EP0169482B1 - Procédé de préparation de 5,6-dihydro-2H-thiopyran-3-carboxaldéhydes - Google Patents

Procédé de préparation de 5,6-dihydro-2H-thiopyran-3-carboxaldéhydes Download PDF

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Publication number
EP0169482B1
EP0169482B1 EP85108899A EP85108899A EP0169482B1 EP 0169482 B1 EP0169482 B1 EP 0169482B1 EP 85108899 A EP85108899 A EP 85108899A EP 85108899 A EP85108899 A EP 85108899A EP 0169482 B1 EP0169482 B1 EP 0169482B1
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EP
European Patent Office
Prior art keywords
acrolein
hydrogen sulfide
crotonaldehyde
mineral oil
thiopyran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP85108899A
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German (de)
English (en)
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EP0169482A3 (en
EP0169482A2 (fr
Inventor
Manfred Dr. Sauerwald
Toni Dr. Dockner
Wolfgang Dr. Rohr
Gernot Dr. Reissenweber
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BASF SE
Original Assignee
BASF SE
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Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to AT85108899T priority Critical patent/ATE40129T1/de
Publication of EP0169482A2 publication Critical patent/EP0169482A2/fr
Publication of EP0169482A3 publication Critical patent/EP0169482A3/de
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Publication of EP0169482B1 publication Critical patent/EP0169482B1/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

Definitions

  • the invention relates to a process for the preparation of 5,6-dihydro-2H-thiopyran-3-car-boxaldehydes, optionally methyl-substituted in the 2,5-position, by reacting acrolein or crotonaldehyde with hydrogen sulfide in mineral oil.
  • 5,6-Dihydro-2H-thiopyran-3-carboxaldehyde are important intermediates for the production of some crop protection products.
  • yields of about 90% are obtained if acrolein is reacted with hydrogen sulfide in the presence of acids or bases in an autoclave at pressures between 0 and 10 bar and the reaction product is treated with acid.
  • chlorinated hydrocarbons such as e.g. Chloroform used and for the dehydration stage large amounts (10 to 50 mol% or on acrolein) of mineral acids such as e.g. Phosphoric acid or sulfuric acid are required; this leads to problems with the reactor equipment, especially when using the highly corrosive phosphoric acid.
  • the aqueous phase must be separated off, extracted, the organic phase dried and, in most cases, the solvent must be distilled off before the end product is distilled. This takes time and money.
  • acrolein or crotonaldehyde and hydrogen sulfide are reacted with one another in a high-boiling hydrocarbon as a solvent by simultaneously feeding hydrogen sulfide with acrolein to a reactor which is discharged from a stirred tank or cylindrical reactors, e.g. Bubble columns or packed columns can exist. While hydrogen sulfide is introduced in gaseous form, acrolein or crotonaldehyde can be added in liquid or gaseous form.
  • the molar ratios of acrolein or crotonaldehyde to hydrogen sulfide can be varied in the range from (3.0-1.5): 1, preferably a molar ratio of (2.2-1.8): 1 is set. It is also possible to add acrolein or crotonaldehyde to the mineral oil and then introduce the required amount of hydrogen sulfide.
  • Mineral oils that boil higher than the starting materials and end products include e.g. Gas oil, heating oil, melted paraffin wax or aromatic hydrocarbon oil. Vacuum gas oil with a boiling point of at least 350 ° C., in particular with a boiling range of 350 ° C. to 500 ° C., is advantageously used as the mineral oil.
  • the formation of the intermediate addition compound of acrolein or crotonaldehyde with hydrogen sulfide takes place without the addition of a catalyst at temperatures between -20 and + 200 ° C, preferably between +20 and + 60 ° C under normal pressure.
  • the cyclization and dehydration of the addition product can take place in the presence of high-boiling acidic substances without prior work-up.
  • Aliphatic or aromatic sulfonic acids in particular mixtures of aliphatic sulfonic acids with alkyl radicals from C 10 to C 3o , benzenesulfonic acid, toluenesulfonic acid or dodecylbenzenesulfonic acid are preferably used as catalysts.
  • the amounts added are 0.0001 to 10 mol%, preferably 0.01 to 5 mol%, in particular 0.1 to 1 mol%.
  • the reaction is expediently carried out at temperatures from +70 to + 130.degree. C., in particular at temperatures from +100 to + 120.degree. C., the water liberated being distilled off, advantageously simultaneously, in vacuo at about 15 mbar or at normal pressure in a weak nitrogen stream becomes.
  • Example 2 The procedure is as in Example 1, but 1000 parts of vacuum residue are used instead of vacuum gas oil. 201 parts of 5,6-dihydro-2H-thiopyran-3-carboxaldehyde are obtained, corresponding to a yield of 87.9%.
  • Example 2 The procedure is as in Example 1, but 100 parts of acrolein are reacted with 35 parts of hydrogen sulfide per hour. 196 parts of 5,6-dihydro-2H-thiopyran-3-carboxaldehyde are obtained, corresponding to a yield of 85.7%, based on acrolein used.
  • acrolein after the addition of 20 liters of nitrogen per hour are pre-evaporated in an evaporator (oil-heated coil cooler) heated to 70 ° C and simultaneously fed with 30 parts of hydrogen sulfide to the reactor, which is filled with 1000 parts of vacuum gas oil heated to 40 to 50 ° C that is continuously pumped around.
  • the reactor consists of an oil-heated double jacket tube with a length of 1300 mm and an inner diameter of 60 mm. After 2 hours, the material supply is stopped and heated to 100 to 120 ° C. in a gentle stream of nitrogen (15 to 20 l / h), the water released being distilled off.
  • the reactor contents are then transferred to a distillation apparatus and the product of value is distilled out of the vacuum gas oil at pressures of 0.1 to 1 mbar. 204 parts of 5,6-dihydro-2H-thiopyran-3-carboxaldehyde are obtained, corresponding to a yield of 89.2%.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (8)

1. Procédé de préparation de 5,6-dihydro-2H-thiopyranne-3-carboxaldéhydes de formule
Figure imgb0003
dans laquelle R représente un atome d'hydrogène ou un groupement méthyle, par réaction d'un aldéhyde a,ß-insaturé avec l'acide sulfhydrique, caractérisé en ce que, dans un premier stade, on fait réagir de l'acroléïne ou du crotonaldéhyde et l'acide sulfhydrique à une température de 20 à 60°C dans une huile minérale dont le point d'ébullition est supérieur au point d'ébullition des produits de départ et des produits finals, et, dans un deuxième stade, on cyclise et on déshydrate à 70-130°C le produit d'addition sans traitement préalable en présence de substances acides de point d'ébullition élevé, on chasse par distillation l'eau libérée sous pression normale ou sous pression réduite et on obtient le 5,6-dihydro-2H-thio- pyranne-3-carboxaldéhyde par distillation sous pression réduite.
2. Procédé selon la revendication 1, caractérisé en ce qu'on utilise comme huile minérale un gazole sous vide ayant un point d'ébullition d'au moins 350°C.
3. Procédé selon la revendication 1, caractérisé en ce qu'une partie de l'huile minérale utilisée est après la réaction envoyée à la combustion dans une centrale et est remplacée par de l'huile minérale fraîche.
4. Procédé selon la revendication 1, caractérisé en ce qu'on amène dans la réacteur l'acroléïne ou le crotonaldéhyde et l'acide sulfhydrique simultanément avec un rapport de (3-1,5) :1, ou bien on met préalablement l'acrolèïne ou le crotonaldéhyde dans l'huile minérale puis on envoie la quantité nécessaire d'acide sulfhydrique.
5. Procédé selon la revendication 1, caractérisé en ce qu'on amène dans le réacteur l'acroléïne ou le crotonaldéhyde et l'acide sulfhydrique simultanément avec un rapport de (2,2-1,8) :1, ou bien on met préalablement l'acroléïne ou le crotonaldéhyde dans l'huile minérale puis on envoie la quantité nécessaire d'acid sulfhydrique.
6. Procédé selon la revendication 1, caractérisé en ce qu'on amène au réacteur l'acide sulfhydrique sous forme gazeuse et l'acroléïne ou le crotonaldéhyde sous forme liquide ou gazeuse.
7. Procédé selon la revendication 1, caractérisé en ce que les substances acides de point d'ébullition élevé sont des acides sulfoniques aliphatiques ou aromatiques de point d'ébullition élevé.
8. Procédé selon la revendication 7, caractérisé en ce que les acides sulfoniques aliphatiques ou aromatiques de point d'ébullition élevé sont l'acide tridécylsulfonique ou l'acide dodécylben- zènesulfonique.
EP85108899A 1984-07-25 1985-07-16 Procédé de préparation de 5,6-dihydro-2H-thiopyran-3-carboxaldéhydes Expired EP0169482B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT85108899T ATE40129T1 (de) 1984-07-25 1985-07-16 Verfahren zur herstellung von 5,6-dihydro-2hthiopyran-3-carboxaldehyden.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3427404 1984-07-25
DE19843427404 DE3427404A1 (de) 1984-07-25 1984-07-25 Verfahren zur herstellung von 5,6-dihydro-2h-thiopyran-3-carboxaldehyden

Publications (3)

Publication Number Publication Date
EP0169482A2 EP0169482A2 (fr) 1986-01-29
EP0169482A3 EP0169482A3 (en) 1986-12-30
EP0169482B1 true EP0169482B1 (fr) 1989-01-18

Family

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EP85108899A Expired EP0169482B1 (fr) 1984-07-25 1985-07-16 Procédé de préparation de 5,6-dihydro-2H-thiopyran-3-carboxaldéhydes

Country Status (9)

Country Link
US (1) US4670567A (fr)
EP (1) EP0169482B1 (fr)
JP (1) JPS6137779A (fr)
AT (1) ATE40129T1 (fr)
BR (1) BR8503464A (fr)
CA (1) CA1256886A (fr)
DE (2) DE3427404A1 (fr)
HU (1) HU198470B (fr)
IL (1) IL75875A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9510612B2 (en) * 2014-11-18 2016-12-06 International Flavors & Fragrances Inc. Flavor and fragrance compositions containing thiopyran-carbaldehyde

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7003166A (fr) * 1969-04-17 1970-10-20
DE2856908A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue chinoloncarbonsaeure-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische praeparate
DE3125920A1 (de) * 1981-07-01 1983-01-20 Basf Ag, 6700 Ludwigshafen "verfahren zur herstellung von sulfiden"

Also Published As

Publication number Publication date
BR8503464A (pt) 1986-04-15
JPS6137779A (ja) 1986-02-22
HU198470B (en) 1989-10-30
CA1256886A (fr) 1989-07-04
JPH0586789B2 (fr) 1993-12-14
IL75875A (en) 1988-06-30
IL75875A0 (en) 1985-11-29
DE3427404A1 (de) 1986-01-30
EP0169482A3 (en) 1986-12-30
US4670567A (en) 1987-06-02
ATE40129T1 (de) 1989-02-15
DE3567655D1 (en) 1989-02-23
HUT38925A (en) 1986-07-28
EP0169482A2 (fr) 1986-01-29

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