EP0549663B1 - Mundspülung mit farbwechsel - Google Patents
Mundspülung mit farbwechsel Download PDFInfo
- Publication number
- EP0549663B1 EP0549663B1 EP91916720A EP91916720A EP0549663B1 EP 0549663 B1 EP0549663 B1 EP 0549663B1 EP 91916720 A EP91916720 A EP 91916720A EP 91916720 A EP91916720 A EP 91916720A EP 0549663 B1 EP0549663 B1 EP 0549663B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquids
- bottle
- liquid
- mouthrinse
- compartments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002324 mouth wash Substances 0.000 title claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 132
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 claims description 24
- 239000000975 dye Substances 0.000 claims description 20
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 14
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- 230000002272 anti-calculus Effects 0.000 claims description 9
- 230000002882 anti-plaque Effects 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- 229920000388 Polyphosphate Polymers 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000001205 polyphosphate Substances 0.000 claims description 6
- 235000011176 polyphosphates Nutrition 0.000 claims description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 239000004075 cariostatic agent Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 150000001340 alkali metals Chemical class 0.000 claims description 4
- -1 benzoate ester Chemical class 0.000 claims description 4
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 4
- 239000001043 yellow dye Substances 0.000 claims description 4
- MDNWOSOZYLHTCG-UHFFFAOYSA-N Dichlorophen Chemical compound OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1O MDNWOSOZYLHTCG-UHFFFAOYSA-N 0.000 claims description 3
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 3
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 239000005864 Sulphur Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 239000001045 blue dye Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229910052736 halogen Chemical group 0.000 claims description 2
- 150000002367 halogens Chemical group 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims 2
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical class C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 claims 1
- 239000003086 colorant Substances 0.000 abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 229910001515 alkali metal fluoride Inorganic materials 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 230000000675 anti-caries Effects 0.000 description 2
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- XJRPTMORGOIMMI-UHFFFAOYSA-N ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(N)=NC=1C(F)(F)F XJRPTMORGOIMMI-UHFFFAOYSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- QDGIEIGBQXURRS-UHFFFAOYSA-N 1-(3-chlorophenyl)-3-(3,4-dichlorophenyl)urea Chemical compound ClC1=CC=CC(NC(=O)NC=2C=C(Cl)C(Cl)=CC=2)=C1 QDGIEIGBQXURRS-UHFFFAOYSA-N 0.000 description 1
- IYOLBFFHPZOQGW-UHFFFAOYSA-N 2,4-dichloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=C(Cl)C(C)=C1Cl IYOLBFFHPZOQGW-UHFFFAOYSA-N 0.000 description 1
- NCKMMSIFQUPKCK-UHFFFAOYSA-N 2-benzyl-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1CC1=CC=CC=C1 NCKMMSIFQUPKCK-UHFFFAOYSA-N 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- UOWIFEANNONTKY-UHFFFAOYSA-N 2-hydroxy-5-octanoyl-n-[3-(trifluoromethyl)phenyl]benzamide Chemical compound CCCCCCCC(=O)C1=CC=C(O)C(C(=O)NC=2C=C(C=CC=2)C(F)(F)F)=C1 UOWIFEANNONTKY-UHFFFAOYSA-N 0.000 description 1
- 229940061334 2-phenylphenol Drugs 0.000 description 1
- ZJIQNOMMMRNUEM-UHFFFAOYSA-N 3,4-dichloro-n-(3,5-dichlorophenyl)-2-hydroxybenzamide Chemical compound OC1=C(Cl)C(Cl)=CC=C1C(=O)NC1=CC(Cl)=CC(Cl)=C1 ZJIQNOMMMRNUEM-UHFFFAOYSA-N 0.000 description 1
- YJESMCOKCBFYBX-UHFFFAOYSA-N 3,5,6-trichloro-n-(3-chlorophenyl)-6-hydroxycyclohexa-2,4-diene-1-carboxamide Chemical compound C1=C(Cl)C=C(Cl)C(O)(Cl)C1C(=O)NC1=CC=CC(Cl)=C1 YJESMCOKCBFYBX-UHFFFAOYSA-N 0.000 description 1
- DHXRZKZQWUOVLK-UHFFFAOYSA-N 3-bromo-n-[3-bromo-5-(trifluoromethyl)phenyl]-2-hydroxybenzamide Chemical compound OC1=C(Br)C=CC=C1C(=O)NC1=CC(Br)=CC(C(F)(F)F)=C1 DHXRZKZQWUOVLK-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- CTFFKFYWSOSIAA-UHFFFAOYSA-N 5-bromo-n-(4-bromophenyl)-2-hydroxybenzamide Chemical compound OC1=CC=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 CTFFKFYWSOSIAA-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- CKGWFZQGEQJZIL-UHFFFAOYSA-N amylmetacresol Chemical compound CCCCCC1=CC=C(C)C=C1O CKGWFZQGEQJZIL-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- JFIOVJDNOJYLKP-UHFFFAOYSA-N bithionol Chemical compound OC1=C(Cl)C=C(Cl)C=C1SC1=CC(Cl)=CC(Cl)=C1O JFIOVJDNOJYLKP-UHFFFAOYSA-N 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- OBRMNDMBJQTZHV-UHFFFAOYSA-N cresol red Chemical compound C1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(C)C(O)=CC=2)=C1 OBRMNDMBJQTZHV-UHFFFAOYSA-N 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- ANUSOIHIIPAHJV-UHFFFAOYSA-N fenticlor Chemical compound OC1=CC=C(Cl)C=C1SC1=CC(Cl)=CC=C1O ANUSOIHIIPAHJV-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 238000010944 pre-mature reactiony Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- PRZSXZWFJHEZBJ-UHFFFAOYSA-N thymol blue Chemical compound C1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=CC(O)=C(C(C)C)C=2)C)=C1C PRZSXZWFJHEZBJ-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- KVSKGMLNBAPGKH-UHFFFAOYSA-N tribromosalicylanilide Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 KVSKGMLNBAPGKH-UHFFFAOYSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
- B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
- B65D1/04—Multi-cavity bottles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3283—Cylindrical or polygonal containers, e.g. bottles, with two or more substantially axially offset, side-by-side compartments for simultaneous dispensing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/45—Colour indicators, e.g. pH- or Redox indicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/07—Bottles and jars with drinking cup
Definitions
- the present invention relates to a mouthrinse product comprising several liquids stored in separate compartments of a multi-compartment bottle. As viewed by the consumer, the liquids in the compartments are of different colors, but when liquids are dispensed from the bottle they combine to form a liquid of yet another color.
- FR-A-944 506 discloses dentifrices, made of paste and more or less fluid liquids, with two different compositions contained in different recipients and brought into contact with each other at the moment of use in such a way that they react together to produce a colour change.
- the mouthrinse product of the invention comprises a bottle having a plurality of separate compartments each having its own open spout through which liquid stored therein may be dispensed.
- Each of the compartments is filled with an orally acceptable liquid, at least one of the liquids having a first color and at least another of the liquids having a second color, the liquids being out of contact with one another while they are stored in the compartments and the bottle having at least a transparent portion through which the liquids stored within the compartments may be seen.
- the compartments and spouts are arranged such that when the bottle is tipped from a normal vertical non-dispensing position to a dispensing position, the liquids will flow out of the compartments via the open spouts, and, after they exit the bottle, will be combined to form a liquid of a third color.
- Completing the mouthrinse product is a removable cap means for sealingly closing the open spouts.
- the liquids having the first color are at a first pH, at least one of the other liquids is at a second pH and the dispensed liquid admixture is at a third pH; the liquids having the first color comprising an orally acceptable dye having one color at the first pH and another color at the third pH.
- Orally acceptable indicator dyes such as phenolphthalein, may be used as the dye that changes color depending on pH.
- Completing the mouthrinse product is a therapeutically effective amount of an oral hygiene medicament in at least one of the liquids stored in the bottle.
- at least one of the liquids in the bottle comprises one part of a two-part orally acceptable effervescent couple, while at least another of the liquids comprises the other part of the effervescent couple, the two parts of the effervescent couple reacting to produce carbon dioxide when the liquids are combined after they have been dispensed from the bottle.
- Fig. 1 shows a mouthrinse product of the invention comprising a bottle 1 and cap 2.
- Bottle 1 contains red, colorless and blue liquids in compartments 3, 4 and 5, respectively, When the bottle 1 is tipped as shown in Fig. 4, the liquids are separately dispensed from compartments 3, 4, and 5 and are then combined in cap 4 to form an aqua orally acceptable mouthrinse M.
- the composition of the liquids will be discussed in detail hereinafter.
- each of compartments 3, 4, 5 is defined by its own continuous wall 3a, 4a, 5a respectively, compartment 4 being joined to compartments 3 and 5 by means of webs 6 that extend from the bottom of the bottle 1 to the spouts 3b, 4b, 5b (Fig. 3). In this manner, the liquids in compartments 3, 4, 5 are prevented from contacting one another while they are stored in the compartments.
- bottle 1 On its front and rear surfaces, bottle 1 is provided with ribs 7 that cooperate with ribs 8 provided inside cap 2, whereby cap 2 may be snap-fitted onto bottle 1 and readily disengaged therefrom.
- Cap 2 is also provided with flexible gasket 9 that enters spouts 3b, 4b, 5b when cap 2 is snapped onto bottle 1, thereby sealingly closing the spouts.
- bottle 1 and cap 2 are each made of plastic.
- bottle 1 is formed by blow-molding, while cap is injection molded.
- bottle 1 may be of glass or other suitable material, while cap 2 may be of metal, rubber or the like.
- bottle 1 is made of a transparent material, such as a transparent plastic, so that all of the liquids stored in bottle 1 can be seen. If desired, however, only part of bottle 1 may be transparent.
- Figs. 5 and 6 show a mouthrinse product comprising bottle 20 having compartments 21 and 22 defined by walls 21a and 22a, respectively, that are joined together via common wall 23 without any intermediate web. Compartments 21 and 22 terminate in spouts 24 to which are screw threaded caps 25 to sealingly close spouts 24.
- Other bottles suitable for use in the present invention include the multi-compartment bottles of U.S. Design Patents 189,932, 190,101, 214,549, 287,571, 288,526, and 290,225 and U.S. Patent 3,729,553.
- Bottle 1 has a distinctive shape provided by the upwardly tapering walls 3a and 5a and by the rectangular cross-section of compartment 4 and the semi-circular cross-sections of compartments 3 and 5.
- any suitable shape may be used such as provided by the uniform, circular cross-section of compartments 21 and 22 of bottle 20.
- Compartments 3, 4, 5 and 21, 22 and spouts 3b, 4b, 5b and 25 are proportioned such that the ratio of the liquids dispensed from compartments 3, 4, 5 or 21, 22 to form the dispensed mouthrinse M will provide the desired reaction between the liquids and preferably will ensure that substantially all of the liquids in compartments 3, 4 5 or 21, 22 are emptied at about the same time.
- each of compartments 3, 4, 5 and 21, 22 with substantially the same volume, whereby each compartment will contain substantially the same amount of liquid, and to provide spouts 3b, 4b, 5b or 25 with the same cross-sectional area, whereby the liquids in compartments 3, 4, 5 or 21,22 are dispensed from the bottle 1 or 20 at substantially the same flow rate and in substantially the same amount.
- compartments 3, 4, 5 contain red, colorless and blue liquids, respectively.
- the red liquid has an alkaline pH and contains phenolphthalein and a yellow dye, while the blue liquid contains a blue dye and the colorless water-white liquid contains no dyes.
- the blue and colorless liquids may both be at acid pH or one may be acidic and the other may be substantially neutral.
- the red liquid is red because phenolphthalein is red at alkaline pH, the small amount of yellow dye being masked or hidden by the phenolphthalein.
- the liquids When bottle 1 is tipped from the vertical, non-dispensing position to the dispensing position shown in Fig. 4, the liquids will flow out of compartments 3, 4 5 and be admixed in cap 2 to form the mouthrinse M. The consumer would expect the liquids to combine to form a purple mouthrinse M. However, the liquid or liquids at acid pH will react with the red liquid to form a mouthrinse M of pH from about 5.0 to abut 8.5.
- the phenolphthalein in the mouthrinse M becomes colorless, and mouthrinse M is thus aqua resulting from the lue and yellow dyes in mouthrinse M, contrary to the consumer's expectation.
- the liquids can be dispensed into any suitable cup or glass, if desired, rather than into cap 2.
- Compartments 21 and 22 of bottle 20 may be filled with the red and blue liquids described above, whereby after they are dispensed from bottle 20 the liquids will also combine to form an aqua mouthrinse M (not shown).
- alkaline and acidic liquids when used, they will contain an orally acceptable base and an orally acceptable acid, respectively, as a two-part effervescent couple, so that mouthrinse M will be effervescent, resulting from carbon dioxide bubbles B formed by the reaction between the acid in the acidic liquid and the base in the alkaline liquid.
- the three-colored mouthrinse in bottle 1 will dispense a mouthrinse M of a fourth and different color, the effervescence being a preferred but optional feature.
- the consumer appeal of the product results from a unique combination of container construction and dye chemistry.
- color and “colors” includes colors of any hue and intensity, including black, white and colorless.
- the liquids may comprise an opacifying agent, such as droplets of mineral oil, to provide a pastel effect.
- phenolphthalein is used in the above description and the following Examples, other orally acceptable indicator dyes can be used if they provide a color change at the pH of the dispensed mouthrinse, namely when at a pH in the range of from about 5.0 to about 9.0. See, for example, Food Chemical Codex, Third Edition, National Academy Press, Washington, D.C., 1981, pages 568-569, which describes orally acceptable indicator dyes.
- Useful orally acceptable indicator dyes include bromocresol purple (pH 5.2 yellow to pH 6.8 purple), bromothymol blue (pH 6.0 yellow to pH 7.6 blue), cresol red (pH 7.2 yellow to pH 8.8 blue),neutral red (pH 6.8 red to pH 8.0 orange), phenol red (pH 6.8 yellow to pH 8.2 red), thymol blue (pH 1.2 red to pH 8.0 yellow; pH 9.2 blue to pH 8.0 yellow).
- the present invention thus provides a mouthrinse product wherein at least one of the liquids in a multi-compartment bottle contains an orally acceptable indicator dye that has different colors at different pH values and at least one of the other liquids in the bottle will provide the dispensed mouthrinse with a pH at which the indicator dye changes color. If the indicator dye, like phenolphthalein, becomes colorless, then the liquids in the compartments of the bottle may employ the "hidden" dye technique described above so that the mouthrinse M is different in color than any of the liquids in the bottle.
- the indicator dye is not colorless when in its compartment or in the combined mouthrinse mixture, such as bromocresol purple
- the indicator dye as the sole dye in any of the liquids in the bottle.
- two liquids can be stored in separate compartments in the bottle, one liquid containing the indicator dye and being at a first pH and the other being colorless or containing a suitable dye and being at a second pH, whereby the liquids after they are dispensed from the bottle will form a mouthrinse mixture at a third pH having a different color than any of the liquids in the bottle.
- the mouthrinse of the invention will also include a therapeutically effective amount of an oral hygiene medicament.
- All of the liquids in the multi-compartment bottle may contain the oral hygiene medicament or the oral hygiene medicament may be in only some of the liquids. For example, if one of the liquids is at a pH that will adversely affect the oral hygiene medicament, then the medicament will be located in one of the other liquids.
- Any of the oral hygiene medicaments suitable for use in a mouthrinse product may be used in the present invention, such as anti-caries agents, anti-calculus agents, anti-plaque agents, anti-microbial agents or the like.
- Suitable anti-caries agents include fluoride ion sources, such as alkali metal fluorides, alkali metal monofluorophosphates, stannous fluoride and the like.
- fluoride ion sources such as alkali metal fluorides, alkali metal monofluorophosphates, stannous fluoride and the like.
- an alkali metal fluoride most preferably sodium fluoride, will be used.
- the anti-caries agent is used in an anti-caries effective amount.
- fluoride ion sources may be used in an amount sufficient to provide from abut 25 ppm to about 1000 ppm, preferably from about 25 to about 300 ppm fluoride, based on the total weight of the mouthrinse.
- Suitable anti-calculus agents include the linear molecularly dehydrated polyphosphate salts, including alkali metal tripolyphosphates and pyrophosphates, such as sodium tripolyphosphate, di- and/or tetrasodium pyrophosphate, di- and/or tetrapotassium pyrophosphate and the like. If necessary, stabilizing agents may be used with the anticalculus agent.
- the polyphosphate anticalculus agent may be used in an amount of up to about 5%, preferably from about 0.5 to about 2%, by weight, based on the total weight of the mouthrinse. As described in Gaffar et al. U.S.
- the linear polyphosphates may be used in combination with an amount of a fluoride ion source sufficient to provide about 25 to about 1000 ppm fluoride ions and about 0.005 to about 3% by weight, based on the total weight of the mouthrinse, of a synthetic anionic linear polymeric polycarboxylate having a molecular weight of from about 2000 to about one million, as inhibitors of enzymatic hydrolysis of the polyphosphate anti-calculus agent.
- the fluoride ion source when used, may serve both as an anti-caries agent and an enzyme inhibitor.
- the mouthrinse provides anti-calculus and anti-plaque activity
- the oral hygiene medicament comprises a water-soluble alkali metal tripolyphosphate salt and a substantially water-insoluble noncationic anti-bacterial agent, whereby the mouthrinse is useful in the treatment of gum disease.
- one or more of the liquids in the bottle will contain an orally acceptable alcoholic solubilizing agent to solubilize the water-insoluble anti-bacterial noncationic agent.
- Useful noncationic anti-bacterial agents include compounds of formula (I): in which R 1 is oxygen, sulphur, or alkylene of from one to six carbon atoms and each of R 2 to R 6 and R 12 to R 16 is hydrogen, hydroxyl or halogen; phenolic or bisphenolic compounds; benzoate esters; or halogenated carbanilides.
- Suitable compounds of formula (I) include 5,5'-dichloro-2,2'-dihydroxydiphenylmethane, 2,2'-dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane, 3,3'-dibromo-5,5'-dichloro-2,2'-dihydroxydiphenylether, and preferably 2,4,4'-tricolor-2'-hydroxydiphenylether (triclosan).
- phenolic compounds which include the halogenated salicylanilides, include, for example, 2-phenylphenol, 4-chlorophenol, 4-chloro-3-methylphenol, 4-chloro-3-methylphenol, 4-chloro-3,5-dimethylphenol, 2,4-dichloro-3,5-dimethylphenol, 5-methyl-2-pentylphenol, 4-isopropyl-3-methylphenol, 5-chloro-2-hydroxydiphenylmethane, 4',5-dibromosalicylanilide, 3,4',5-tribromosalicylanilide, 2,3,3',5-tetrachlorosalicylanilide, 3,3',4,5'-tetrachlorosalicylanilide, 3,5'dibromo-3'-trifluoromethylsalicylanilide, and 5-n-octanoyl-3'-trifluoromethylsalicylanilide.
- bisphenolic compounds include, for example, 2,2'-methylenebis(3,4,6-trichlorophenol), 2,2'-methylenebis(4-chlorophenol), 2,2'methylenebis(4-chloro-6-bromophenol), bis(2-hydroxy-3,5-dichlorophenyl)sulphide, and bis(2-hydroxy-5-chlorophenyl)sulphide.
- benzoate esters include, for example, esters of hydroxybenzoic acid, especially the methyl, ethyl, propyl, isopropyl, butyl, isobutyl, hexyl, heptyl and benzyl esters.
- halogenated carbanilides include, for example, 3,4,4'-trichlorocarbanilide, 3-trifluoromethyl-4,4'-dichlorocarbanilide, and 3,3',4-trichlorocarbanilide.
- the noncationic anti-bacterial agent will be used in an amount of from about 0.01 to about 2%, preferably about 0.05 to about 1.0%, by weight, based on the total weight of the mouthrinse.
- the mouthrinse of the invention will comprise from about 45 to abut 95%, by weight of water, based on the total weight of the mouthrinse, and the pH of the mouthrinse formed after the liquids dispensed from the bottle are combined will usually be substantially neutral, although depending on the inidcator dye used, a pH of from about 5.0 to about 9.0 may be useful.
- an effervescent couple comprising an orally acceptable acid and an rally acceptable base, she effervescent couple reacting to produce carbon dioxide.
- the acid and base will be present in separate liquids stored in separate compartments to prevent premature reaction of the couple.
- Useful orally acceptable acids include organic acids, such as citric acid, tartaric acid, malic acid, fumaric acid and the like, while useful orally acceptable bases include metal carbonate and bicarbonate salts, such as alkali or alkaline earth metal carbonates and bicarbonates and the like.
- a presently preferred effervescent couple is citric acid and a sodium bicarbonate-sodium carbonate mixture.
- each moiety of the effervescent couple may be present in an amount of from about 0.5 to abut 6% by weight, based on the weight of the liquid containing the moiety.
- Various optional conventional oral hygiene components may also be included, such as orally acceptable alcohols, excipients, detergents, buffering agents, flavoring agents, sweetening agents and the like.
- the mouthrinse contains from about 1 to about 20% of glycerine, sorbitol or propylene glycol or the like to provide body and proper "mouthfeel".
- the mouthrinse is used as described above by dispensing the liquids the bottle to form the mouthrinse and applying it to the teeth and other surfaces of the oral cavity.
- Red, blue and colorless liquids were prepared by admixing the following ingredients: INGREDIENTS RED LIQUID BLUE LIQUID COLORLESS LIQUID Deionized Water 67.224 74.0678 71.230 Ethanol, 190 Proof 14.480 12.5000 12.500 Glycerin 2.000 12.0000 12.000 Sodium Bicarbonate 2.190 ------- --- Sodium Carbonate 2.800 ------- Citric Acid ------ ---------- Nonionic Surfactant 1.000 1.0000 1.000 Phenolphthalein 0.020 ------- Sodium Citrate ------ ------- 0.010 Cetylpyridinium Chloride ------ 0.0750 0.075 Sodium Saccharin 0.035 0.0350 0.035 Flavor 0.250 0.2500 0.250 FD&C Blue #1 ------ 0.0022 ------ FD&C Yellow #5 0.001 ------- ------ Disodium Hydrogen Phosphate ------------
- the pH of the red liquid was 10.0
- the pH of the colorless liquid was 2.5
- the pH of the blue liquid was 4.5.
- Equal amounts of the three liquids, were filled into compartments 3, 4, 5 of 510 g (18 ounce) bottles of the type shown in Figs. 1-4.
- the liquids after being dispensed from the bottle combined to form an effervescent anti-plaque mouthrinse having a pH of 6.7 and an aqua color.
- the effervescence was produced by carbon dioxide bubbles formed by the reaction of sodium bicarbonate and sodium carbonate in the red liquid and citric acid in the colorless liquid.
- Red and blue liquids were prepared by admixing the following ingredients: INGREDIENTS RED LIQUID BLUE LIQUID DEIONIZED WATER 69.8744 72.1742 ETHANOL, 190 PROOF 13.5000 12.5000 GLYCERIN 12.0000 12.0000 SODIUM BICARBONATE 1.4600 ------- SODIUM CARBONATE 1.8666 ------- CITRIC ACID ------- 1.9334 NONIONIC SURFACTANT 1.0000 1.0000 PHENOLPHTHALEIN 0.0134 ------- SODIUM CITRATE ------- 0.0066 CETYLPYRIDINIUM CHLORIDE ------- 0.1000 SODIUM SACCHARIN 0.0350 0.0350 FLAVOR 0.2500 0.2500 FD&C BLUE #1 ------- 0.0008 FD&C YELLOW #5 0.0006 ------- 100.0000% ⁇ 100.0000% ⁇
- the red liquid had a pH of 10.0 while the blue liquid had a pH of 2.5.
- the liquids formed an aqua effervescent, anti-plaque mouthrinse having a pH of 7.0.
- Red and blue liquids are prepared by admixing the following ingredients to obtain a red alkaline liquid and an acidic blue liquid, which when mixed together form an aqua, effervescent mouthrinse having anti-caries, anti-calculus and anti-plaque activity.
- the red and blue liquids are filled into compartments of the two-compartment bottle shown in Figs. 5 and 6 to provide a 510 g (18 ounce) mouthrinse product of the invention.
- Red, blue and colorless liquids were prepared by admixing the following ingredients.
- the pH of the red liquid was 10.0, the pH of the colorless liquid was 6.5 and the pH of the blue liquid was 2.5.
- Equal amounts of the three liquids were filled into compartments 3, 4, 5 of 18 ounce bottles of the type shown in Figs. 1-4.
- the liquid after being dispensed from the bottle combined to form an effervescent anti-plaque mouthrinse having a pH of 6.7 and an aqua color.
- the effervescence was produced by carbon dioxide bubbles formed by the reaction of sodium bicarbonate and sodium carbonate in the red liquid and citric acid in the colorless liquid.
- This Example illustrates the formulation flexibility provided by the present invention.
- all of the flavor is present in the colorless, substantially neutral phase, which permits the use of acid- or alkaline-sensitive flavors.
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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Claims (10)
- Mundspülungs-Produkt, welches aufweist:A. eine Flasche mit mehreren getrennten Kammern, wovon jede ihr eigenes offenes Gießteil besitzt, durch welches darin aufbewahrte Flüssigkeit ausgegeben werden kann, und mit oral annehmbaren Flüssigkeiten, welche jede dieser Kammern füllen, wobei mindestens eine von den Flüssigkeiten eine erste Farbe aufweist und mindestens eine weitere Flüssigkeit eine zweite Farbe aufweist, wobei die Flüssigkeiten nicht miteinander in Kontakt stehen, während sie in den Kammern aufbewahrt werden; wobei die Flasche zumindest einen transparenten Abschnitt aufweist, durch welchen hindurch die in den Kammern aufbewahrten Flüssigkeiten gesehen werden können; wobei die Kammern und Gießteile so angeordnet sind, daß wenn die Flasche aus einer normalen vertikalen, nicht zum Ausgeben geeigneten Lage in eine Lage zum Ausgeben gekippt wird, die Flüssigkeiten durch die Gießteile aus den Kammern herausfließen, und nachdem sie die Flasche verlassen haben, miteinander vereint werden, um ein Flüssigkeitsgemisch mit einer dritten Farbe zu bilden; und mit einer abnehmbaren Kappeneinrichtung zum dichten Verschließen der Gießteile;B. wobei die Flüssigkeiten mit der ersten Farbe einen ersten pH-Wert aufweisen, mindestens eine weitere von den Flüssigkeiten einen zweiten pH-Wert aufweist und das ausgegebene Flüssigkeitsgemisch einen dritten pH-Wert aufweist; wobei die Flüssigkeiten mit der ersten Farbe einen oral annehmbaren Farbstoff mit einer Farbe bei dem ersten pH-Wert und einer anderen Farbe bei dem dritten pH-Wert aufweist; undC. eine therapeutisch wirksame Menge eines Oral-Hygiene-Medikaments in mindestens einer von diesen sich in der Flasche befindlichen Flüssigkeiten.
- Mundspülungs-Produkt nach Anspruch 1, wobei die Flasche ein oberes Ende und einen Boden besitzt und drei in Längsrichtung sich erstreckende Kammern aufweist, wovon jede ihr eigenes Gießteil an dem oberen Ende jeder Kammer hat, der erste und zweite pH-Wert alkalisch bzw. sauer sind, die erste Kammer eine rote Flüssigkeit bei alkalischen pH-Wert als die Flüssigkeit mit der ersten Farbe aufbewahrt und Phenolphatelein als den oral annehmbaren Farbstoff aufweist, die zweite Kammer die Flüssigkeit mit der zweiten Farbe aufbewahrt und die dritte Kammer eine dritte Flüssigkeit aufbewahrt, wovon zumindest eine von den Flüssigkeiten in der zweiten und dritten Kammer einen sauren pH-Wert aufweist.
- Mundspülungs-Produkt nach Anspruch 2, wobei die rote Flüssigkeit auch einen oral annehmbaren gelben Farbstoff aufweist, die Flüssigkeit in der zweiten Kammer eine blaue Flüssigkeit ist, welche einen oral annehmbaren blauen Farbstoff aufweist, die Flüssigkeit in der dritten Kammer farblos ist und das Flüssigkeitsgemisch Aqua ist.
- Mundspülungs-Produkt nach Anspruch 3, wobei die Flasche transparent ist und gegenüberliegende parallele abgeflachte Seiten zwischen dem oberen Ende und dem Boden aufweist.
- Mundspülungs-Produkt nach einem der Ansprüche 1 bis 4, wobei mindestens eine der Flüssigkeiten in der Flasche einen Teil eines zweiteiligen oral annehmbaren, eine Sprudelwirkung erzeugenden Paares und zumindest eine weitere von diesen Flüssigkeiten in der Flasche den anderen Teil des die Sprudelwirkung erzeugenden Paares aufweist, die zwei Teile des die Sprudelwirkung erzeugenden Paares reagieren, so daß Kohlendioxid erzeugt wird, wenn die Flüssigkeiten vereint werden, um das ausgegebene Flüssigkeitsgemisch zu bilden.
- Mundspülungs-Produkt nach Anspruch 5, wobei das die Sprudelwirkung erzeugende Paar Natriumhydrogencarbonat und Natriumcarbonat und eine oral annehmbare organische Säure aufweist.
- Mundspülungs-Produkt nach einem der Ansprüche 1 bis 6, wobei das orale Hygienemedikament ein Anti-Karies-Agens, ein Anti-Konkrement-Agens, ein Anti-Plaque-Agens und/oder ein antimikrobielles Agens aufweist.
- Mundspülungs-Produkt nach Anspruch 7, wobei das Oral-Hygiene-Medikament ein wasserlösliches Alkalimetallpolyphosphat und ein im wesentlichen wasserunlösliches nicht-kationisches antibakterielles Agens aufweist, wodurch das Mundspülmittel eine Anti-Konkrement- und eine Anti-Plaque-Aktivität besitzt.
- Mundspülungs-Produkt nach Anspruch 8, wobei das wasserlösliche Alkalimetallpolyphosphat Natriumtripolyphosphat ist und das nicht-kationische antibakterielle Agens aus der Gruppe ausgewählt wird, die aus einem Diphenylether der Formel (I) besteht:
- Mundspülungs-Produkt nach Anspruch 9, wobei die Verbindung der Formel (I) aus der aus Gruppe bestehend aus 5,5'-Dichlor-2,2'-Dihydroxydiphenylmethan; 2,2'-Dihydroxy-3,5,6,3',5',6'-Hexachlordiphenylmethan, 3,3'-Dibrom-5,5'-Dichlor-2,2'-Dihydroxydiphenylether und 2,4,4'-Trichlor-2'-Hydroxydiphenylether gewählt wird.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/580,648 US5154917A (en) | 1990-09-11 | 1990-09-11 | Color change mouthrinse |
PCT/US1991/006495 WO1992004007A1 (en) | 1990-09-11 | 1991-09-10 | Color change mouthrinse |
US580648 | 2000-05-30 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0549663A1 EP0549663A1 (de) | 1993-07-07 |
EP0549663A4 EP0549663A4 (de) | 1994-02-16 |
EP0549663B1 true EP0549663B1 (de) | 1997-07-30 |
Family
ID=24321938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91916720A Expired - Lifetime EP0549663B1 (de) | 1990-09-11 | 1991-09-10 | Mundspülung mit farbwechsel |
Country Status (10)
Country | Link |
---|---|
US (1) | US5154917A (de) |
EP (1) | EP0549663B1 (de) |
JP (1) | JPH06500998A (de) |
AT (1) | ATE156010T1 (de) |
CA (1) | CA2089727A1 (de) |
DE (1) | DE69127090T2 (de) |
HK (1) | HK1001718A1 (de) |
IE (1) | IE80895B1 (de) |
WO (1) | WO1992004007A1 (de) |
ZA (1) | ZA917172B (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008036506A2 (en) * | 2006-09-19 | 2008-03-27 | Ultradent Products, Inc. | Water and sodium hypochlorite indicating endodontic monitoring devices |
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GB2275667B (en) * | 1993-03-05 | 1997-01-15 | Gilbeys Of Ireland | Improvements in and relating to beverage containers |
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US8870027B2 (en) | 2012-03-15 | 2014-10-28 | David G. Kraenzle | Multi-bottle containers for dispensing measured quantities of liquids |
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US9044083B2 (en) | 2012-08-15 | 2015-06-02 | Children Oral Care, Llc | Illuminated multi-light flashing toothbrush and method of use |
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-
1990
- 1990-09-11 US US07/580,648 patent/US5154917A/en not_active Expired - Fee Related
-
1991
- 1991-09-10 EP EP91916720A patent/EP0549663B1/de not_active Expired - Lifetime
- 1991-09-10 JP JP3515902A patent/JPH06500998A/ja active Pending
- 1991-09-10 CA CA002089727A patent/CA2089727A1/en not_active Abandoned
- 1991-09-10 DE DE69127090T patent/DE69127090T2/de not_active Expired - Fee Related
- 1991-09-10 ZA ZA917172A patent/ZA917172B/xx unknown
- 1991-09-10 IE IE317891A patent/IE80895B1/en not_active IP Right Cessation
- 1991-09-10 AT AT91916720T patent/ATE156010T1/de not_active IP Right Cessation
- 1991-09-10 WO PCT/US1991/006495 patent/WO1992004007A1/en active IP Right Grant
-
1998
- 1998-01-23 HK HK98100652A patent/HK1001718A1/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008036506A2 (en) * | 2006-09-19 | 2008-03-27 | Ultradent Products, Inc. | Water and sodium hypochlorite indicating endodontic monitoring devices |
WO2008036506A3 (en) * | 2006-09-19 | 2008-05-22 | Ultradent Products Inc | Water and sodium hypochlorite indicating endodontic monitoring devices |
Also Published As
Publication number | Publication date |
---|---|
IE80895B1 (en) | 1999-06-02 |
DE69127090D1 (de) | 1997-09-04 |
WO1992004007A1 (en) | 1992-03-19 |
US5154917A (en) | 1992-10-13 |
ZA917172B (en) | 1992-06-24 |
CA2089727A1 (en) | 1992-03-12 |
DE69127090T2 (de) | 1998-02-26 |
JPH06500998A (ja) | 1994-01-27 |
EP0549663A1 (de) | 1993-07-07 |
EP0549663A4 (de) | 1994-02-16 |
ATE156010T1 (de) | 1997-08-15 |
HK1001718A1 (en) | 1998-07-03 |
IE913178A1 (en) | 1992-03-11 |
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