EP0244115A3 - Agents anti-arrhytmiques contenant des dérivés de phényl-pipérazine - Google Patents
Agents anti-arrhytmiques contenant des dérivés de phényl-pipérazine Download PDFInfo
- Publication number
- EP0244115A3 EP0244115A3 EP87303234A EP87303234A EP0244115A3 EP 0244115 A3 EP0244115 A3 EP 0244115A3 EP 87303234 A EP87303234 A EP 87303234A EP 87303234 A EP87303234 A EP 87303234A EP 0244115 A3 EP0244115 A3 EP 0244115A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- alkyl
- piperazine
- phenyl
- arrhythmia agents
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868609630A GB8609630D0 (en) | 1986-04-19 | 1986-04-19 | Anti-arrhythmia agents |
GB8609630 | 1986-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0244115A2 EP0244115A2 (fr) | 1987-11-04 |
EP0244115A3 true EP0244115A3 (fr) | 1988-10-05 |
Family
ID=10596521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP87303234A Ceased EP0244115A3 (fr) | 1986-04-19 | 1987-04-14 | Agents anti-arrhytmiques contenant des dérivés de phényl-pipérazine |
Country Status (18)
Country | Link |
---|---|
US (1) | US4788196A (fr) |
EP (1) | EP0244115A3 (fr) |
JP (1) | JPS62255480A (fr) |
KR (1) | KR870010015A (fr) |
CN (1) | CN87102873A (fr) |
AU (1) | AU577218B2 (fr) |
DD (1) | DD261787A5 (fr) |
DK (1) | DK195587A (fr) |
FI (1) | FI871694A (fr) |
GB (1) | GB8609630D0 (fr) |
HU (1) | HUT44027A (fr) |
IL (1) | IL82221A0 (fr) |
MY (1) | MY101208A (fr) |
NO (1) | NO871594L (fr) |
PL (1) | PL265207A1 (fr) |
PT (1) | PT84695B (fr) |
YU (1) | YU70787A (fr) |
ZA (1) | ZA872744B (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8800694D0 (en) * | 1988-01-13 | 1988-02-10 | Pfizer Ltd | Antiarrhythmic agents |
US4906634A (en) * | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
FR2644787B1 (fr) * | 1989-03-22 | 1995-02-03 | Roussel Uclaf | Nouveaux steroides 21 aminosubstitues, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
US5356559A (en) * | 1991-07-19 | 1994-10-18 | Hoffmann-La Roche Inc. | Optically active piperazinyl derivatives as liquid crystals |
AU692439B2 (en) * | 1993-03-29 | 1998-06-11 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
ATE202345T1 (de) * | 1993-03-29 | 2001-07-15 | Astrazeneca Ab | Heterozyklische derivate als plätchenaggregationsinhibitoren |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
GB9326373D0 (en) * | 1993-12-23 | 1994-02-23 | Zeneca Ltd | Chemical compounds |
GB9326232D0 (en) * | 1993-12-23 | 1994-02-23 | Zeneca Ltd | Chemical compounds |
US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5690944A (en) * | 1994-12-20 | 1997-11-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic compositions containing lactate dehydrogenase inhibitors |
WO1996038416A1 (fr) * | 1995-06-01 | 1996-12-05 | Zeneca Limited | Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}butyrique inhibiteur d'adhesion cellulaire |
PL326700A1 (en) * | 1995-11-17 | 1998-10-26 | Warner Lambert Co | Sulphonamide-based inhibitors of intercellular substance metaloproteinases |
US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
CA2260872A1 (fr) * | 1996-08-14 | 1998-02-19 | Elaine Sophie Elizabeth Stokes | Derives de pyrimidine substituee et leur usage pharmaceutique |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
EP0966460A1 (fr) | 1997-02-13 | 1999-12-29 | Zeneca Limited | Composes heterocycliques utilises comme inhibiteurs de l'oxydo-squalene cyclase |
AU5999798A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
US6083991A (en) | 1997-06-04 | 2000-07-04 | University Of Florida Research Foundation, Inc. | Anti-arrhythmic composition and methods of treatment |
GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
HU226859B1 (en) * | 1997-10-27 | 2009-12-28 | Neurosearch As | Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them |
GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
CA2572874A1 (fr) * | 2004-07-02 | 2006-01-12 | Sankyo Company Limited | Derive d'uree |
WO2007074753A1 (fr) * | 2005-12-27 | 2007-07-05 | Daiichi Sankyo Company, Limited | Produit pharmaceutique comprenant un dérivé de l'urée substitué |
AU2009230127B2 (en) | 2008-03-26 | 2011-12-22 | Daiichi Sankyo Company, Limited | Novel tetrahydroisoquinoline derivative |
EA018198B1 (ru) | 2008-06-12 | 2013-06-28 | Янссен Фармацевтика Нв | Диаминопиридиновые, пиримидиновые и пиридазиновые модуляторы гистаминового рецептора h |
GB0818241D0 (en) * | 2008-10-06 | 2008-11-12 | Cancer Res Technology | Compounds and their use |
WO2010141805A1 (fr) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Amides hétérocycliques en tant que modulateurs de la trpa1 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE485737A (fr) * | 1947-11-12 | |||
US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
DE942029C (de) * | 1951-06-22 | 1956-04-26 | American Cyanamid Co | Verfahren zur Herstellung von neuen, in 1-Stellung substituierten 4-Aminopiperazinderivaten |
US3306903A (en) * | 1965-10-07 | 1967-02-28 | Council Scient Ind Res | 1-aminopyridyl-4-(phenyl or pyridyl)-piperazines and intermediates |
US4287195A (en) * | 1978-07-14 | 1981-09-01 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
US4255575A (en) * | 1979-05-04 | 1981-03-10 | Richardson-Merrell Inc. | 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives |
AU2108283A (en) * | 1979-07-13 | 1984-03-29 | Dr. Karl Thomae Gmbh | 2-amino benzoic acid derivatives |
US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
US4544654A (en) * | 1984-03-20 | 1985-10-01 | Schering A.G. | Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof |
US4639524A (en) * | 1984-07-09 | 1987-01-27 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
DE3428526A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue aminoalkohole, verfahren zu deren herstellung sowie diese verbindung enthaltende arzneimittel |
US4569801A (en) * | 1984-10-15 | 1986-02-11 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamines |
US4596827A (en) * | 1984-10-15 | 1986-06-24 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamine compounds used for treating arrhythmia |
GB8603120D0 (en) * | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
AU7642187A (en) * | 1986-07-01 | 1988-01-29 | Maude, A.E. | Impregnation process and apparatus with a vacuum pump valve control system |
-
1986
- 1986-04-19 GB GB868609630A patent/GB8609630D0/en active Pending
-
1987
- 1987-04-14 EP EP87303234A patent/EP0244115A3/fr not_active Ceased
- 1987-04-15 DK DK195587A patent/DK195587A/da not_active Application Discontinuation
- 1987-04-15 NO NO871594A patent/NO871594L/no unknown
- 1987-04-15 CN CN198787102873A patent/CN87102873A/zh active Pending
- 1987-04-16 AU AU71731/87A patent/AU577218B2/en not_active Expired - Fee Related
- 1987-04-16 PT PT84695A patent/PT84695B/pt unknown
- 1987-04-16 ZA ZA872744A patent/ZA872744B/xx unknown
- 1987-04-16 IL IL82221A patent/IL82221A0/xx unknown
- 1987-04-16 FI FI871694A patent/FI871694A/fi not_active Application Discontinuation
- 1987-04-16 PL PL1987265207A patent/PL265207A1/xx unknown
- 1987-04-16 DD DD87301901A patent/DD261787A5/de unknown
- 1987-04-17 MY MYPI87000499A patent/MY101208A/en unknown
- 1987-04-17 US US07/039,508 patent/US4788196A/en not_active Expired - Lifetime
- 1987-04-17 HU HU871713A patent/HUT44027A/hu unknown
- 1987-04-17 YU YU00707/87A patent/YU70787A/xx unknown
- 1987-04-18 KR KR870003727A patent/KR870010015A/ko not_active Application Discontinuation
- 1987-04-20 JP JP62097245A patent/JPS62255480A/ja active Pending
Non-Patent Citations (1)
Title |
---|
EUR. J. MED. CHEM. - CHIM. THER., vol. 21, no. 1, 1986, pages 5-8; S. ABUZAR et al.: "Synthesis of some new 7-chloro-4-substituted quinolines as potential antiparasitic agents (1)" * |
Also Published As
Publication number | Publication date |
---|---|
PT84695A (en) | 1987-05-01 |
DD261787A5 (de) | 1988-11-09 |
MY101208A (en) | 1991-08-17 |
AU577218B2 (en) | 1988-09-15 |
PT84695B (en) | 1989-05-23 |
EP0244115A2 (fr) | 1987-11-04 |
DK195587A (da) | 1987-10-20 |
NO871594D0 (no) | 1987-04-15 |
PL265207A1 (en) | 1988-07-21 |
JPS62255480A (ja) | 1987-11-07 |
FI871694A (fi) | 1987-10-20 |
YU70787A (en) | 1988-10-31 |
FI871694A0 (fi) | 1987-04-16 |
DK195587D0 (da) | 1987-04-15 |
HUT44027A (en) | 1988-01-28 |
AU7173187A (en) | 1987-11-05 |
KR870010015A (ko) | 1987-11-30 |
US4788196A (en) | 1988-11-29 |
NO871594L (no) | 1987-10-20 |
IL82221A0 (en) | 1987-10-30 |
ZA872744B (en) | 1988-11-30 |
CN87102873A (zh) | 1987-10-28 |
GB8609630D0 (en) | 1986-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19870418 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE |
|
17Q | First examination report despatched |
Effective date: 19890404 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 19890925 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: CROSS, PETER EDWARD, DR. Inventor name: DICKINSON, ROGER PETER, DR. |