EP0215072A1 - Fluides antiseptiques - Google Patents

Fluides antiseptiques

Info

Publication number
EP0215072A1
EP0215072A1 EP86901752A EP86901752A EP0215072A1 EP 0215072 A1 EP0215072 A1 EP 0215072A1 EP 86901752 A EP86901752 A EP 86901752A EP 86901752 A EP86901752 A EP 86901752A EP 0215072 A1 EP0215072 A1 EP 0215072A1
Authority
EP
European Patent Office
Prior art keywords
fluid
vinyl
skin
pyrrolidinone
antiseptic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86901752A
Other languages
German (de)
English (en)
Other versions
EP0215072A4 (fr
Inventor
Bruno Anthony Gluck
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Individual
Original Assignee
Individual
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Publication date
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Publication of EP0215072A1 publication Critical patent/EP0215072A1/fr
Publication of EP0215072A4 publication Critical patent/EP0215072A4/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0076—Sprayable compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • the invention relates to dual purpose antiseptic fluids, which additionally to being effective skin disinfectants are also capable on drying to form skin protective film with residual antibacterial properties.
  • antiseptic fluids while primarily applied as skin disinfectants for pre- and post surgery, dermatological infections, burn treatment as well as first aid for superficial wounds, cuts and abrasions, offer the additional advantage of a temporary or longer lasting skin and wound dressing depending on the film forming polymer used, without impairing the normal physiological activity of the skin.
  • the invention also relates to medical, surgical and veterinary devices in particular to liquid applicators for antiseptic fluids to the human skin for medical, pre-and post surgical applications and first-aid
  • Antiseptic fluids are solutions of a substance of known antibacterial properties dissolved in a solvent such as water or a lower alcohol or mixture of both.
  • the bactericidal substance is, after application, deposited directly onto the skin and can through its contact cause to persons known to have hypersensitive skin, or to be allergic, considerable discomfort through reddening, itching or other sensations.
  • plastic bandages are usually solutions of an acrylic or methacrylic co-polymer dissolved in a volatile non-aqueous organic solvent of low boiling point such as ethyl acetate, acetone, ethyl alcohol or methylene chloride or mixtures thereof, reducing drying time to a minimum.
  • liquid bandages Although they protect the treated areas through their coherent film formation acting as a physical barrier against outside contamination and possible infection, they have no antibacterial activity and should therefore only be applied after disinfection of the skin.
  • a serious disadvantage of these liquid bandages is that the non-aqueous solvent for the film forming polymer can cause considerable pain if applied to open wounds, cuts and abrasions. For good adherence, such liquid bandages can only be applied to perfectly dry skin. This makes them less suitable where the skin is contaminated by body fluids such as blood, strong perspiration or pus.
  • these liquid bandages suffer from the disadvantage that the film consisting of a non-porous water-insoluble polymer closes the pores of the skin hermetically, thus not allowing it to perform its normal physiological functions. Modifications of such films have been claimed to make them semi-permable to be better able to cope with the body fluids exuded from the skin.
  • More recently spray plastic bandages have been described, whereby the polymer is dissolved in an organic solvent or the propellant itself to form a film on the skin removable by washing with soap and water.
  • a spray bandage is also described in Australian Patent No. 527 826 where the film consisting of a water insoluble polymer such as polybutylmethacrylate is dissolved in an organic solvent containing a water soluble bactericide such as a quaternary ammonium compound and bacteriostat such as a chlorinated hydroxydiphenylether.
  • the water soluble bactericide will be leached out from the polymeric film for the immediate disinfection of the skin and that the resulting porous film will subsequently allow sufficient humidity to pass through, for the remaining bacteriostat in its anhydrous medium to exert residual antibacterial activity.
  • antiseptic preparations being aqueous solutions of an iodine complex with ⁇ oly(N-vinyl-2-pyrrolidinone), which after application leaves a film ⁇ f. the iodine complex on the skin.
  • This film formation is only incidental to the disinfecting properties and because of the thinness of the film as it is removed immediately when in contact with moisture, it cannot be regarded as a protective wound dressing.
  • the antiseptic fluid is held in an open container and the swab dipped into its content, which is discarded after the operation, causing a waste of the larger part which remained unused. Furthermore, the swabs or sponges discarded after use could easily be mistakenly included in the swab count if contaminated with clotted blood or after use with an iodine disinfectant because of similarity of colour.
  • An improvement in the art is disclosed in US Patent No.
  • the present invention thus relates to a dual purpose antiseptic fluid which additionally to being a liquid disinfectant for broken and unbroken skin, open wounds, burns, cuts and abrasions, leaves a protective dressing in form of an elastic film over the treated areas with residual antibacterial properties.
  • the dual purpose antiseptic fluid of the invention after disinfection provides an elastic dressing which does not interfere with the normal physiological activity of the skin and is removable with water or with soap and water.
  • the antiseptic fluid of the invention causes a minimum or irritancy to sensitive skin otherwise caused by the direct contact and deposition of the bactericide and/or bacteristat direct onto the skin.
  • the invention also relates to a simple, reusable device for the application of the antiseptic fluid in an economic and effective manner to surfaces such as skin.
  • the invention therefore provides a dual-purpose antiseptic fluid comprising at least one bactericide and/or bacteristat at least one water-soluble or water-dispersable film forming polymer and water.
  • the fluid of the invention may optionally contain a water miscible, non-toxic volatile co-solvent such as a lower alcohol, e.g. ethanol. isopropanol, or the like.
  • a water miscible, non-toxic volatile co-solvent such as a lower alcohol, e.g. ethanol. isopropanol, or the like.
  • the use of a slow drying solvent in such antiseptic fluids allows sufficient time for the active ingredients to act as in any other antiseptic fluid to assure complete disinfection of the treated skin area. It is generally accepted that for efficient skin disinfection, the composition should be in contact with the skin for about 30 to about 90 seconds. For practical purposes however, the drying time of the solvent should be adjusted by the addition of the appropriate quantity of a water miscible volatile co-solvent such as ethanol or isopropanol, so that film forming takes place preferably between about 30 and about 60 seconds. It is also preferred that the concentration of the active ingredient is sufficient to achieve complete disinfection of the skin during film formation.
  • co-solvent content might be raised as high as 70% by volume to reduce drying time to a few seconds only.
  • additional bactericidal power of co-solvents such as ethanol at this concentration assures asepsis of the skin even within the reduced drying time.
  • a distinct advantage of the dual purpose antiseptic fluid of the invention containing a water-retaining film forming polymer is that after disinfection of the skin, not only residual antibacterial activity is maintained, but that it is directed simultaneously against the outside environment and the skin. Thus, even if a slow acting bacteristat is employed, disinfection of the skin is continued even if the film has been formed before asepsis of the skin has been achieved. There is also the important added advantage that after normal disinfection of the skin the remaining bacterial flora residing in the depth of the skin tissue, often protected by fatty matter, and brought to the surface at a later time by perspiration, is destroyed on contact with the active ingredient in the film.
  • quaternary ammonium compounds can reasonably be understood, as, on dissolving the film forming polymer, a protective colloid is formed around the molecule of the bactericide, and which without interfering with its antibacterial activity is preventing its direct contact with the skin not only during disinfection but even more so once film forming has set in.
  • Another advantage of the protective colloid and the film formation around the molcule of the bactericide is that the possible deactivation through organic matter is reduced and residual antibacterial activity is increased.
  • the use of a water soluble polymer has the further advantage that by selecting, polymers of sufficient high molecular weight, the viscosity of the antiseptic fluid can be adjusted to be sufficiently high as to avoid unnecessary and annoying run-off after application.
  • plasticisers are for example the polyethylene glycols or a surface active substance such as the nonylphenolpolyethoxy condensates to assure even spreading of the antiseptic fluid on the skin prior to filmformation in emergencies on unwashed skin and those people whose skin is oily or fatty.
  • the fluids of the invention optionally may contain a moisturiser. This is especially useful to enhance the moisture retaining properties of the polymeric film. Some moisturises may additionally act as a plasticiser. Examples of suitable moisturisers include glycerol, sorbitol, diethylene glycol. polyethylene glycol 400 and nonionic lanolin derivatives. Suitable bactericides and bacterisetats which may be employed in compositions of the invention include halogenated hydroxydiphenyl derivatives or halogenated salicyl and carbanilides.
  • bactericides and/or bacteristats are those of the formula
  • each of R 1 to R 9 may be hydrogen, halogen, lower alkyl, haloloweralkyl, lower alkoxy, allyl, cyano, amino or acetyl and the O-acyl derivatives thereof provided that at least one of R 1 to R 9 is halogen:
  • each of X 1 to X 10 may be hydrogen, halogen, haloalkyl, nitro or alkoxy provided that at least one of X 1 to X 9 is halogen:
  • each of Y 1 to Y 9 is hydrogen or halogen, provided that at least two of Y 1 to Y 9 are halogen;
  • each of Z, to Z 8 may be hydrogen or halogen provided that there is at least two halogen substituents on each Phehyl ring.
  • Examples of the preferred bactericides and/or bacteristats include 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan); 2,2'-dihydroxy-3,3',5,5' 6,6'- hexachlorodiphenylmethane systematic name (hexachlorophene); 3,5,4'-tribromosalicylanilide (tribromsalan), 3,4,4'-trichloro- or 3-trifluoromethyl-4,4'-dichlorocarbanilides (triclocarban and cloflucarban), chlorhexidine digluconate, cetyl trimethylammonium bromide, benzalkonium chloride and iodine complexes known as iodophors.
  • triclosan 2,4,4'-trichloro-2'-hydroxydiphenyl ether
  • the concentration of the active ingredient should be within the range recommended by the manufacturers, and be no different to those used in standard antiseptic solutions.
  • the film forming polymers, which provide films with sufficient water retention to allow for bactericidal bacteristatic activity of the incorporated active ingredients are, for example, methylcellulose, ethylcellulose.
  • Suitable polymers are for example co-polymers of vinyl acetate and crotonic acid, ter-polymers of N-vinyl-2-pyrrolidinone with vinyl acetate and alkylaminoacrylates or methacrylates.
  • Suitable polymers are also methylcellulose, ethylhydroxycellulose or hydroxymethylcellulose or ethylcellulose.
  • a suitable grade used in conjunction with a povidone-iodine or a povidone-iodine copolymer, they have the added advantage that viscous, non-running fluids are obtained allowing an even covering of well defined areas of the skin, resulting in a longer lasting antiseptic protective film against post-operative infections, with higher resistance against abrasions when applied under plaster casts and bandages than was hitherto possible to obtain.
  • N-vinyl-2-pyrrolidinone is a co-monomer
  • the co-polymer can be directly complexed with iodine using the poly(N-vinyl-2-pyrrolidinone) component to serve as the iodine carrier.
  • the water soluble alkali metal salts of carboxymethylcellulose can be used in conjunction with other polymeric film forming substances at a pH preferably between 7.0 and 8.0, but not much below pH 6.0. Due to their ionic character care has to be taken in the choice of the bactericides being part of the composition as to their compatibility. Thus they cannot be used in conjunction with cationic substances such as quaternary ammonium compounds.
  • Suitable examples of substances for partial salt formation of these polymers to render them more hydrophilic or even completely watersoluble are: 2-aminomethylpropanol, diethylaminopropylamine and tri-isopropanolamine.
  • the dual purpose antiseptic fluids according to this invention are suitably applied by any conventional method such as painting, swabbing or dabbing onto the skin or by means of a suitable applicator.
  • the invention provides apparatus for applying a fluid to a surface, which apparatus comprises a container for said fluid defining a reservoir, an applicator head in fluid communication therewith, fluid flow restricting means between said reservoir and said applicator head, first cap means associated with said container for filling with fluid and second cap means for said applicator head to prevent evaporation of fluid therefrom, wherein said applicator head comprises a resilient porous pad held in a dome shaped cap in content with said fluid flow restricting means.
  • Figure 1 is a representation of an applicator suitable for employing with the antiseptic fluids of the invention.
  • Figure 2 is an enlarged cut-away view of the applicator head depicted in Figure 1.
  • the antiseptic fluids of the invention may be applied by various known means such as spraying, swabbing, dipping, painting and the like.
  • the fluids may also be applied from an applicator of the type depicted in the drawings.
  • an applicator (1) is made up of a reservoir (2) for antiseptic fluid and has an outer cap (3) which may incorporate a clip (4) so that the applicator can be carried securely in a pocket or the like.
  • the reservoir (2) is closed with a perforated shaped cap (5) covered with a resilient pourous pad (6) and held in place by a collar (7) .
  • the pad (6) is preferably made of a synthetic resilient plastic material such as open polyurthane foam, multilayers of finely woven cotton cloth or absorben felt.
  • the pad (6) is held over a perforated dome shaped cap (5) clipped in place allowing through flow of the antiseptic fluid.
  • a rigid plastic material unaffected by the antiseptic fluid is to be selected. Suitable plastic materials are polyvinylchloride, polyethylene and propylene. styrene and similar polymeric materials.
  • the perforation of the cap (5) is such that the pad (6) is evenly moistened, preferably by a number of small symmetrically placed holes.
  • the size of the perforations depending on the viscosity of the fulid is to be such that by inverting the applicator (1) no gravity feed into the pad occurs and a small amount of pressure on the reservoir (2) is needed for the necessary amount of fluid to moisten it.
  • the applicator when not in use, is hermetically closed by a removable outer cap (3) which either screws or clips on, made of a similar material as the perforated dome-shaped cap (5). This assures that any vapours from the antiseptic fluid cannot escape, thus keeping the pad (6) continuously moist. This assures the the device not only being protected from outside contamination but being always ready for use since no drying of the surface can occur.
  • the reservoir (2) is suitably made from a resilient semi-rigid material such as high density polyethylene or propylene, enabling the antiseptic fluid to flow when inverted into the pad (6) on applying pressure to the side walls.
  • a preferred manner of filling the antiseptic fluid is by way of a flexible bag (not shown) which is connected to the perforated cap (5).
  • the semi-rigid reservoir (2) will incorporate an air-vent.
  • the flexible bag may be made up from any suitable material such as polyethylene or propylene, nylon and the like.
  • pH adjustments were made with phosphoric acid or an organic acid such as citric or lactic acid or with a mild alkali such as trithanolamine.
  • EXAMPLE 1 First Aid Disinfectant and Dressing iodine complex with N-vinyl-2-pyrrolidinone: vinyl acetate co-polymer, ratio 70:30, available iodine 10% 5.0g co-polymer of N-vinyl-2-pyrrolidinone: vinyl acetate, ratio 30:70 5.0g nonylphenolpolyethoxy(14) condensate 0.1g ethanol 30.0ml water, dist to make 100.0ml
  • the iodine complex of the co-polymer was obtained by using published standard methods for complexing with poly(N-vinyl--2-pyrrolidinone).
  • EXAMPLE 2 First Aid Disinfectant and Dressing chlorhexidine gluconate 0.05g co-polymer of vinylacetate with crotonic acid 3.00g polyethylene glycol 400 0.30g ethanol 40.00mL
  • 2-aminomethylpropanol 0.24g water, dist. to make 100.00mL
  • the polymer was dissolved by adding it to the solvent mixture containing the chlorhexidine and the polyethylene glycol and sufficient quantity of the 2-aminoraethylpropanol added to obtain solution.
  • the pH was kept between 6 to 7.
  • the composition is suitable to be packed as an aerosol spray, using hydrocarbons as propellant.
  • Example 3 Antiseptic Preppinq Fluid and Dressing This fluid is useful for disinfection of the skin prior to insertion of a hypodermic needle, canule or general disinfection prior and post surgery: povddone-iodine containing 10% available iodine 10.0g co-polymer of N-vinyl-2-pyrrolidinone: vinyl acetate, ratio 50:50 10.0g polyvinylpyrrolidone K 90 2.0g nonylphenolypolyethoxy(14) condensate 0.1g polyethylene glycol 400 0.1g water, dist. to make 100.0mL EXAMPLE 4
  • Viscous Antiseptic Prepping Fluid This fluid is useful as a non-running, viscous antiseptic fluid for surgical prepping and dressing: povidone-iodine containing 10% available iodine 10.0g hydroxyethylcellulose 1.0g glycerol 1.0g nonylphenolethoxylate 0.25g water, dist. to make 100.0mL
  • the hydroxyethylcellulose grades of suitable viscosity properties should be selected to give sufficient viscosity so that a free-flowing, sufficiently viscous film forming fluid is obtained which is able to accurately delineate the defined areas of skin to which it is applied.
  • methylhydroxyethylcellulose grades of suitable viscosity properties should be selected to give sufficient viscosity so that a free-flowing, sufficiently viscous film forming fluid is obtained which is able to accurately delineate the defined areas of skin to which it is applied.
  • chlorhexidine acetate 0.5g ter-polymer of vinyl acetate, vinyl propionate and crotonic acid 6.0g ethanol 70.0mL
  • the method of preparation was the same as in Example 2.
  • the fluid is applied by wetting the complete hand and letting the solvent evaporate before putting on surgical gloves. In case of emergencies where no gloves are available, the procedure is repeated twice.
  • This fluid is useful as an antiseptic fluid for certain light dermatological infections: trichlorophenoxydiphenylether 0.2g co-polymer of N-vinyl-2-pyrrolidinone: vinyl acetate, ratio 20:80 8.0g nonionic lanolin derivative 70.0mL water, dist. to make 100.0mL
  • Tylopur MH 1000 2.0g water to make 100.0mL
  • the Antarox products were added to the solution of the Tylopur.
  • the pH was then adjusted to 4.5.
  • Antarox VRO 20 and Antarox Co 880 are from GAF Corp USA, Tylopur MH is a methyl hydroxyethylcellulose available from Hoechst AG,W. Germany.
  • This fluid is manufactured as described in Example 8.
  • the pH is to adjusted to a pH 4 with phosphoric acid.

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Abstract

Fluides antiseptiques à double effet qui, tout en étant des désinfectants cutanés efficaces, peuvent sécher pour former un film de protection de la peau présentant des propriétés antibactériennes résiduelles. Ces fluides antiseptiques sont appliqués principalement comme désinfectants cutanés contre les infections dermatologiques, avant et après une intervention chirurgicale, dans le traitement de brûlures, ainsi que comme premiers soins en cas de plaies, coupures et abrasions superficielles, tout en présentant l'avantage supplémentaire de former un pansement temporaire ou de plus longue durée de la peau et des plaies, suivant le polymère filmogène utilisé, sans entraver l'activité physiologique normale de la peau. L'invention a trait également à des instruments médicaux chirurgicaux et vétérinaires, notamment à des applicateurs de liquide pour fluides antiseptiques sur la peau humaine pour des applications médicales, avant et après une intervention chirurgicale et comme premiers soins.
EP19860901752 1985-03-13 1986-03-13 Fluides antiseptiques. Withdrawn EP0215072A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPG967985 1985-03-13
AU9679/85 1985-03-13
CA000522230A CA1290250C (fr) 1985-03-13 1986-11-05 Liquides antiseptiques

Publications (2)

Publication Number Publication Date
EP0215072A1 true EP0215072A1 (fr) 1987-03-25
EP0215072A4 EP0215072A4 (fr) 1990-01-08

Family

ID=25642912

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860901752 Withdrawn EP0215072A4 (fr) 1985-03-13 1986-03-13 Fluides antiseptiques.

Country Status (9)

Country Link
EP (1) EP0215072A4 (fr)
JP (1) JP2559225B2 (fr)
KR (1) KR940010078B1 (fr)
AU (1) AU586243B2 (fr)
CA (1) CA1290250C (fr)
DK (1) DK542486A (fr)
FI (1) FI864514A (fr)
NO (1) NO864519L (fr)
WO (1) WO1986005391A1 (fr)

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US5459879A (en) * 1989-05-22 1995-10-24 Board Of Regents, The University Of Texas System Protective coverings
US5483697A (en) * 1989-05-22 1996-01-16 Board Of Regents The University Of Texas Multilayer protective coverings with a sealing solution
NZ243311A (en) * 1991-06-28 1995-02-24 Calgon Corp Composition for treatment of skin and nails which comprises an ampholyte terpolymer comprising non-ionic, cationic and anionic monomers
NZ267488A (en) * 1993-07-28 1997-09-22 Pfizer Topical psoriasis treatment composition comprising a film-forming agent
US6113893A (en) * 1993-07-28 2000-09-05 Pfizer Inc. Psoriasis treatment
AUPN262595A0 (en) * 1995-04-24 1995-05-18 Novapharm Research (Australia) Pty Limited Biocidal surface films
US6730294B1 (en) 1995-04-24 2004-05-04 Novapharm Research (Australia) Pty Limited Method of forming a water soluble biocidal film on a solid surface
US6579516B1 (en) 1995-06-13 2003-06-17 Zahra Mansouri Methods of delivering materials into the skin, and compositions used therein
US6096324A (en) * 1995-06-13 2000-08-01 Laboratory Skin Care Methods of delivering materials into the skin, and compositions used therein
US5660823A (en) * 1995-10-11 1997-08-26 Isp Investments Inc. Fast drying, film forming iodine release solution
GB9522314D0 (en) * 1995-11-01 1996-01-03 Bristol Myers Squibb Co Water soluble films
CN1063610C (zh) * 1996-02-06 2001-03-28 天津市医药工业技术研究所 广谱性杀菌制剂
JP2001505532A (ja) * 1996-06-24 2001-04-24 バイオ―セイフ エンタープライジズ，インコーポレイテッド 抗菌性組成物
US5908631A (en) * 1997-02-27 1999-06-01 L'oreal S.A. Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose
AU5038299A (en) * 1998-07-09 2000-02-01 Rhodia Chimie Process for the biocidal treatment of surfaces
US6238575B1 (en) * 1998-07-29 2001-05-29 Microban Products Company Antimicrobial treatment of enclosed systems having continuous or intermittent fluid flow
US7566740B2 (en) * 1998-10-06 2009-07-28 Bml Pharmaceuticals, Inc. Method of treating mucositis
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US6838078B2 (en) 2002-01-16 2005-01-04 3M Innovative Properties Company Film-forming compositions and methods
US7147873B2 (en) 2002-01-16 2006-12-12 3M Innovative Properties Company Antiseptic compositions and methods
US7005031B2 (en) 2002-01-16 2006-02-28 3M Innovative Properties Company Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods
WO2004018003A1 (fr) 2002-08-20 2004-03-04 Alda Pharmaceuticals Corp. Desinfectant a large spectre
US20060216267A1 (en) 2002-08-20 2006-09-28 Kovacs Stephen G Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis
CA2533950C (fr) 2005-01-28 2013-10-22 B. Braun Medical Ag Desinfectant virocide
US9247736B2 (en) 2005-12-14 2016-02-02 3M Innovative Properties Company Antimicrobial adhesive films
EP2091324B1 (fr) 2006-10-27 2016-12-28 3M Innovative Properties Company Compositions antimicrobiennes
US8771725B2 (en) 2007-10-12 2014-07-08 Chesson Laboratory Associates, Inc. Poly(urea-urethane) compositions useful as topical medicaments and methods of using the same
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US20150126944A1 (en) * 2013-11-07 2015-05-07 Chlorhexidine Optimal Products For Skin LLC System for applying a small quantity of antiseptic
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Also Published As

Publication number Publication date
AU5660686A (en) 1986-10-13
KR940010078B1 (ko) 1994-10-21
DK542486D0 (da) 1986-11-13
EP0215072A4 (fr) 1990-01-08
NO864519D0 (no) 1986-11-12
KR870700016A (ko) 1987-02-28
FI864514A0 (fi) 1986-11-06
JPS62502309A (ja) 1987-09-10
JP2559225B2 (ja) 1996-12-04
NO864519L (no) 1986-11-12
FI864514A (fi) 1986-11-06
WO1986005391A1 (fr) 1986-09-25
CA1290250C (fr) 1991-10-08
DK542486A (da) 1986-11-13
AU586243B2 (en) 1989-07-06

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