EP0555235A4 - Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity - Google Patents

Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity

Info

Publication number
EP0555235A4
EP0555235A4 EP19910917319 EP91917319A EP0555235A4 EP 0555235 A4 EP0555235 A4 EP 0555235A4 EP 19910917319 EP19910917319 EP 19910917319 EP 91917319 A EP91917319 A EP 91917319A EP 0555235 A4 EP0555235 A4 EP 0555235A4
Authority
EP
European Patent Office
Prior art keywords
group
thiochromanyl
retinoid
activity
tetrahydroquinolinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910917319
Other languages
English (en)
Other versions
EP0555235A1 (en
Inventor
Roshantha A. S. Chandraratna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of EP0555235A1 publication Critical patent/EP0555235A1/en
Publication of EP0555235A4 publication Critical patent/EP0555235A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP19910917319 1990-10-09 1991-09-24 Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity Withdrawn EP0555235A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59512890A 1990-10-09 1990-10-09
US595128 1990-10-09

Publications (2)

Publication Number Publication Date
EP0555235A1 EP0555235A1 (en) 1993-08-18
EP0555235A4 true EP0555235A4 (en) 1993-11-10

Family

ID=24381853

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910917319 Withdrawn EP0555235A4 (en) 1990-10-09 1991-09-24 Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity

Country Status (13)

Country Link
EP (1) EP0555235A4 (hu)
JP (1) JPH06501684A (hu)
AU (1) AU657100B2 (hu)
CA (1) CA2091763A1 (hu)
FI (1) FI931624A (hu)
HU (1) HUT63412A (hu)
IE (1) IE913568A1 (hu)
IL (1) IL99618A0 (hu)
NZ (1) NZ240059A (hu)
PL (1) PL168075B1 (hu)
PT (1) PT99189A (hu)
WO (1) WO1992006092A1 (hu)
ZA (1) ZA918025B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602130A (en) * 1987-03-20 1997-02-11 Allergan Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
US7452911B2 (en) 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
CN107176945B (zh) 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284288A1 (en) * 1987-03-20 1988-09-28 Allergan, Inc Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
EP0419132A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
EP0419130A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and A 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816466A (en) * 1971-12-22 1974-06-11 Warner Lambert Co Flavanoid ring systems
US3868379A (en) * 1972-04-28 1975-02-25 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2H-1-benzothiopyran-3-carboxylic acid 1,1-dioxide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284288A1 (en) * 1987-03-20 1988-09-28 Allergan, Inc Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
EP0419132A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
EP0419130A2 (en) * 1989-09-19 1991-03-27 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and A 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9206092A1 *

Also Published As

Publication number Publication date
HUT63412A (en) 1993-08-30
JPH06501684A (ja) 1994-02-24
PL168075B1 (pl) 1995-12-30
FI931624A0 (fi) 1993-04-08
HU9301031D0 (en) 1993-07-28
CA2091763A1 (en) 1992-04-10
AU657100B2 (en) 1995-03-02
WO1992006092A1 (en) 1992-04-16
EP0555235A1 (en) 1993-08-18
IL99618A0 (en) 1992-08-18
FI931624A (fi) 1993-04-08
IE913568A1 (en) 1992-04-22
PT99189A (pt) 1992-09-30
AU8614991A (en) 1992-04-28
NZ240059A (en) 1993-10-26
ZA918025B (en) 1992-06-24

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Legal Events

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