EP0659085A1 - Verfahren zur verhüttung der zellvermehrung mittels apolipoprotein-e - Google Patents

Verfahren zur verhüttung der zellvermehrung mittels apolipoprotein-e

Info

Publication number
EP0659085A1
EP0659085A1 EP93919995A EP93919995A EP0659085A1 EP 0659085 A1 EP0659085 A1 EP 0659085A1 EP 93919995 A EP93919995 A EP 93919995A EP 93919995 A EP93919995 A EP 93919995A EP 0659085 A1 EP0659085 A1 EP 0659085A1
Authority
EP
European Patent Office
Prior art keywords
cells
apoe
proliferation
apolipoprotein
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93919995A
Other languages
English (en)
French (fr)
Other versions
EP0659085A4 (de
Inventor
Tikva Vogel
Amos Panet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Publication of EP0659085A1 publication Critical patent/EP0659085A1/de
Publication of EP0659085A4 publication Critical patent/EP0659085A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP93919995A 1992-08-12 1993-08-12 Verfahren zur verhüttung der zellvermehrung mittels apolipoprotein-e. Withdrawn EP0659085A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92897992A 1992-08-12 1992-08-12
US928979 1992-08-12
PCT/US1993/007582 WO1994004178A1 (en) 1992-08-12 1993-08-12 Method of inhibiting cell proliferation using apolipoprotein e

Publications (2)

Publication Number Publication Date
EP0659085A1 true EP0659085A1 (de) 1995-06-28
EP0659085A4 EP0659085A4 (de) 1996-06-12

Family

ID=25457115

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93919995A Withdrawn EP0659085A4 (de) 1992-08-12 1993-08-12 Verfahren zur verhüttung der zellvermehrung mittels apolipoprotein-e.

Country Status (9)

Country Link
EP (1) EP0659085A4 (de)
JP (1) JPH08502730A (de)
KR (1) KR950702430A (de)
AU (1) AU673543B2 (de)
CA (1) CA2141598A1 (de)
IL (1) IL106664A0 (de)
NZ (1) NZ255732A (de)
WO (1) WO1994004178A1 (de)
ZA (1) ZA935879B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP0715521A4 (de) * 1993-08-12 1998-01-14 Bio Technology General Corp Methode zur inhibition des kaposi-sarkoms
IL120005A (en) * 1997-01-14 2000-08-31 Ramot University Authority Of Pharmaceutical compositions for the treatment of the eye
US6593291B1 (en) * 1997-02-06 2003-07-15 Entremed, Inc. Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease
AU4449900A (en) * 1999-03-17 2000-10-04 Entremed, Inc Compositions and methods of use of ldl-like receptor ligands for the treatment of cancer and angiogenic-based disease
WO2001037853A2 (en) * 1999-11-23 2001-05-31 North Shore - Long Island Jewish Health System Methods and agents for the inhibition of smooth muscle cell proliferation
US20020182587A1 (en) * 2001-03-02 2002-12-05 Sivaram Pillarisetti Methods and compositions for the treatment and prevention of smooth muscle cell proliferation
JP5706818B2 (ja) * 2008-07-01 2015-04-22 コグノッシ， インコーポレイテッド ＡｐｏＥペプチドにより癌を治療する方法
CN102917727B (zh) 2010-01-06 2017-10-17 康石医药科技（上海）有限公司 Apoe肽及其用途
JP6031718B2 (ja) * 2011-09-20 2016-11-30 国立大学法人 熊本大学 リポ蛋白を用いたα２−マクログロブリンの神経保護抑制効果抑止剤及び眼科用組成物
WO2022059703A1 (ja) * 2020-09-16 2022-03-24 国立大学法人大阪大学 がん治療用医薬、免疫賦活剤および抗がん物質のスクリーニング方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002751A1 (en) * 1989-08-18 1991-03-07 Scripps Clinic And Research Foundation Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1992010512A1 (en) * 1990-12-10 1992-06-25 The Scripps Research Institute Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1995005190A1 (en) * 1993-08-12 1995-02-23 Bio-Technology General Corp. Method of inhibiting kaposi's sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0600875A4 (de) * 1991-06-26 1995-01-25 Bio Technology General Corp Reinigung rekombinanten apolipoproteins-e aus bakterien.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002751A1 (en) * 1989-08-18 1991-03-07 Scripps Clinic And Research Foundation Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1992010512A1 (en) * 1990-12-10 1992-06-25 The Scripps Research Institute Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1995005190A1 (en) * 1993-08-12 1995-02-23 Bio-Technology General Corp. Method of inhibiting kaposi's sarcoma

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9404178A1 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 23, 15 August 1991 pages 15009-15015, DYER ET AL 'ONLY MULTIMERS OF A SYNTHETIC PEPTIDE OF HUMAN APOLIPOPROTEIN E ARE BIOLOGICALLY ACTIVE' *

Also Published As

Publication number Publication date
KR950702430A (ko) 1995-07-29
CA2141598A1 (en) 1994-03-03
AU5007293A (en) 1994-03-15
ZA935879B (en) 1994-03-11
JPH08502730A (ja) 1996-03-26
NZ255732A (en) 1997-05-26
AU673543B2 (en) 1996-11-14
EP0659085A4 (de) 1996-06-12
IL106664A0 (en) 1993-12-08
WO1994004178A1 (en) 1994-03-03

Similar Documents

Publication Publication Date Title
Crouch et al. Interactions of pulmonary surfactant protein D (SP-D) with human blood leukocytes.
AU710061B2 (en) Amphipathic molecules as cholesterol and other lipid uptake inhibitors
US5856302A (en) Therapeutic uses of bactericidal/permeability-increasing protein dimer products
EP0378364A2 (de) PF4-Analoge und Fragmente und sie enthaltende pharmazeutische Zusammensetzungen
PT690720E (pt) Utilizacoes terapeuticas de produtos de proteina bactericida indutora de permeabilidade
WO1993010808A1 (en) INHIBITING TRANSFORMING GROWTH FACTOR β TO PREVENT ACCUMULATION OF EXTRACELLULAR MATRIX
AU673543B2 (en) Method of inhibiting cell proliferation using apolipoprotein E
US5869055A (en) Anti-inflammatory CD14 polypeptides
EP1357930B1 (de) Histidine-rich glycoprotein (hrgp) zur hemmung der angiogenese
EP0341273B1 (de) Biologische materialien, deren herstellung und verwendung in der therapie
MXPA00011398A (es) Analogo de remocion de proteina que incrementa la actividad bactericida/permeabilidad (bpi).
US6515104B1 (en) Therapeutic peptide-based constructs derived from domain II of bactericidal/permeability-increasing protein
US20140171365A1 (en) Pegylated human hdl particle and process for production thereof
AU691085B2 (en) Anti-inflammatory CD14 polypeptides
JP3030386B2 (ja) 抗ガン剤
US5942220A (en) Inhibitor of cytokine activity and applications thereof
AU3592593A (en) Novel methods and compositions for treatment of angiogenic diseases
US20050026841A1 (en) Hab18g/cd147 its antagonist and application
US5770561A (en) Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products
US5693481A (en) Inhibitor of cytokine activity and applications thereof
US6423825B1 (en) Therapeutic derivative compounds derived from domain II of bactericidal/permeability-increasing protein
JP2517956B2 (ja) 血糖低下剤
AU7526494A (en) Method of inhibiting kaposi's sarcoma
WO1991005803A1 (en) Recombinant human thrombomodulin
NZ536040A (en) Truncated 24 kDa basic fibroblast growth factor

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19950310

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

RHK1 Main classification (correction)

Ipc: A61K 38/00

RHK1 Main classification (correction)

Ipc: A61K 37/02

A4 Supplementary search report drawn up and despatched

Effective date: 19960419

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19970610