EP0621866A4 - Process for preparing 3-acylestratrienes and acylbenzenes. - Google Patents

Process for preparing 3-acylestratrienes and acylbenzenes.

Info

Publication number
EP0621866A4
EP0621866A4 EP93902956A EP93902956A EP0621866A4 EP 0621866 A4 EP0621866 A4 EP 0621866A4 EP 93902956 A EP93902956 A EP 93902956A EP 93902956 A EP93902956 A EP 93902956A EP 0621866 A4 EP0621866 A4 EP 0621866A4
Authority
EP
European Patent Office
Prior art keywords
acylestratrienes
acylbenzenes
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93902956A
Other languages
English (en)
Other versions
EP0621866A1 (en
Inventor
Neil Howard Baine
Michael Mcguire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0621866A1 publication Critical patent/EP0621866A1/en
Publication of EP0621866A4 publication Critical patent/EP0621866A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N30/00—Piezoelectric or electrostrictive devices
    • H10N30/20—Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP93902956A 1992-01-06 1993-01-06 Process for preparing 3-acylestratrienes and acylbenzenes. Withdrawn EP0621866A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81718092A 1992-01-06 1992-01-06
PCT/US1993/000078 WO1993014107A1 (en) 1992-01-06 1993-01-06 Process for preparing 3-acylestratrienes and acylbenzenes
US817180 2001-03-27

Publications (2)

Publication Number Publication Date
EP0621866A1 EP0621866A1 (en) 1994-11-02
EP0621866A4 true EP0621866A4 (en) 1996-03-20

Family

ID=25222515

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93902956A Withdrawn EP0621866A4 (en) 1992-01-06 1993-01-06 Process for preparing 3-acylestratrienes and acylbenzenes.

Country Status (21)

Country Link
EP (1) EP0621866A4 (sv)
JP (1) JPH07503008A (sv)
KR (1) KR940704064A (sv)
CN (1) CN1077200A (sv)
AP (1) AP361A (sv)
AU (1) AU3434793A (sv)
BG (1) BG98888A (sv)
BR (1) BR9305707A (sv)
CA (1) CA2127274A1 (sv)
FI (1) FI943213A (sv)
HU (1) HUT67566A (sv)
IL (1) IL104303A0 (sv)
MA (1) MA22762A1 (sv)
MX (1) MX9300026A (sv)
NO (1) NO942531L (sv)
OA (1) OA09959A (sv)
RU (1) RU94037761A (sv)
SI (1) SI9300005A (sv)
SK (1) SK80194A3 (sv)
WO (1) WO1993014107A1 (sv)
ZA (1) ZA938B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ252866A (en) * 1992-04-30 1996-09-25 Smithkline Beecham Corp 17-acyl-estra-1,3,5(10)-triene-3-carboxylic acids; precursors
GB9411103D0 (en) * 1994-06-03 1994-07-27 Smithkline Beecham Corp Compounds
GB9608045D0 (en) * 1996-04-18 1996-06-19 Pharmacia Spa Process for preparing steroids having a carboxamide side-chain
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
JP5793996B2 (ja) * 2011-06-29 2015-10-14 セントラル硝子株式会社 フルオロ硫酸芳香環エステル類の製造方法
ES2873962T3 (es) 2014-06-06 2021-11-04 Scripps Research Inst Compuestos de fluoruro de azufre (VI) y métodos para la preparación de los mismos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
US4970205A (en) * 1988-12-23 1990-11-13 Smithkline Beecham Corporation Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D. A. HOLT ET AL: "Steroidal A ring aryl carboxylic acids: anew class of steroid 5alpha-reductase inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 3, WASHINGTON US, pages 937 - 942 *
D. A. HOLT ET AL: "Synthesis of a steroidal A ring aromatic sulfonic acid as inhibitor of steroid 5alpha-reductase.", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 56, MA US, pages 4 - 7, XP023431215, DOI: doi:10.1016/0039-128X(91)90106-6 *
M. A. LEVY ET AL.: "3-Phosphinic acid and 3-phosphonic acid steroids as inhibitors of steroid 5alpha-reductase: species comparison and mechanistic studies.", BIOORGANIC CHEMISTRY, vol. 19, no. 3, pages 245 - 260, XP024022783, DOI: doi:10.1016/0045-2068(91)90050-Y *
See also references of WO9314107A1 *

Also Published As

Publication number Publication date
RU94037761A (ru) 1997-05-27
WO1993014107A1 (en) 1993-07-22
NO942531D0 (no) 1994-07-05
SK80194A3 (en) 1994-12-07
MA22762A1 (fr) 1993-10-01
AU3434793A (en) 1993-08-03
FI943213A0 (sv) 1994-07-05
HU9402029D0 (en) 1994-09-28
NO942531L (no) 1994-07-05
JPH07503008A (ja) 1995-03-30
KR940704064A (ko) 1994-12-12
AP361A (en) 1994-09-09
BG98888A (en) 1995-05-31
EP0621866A1 (en) 1994-11-02
MX9300026A (es) 1993-12-01
SI9300005A (en) 1993-09-30
CN1077200A (zh) 1993-10-13
CA2127274A1 (en) 1993-07-22
ZA938B (en) 1994-06-16
AP9300474A0 (en) 1993-01-31
IL104303A0 (en) 1993-05-13
HUT67566A (en) 1995-04-28
BR9305707A (pt) 1996-12-31
OA09959A (en) 1995-12-11
FI943213A (sv) 1994-07-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Ipc: C07J 51/00

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Effective date: 19960425