EP0349558A1 - Substance d'immobilisation - Google Patents

Substance d'immobilisation

Info

Publication number
EP0349558A1
EP0349558A1 EP88902404A EP88902404A EP0349558A1 EP 0349558 A1 EP0349558 A1 EP 0349558A1 EP 88902404 A EP88902404 A EP 88902404A EP 88902404 A EP88902404 A EP 88902404A EP 0349558 A1 EP0349558 A1 EP 0349558A1
Authority
EP
European Patent Office
Prior art keywords
substance according
adhesives
adhesins
immobilization
immobilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP88902404A
Other languages
German (de)
English (en)
Inventor
Wolfgang Georg Konrad MÜLLER-LIERHEIM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Mueller-Lierheim AG
Original Assignee
Dr Mueller-Lierheim AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Mueller-Lierheim AG filed Critical Dr Mueller-Lierheim AG
Publication of EP0349558A1 publication Critical patent/EP0349558A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier

Definitions

  • the following procedure can be carried out for obtaining the adhesins.
  • the corresponding E. coli bacteria can be cultivated on agar in, for example, petri dishes. Separation of the adhesins from the cell membranes of the bacteria are first sonicated and then separated by ultracentrifugation and then purified by subsequent chromatographic purification. In the cultivation in 10 petri dishes with a diameter of 14 cm, about 40 to 50 mg of coarsely purified adhesins or about 30 mg of highly purified adhesions are obtained.
  • the non-fimbria-associated adhesins obtained can have the following specificities depending on the E. coli strain:
  • NFA non-fimbria associated adhesins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Substance d'immobilisation se caractérisant par le fait qu'elle contient des protéines adhésives (adhésines) isolées des structures extra-cellulaires, en particulier fibrilles, villosités, membranes ou capsules extérieures de bactéries gram-négatives, en particulier des colibacilles. Cette substance permet de fixer sur des supports des cellules, notamment des cellules de mammifères, des tissus, des substances pharmaceutiques actives, des anticorps, et des facteurs de croissance.
EP88902404A 1987-03-20 1988-03-17 Substance d'immobilisation Withdrawn EP0349558A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3709101 1987-03-20
DE19873709101 DE3709101A1 (de) 1987-03-20 1987-03-20 Immobilisierungssubstanz

Publications (1)

Publication Number Publication Date
EP0349558A1 true EP0349558A1 (fr) 1990-01-10

Family

ID=6323543

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88902404A Withdrawn EP0349558A1 (fr) 1987-03-20 1988-03-17 Substance d'immobilisation

Country Status (3)

Country Link
EP (1) EP0349558A1 (fr)
DE (1) DE3709101A1 (fr)
WO (1) WO1988007078A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8826116D0 (en) * 1988-11-08 1988-12-14 Danbiosyst Ltd Adhesive drug delivery composition
SE8804164A0 (sv) * 1988-11-17 1990-05-18 Per Prisell Farmaceutisk beredning
DE3936568C2 (de) * 1989-11-03 1997-06-19 Karlheinz Prof Dr Dr Schmidt Wirkstoffkomplex für die Herstellung von biologischen Teilen in Form von Organen für Lebewesen; Verfahren zum Herstellen desselben und seine Verwendung
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
IT1255657B (it) * 1992-05-29 1995-11-09 Colture di tessuto di mucosa congiuntivale differenziata, procedimentoper la loro preparazione e supporti per il loro uso.
US5928635A (en) * 1994-12-07 1999-07-27 Schmidt; Karlheinz Process for producing active agent complexes
US5916553A (en) * 1992-09-17 1999-06-29 Schmidt; Karlheinz Complex for inducing bone growth in the mastoid cavity
US7214654B1 (en) 1994-12-07 2007-05-08 Karlheinz Schmidt Agent for the manufacture of biological parts including an active ingredient complex and carrying materials suitable for the active ingredient complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8807078A1 *

Also Published As

Publication number Publication date
WO1988007078A1 (fr) 1988-09-22
DE3709101A1 (de) 1988-09-29

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Legal Events

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