EP0232835B1 - Salbenkessel zur Herstellung pharmazeutischer oder kosmetischer Suspensionen - Google Patents

Salbenkessel zur Herstellung pharmazeutischer oder kosmetischer Suspensionen Download PDF

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Publication number
EP0232835B1
EP0232835B1 EP87101450A EP87101450A EP0232835B1 EP 0232835 B1 EP0232835 B1 EP 0232835B1 EP 87101450 A EP87101450 A EP 87101450A EP 87101450 A EP87101450 A EP 87101450A EP 0232835 B1 EP0232835 B1 EP 0232835B1
Authority
EP
European Patent Office
Prior art keywords
vessel
heads
ointment
spraying
homogenising
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP87101450A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0232835A2 (de
EP0232835A3 (en
Inventor
Brigitte Chalupka
Hans Gehringer
Herbert Dr. Hocke
Peter Dr. Kiefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AT87101450T priority Critical patent/ATE53175T1/de
Publication of EP0232835A2 publication Critical patent/EP0232835A2/de
Publication of EP0232835A3 publication Critical patent/EP0232835A3/de
Application granted granted Critical
Publication of EP0232835B1 publication Critical patent/EP0232835B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/04—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/10—Maintenance of mixers
    • B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
    • B01F35/1452—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids
    • B01F35/1453—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means using fluids by means of jets of fluid, e.g. air

Definitions

  • the invention relates to a device for the formulation of pharmaceutical and cosmetic ointments or creams, consisting of a stirrer-equipped ointment kettle with product and rinsing liquid feed lines, spray heads for cleaning purposes, a bottom drain valve and a safety valve as well as a homogenizing device arranged in the kettle or connected to the kettle by bypass .
  • Ointment kettles with such internals are known and are sold by various manufacturers.
  • FR-A-2394321 describes a stirred tank which is equipped with spray nozzles for cleaning purposes in the axis area. However, these spray nozzles essentially only capture the agitator and the area of the shaft seal. It is not intended to clean the entire inner surface of the boiler using spray nozzles.
  • an ointment kettle having the usual internals in that one or more fixed spray heads or heads arranged at different heights and at least one pivotable spray head for spraying the rinsing liquid are installed in the kettle in such a way that the entire Inner surface of the boiler is detected and the spray heads can be fed separately via separate feed lines. This ensures that spray jets from different spray heads do not interfere with each other and - if necessary - the full pump capacity can be specifically introduced into a spray head.
  • the fixed spray nozzles are attached to a single spray arm consisting of concentric tubes at different heights.
  • a windshield wiper is also provided in the ointment kettle, which is actuated from the outside via an axially displaceable rotary lever.
  • the new ointment kettle can be cleaned quickly, effectively and reproducibly by CIP cleaning. Compared to conventional cleaning, the cleaning times - and thus the production downtimes - can be significantly reduced, so that the system works with greater economy (capacity gain, significant reduction in personnel costs and energy savings). From the apparatus point of view, there is a further major advantage in that no entirely new apparatus concept is necessary, but rather the necessary modifications and improvements can be built into existing or only slightly modified apparatus.
  • the homogenizer 15 is accommodated in an axial extension 18 on the bottom of the boiler (see FIG. 2). If an annular gap 21 remains between the inner wall of the extension 18 and the homogenizer shaft 20 leading to the motor 19 arranged on the outside, this annular gap 21 forms a dead space which is problematic with regard to perfect cleaning. For this reason, the drive shaft 20 of the homogenizer 15 is provided with inclined pump grooves 22 which (with the homogenizer running) cause an axial forced flow in the annular gap 21 (see FIGS. 2 and 3). This ensures, on the one hand, good product mixing during production and, on the other hand, an intensive action of the rinsing liquid in the axial extension 18 in the cleaning phase.
  • the windshield wiper 16 shown in FIG. 4 is required if a sight glass 23 is fitted in the upper dished end 2. Then this must be cleaned during production.
  • the wiper blade 24 is arranged at the lower end of a U-shaped lever 25 with a handle 26.
  • the lever 25 is rotatable about the longitudinal axis for actuating the windshield wiper and can also be displaced in the axial direction. The axial displacement is made possible by the guide 28 secured in the dished bottom 2 with O-ring seals 27.
  • the windshield wiper 16 is lowered for CIP cleaning of the boiler. It is thereby achieved that the sight glass 23 and the entire windshield wiper 16 are flowed everywhere by the washing liquid.
  • the product and energy lines (not shown in FIG. 1), which also have to be cleaned, are connected to the CIP flow or CIP return, the spray heads 8, 9 and 12 are inserted and connected to the associated detergent pump .
  • the spray head 12 is set in rotation or back and forth movement. The rinsing process then runs according to a predetermined cycle.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Cleaning By Liquid Or Steam (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Nozzles (AREA)
EP87101450A 1986-02-14 1987-02-03 Salbenkessel zur Herstellung pharmazeutischer oder kosmetischer Suspensionen Expired - Lifetime EP0232835B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT87101450T ATE53175T1 (de) 1986-02-14 1987-02-03 Salbenkessel zur herstellung pharmazeutischer oder kosmetischer suspensionen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863604694 DE3604694A1 (de) 1986-02-14 1986-02-14 Salbenkessel zur herstellung pharmazeutischer oder kosmetischer suspensionen
DE3604694 1986-02-14

Publications (3)

Publication Number Publication Date
EP0232835A2 EP0232835A2 (de) 1987-08-19
EP0232835A3 EP0232835A3 (en) 1989-01-04
EP0232835B1 true EP0232835B1 (de) 1990-05-30

Family

ID=6294100

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87101450A Expired - Lifetime EP0232835B1 (de) 1986-02-14 1987-02-03 Salbenkessel zur Herstellung pharmazeutischer oder kosmetischer Suspensionen

Country Status (4)

Country Link
EP (1) EP0232835B1 (es)
AT (1) ATE53175T1 (es)
DE (2) DE3604694A1 (es)
ES (1) ES2015274B3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246287A (en) * 1986-10-28 1993-09-21 British Nuclear Fuels Plc Colloidal grout mixing apparatus and method
DE4213344C2 (de) * 1992-04-23 1998-10-08 Flexible Fertigungstechnik Gmb Gerät zur Herstellung eines reaktiven Mehrkomponentengemisches
US5833364A (en) * 1993-11-17 1998-11-10 Calgon Corporation Chemical delivery and on-site blending system for producing multiple products
DE102010028883A1 (de) 2010-05-11 2011-11-17 Dürr Ecoclean GmbH Prozessbehälter
CN115870293B (zh) * 2023-02-09 2023-05-09 河北永丰药业有限公司 一种煎熬设备清垢装置及利用其的利咽解毒颗粒煎熬系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE883326C (de) * 1951-11-25 1953-07-16 Hans Koehler Einrichtung zur Herstellung von Arzneimitteln
CH549511A (de) * 1973-03-29 1974-05-31 Brogli & Co Ag Einrichtung zum entleeren eines behaelters, beispielsweise eines behandlungsgefaesses.
DE2726800A1 (de) * 1977-06-14 1979-01-04 Dejonge Ag Vorrichtung zum reinigen von ruehrgutbehaeltern
DE3114307C2 (de) * 1981-04-09 1983-01-13 Alfred Kärcher GmbH & Co, 7057 Winnenden Reinigungsvorrichtung für den Mischraum eines Betonmischers

Also Published As

Publication number Publication date
DE3762949D1 (de) 1990-07-05
ATE53175T1 (de) 1990-06-15
EP0232835A2 (de) 1987-08-19
ES2015274B3 (es) 1990-08-16
DE3604694A1 (de) 1987-08-20
EP0232835A3 (en) 1989-01-04

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