EP0448198B1 - Strömungsmittel-Mischvorrichtung - Google Patents
Strömungsmittel-Mischvorrichtung Download PDFInfo
- Publication number
- EP0448198B1 EP0448198B1 EP91300667A EP91300667A EP0448198B1 EP 0448198 B1 EP0448198 B1 EP 0448198B1 EP 91300667 A EP91300667 A EP 91300667A EP 91300667 A EP91300667 A EP 91300667A EP 0448198 B1 EP0448198 B1 EP 0448198B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- conduit
- fluid
- mixing chamber
- port
- axis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title claims description 118
- 239000000523 sample Substances 0.000 claims description 57
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000003260 vortexing Methods 0.000 description 11
- 239000000872 buffer Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000004891 communication Methods 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
Definitions
- the present invention relates to the field of fluid handling devices and more particularly to an improved fluid mixing device. Still more particularly the fluid mixing device may be adapted for use in mixing liquids used in automated clinical chemistry analyzers.
- GB-A-2 0969 911 describes an atomizer including a first mixer stage which has a cylindrical fluid mixing sonic cavitation chamber provided with a first fluid inlet to direct fluid, e.g. a gas, within the chamber along the longitudinal axis of the chamber and a second fluid inlet tangentially positioned to intersect the chamber in order to create a fluid vortex within the chamber.
- a deflector plate is provided in proximity to the first fluid inlet to direct a portion of the longitudinal flow into the vortex flow of the second fluid, e.g. a liquid.
- the atomizer so described is intended for use in feeding combustion chambers with combustible fluids.
- US-A-3 867 195 proposes a syrup production device wherein sugar crystals are dropped into a vortex of water formed by rapid supply of water through a water inlet arranged tangentially to a cylindrical vertically disposed mixing chamber. The vortex entrains the sugar crystals to form a syrup which is removed through a bottom outlet ejector to a storage or further treatment area.
- the apparatus described provides for return of some of the syrup from the storage/treatment area through the outlet conduit via a re-circulation conduit.
- a common requirement in fluid handling systems is the mixing of two fluid flows to form a third fluid flow.
- automated clinical chemistry analyzers frequently require two fluid flows to be mixed together to form a third fluid flow that is then analyzed.
- a first fluid may be, for example, a patient sample such as serum, plasma, urine or spinal fluid (CSF).
- the second fluid may be a buffer which, when combined with the first fluid, controls primarily the pH, ionic strength and surfactant properties of the resulting mixture.
- a mixing chamber 100 includes a vertical conduit 108 which is adapted to receive a probe 102 having a tip 104.
- a conduit 106 is "T"-ed into the side of and is perpendicular to the conduit 108.
- the conduit 106 is connected to a source of buffer which is to mix with sample ejected through the probe tip 104.
- An exit conduit 110 forms a right angle with the conduit 108 to draw the combined sample and buffer from the mixing chamber 100.
- the "T" configuration of the prior art system may impede mixing of the sample and buffer for several reasons.
- the flows may simply combine without mixing, resulting in laminar, separate flows within the conduits 108 and 110.
- the degree of laminar, separate flow is influenced by the vertical position of the tip 104 within the conduit 108, thus making the system sensitive to routine changes in probe tip position that occur, for example, due to normal wear and tear and routine replacement of the probe 102.
- an air bubble may be trapped directly below the tip 104 within the flow of sample from the tip 104. Such an air bubble vibrates rapidly within the conduit 108, resulting in pulses or bursts of sample within the flow of buffer.
- air trapped above the conduit 106 while not causing pulses or bursts in the combined flow, does gradually break up, flowing to the flow cell where such disbursed air can collect, adversely affecting measurements.
- the improved fluid mixing device of the present invention overcomes the limitations noted in the prior device.
- the improved fluid mixing device may be formed directly in the sample injection cell and, more particularly, may replace the mixing chamber found in the prior art sample injection cell.
- the improved fluid mixing device includes a mixing chamber having a cylindrical side wall, end walls and a major axis parallel to and coaxial with the cylindrical side wall.
- a first fluid conduit joins the mixing chamber at a first fluid port formed in one of the end walls.
- a second fluid conduit joins the mixing chamber at a second fluid port, the second port being formed in the cylindrical side wall.
- the second fluid conduit and second fluid port are offset with respect to the major axis to direct a fluid flow from the second conduit through the second port generally along the side wall and around the major axis of the mixing chamber, creating a swirling action within the mixing chamber.
- a third fluid conduit joins the mixing chamber at a third port in the other end and serves as an exit conduit for the fluids mixed in the mixing chamber.
- the mixing chamber may form a first stage of a mixing device or configuration.
- a second stage includes positioning the third port off-center in the second end and generally aligning the third fluid conduit with the major axis.
- a third stage of the mixing device or configuration disclosed herein may include a fourth conduit intersecting the third conduit. Center lines of the third and fourth conduits are offset and do not intersect.
- the improved fluid mixing device of the present invention thoroughly and completely mixes the two streams of inlet fluids.
- the improved mixing results in more consistent performance and better average precision in the measurement of electrolytes.
- Figure 1 is an overall exterior view of a sample injection cell including an improved mixing device or configuration in accordance with the present invention as well as a sample probe.
- Figure 2 is an enlarged partial cross-section view of the improved fluid mixing configuration of the injection cell of Figure 1.
- Figure 3 is a partial cross-section view taken along line 3 - 3 of Figure 2 with the probe removed for clarity.
- Figure 4 is a partial cross-section view taken along line 4 - 4 of Figure 2.
- Figure 5 is a partial cross-section view of a mixing chamber of a prior-art sample injection cell.
- a sample injection cell 10 may include an improved fluid mixing device or configuration 12 in accordance with the present invention.
- the sample injection cell 10 is generally a vertical cylinder and may be formed from cast acrylic.
- the cell 10 includes an upper portion 14 and a lower portion 16.
- the upper portion 14 includes an open end 18 and tapered surfaces 20 leading to a vertical central cylindrical bore 22.
- a horizontal conduit 24 leads to and is in communication with the bore 22.
- the lower portion 16 includes the mixing configuration 12 more particularly described with reference to Figures 2 - 4 below.
- the upper and lower portions 14 and 16 are joined by, for example, screws 26 (only one of which is shown in Figure 1).
- a sample probe assembly 28 includes a fluid carrying conduit 30 which may be attached via a hose 32 to pumps, for example, for aspirating sample from sample containers (not shown) and discharging the aspirated sample into the cell 10.
- the probe assembly 28 includes an arm 33 connected to a probe assembly positioning device, all of which is well-known in the art.
- the probe assembly 28 and cell 10, but for the mixing configuration 12 of the present invention may be as used in the prior art commercially available SYNCHRON CX®3 Clinical System described above and is otherwise well-known in the art.
- the configuration 12 includes a mixing chamber 34 having a cylindrical side wall 36 and upper and lower ends 38, 40, respectively.
- the cylindrical wall 36 of the mixing chamber 34 includes a major central coaxial axis 37.
- the axis 37 is inclined slightly with respect to vertical and, in the embodiment disclosed herein, is inclined approximately 8.5 degrees.
- the end 40 is perpendicular to the axis 37 and the upper end 38 is angled slightly from the axis 37 to be generally horizontal (as seen in Figure 2).
- the upper end 38 is angled about 81.5 degrees from the axis, bringing the end 38 to its generally horizontal position as just described.
- a slightly enlarged bore 42 immediately above the end 38 receives and supports a rigid washer 44.
- a second slightly enlarged bore 46 immediately above the bore 42 receives and holds a quad ring 48.
- the quad ring 48 is retained within the bore 46 by clamping pressure applied via the upper portion 14.
- the quad rind 48 provides a seal between the upper portion 14 and lower portion 16 and, as is described below, provides a seal between the removable probe conduit 30 and the mixing configuration 12.
- the probe conduit 30 may be considered a first fluid conduit when the probe is positioned as shown in Figure 2 with the probe seated against the quad ring 48.
- the probe conduit 30 or first fluid conduit enters the mixing chamber 34 through the upper end 38 and is angled, in the embodiment disclosed herein, approximately 8.5 degrees with respect to the major axis 37.
- a second fluid conduit 50 ( Figures 1 to 3) is in communication with the mixing chamber 34.
- the second fluid conduit 50 narrows to include a reduced portion 56 proximate the mixing chamber 34 and enters the mixing chamber 34 via a port 58.
- the conduit 50 including the reduced portion 56 is offset with respect to the axis 37 and enters the mixing chamber 34 off-center as illustrated in Figure 3 such that fluid flow through the port 58 is directly substantially around the axis 37 and along the cylindrical wall 36.
- a third fluid conduit 52 exits mixing chamber 34 through the lower end 40 via a port 60.
- a center line of the conduit 52 is generally parallel to the axis 37 of the mixing chamber 34.
- a fourth fluid conduit 62 is in communication with the lower end of the fluid conduit 52.
- the center line of the conduit 62 as seen in Figure 4, is offset with respect to the center line of the conduit 52 and is slightly displaced such that the center line of the conduit 62 falls substantially at the periphery or is tangential with respect to the wall of the conduit 52.
- the conduits 52 and 62 are joined at an intersection identified generally at 64.
- a drain conduit 66 ( Figures 1 to 3) is also in communication with the mixing chamber 34 at a port 68.
- the drain conduit 66 is offset with respect to the axis 37 and is generally horizontal as seen in Figure 2.
- the port 68 is located near the upper end 38 to help reduce the amount of air that may otherwise become trapped at the top of the mixing chamber 34.
- the probe assembly 28 is inserted into the cell 10 with probe tip 70 coming to rest within the mixing chamber 34.
- a tapered surface 72 formed on the outside of the conduit 30 and proximate the tip 70 is urged against the quad ring 48, sealing the tip 70 within the mixing chamber 34.
- Fluid sample which may be in the form of liquid patient serum, is held within the probe conduit 30.
- the conduit 50 is connected to a source of fluid, such as liquid buffer as described above.
- pumping means (not shown) are operated to eject the serum sample from the probe conduit 30 into the mixing chamber.
- pumping means pumps diluent or buffer via the fluid conduit 50 through the port 58 into the mixing chamber 34.
- the stream formed by the buffer entering the mixing chamber 34 creates a rapid fluid vortexing action about the axis 37 within the chamber 34. Interference by the probe conduit 30 in the flow from the conduit 50 and port 58 prevent a coherent vortex or cyclone from forming within the mixing chamber 34, introducing turbulence into the vortex to help prevent the sample from becoming trapped within the center of the vortex. Gas bubbles which generally collect between the port 58 and the rigid washer 44 are immediately swept away by this rapid vortexing fluid action within the mixing chamber 34.
- the probe conduit 30, which may also be considered as a first fluid conduit, is generally vertical and is thus angled slightly (in the embodiment disclosed, about 8.5 degrees) with respect to the axis 37.
- the angle difference directs the fluid flow from the conduit 30 toward the lower bottom corner of the mixing chamber 34 and into the rapidly circulating or spinning wall or side of the fluid vortex created within the mixing chamber 34.
- the fluid flow from the conduit 30 is not injected into the center of the vortex created within the mixing chamber 34 where it might otherwise become entrapped, decreasing the mixing action. The result is a thorough and rapid mixing of the two fluids within the mixing chamber 34.
- the fluids continue their vortexing action, and are forced through the port 60 into the fluid conduit 52.
- the port 60 at the interface formed by the port 60 between the mixing chamber 34 and the conduit 52, further turbulence is created.
- the port 60 in effect slices off the advancing rapidly vortexing fluid within the mixing chamber 34. This slicing, rotation-inducing action creates further mixing and in turn creates a vortexing or rotational fluid action or movement within the conduit 52.
- the rotating column of fluid moving through the fluid conduit 52 is again subject to not only a change in direction but a further change in rotation, the advancing fluid creating yet another rotational or vortexing action within the conduit 62.
- the mixing configuration 12 may be considered as including three distinct mixing stages.
- the first stage comprises the mixing chamber 34 in which the rapid vortexing and injection action between first and second fluid flows is created.
- the second stage includes the port 60 which "slices" this rapidly rotating fluid mass as the mass advances from the mixing chamber 34 into the fluid conduit 52.
- the intersection 64 and the conduit 62 form yet a third mixing stage, with the change in direction of the fluid mass as well as the creation of yet another vortexing or rotational effect within the conduit 62 yet further enhancing the mixing action of the configuration 12.
- the probe 30 may be raised slightly, wash fluid introduced via the conduit 24 with the drain conduit 66 operating to aspirate or drain the wash fluid from the sample cell 10.
- the present invention provides significant improvements over the prior-art system described in the Background.
- the placement of the port 58 near the upper end 38 and flow of fluid from port 58 parallel to the upper end 38 substantially reduces the volume of air that could be trapped with the mixing chamber 34.
- the rapid vortexing action created within the chamber 34 rapidly and completely sweeps any trapped air from the chamber 34. This action passes entrapped air through the electrolyte measuring flow cell before measurements are made and eliminates air that might otherwise become trapped in the flow from the conduit 30, leading to bursts or pulses of sample entrained within the buffer flow.
- the rapid vortexing action within the chamber 34, as well as the mixing occurring at the port 60 and intersection 64 eliminates laminar flow otherwise present in the prior-art system.
- the mixing distance of the prior-art system in Figure 5, that is, the linear length of the fluid travel within the conduits 108, 110 through which mixing may occur before the fluid leaves the cell is effectively many times multiplied by the vortexing, sectioning and rotational actions created by the mixing configuration 12.
- the mixing device or configuration 12 of the present invention overcomes the limitations of the prior art, providing rapid, sure, effective mixing without substantial increased costs or external parts.
- the flow rate of fluid from the port 58 may be affected by the diameter of the reduced portion 56 and the speed at which fluid rotates within the mixing chamber can be altered by the amount by which the port 58 is offset from the axis 37.
- the conduit 30 and end 70 may be replaced by a conduit entering the mixing chamber 34 through a port formed in the end 38. In such an instance, such a port and conduit should direct the fluid flow into the fluid wall or side of the spinning fluid vortex to accomplish rapid, thorough mixing.
- Such modifications and others may be developed through routine experimentation where high "shutter" speed video recording may be used to assist in the evaluation of such modifications.
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Nozzles (AREA)
Claims (13)
- Strömungsmittel-Mischvorrichtung umfassend:- eine Mischkammer (34) mit gegenüberliegenden End- oder Stirnwandungen (38, 40), einer allgemein zylindrischen Seitenwandung (36) und einer bezüglich der zylindrischen Seitenwandung koaxialen Achse (37);- Mittel zur Aufnahme einer ersten Strömungsmittelleitung (30) in die Mischkammer an einer ersten Strömungsmittelöffnung, wobei die erste Strömungsmittelöffnung in einer der End- bzw. Stirnwandungen (38) vorgesehen ist und die erste Leitung einen Winkel bezüglich der Mischkammerachse besitzt;sowie umfassend- eine zweite Strömungsmittelleitung (50), welche mit der Mischkammer durch eine in der zylindrischen Seitenwandung vorgesehene zweite Strömungsmittelöffnung verbunden ist, wobei die zweite Strömungsmittelleitung einen Strömungsmittelfluß aus der zweiten Strömungsmittelleitung durch die zweite Öffnung in die Mischkammer hinein richtet, zur Erzeugung einer Wirbel- bzw. Strudelwirkung bei der Injektion des Strömungsmittels in die Mischkammer aus der zweiten Leitung; und- eine dritte Strömungsmittelleitung (52), welche mit der Mischkammer an einer dritten Öffnung (60) an der gegenüberliegenden End- bzw. Stirnwandung (40) verbunden ist.
- Strömungsmittel-Mischvorrichtung umfassend:- eine Mischkammer (34) mit gegenüberliegenden End- bzw. Stirnwandungen (38, 40), einer allgemein zylindrischen Seitenwandung (36) und einer bezüglich der zylindrischen Seitenwandung koaxialen Achse;- Mittel zur Aufnahme einer ersten Strömungsmittelleitung (30) in der Mischkammer an einer ersten Strömungsmittelöffnung, wobei die erste Strömungsmittelöffnung in einer der End- bzw. Stirnwandungen vorgesehen ist und den Eintritt von Strömungsmittel in die Kammer gestattet;- eine zweite Strömungsmittelleitung (50), welche mit der Mischkammer an einer in der zylindrischen Seitenwandung vorgesehenen zweiten Strömungsmittelöffnung verbunden ist, wobei die zweite Strömungsmittelleitung bezüglich der Mischkammer versetzt ist, um einen Strömungsmittelstrom aus der zweiten Leitung durch die zweite Öffnung in nichttangentialer Richtung zwischen der Seitenwandung und der Achse der Mischkammer und um die Mischkammerachse herum zu richten, um hierdurch eine Durchwirbelungswirkung beim Injizieren des Strömungsmittels in die Mischkammer aus der zweiten Leitung hervorzurufen;des weiteren umfassend- eine dritte Strömungsmittelleitung (52), welche mit der Mischkammer an einer dritten Öffnung (60) an der gegenüberliegenden End- bzw. Stirnwandung verbunden ist.
- Strömungsmittel-Mischvorrichtung, umfassend:- eine Mischkammer (34) mit gegenüberliegenden End- bzw. Stirnwandungen (38, 40), einer allgemein zylindrischen Seitenwandung (36) und einer bezüglich der zylindrischen Seitenwandung koaxialen Achse (37);- Mittel zur Aufnahme einer ersten Strömungsmittelleitung (30) in einer End- bzw. Stirnwandung, wobei die erste Strömungsmittelleitung eine erste Strömungsmittelöffnung besitzt;- eine zweite Strömungsmittelleitung (50), welche mit der Mischkammer an einer zweiten Strömungsmittelöffnung verbunden ist, wobei die zweite Strömungsmittelleitung die Einleitung einer Strömungsmittelströmung aus der zweiten Leitung in die Mischkammer in solcher Richtung bewirkt, daß hierdurch eine Wirbelungs- bzw. Drallwirkung bei der Injektion des Strömungsmittels in die Mischkammer aus der zweiten Leitung hervorgerufen wird;- eine dritte Strömungsmittelleitung (52), welche mit der Mischkammer an einer dritten Öffnung (60) an der gegenüberliegenden End- bzw. Stirnwandung (40) verbunden ist; sowie- eine vierte Leitung (62), welche die dritte Leitung schneidet, wobei eine Achse durch die dritte Leitung und eine Achse durch die vierte Leitung relativ gegeneinander versetzt sind.
- Vorrichtung nach einem der Ansprüche 1 bis 3, bei welcher die dritte Leitung (52) allgemein parallel zur Mischkammerachse ist.
- Vorrichtung nach einem der Ansprüche 1 bis 4, bei welcher die dritte Öffnung (60) relativ bezüglich der Achse durch die Mischkammer versetzt ist.
- Vorrichtung nach Anspruch 1 oder nach Anspruch 2, mit einer die dritte Leitung schneidenden vierten Leitung (62), wobei eine Achse der dritten Leitung und eine Achse der vierten Leitung relativ zueinander versetzt sind.
- Vorrichtung nach einem der Ansprüche 1 bis 6, bei welcher die erste Leitung einen sich in die Mischkammer erstreckenden überstehenden Teil aufweist und die erste Öffnung (70) sich an einem Stirnende des überstehenden Teils befindet.
- Vorrichtung nach einem der Ansprüche 2 bis 7, bei welcher die erste Leitung unter einem Winkel bezüglich der Mischkammer-Achse verläuft, derart daß Strömungsmittel aus der ersten Leitung in Richtung auf die Seitenwandung (36) gerichtet wird.
- Vorrichtung nach einem der Ansprüche 1 bis 8, bei welcher die zweite Leitung gegenüber der Mischkammer um weniger, als einer Tangente entsprechen würde, versetzt ist, um einen Strömungsmittelstrom aus der zweiten Leitung durch die zweite Öffnung teilweise in Richtung auf einen sich einwärts erstreckenden überstehenden Teil der ersten Strömungsmittelleitung zu lenken, um hierdurch eine turbulente Durchwirbelungs- bzw. Drallwirkung hervorzurufen.
- Vorrichtung nach einem der Ansprüche 1 bis 9, mit Mitteln (42, 44, 46, 48) zur Aufnahme einer Sondenspitze in einer End- bzw. Stirnwandung (38) der Mischkammer, wobei die Probenspitze die erste Strömungsmittelöffnung bildet bzw. aufweist; und bei welcher die zweite Strömungsmittelleitung bezüglich der Mischkammer so angeordnet ist, daß die Sondenspitze bei Einsetzen in der Wandung sich wenigstens auf gleichem Niveau mit der zweiten Strömungsmittelleitung befindet.
- Vorrichtung nach Anspruch 10, bei welcher die Probenspitze sich unterhalb der zweiten Leitung befindet.
- Vorrichtung nach einem der Ansprüche 1 bis 11, bei welcher die Mischkammer frei von jeglichen rotierenden mechanischen Mischorganen ist.
- Vorrichtung nach einem der Ansprüche 1 bis 12, bei welcher die dritte Öffnung (60) sich in der gegenüberliegenden End- bzw. Stirnwandung (40) befindet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48359990A | 1990-02-22 | 1990-02-22 | |
US483599 | 1990-02-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0448198A1 EP0448198A1 (de) | 1991-09-25 |
EP0448198B1 true EP0448198B1 (de) | 1995-07-12 |
Family
ID=23920728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91300667A Expired - Lifetime EP0448198B1 (de) | 1990-02-22 | 1991-01-29 | Strömungsmittel-Mischvorrichtung |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0448198B1 (de) |
JP (1) | JP2505504Y2 (de) |
AU (1) | AU636440B2 (de) |
CA (1) | CA2035067C (de) |
DE (1) | DE69111102T2 (de) |
ES (1) | ES2089123T3 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6296809B1 (en) * | 1998-02-27 | 2001-10-02 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
WO2003010513A1 (fr) * | 2001-07-26 | 2003-02-06 | Matsushita Electric Industrial Co., Ltd. | Procede de mesure de densite de solution, cellule d'echantillon utilisee pour ledit procede et dispositif de mesure de densite de solution |
CN114674612B (zh) * | 2022-03-25 | 2022-10-21 | 中煤浙江检测技术有限公司 | 一种水质在线取样方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB909865A (en) * | 1959-05-08 | 1962-11-07 | Courtaulds Ltd | Improvements in and relating to the mixing of fluids |
GB979675A (en) * | 1961-07-05 | 1965-01-06 | Basf Ag | Apparatus for introducing and homogeneously dispersing or dissolving powdered free-flowing materials in liquids |
DE1542479C3 (de) * | 1965-04-05 | 1974-04-18 | Georg 5410 Hoehr-Grenzhausen Steuler | Vorrichtung zum Vermischen einer Hauptflüssigkeit mit einem pulverformigen, flüssigen oder gasförmigen Zusatzstoff |
US3867195A (en) * | 1972-08-25 | 1975-02-18 | Anton Pfeuffer | Apparatus for continuous production of syrup |
BE795321A (fr) * | 1972-09-20 | 1973-08-13 | Gardinier Ets | Reacteur adapte aux reactions entre deux fluides |
FR2318831A1 (fr) * | 1975-07-22 | 1977-02-18 | Nouveaux Ets Sueur | Appareil de brassage pour le traitement d'eaux usees par injection de gaz |
CA1180734A (en) * | 1981-04-21 | 1985-01-08 | David R.P. Simpkins | Atomizer |
DE3640315A1 (de) * | 1986-11-26 | 1988-06-09 | Gutehoffnungshuette Man | Vorrichtung zum belueften von fluessigkeiten, insbesondere fuer eine flotation |
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1991
- 1991-01-28 CA CA002035067A patent/CA2035067C/en not_active Expired - Fee Related
- 1991-01-29 EP EP91300667A patent/EP0448198B1/de not_active Expired - Lifetime
- 1991-01-29 ES ES91300667T patent/ES2089123T3/es not_active Expired - Lifetime
- 1991-01-29 DE DE69111102T patent/DE69111102T2/de not_active Expired - Fee Related
- 1991-01-31 AU AU70181/91A patent/AU636440B2/en not_active Ceased
- 1991-02-21 JP JP1991034432U patent/JP2505504Y2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU7018191A (en) | 1991-08-29 |
EP0448198A1 (de) | 1991-09-25 |
AU636440B2 (en) | 1993-04-29 |
ES2089123T3 (es) | 1996-10-01 |
CA2035067C (en) | 1995-06-27 |
DE69111102T2 (de) | 1995-11-16 |
DE69111102D1 (de) | 1995-08-17 |
JP2505504Y2 (ja) | 1996-07-31 |
JPH0488855U (de) | 1992-08-03 |
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