EP0292551A1 - Composition de stockage stable pour utilisations diverses - Google Patents

Composition de stockage stable pour utilisations diverses

Info

Publication number
EP0292551A1
EP0292551A1 EP19880900297 EP88900297A EP0292551A1 EP 0292551 A1 EP0292551 A1 EP 0292551A1 EP 19880900297 EP19880900297 EP 19880900297 EP 88900297 A EP88900297 A EP 88900297A EP 0292551 A1 EP0292551 A1 EP 0292551A1
Authority
EP
European Patent Office
Prior art keywords
cream
weight
storage stable
added
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880900297
Other languages
German (de)
English (en)
Inventor
Ray I. Sheppard
Juvenal A. Cuni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arseco Inc
Original Assignee
Arseco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/003,161 external-priority patent/US4847078A/en
Application filed by Arseco Inc filed Critical Arseco Inc
Publication of EP0292551A1 publication Critical patent/EP0292551A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a sugar-containing composition useful in topical applications having enhanced storage stability and a method for imparting the storage stability to the composition.
  • One of the primary factors which determines the practical usefulness of a topical cream composition is storage stability. Lengthening of the "shelf life" of a cream prior to the onset of' composition separation or crystallization offers obvious advantages such as ease of inventory management, reduction of waste incurred in disposing of creams which are no longer active and removal of the additional burden and uncertainty involved in re ⁇ mixing a composition prior to application in cases where this procedure is possible. Additionally, when the topical cream is being utilized as a medicament, a further advantage of reduction of inadvertent administration of a composition which can no longer perform its intended function is obtained.
  • It is another object of the present invention to provide a cream base for a topical cream composition comprising wax compounds, thickness and surfactants.
  • the present invention contemplates a storage stable topical composition
  • a storage stable topical composition comprising: (a) about 5 to about 30% by weight of a cream base wherein said cream base comprises:
  • the balance being substantially water; (b) about 0.1 to about 7% by weight of a topically active ingredient;
  • the present invention further contemplates a storage stable cosmetic composition wherein the sugar level may be reduced to as low as 20% by weight, with the amount by weight of the cream base being adjusted upward as necessary, up to 70% by weight or more.
  • the enhanced storage stability property of the cream compositions is derived from the combination of the ingredients therein which will be discussed in detail below.
  • the vehicle for the topical composition for the present invention is a cream base made up of one or more compounds chosen from each of the categories of waxes, thickeners and surfactants. Each of the categories and their contribution(s) to the cream base are detailed below.
  • Wax compounds are useful as emollients and humectants in topical applications. That is, they aid in softening, moisturizing and lubricating the skin. The presence of such e ollient/humectant materials promotes the production and application of a cream which will not irritate the skin through abrasion.
  • the wax compounds preferred, according to the present invention are cetyl alcohol, stearyl alcohol, beeswax, natural or synthetic candelilla, carnauba, jojoba oil, and ceresine.
  • Thickening agents serve to add body to the composition by increasing the viscosity of the cream. The presence of such thickeners in a sufficient amount promotes the production of a cream composition of a consistency suitable for topical application.
  • Preferred thickening agents are synthetic clays, cellulose ether compounds and polyethylene glycol compounds. Most preferred thickening agents are Laponite XLG (a synthetic clay) , Methocel (methyl cellulose) , Ethocel (ethyl cellulose) , Natrosol (a cellulose ether compound) , carboxymethylcellulose and PEG 400 (polyethylene glycol 400) .
  • Surface active agents or surfactants serve a multitude of purposes in topical compositions.
  • surfactants cause them to orient at solid/liquid or liquid/liquid interfaces.
  • the structure of surfactants also functions to decrease the contractive forces at the juncture of two liquids, the surface tension, thereby promoting the dispersion of one liquid in another.
  • these additives promote the dispersion or suspension of solids in a solution. This feature is important in emulsifying the wax compounds, dispersing the thickeners and also providing some assistance in the penetration of the resultant cream into the skin.
  • Preferred surfactants, according to this invention are polyethylene glycol ether compounds and sorbitan monooleate compounds.
  • Most preferred surface active agents are Tergitol 15-S.-9 (a polyethylene glycol ether compound) , nonoxynol 9 (nonylphenyl polyethylene glycol ether) , and Polysorbate 80 (polyoxyethylene 20 sorbitan.mono-oleate) .
  • surfactants exhibit anti-microbial properties.
  • the structural nature of these compounds as discussed above permits the surfactants to damage or disrupt the cell membrane of microbes through inactivation of the enzymes which maintain said membranes or by physical disorganization of the membranes.
  • the surfactant ingredient(s) may enhance activity.
  • topically active ingredient found in the composition is, of course, responsible for the bulk of the activity or useful utility of the present invention.
  • suitable pharmaceutical active ingredients include povidone iodine, bacteriostatic agents, antibiotics, anti-inflammatory agents, microbicidal agents and vitamins, while the cosmetic active ingredients include aloe and vitamins.
  • Suitable bacteriostats are acrisorcin, resorcinol, fluorouracil, benzoyl peroxide, dichlorindolene and hexachlorophene, for example.
  • Suitable anti-inflammatory agents include, dimethyl sulfoxide, hydrocortisone , betamethasone benzoate and methylsalicylate, for example.
  • Antibiotics usable in the present invention include Bacitracin, Amphotericin B, chloramphenicol and polymyzin B sulfate, for example.
  • vitamins A and E are capable of being suspended in a topical cream of the type contemplated by the present invention in both medicinal and cosmetic applications.
  • suitable microbicides include iodine, gluconate and hydrogen peroxide, for example.
  • a sugar compound is also present in the topical cream of the present invention.
  • the sugars contemplated by the present invention are mono- and di-saccharide compounds, including their liquid forms and stereoisomers.
  • Preferred sugar compounds are glucose, fructose and sucrose. These compounds provide nutrition to the skin to which the cream is applied, and, in the case of a pharmaceutical use such as antiseptic treatment of an open wound, aid in the healing process. Also, some sugars, such as sucrose, exhibit anti-bacterial activity, which enhances the activity of the resultant topical cream. Thus, the cream containing sugar with no other active ingredient will be a useful product.
  • the moisture control ingredient required by the present claims is, preferably, selected from the group consisting of finely divided silicon dioxide (Cab-O-Sil M-5) , anhydrous lanolin and cholesterol.
  • This component absorbs any excess moisture in the topical cream composition thereby maintaining the delicate balance between the ingredients of the cream. Since the equilibrium which exists between the components in the cream is able to be maintained, the tendency for any one of those components to release from the others is reduced.
  • the storage stable topical cream formulation contemplated by the present invention may be manufactured by art- recognized methodology, with the following set forth as exemplary.
  • the cream based carrier vehicle must be prepared using a standard oil-in-water emulsion technique.
  • Step 1 In a suitable reaction vessel, 20 to 30 weight % of the total water needed is heated to a temperature in the range of 90° - 100° C. Then 0.175 - 0.4 weight % of a first thickener is added to the heated water, and the mixture is subjected to agitation until a product with the consistency of a paste is obtained. The remainder of the water necessary (to make up the 100 weight % of the cream base given the desired weight percentages of the additives) is added to the paste, and the resultant formulation is agitated until said paste is completely dissolved in the solution. Next, 0.5 - 3 weight % of a second thickener is added slowly with concomitant mixing until said second thickener is also completely dissolved. A first surfactant is then added, the mixture agitated thoroughly, and the resultant solution is set aside.
  • Step 2 In a second suitable reaction vessel, the desired waxes, a third thickener and a second surfactant undergo thorough agitation and heating to a temperature in the range of 70° - 90°C.
  • Step 3 Heat the product of step 1 to a temperature in the range of 70° - 80°C. Under continual agitation, add the product of step 2 to the heated product of step 1. After the addition is completed, agitation is continued until a cream with a firm consistency and uniform composition is obtained. The firm and uniform cream is then cooled to a temperature in the range of 20° - 30°C.
  • the pharmaceutical cream can be manufactured using standard mixing procedure.
  • the desired amount of the active ingredient is added to the cream prepared above and the mixture is subjected to agitation until the two components are well dispersed.
  • the sugar component is added, and the resultant formulation is agitated thoroughly.
  • the moisture flow control ingredient is added and agitation is applied until a homogenous composition results.
  • the procedure outlined above is based on production of the topical cream product on a continuous basis. That is, the carrier cream base is utilized immediately after its production in the manufacture of the final product.
  • preservative compound in an amount of about 0.05 to about
  • the cream base is capable of being formulated at a separate time and/or production facility than the topical cream.
  • any combination of the cream base and some of the other three components may be combined separately from the ultimate product.
  • the cream base, sugar and moisture control agent may be preserved and shipped to another site where active ingredient is manufactured.
  • the preservative may be any of those known in the art to preserve such cream bases, preferably povidone i ⁇ dine or a paraben, for example, methylparaben and butylparaben.
  • povidone iodine as the active ingredient provides a pharmaceutically effective cream having anti- infective properties. Utilizing the povidone iodine complex rather than iodine itself offers the advantage of increased stability of the iodine in the resultant cream product and enhanced pharmaceutical acceptance without the sacrifice of the anti-infective properties of the elemental halogen compound. Also, povidone iodine is sugar compatible which contributes to the overall stability of the product cream.
  • a topical anti-infective composition of the present invention may be applied directly to the injured skin or indirectly to the skin through application to a dressing material or in any other manner known in the art for the juxtaposition of a medicament in cream form with the affected area of the body.
  • the combination of anti-infective and tissue growth promotion activities of a composition of the present invention renders it useful for treating conditions involving open wounds or burns.
  • the open wounds can be of the type resulting from a skin trauma such as gunshot and knife wounds as well as those induced by other means such as sores or carbuncles.
  • compositions of the present invention also results in excellent pharmaceutical acceptance.
  • the replacement of elemental iodine with the povidone iodine complex produces drastic improvement in this area.
  • the incidence of skin irritation and staining as well as the onset of allergic reactions often brought on by elemental iodine is reduced very significantly since the PVP-iodine complex is both non-irritating and non-sensitizing.
  • the sugar and other additives are safe for use on human skin, inert to PVP-iodine, i.e., do not react with the complex to release elemental iodine, and compatible with PVP-iodine and each other.
  • the amount of the active ingredient in the composition depends on such factors as the type of injury or dysfunction, the degree of healing which has already been induced, if any, and the skin type of the patient. Those skilled in the art will make an assessment based on these factors and any others which become apparent in the specific case and use the appropriate strength formulation.
  • the sugar requirement of said cream is reduced. That is, the cream may be formulated with a sugar content as low as 20% by weight of the product cream. This decrease is due to the reduction in the demand for nutrition supplied to the skin.
  • a cosmetic designed for routine daily use as a moisturizer or some form of colorant does not require the tissue regenerative capability of, for example, a medicament useful for the treatment of open wounds wherein skin growth is absolutely essential to the healing process.
  • the quantity of cream base is oppositely altered to complete the cream composition.
  • compositions of the present invention may be applied directly to the skin by hand, applicator or in any other manner known in the art for the juxtaposition of a cosmetic in cream form with the desired area of
  • the amount of active ingredient in the cosmetic topical cream depends on such factors as the intended use of the cosmetic (a corrective moisturizer as opposed to a fortified colorant, for example) and the nature of the skin of the recipient (dry, normal, or oily, for example) . Those skilled in the art will make an assessment based on these factors and any others which become apparent in the case of a specific cosmetic and provide the appropriate relative amounts of ingredients.
  • the topical cream of the present invention exhibits enhanced storage stability properties. That is, the cream does not separate or suffer from the crystallization of the various components suspended in the cream for a long period of time. This results in an increased shelf life and enhanced usefulness of the topical formulation.
  • the proposed moisture-control ingredient imparts much of the marked improvement in storage stability to the composition. This theory is contemplated due to the properties of the sugar ingredient of the cream. Sugars will dissolve in almost anything with a high moisture content. This characteristic is a serious detriment to the formation of a product with the consistency of a cream. However, the moisture control ingredient absorbs the excess moisture and stabilizes the equilibrium between the components of the product cream.
  • cream compositions containing an effective amount of a moisture control ingredient are capable of maintaining a high sugar concentration dispersed therein for long periods of time.
  • Example 1 Anti-Infection Cream A. Preparation of the cream base Step 1: In a suitable reaction vessel, 174.5 ml of water 11 is heated to 95°C. 2.5 gm Methocel is then added, and the mixture is agitated until a paste is formed. 698 ml water cooled to 5°C, is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 15 gm Laponite is then added slowly with agitation until the thickener is completely dissolved. 10 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 40 gm cetyl alcohol, 30 gm stearyl alcohol, 20 gm polyethylene glycol 400 and 10 gm Polysorbate 80 are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 174.2 ml of water is heated to 93°C. 3.0 gm Ethocel is then added, and the mixture is agitated until a paste is formed. 696.8 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 12 gm of Laponite is then added slowly with agitation until the thickener is completely dissolved. 12 gm nonoxynol 9 is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 20 gm ceresine, 40 gm cetyl alcohol, 10 gm beeswax and 20 gm polyethylene glycol 400 and 15 gm Tergitol are heated to 77*C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 77°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 171.6 ml of water is heated to 95°C. 3.8 gm carboxymethyl cellulose is then added, and the mixture is agitated until a paste is formed. 656.6 ml of water having been cooled to 0°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 21 gm of Ethocel is then added slowly with agitation until the thickener is completely dissolved. 12 gm Polysorbate 80 is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm stearyl alcohol, 25 gm jojoba oil, 15 gm ceresine, 20 gm Methocel, and 15 gm Nonoxynol 9 are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 176.4 ml of water is heated to 100°C. 1.8 gm Natrosol is then added, and the mixture is agitated until a paste is formed. 705.8 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 13 gm of Laponite is then added slowly with agitation until the thickener is completely dissolved. 5.5 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm cetyl alcohol, 30 gm synthetic candelilla, 17.5 gm carboxymethyl- cellulose, and 20.0 gm Polysorbate 80 are heated to 72°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 72"C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Example 5 Anti-Infection Cream A. Preparation of the 'cream base
  • Step 1 In a suitable reaction vessel, 172.6 ml of water is heated to 97°C. 2.0 gm Methocel is then added, and the mixture is agitated until a paste is formed. 690.4 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 25 gm of Methocel is then added slowly with agitation until the thickener is completely dissolved. 10 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 40 gm beeswax, 30 gm jojoba oil, 20 gm polyethylene glycol 400, and 10 gm Polysorbate 80 are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Example 6 Anti-Infection Cream A. Preparation of the cream base Step 1: In a suitable reaction vessel, 176 ml of water is heated to 98°C. 2.5 gm Methocel is then added, and the mixture is agitated until a paste is formed.
  • Step 2 In a second reaction vessel, 20 gm cetyl alcohol, 40 gm natural candelilla, 10 gm stearyl alcohol, and 20 gm Methocel, and 10 gm Tergitol are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 174.8 ml of water is heated to 90 ° C . 2 gm Natrosol is then added, and the mixture is agitated until a paste if formed. 699.2 ml of water having been cooled to 0°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 12 gm of Natrosol is then added slowly with agitation until the thickener is completely dissolved. 10 gm Polysorbate 80 is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm ceresine, 25 gm carnauba, 15 gm cetyl alcohol, and 20 gm carboxymethyl cellulose, and 12 gm Polysorbate 80 are heated to 77°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 77°C whereupon the product of Step 2 above is heated to 77°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 175 ml of water is heated to 92°C. 2 gm Ethocel is then added, and the mixture is agitated until a paste is formed. 702.8 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 12 gm of Ethocel is then added slowly with agitation until the thickener is completely dissolved. 10 gm Polysorbate 80 is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm stearyl alcohol, 30 g natural candelilla, 17.5 gm Methocel, and 20 gm Polysorbate 80 are heated to 72°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 72 * C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step l In a suitable reaction vessel, 174.8 ml of water is heated to 91°C. 2 gm carboxymethyl cellulose is then added, and the mixture is agitated until a paste is formed. 699.2 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 12 gm of Methocel is then added slowly with agitation until the thickener is completely dissolved. 12 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 40 gm cetyl alcohol, 30 gm stearyl alcohol, 20 gm polyethylene glycol 400, and 10 gm nonoxynol 9 are heated to 79°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 79°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 174.6 ml of water is heated to 95°C. 2.5 gm Ethocel is then added, and the mixture is agitated until a paste is formed. 698.4 ml- of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 12 gm of Methocel is then added slowly with agitation until the thickener is completely dissolved. 7.5 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 20 gm ceresine, 40 gm stearyl alcohol, 10 gm beeswax, 20 gm Laponite, and 15 gm Tergitol are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 172.9 ml of water to 96°C. 3 gm Laponite is then added, and the mixture is agitated until a paste is formed. 691.6 ml of water having been cooled to 0°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 20 gm of Ethocel is then added slowly with agitation until the thickener is completely dissolved. -7.5 gm Polysorbate 80 is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm cetyl alcohol, 25 gm carnauba, 15 gm beeswax, 20 gm Natrosol, and 15 gm Tergitol are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 173.8 ml of water is heated to 100°C. 3.5 gm Methocel is then added, and the mixture is agitated until a paste is formed. 695.2 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 20 gm of Ethocel is then added slowly with agitation until the thickener is completely dissolved. 10 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm stearyl alcohol, 30 gm cetyl alcohol, 17.5 gm carboxymethyl cellulose, and 20 gm Polysorbate 80 are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 1 In a suitable reaction vessel, 174.3 ml of water is heated to 95°C. 3.5 gm Ethocel is then added, and the mixture is agitated until a paste is formed. 697.2 ml of water having been cooled to 5°C is added, and agitation 21 is subsequently applied until the thickener/water paste is completely dissolved. 15 gm of Methocel is then added slowly with agitation until the thickener is completely dissolved. 10 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 40 gm ceresine, 30 gm stearyl alcohol, 20 gm Methocel, and 10 gm Tergitol are heated to 72°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 72"C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Example 14 Cosmetic Cream A. Preparation of the cream base
  • Step 1 In a suitable reaction vessel, 177.1 ml of water is heated to 93°C. 1.8 gm of Methocel is then added, and the mixture is agitated until a paste is formed. 708.6 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 15 gm of Ethocel is then added slowly with agitation until the thickener is completely dissolved. 10 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 30 gm cetyl alcohol, 30 gm stearyl alcohol, 17.5 gm polyethylene glycol 400, and 10 gm Polysorbate 80 are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75 ⁇ C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Example 15 Cream Base Suitable for Discontinuous
  • Step 1 In a suitable reaction vessel, 174.35 ml of water is heated to 95°C. 2.5 gm Methocel is then added, and the mixture is agitated until a paste is formed. 697.40 ml of water having been cooled to 5°C is added, and agitation is subsequently applied until the thickener/water paste is completely dissolved. 15 gm of Laponite is then added slowly with agitation until the thickener is completely dissolved. 10 gm Tergitol is added, and the resulting mixture is blended and set aside.
  • Step 2 In a second reaction vessel, 40 gm cetyl alcohol, 30 gm stearyl alcohol, 20 gm polyethylene glycol 400 and 10 gm Polysorbate 80 are heated to 75°C while agitation is supplied.
  • Step 3 The mixture of Step 1 above is heated to 75°C whereupon the product of Step 2 above is added to the newly heated product of Step 1 under conditions of constant agitation. Agitation is continued until a firm and uniform cream is obtained. The resultant cream base is cooled to room temperature.
  • Step 4 Add 0.75 gm of povidone iodine and agitate until the resulting, preserved cream base is homogenous throughout.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composition de stockage stable pour utilisations diverses, se prêtant particulièrement bien aux utilisations pharmaceutiques et cosmétiques, qui comprend un ingrédient actif, un sucre, un agent de contrôle de l'humidité et une crème à titre de base. La crème servant de base comprend un ou plusieurs ingrédients appartenant à chacun des groupes suivants: composés de cire, agents épaississants et agents tensio-actifs, en dispersion aqueuse.
EP19880900297 1986-12-08 1987-12-03 Composition de stockage stable pour utilisations diverses Withdrawn EP0292551A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93915386A 1986-12-08 1986-12-08
US939153 1986-12-08
US07/003,161 US4847078A (en) 1987-01-14 1987-01-14 Storage stable topical composition having moisture control agent
US3161 1987-01-14

Publications (1)

Publication Number Publication Date
EP0292551A1 true EP0292551A1 (fr) 1988-11-30

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ID=26671409

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880900297 Withdrawn EP0292551A1 (fr) 1986-12-08 1987-12-03 Composition de stockage stable pour utilisations diverses

Country Status (4)

Country Link
EP (1) EP0292551A1 (fr)
JP (1) JPH01502189A (fr)
CA (1) CA1306948C (fr)
WO (1) WO1988004168A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034421A (en) * 1988-12-13 1991-07-23 Fuisz Pharmaceutical Ltd. Moderated spun fibrous system and method of manufacture
SE9003614L (sv) * 1990-11-13 1992-05-14 Kurt G I Nilsson Kosmetisk produkt
US5879717A (en) * 1993-02-10 1999-03-09 Rita McConn-Stern Wound healing compositions containing iodine and sucrose
GB2274988A (en) * 1993-02-10 1994-08-17 Mcconn Stern Rita Iodine containing wound-healing preparations
GR940100370A (el) * 1993-07-28 1994-07-26 Johnson & Johnson Consumer Products Inc. Μια σπερμοκτονος λιπαντικη αντι-ιου συνθεση και μεθοδος χρησης της.
US5837266A (en) * 1996-04-30 1998-11-17 Hydromer, Inc. Composition, barrier film, and method for preventing contact dermatitis
CA2322503A1 (fr) 1998-03-12 1999-09-16 Donald Carroll Roe Article absorbant jetable ayant une composition pour le soin de la peau contenant un enzyme inhibiteur
AU2093101A (en) * 1999-12-17 2001-06-25 Procter & Gamble Company, The Compositions for efficient release of active ingredients
DE60237475D1 (de) * 2001-12-21 2010-10-07 Alcon Inc Verwendung von synthetischen anorganischen nanoteilchen als träger für augenmedikamente
EP1471925A2 (fr) * 2001-12-21 2004-11-03 Alcon, Inc. Utilisation de nanoparticules inorganiques dans le but de modifier la viscosite et d'autres proprietes physiques de compositions pharmaceutiques ophtalmiques et otiques
WO2005046349A2 (fr) * 2003-11-14 2005-05-26 Aquanova German Solubilisate Technologies (Agt) Gmbh Composition huileuse contenant un principe actif fluide
WO2009088826A1 (fr) * 2007-12-31 2009-07-16 3M Innovative Properties Company Compositions antiseptiques liquides contenant de l'iode et un sucre et/ou un alcool de sucre
JP5900978B2 (ja) * 2012-10-31 2016-04-06 公立大学法人福岡県立大学 皮膚創傷部治癒用組成物及び同皮膚創傷部治癒用組成物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859436A (en) * 1968-10-02 1975-01-07 Kolmar Laboratories Sugar composition for topical application
DE2036248A1 (en) * 1970-07-22 1972-01-27 Jörg geb. Köpfer, Lotte, 7141 Schwieberdingen Antifungal skin compsn - combining a high sugar content with a fatty substance
EP0015030A3 (fr) * 1979-02-23 1981-02-11 THE PROCTER & GAMBLE COMPANY Compositions de conditionnement de la peau
AU536885B2 (en) * 1979-04-18 1984-05-31 R. A. Knutson Wound and burn dressing
EP0080879B1 (fr) * 1981-11-28 1986-10-01 Sunstar Kabushiki Kaisha Composition pharmaceutique contenant de l'interféron stabilisé
US4496556A (en) * 1982-08-16 1985-01-29 Norman Orentreich Topical applications for preventing dry skin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8804168A1 *

Also Published As

Publication number Publication date
CA1306948C (fr) 1992-09-01
JPH01502189A (ja) 1989-08-03
WO1988004168A1 (fr) 1988-06-16

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