EP0424504B1 - NOVEL 9$g(a)-HYDROXY-3-OXO-4,24(25)-STIGMASTADIEN-26-OIC ACID DERIVATIVES, A PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME - Google Patents

NOVEL 9$g(a)-HYDROXY-3-OXO-4,24(25)-STIGMASTADIEN-26-OIC ACID DERIVATIVES, A PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Download PDF

Info

Publication number
EP0424504B1
EP0424504B1 EP90907364A EP90907364A EP0424504B1 EP 0424504 B1 EP0424504 B1 EP 0424504B1 EP 90907364 A EP90907364 A EP 90907364A EP 90907364 A EP90907364 A EP 90907364A EP 0424504 B1 EP0424504 B1 EP 0424504B1
Authority
EP
European Patent Office
Prior art keywords
hydroxy
oxo
stigmastadien
oic acid
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP90907364A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0424504A1 (en
Inventor
Gábor AMBRUS
Andrea Maderspach
Antalné JEKKEL
András JAVOR
Eva Ilkoey
György HAJ0S
László Szporny
József Nagy
Gyula Horvath
Imre Moravcsik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Priority to AT90907364T priority Critical patent/ATE104313T1/de
Publication of EP0424504A1 publication Critical patent/EP0424504A1/en
Application granted granted Critical
Publication of EP0424504B1 publication Critical patent/EP0424504B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP90907364A 1989-05-11 1990-05-10 NOVEL 9$g(a)-HYDROXY-3-OXO-4,24(25)-STIGMASTADIEN-26-OIC ACID DERIVATIVES, A PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Expired - Lifetime EP0424504B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT90907364T ATE104313T1 (de) 1989-05-11 1990-05-10 Neue 9-g(a)-hydroxy-3-oxo-4,24(25)-stigmastadien26-s|urederivate,verfahren zur herstellung und heilmittel daraus.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU235989 1989-05-11
HU235989 1989-05-11
PCT/HU1990/000033 WO1990013559A1 (en) 1989-05-11 1990-05-10 NOVEL 9α-HYDROXY-3-OXO-4,24(25)-STIGMASTADIEN-26-OIC ACID DERIVATIVES, A PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publications (2)

Publication Number Publication Date
EP0424504A1 EP0424504A1 (en) 1991-05-02
EP0424504B1 true EP0424504B1 (en) 1994-04-13

Family

ID=10958990

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90907364A Expired - Lifetime EP0424504B1 (en) 1989-05-11 1990-05-10 NOVEL 9$g(a)-HYDROXY-3-OXO-4,24(25)-STIGMASTADIEN-26-OIC ACID DERIVATIVES, A PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Country Status (17)

Country Link
US (1) US5112815A (fi)
EP (1) EP0424504B1 (fi)
KR (1) KR920701232A (fi)
CN (1) CN1048857A (fi)
AT (1) ATE104313T1 (fi)
AU (1) AU638993B2 (fi)
DE (1) DE69008103T2 (fi)
DK (1) DK0424504T3 (fi)
ES (1) ES2055429T3 (fi)
FI (1) FI910159A0 (fi)
GR (1) GR1002174B (fi)
HR (1) HRP920777A2 (fi)
IL (1) IL94272A (fi)
NZ (1) NZ233657A (fi)
WO (1) WO1990013559A1 (fi)
YU (1) YU47914B (fi)
ZA (1) ZA903628B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000158A1 (en) * 1993-06-25 1995-01-05 Bio-Sphere Technology Dietary supplement incorporating beta-sitosterol and pectin
JP3873097B2 (ja) * 1997-11-06 2007-01-24 独立行政法人理化学研究所 抗肥満剤及び脂質代謝改善剤
US6531462B2 (en) 1997-11-06 2003-03-11 Riken Medicament for treating obesity and improving lipid metabolism
US5952393A (en) * 1998-02-12 1999-09-14 Sorkin, Jr.; Harlan Lee Composition for reducing serum cholesterol levels
JP2003520846A (ja) 2000-01-28 2003-07-08 ザ プロクター アンド ギャンブル カンパニー 心血管系の健康用の風味の良いアルギニン化合物およびその使用
US20030045473A1 (en) * 2002-07-19 2003-03-06 Sarama Robert Joseph Compositions, kits, and methods for cardiovascular health

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062880A (en) * 1976-04-30 1977-12-13 The Upjohn Company 9α-Hydroxy-bis-nor-cholanic acid
US4214051A (en) * 1977-10-21 1980-07-22 The Upjohn Company Process for preparing 9α-OH BN acid methyl ester
US4429041A (en) * 1981-05-11 1984-01-31 The Upjohn Company Process of producing 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid
US4425429A (en) * 1981-07-24 1984-01-10 The Upjohn Company Composition of matter and process
US4755463A (en) * 1982-05-25 1988-07-05 Wisconsin Alumni Research Foundation Process for preparing steroids

Also Published As

Publication number Publication date
GR900100356A (el) 1991-10-10
DE69008103T2 (de) 1994-07-28
CN1048857A (zh) 1991-01-30
US5112815A (en) 1992-05-12
YU92390A (en) 1991-10-31
DE69008103D1 (de) 1994-05-19
ATE104313T1 (de) 1994-04-15
KR920701232A (ko) 1992-08-11
AU5636390A (en) 1990-11-29
WO1990013559A1 (en) 1990-11-15
NZ233657A (en) 1992-03-26
AU638993B2 (en) 1993-07-15
YU47914B (sh) 1996-05-20
IL94272A0 (en) 1991-03-10
GR1002174B (en) 1996-03-07
HRP920777A2 (en) 1994-08-31
DK0424504T3 (da) 1994-05-16
ES2055429T3 (es) 1994-08-16
FI910159A0 (fi) 1991-01-11
EP0424504A1 (en) 1991-05-02
ZA903628B (en) 1991-04-24
IL94272A (en) 1994-04-12

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