wall 21 of the tip member 2.
  • the engaging means 222 e.g., an undercut
  • the packing 4 is first fitted on the inwardly extending tubular portion 26b of the tip member 2 and the rubber cap 5 is fitted on the outwardly extending tubular portion 26a. Then, the holding member 3 is put on the rubber cap 5 so that the lower part of its skirt 32 is engaged with the groove 221 of the tip member 2.
  • sealing means is put on the mouth portion 11 of the syringe body 1 and pushed down, whereby the tip member 2 is moved downward along the mouth portion 11 of the syringe 1 and stopped at a position as shown in Fig. 7.
  • the packing 4 is fitted in the mouth portion 11 of the syringe body 1.
  • the holding member 3 is stopped to move downward at the position where the inner surface of the top wall 31 of the holding member 3 comes into contact with the top wall 21 of the tip member 2.
  • the engaging projection 35 of the holding member 3 is engaged with the engaging means 222 provided in the lower portion of the tip member 2, whereby the holding member 2 is fixed to the mouth portion 11 of the syringe body 1.
  • the prefilled syringe of the present invention is so constructed that the tip member of a synthetic resin is attached to the mouth portion of the syringe body by first fitting the packing in the mouth portion of the syringe, fitting the inwardly extending projection of the tip member in the through-hole of the packing, fitting the rubber cap on the outwardly extending projection of the tip member, mounting the holding member on the rubber cap and then sliding the holding member along the skirt portion of the tip member to fix the tip member to the mouth portion of the syringe body.
  • the prefilled syringe of the present invention has the following advantages:

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (6)

  1. Vorgefüllte Spritze, die aufweist:
    einen Spritzenkörper (1) aus Glas mit einem als Mundstück (11) geformten distalen Ende, das einen ringförmigen Vorsprung von ähnlicher Gestalt wie das Mundstück einer Ampulle aufweist;
    ein Dichtungselement (4) mit einer Durchgangsbohrung (43) in axialer Richtung des Spritzenkörpers (1), wobei das Dichtungselement (4) im Mundstück (11) des Spritzenkörpers (1) angebracht ist;
    ein Spitzenelement (2) mit einer oberen Wand (21), einem davon ausgehenden Randabschnitt (22) und einem röhrenförmigen Vorsprung (23), wobei der Randabschnitt (22) an einem unteren Teil seiner Innenwand mindestens einen nach innen ragenden Eingriffsvorsprung (24) sowie an einem unteren Teil seiner Außenwand eine Eingriffseinrichtung (222) aufweist und mit einem oder mehreren Schlitzen (28) versehen ist, die sich in axialer Richtung des Randes erstrecken, wobei der röhrenförmige Vorsprung (23) einen von der oberen Wand (21) ausgehenden, nach außen ragenden Vorsprung (26a) zur Befestigung der Kanüle aufweist;
    ein Abdeckelement (5) zum Verschließen des nach außen ragenden Vorsprungs (26a) des Spitzenelements (2); und
    ein Halteelement (3) zum Festhalten des Abdeckelements (5) zusammen mit dem Spitzenelement (2) am Mundstück (11) des Spritzenkörpers (1), wobei das Halteelement (3) eine obere Wand (31) mit einer Öffnung (34) und einen Randabschnitt (32) mit einem Eingriffsvorsprung (35) aufweist, der sich mit der Eingriffseinrichtung (222) des Spitzenelements (2) in Eingriff befindet, wobei das Spitzenelement (2) flüssigkeitsdicht an dem Mundstück (11) des Spritzenkörpers (1) befestigt werden kann, indem das Halteelement (3) an dem Spitzenelement (2) angebracht und dann an der Außenwand des Spitzenelements (2) nach unten geschoben wird, wodurch der Randabschnitt (22) des Spitzenelements (2) nach innen gebogen werden kann, so daß der Eingriffsvorsprung (222) des Spitzenelements (2) mit dem Mundstück (11) des Spritzenkörpers (1) in Eingriff gebracht wird;
       dadurch gekennzeichnet, daß der röhrenförmige Vorsprung (23) durch die obere Wand hindurchgeht und einen nach innen ragenden Vorsprung (26b) aufweist, wobei der nach innen ragende Vorsprung (26b) von der oberen Wand ausgeht und in der Durchgangsbohrung (43) des Dichtungselements (4) angebracht ist, um eine im Spritzenkörper (1) enthaltene medizinische Lösung zu dem nach außen ragenden Vorsprung (26a) zu leiten.
  2. Vorgefüllte Spritze nach Anspruch 1, wobei der nach außen ragende Vorsprung (26a) des Spitzenelements (2) exzentrisch zur Achse des Spitzenelements (2) ausgebildet ist.
  3. Vorgefüllte Spritze nach Anspruch 1 oder 2, wobei das Abdeckelement (5) eine elastische Kappe mit einer oberen Wand (51) und einem davon ausgehenden, außen konischen Rand (52) aufweist.
  4. Vorgefüllte Spritze nach Anspruch 3, wobei der außen konische Randabschnitt (52) des Abdeckelements (5) in montierter Position durch die Öffnung (34) in der oberen Wand (31) des Halteelements (3) hindurchgeht.
  5. Vorgefüllte Spritze nach Anspruch 3 oder 4, wobei das Abdeckelement (5) ferner einen von der oberen Wand (51) beabstandeten ringförmigen Vorsprung (53) aufweist, wobei der außen konische Randabschnitt (52) sich zwischen der oberen Wand (51) und dem ringförmigen Vorsprung (53) erstreckt.
  6. Vorgefüllte Spritze nach Anspruch 5, wobei die obere Wand (31) des Halteelements (3) in der montierten Position mit dem ringförmigen Vorsprung (53) des Abdeckelements (5) in Eingriff gebracht werden kann.
EP95107993A 1994-05-27 1995-05-24 Vorgefüllte Spritze Expired - Lifetime EP0685237B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13797594A JP3383966B2 (ja) 1994-05-27 1994-05-27 プレフィルドシリンジ
JP137975/94 1994-05-27

Publications (3)

Publication Number Publication Date
EP0685237A2 EP0685237A2 (de) 1995-12-06
EP0685237A3 EP0685237A3 (de) 1996-05-08
EP0685237B1 true EP0685237B1 (de) 1998-08-26

Family

ID=15211123

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95107993A Expired - Lifetime EP0685237B1 (de) 1994-05-27 1995-05-24 Vorgefüllte Spritze

Country Status (7)

Country Link
US (1) US5624405A (de)
EP (1) EP0685237B1 (de)
JP (1) JP3383966B2 (de)
KR (1) KR100361384B1 (de)
CN (1) CN1129458C (de)
CA (1) CA2150288A1 (de)
DE (1) DE69504241T2 (de)

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Publication number Priority date Publication date Assignee Title
EP0830868A2 (de) * 1996-09-23 1998-03-25 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Vorgefüllte Spritze für medizinische Zwecke
WO2001074424A2 (en) 2000-04-03 2001-10-11 Astrazeneca Uk Limited Pre-filled syringe
US6497684B2 (en) 2000-09-27 2002-12-24 Schering Aktiengesellschaft Syringe with a barrel having a sealing cap to hold a fluid medium within the barrel

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DE19537163C1 (de) * 1995-10-06 1997-01-30 Vetter & Co Apotheker Spritze für medizinische Zwecke
DE19547431A1 (de) * 1995-12-05 1997-06-12 Schering Ag Verschlußsystem für eine sterile Spritze
JP3380705B2 (ja) * 1997-03-12 2003-02-24 株式会社大協精工 注射器兼容器用密封ゴム栓
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GB2341804B (en) * 1998-09-25 2003-02-12 David William Parker Improvements in or relating to hypodermic syringes
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FR2789890B1 (fr) * 1999-02-22 2002-01-18 Lab Contactologie Appl Lca Dispositif pour l'injection d'une lentille intra-oculaire en matiere souple
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DE20105379U1 (de) * 2001-03-27 2001-08-23 Mednet Gmbh Schutzkappe für nadelfreie Injektionssysteme
DE10316127A1 (de) * 2003-04-09 2004-11-04 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Vorgefüllte Spritze oder Karpule für medizinische Zwecke
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AP2008004667A0 (en) * 2006-05-05 2008-12-31 Retractable Technologies Inc Syringe with recessed nose for use with frontal attachments
GB2438590B (en) * 2006-06-01 2011-02-09 Cilag Gmbh Int Injection device
AU2008261084B2 (en) * 2007-06-04 2011-07-28 Becton, Dickinson And Company Positive displacement stopper for a pre-filled syringe
US8740856B2 (en) * 2007-06-04 2014-06-03 Becton, Dickinson And Company Stoppers used in pre-filled syringes
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USD641078S1 (en) 2008-12-29 2011-07-05 Ucb Pharma, S.A. Medical syringe with needle tip cap
WO2010007395A1 (en) 2008-07-18 2010-01-21 Ucb Pharma S.A. Systems for administering medication for rheumatoid arthritis patients
USD660958S1 (en) 2009-07-20 2012-05-29 Ucb Pharma, S.A. Device for administering medication
US8915890B2 (en) * 2009-07-30 2014-12-23 Becton, Dickinson And Company Medical device assembly
CN102740909B (zh) * 2010-02-01 2016-05-04 赛诺菲-安万特德国有限公司 药筒保持器、给药装置和用于将药筒固定在药筒保持器中的方法
US10463803B2 (en) * 2010-11-12 2019-11-05 Stat Medical Devices, Inc. Pen needle with quick release and/or removal system
EP2862587A1 (de) 2013-10-15 2015-04-22 Becton Dickinson France Spitzenkappenanordnung zum Verschließen eines Injektionssystems
US9827376B2 (en) 2014-01-29 2017-11-28 Becton, Dickinson And Company Plunger assembly including a plunger rod for advancing a stopper through a syringe
JP2015167677A (ja) * 2014-03-06 2015-09-28 住友ゴム工業株式会社 ガラスシリンジおよびプレフィルドシリンジ
JP6913156B2 (ja) * 2017-03-22 2021-08-04 テルモ株式会社 メスシリンジ及びシリンジキット
JP7266971B2 (ja) * 2018-05-24 2023-05-01 ニプロ株式会社 シリンジ型噴出装置

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EP0830868A2 (de) * 1996-09-23 1998-03-25 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Vorgefüllte Spritze für medizinische Zwecke
US5833653A (en) * 1996-09-23 1998-11-10 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Prefilled hypodermic syringe
WO2001074424A2 (en) 2000-04-03 2001-10-11 Astrazeneca Uk Limited Pre-filled syringe
US6497684B2 (en) 2000-09-27 2002-12-24 Schering Aktiengesellschaft Syringe with a barrel having a sealing cap to hold a fluid medium within the barrel

Also Published As

Publication number Publication date
CN1119123A (zh) 1996-03-27
CA2150288A1 (en) 1995-11-28
US5624405A (en) 1997-04-29
EP0685237A3 (de) 1996-05-08
KR100361384B1 (ko) 2003-02-05
KR950031120A (ko) 1995-12-18
CN1129458C (zh) 2003-12-03
JPH07313596A (ja) 1995-12-05
JP3383966B2 (ja) 2003-03-10
DE69504241D1 (de) 1998-10-01
DE69504241T2 (de) 1999-01-21
EP0685237A2 (de) 1995-12-06

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