EP0215820A1 - Bioreacteur fluidise et procede de culture de cellules - Google Patents

Bioreacteur fluidise et procede de culture de cellules

Info

Publication number
EP0215820A1
EP0215820A1 EP86901270A EP86901270A EP0215820A1 EP 0215820 A1 EP0215820 A1 EP 0215820A1 EP 86901270 A EP86901270 A EP 86901270A EP 86901270 A EP86901270 A EP 86901270A EP 0215820 A1 EP0215820 A1 EP 0215820A1
Authority
EP
European Patent Office
Prior art keywords
liquid
reaction zone
beads
nutrient medium
liquid nutrient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86901270A
Other languages
German (de)
English (en)
Inventor
Robert C. Dean, Jr.
Peter V. RR 1 GRELA
Subhash B. Karkare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verax Corp
Original Assignee
Verax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verax Corp filed Critical Verax Corp
Publication of EP0215820A1 publication Critical patent/EP0215820A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C12M25/20—Fluidized bed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Abstract

Un réacteur (100) à lit fluidisé et un procédé de réaction particulièrement utiles pour cultiver des cellules, pour des procédés de fermentation et de culture de tissus par exemple, impliquent le traitement d'au moins une partie du fluide sortant du réacteur (100) à lit fluidisé dans une boucle latérale (160), de façon à modifier sa température ou sa composition, par exemple en l'oxygénant. Ce fluide traité est réintroduit dans le réacteur comme partie du fluide à l'origine de la fluidisation du lit.
EP86901270A 1985-02-28 1986-02-06 Bioreacteur fluidise et procede de culture de cellules Withdrawn EP0215820A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70687285A 1985-02-28 1985-02-28
US706872 1985-02-28

Publications (1)

Publication Number Publication Date
EP0215820A1 true EP0215820A1 (fr) 1987-04-01

Family

ID=24839418

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86901270A Withdrawn EP0215820A1 (fr) 1985-02-28 1986-02-06 Bioreacteur fluidise et procede de culture de cellules

Country Status (4)

Country Link
EP (1) EP0215820A1 (fr)
AU (1) AU5452986A (fr)
CA (1) CA1305681C (fr)
WO (1) WO1986005202A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1307225C (fr) * 1988-07-19 1992-09-08 David W. Armstrong Bioreacteur pour la culture de cellules
US5187095A (en) * 1988-12-19 1993-02-16 Baxter International Inc. Apparatus for culturing animal cells
US5102790A (en) * 1988-12-19 1992-04-07 Baxter International Inc. Method for culturing animal cells
CA2011653A1 (fr) * 1989-03-08 1990-09-08 Hiroshi Deno Methode de culture des tissus vegetaux, appareil utilise a cette fin et methode de production de metabolites
AT394576B (de) * 1991-01-16 1992-05-11 Vogelbusch Gmbh Reaktor zur durchfuehrung biologischer reaktionen mittels biokatalysatoren
JP3604715B2 (ja) * 1993-09-07 2004-12-22 サッポロホールディングス株式会社 酒類の製造法
DE19528871C2 (de) * 1994-08-24 1997-08-14 Forschungszentrum Juelich Gmbh Begasungs-Rohrmodul mit selektiv gasdurchlässiger Schlauchmembranen und damit versehene Reaktoren für Zellkulturtechnik sowie Wirbelschicht-Reaktoren für Zellkultivierung
EP0727480A3 (fr) * 1995-02-16 2000-04-12 Forschungszentrum Jülich Gmbh Procédé pour déterminer les pharmacocinétiques ou toxiqocinétiques des substances d'essais utilisant un système de culture de cellules in vitro et dispositif appropriés
EP0727481B1 (fr) * 1995-02-16 2003-04-16 Forschungszentrum Jülich Gmbh Procédé de culture des cellules des organes
AU6710296A (en) * 1995-08-21 1997-03-12 Kyowa Hakko Kogyo Co. Ltd. Immobilized enzyme reaction method
JP4231563B2 (ja) * 1997-09-02 2009-03-04 サッポロビール株式会社 発酵生産物の製造法
EP1087010B1 (fr) * 1999-09-08 2011-11-09 Levitronix LLC Bioréacteur avec pompe à usage unique
DE10016877A1 (de) 2000-04-05 2001-10-18 Scintec Diagnostics Gmbh Zug (Glyko-)Proteine mit hoher Immunreaktivität sowie ein Verfahren zu ihrer Herstellung
DE10127869A1 (de) * 2001-06-08 2003-01-02 Hoefer Bioreact Gmbh Bioreaktor mit wenigstens zwei Reaktionskammern
DE102007020671A1 (de) * 2007-05-01 2008-11-06 Justus-Liebig-Universität Giessen Verfahren und Vorrichtung zum kontaktfreien Materialwachstum in einer strömenden Lösung (FLow suspended solution growth (FSSG))
GB0921836D0 (en) * 2009-12-14 2010-01-27 Prebble Andrew Anaerobic reactor
EP2576758B1 (fr) 2010-06-07 2017-08-02 Jean-Louis Roux Dit Buisson Photobioréacteur à flux continu ou semi-continu et procédé d'utilisation
US20140024090A1 (en) * 2011-12-19 2014-01-23 Shell Oil Company Method and apparatus for converting a carbon source into a hydrocarbon or hydrocarbon precursor
FR3027678B1 (fr) * 2014-10-24 2016-12-30 Viovy Jean Louis Procede de detection d'organismes dans un echantillon dilue
CA3034452A1 (fr) 2016-08-21 2018-03-01 Adva Biotechnology Ltd. Bioreacteur et ses procedes d'utilisation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2705136A (en) * 1951-07-09 1955-03-29 Fritz W Glitsch & Sons Inc Bubble cap riser
NL84921C (fr) * 1953-07-07
GB1165328A (en) * 1966-04-15 1969-09-24 Brewing Patents Ltd Continuous Fermentation Apparatus and Process
US4016044A (en) * 1973-01-10 1977-04-05 Battelle Memorial Institute Method and apparatus for governing the reaction rate of enzymatic reactions
US4048018A (en) * 1974-08-05 1977-09-13 Coughlin Robert W Method of carrying out enzyme catalyzed reactions
US4032407A (en) * 1976-02-24 1977-06-28 The United States Of America As Represented By The United States Energy Research & Development Administration Tapered bed bioreactor
US4138290A (en) * 1976-04-22 1979-02-06 Novo Laboratories, Incorporated Glucose isomerization under expanded bed conditions
GB1584103A (en) * 1977-06-01 1981-02-04 Ranks Hovis Mcdougall Ltd Method and apparatus for promoting fermentation
NL7709179A (nl) * 1977-08-19 1979-02-21 Stamicarbon Werkwijze voor het uitvoeren van enzymatische omzettingen.
DE2940446C2 (de) * 1979-10-05 1982-07-08 B. Braun Melsungen Ag, 3508 Melsungen Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen
US4397953A (en) * 1980-02-26 1983-08-09 Process Engineering Company S A Method and apparatus for anaerobic fermentation
GB2073243B (en) * 1980-03-04 1984-12-05 Tokyo Rikakikai Kk Continuous fermentor or reactor
NZ197992A (en) * 1980-08-18 1984-07-31 Unisearch Ltd Anaerobic bacterial degradation of organic materials
DE3313382A1 (de) * 1982-04-14 1983-10-27 Takeda Chemical Industries Ltd Gas-fluessigkeit-kontaktiervorrichtung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8605202A1 *

Also Published As

Publication number Publication date
AU5452986A (en) 1986-09-24
CA1305681C (fr) 1992-07-28
WO1986005202A1 (fr) 1986-09-12

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Inventor name: DEAN, ROBERT, C., JR.

Inventor name: KARKARE, SUBHASH, B.

Inventor name: GRELA, PETER, V.RR 1