EP0163888A1 - Amidinohydrazones de dérivés de tétraline, de chromone, de thiachromone et de tétrahydroquinoléine, procédé pour leur préparation et leur utilisation dans des médicaments - Google Patents

Amidinohydrazones de dérivés de tétraline, de chromone, de thiachromone et de tétrahydroquinoléine, procédé pour leur préparation et leur utilisation dans des médicaments Download PDF

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Publication number
EP0163888A1
EP0163888A1 EP85104825A EP85104825A EP0163888A1 EP 0163888 A1 EP0163888 A1 EP 0163888A1 EP 85104825 A EP85104825 A EP 85104825A EP 85104825 A EP85104825 A EP 85104825A EP 0163888 A1 EP0163888 A1 EP 0163888A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
mono
atoms
alkylene
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85104825A
Other languages
German (de)
English (en)
Inventor
Hartmut Dr. Stegelmeier
Frank-Joachim Dr. Morich
Andreas Dr. Knorr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of EP0163888A1 publication Critical patent/EP0163888A1/fr
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D345/00—Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
EP85104825A 1984-05-05 1985-04-20 Amidinohydrazones de dérivés de tétraline, de chromone, de thiachromone et de tétrahydroquinoléine, procédé pour leur préparation et leur utilisation dans des médicaments Withdrawn EP0163888A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3416695 1984-05-05
DE19843416695 DE3416695A1 (de) 1984-05-05 1984-05-05 Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
EP0163888A1 true EP0163888A1 (fr) 1985-12-11

Family

ID=6235059

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85104825A Withdrawn EP0163888A1 (fr) 1984-05-05 1985-04-20 Amidinohydrazones de dérivés de tétraline, de chromone, de thiachromone et de tétrahydroquinoléine, procédé pour leur préparation et leur utilisation dans des médicaments

Country Status (11)

Country Link
EP (1) EP0163888A1 (fr)
JP (1) JPS60239454A (fr)
KR (1) KR850008672A (fr)
AU (1) AU4200885A (fr)
DE (1) DE3416695A1 (fr)
DK (1) DK199885A (fr)
ES (1) ES8607271A1 (fr)
FI (1) FI851736L (fr)
GR (1) GR851073B (fr)
HU (1) HUT38609A (fr)
ZA (1) ZA853328B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243982A1 (fr) 1986-05-02 1987-11-04 Mochida Pharmaceutical Co., Ltd. Dérivés de la 1-acyl-2,3-dihydro-4(1H)-quinoléinon-4-oxime, leur procédé de préparation, compositions pharmaceutiques et intermédiaires
EP0315115A2 (fr) * 1987-10-31 1989-05-10 Mochida Pharmaceutical Co., Ltd. Dérivés de la 1-acyl-2,3-dihydro-4(1H)quinolone-4-oxine, procédé de leur production et leur utilisation
EP0456133A1 (fr) * 1990-05-07 1991-11-13 Ciba-Geigy Ag Hydrazones
WO1992003421A2 (fr) * 1990-08-17 1992-03-05 E.I. Du Pont De Nemours And Company Pyrazolines, pyrazolidines et hydrazines arthropodicides
US8269011B2 (en) 2007-06-06 2012-09-18 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US8304546B2 (en) 2008-12-05 2012-11-06 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197331B (en) * 1986-06-26 1989-03-28 Alkaloida Vegyeszeti Gyar Process for producing benzopiran derivatives, as well as insecticide and nematocide compositions comprising these compounds as active ingredient
US5238941A (en) * 1988-03-25 1993-08-24 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions thereof
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
FR2669927B1 (fr) * 1990-11-29 1994-04-08 Adir Cie Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
CA2316944A1 (fr) * 1998-02-20 1999-08-26 Mitsuru Shiraishi Derives d'aminoguanidine hydrazone, procedes de production, et leur utilisation
AU4952700A (en) 1999-06-03 2000-12-28 Takeda Chemical Industries Ltd. Pernasal preparations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1083730A (en) * 1964-10-01 1967-09-20 Bayer Ag Chromone and thiochromone guanylhydrazones
DE2020230A1 (de) * 1969-04-28 1970-11-12 Agronomique Inst Nat Rech Amidinohydrazone und deren Verwendung als antivirale Mittel
US4076726A (en) * 1974-06-01 1978-02-28 Akzona Incorporated Amidino-hydrazone derivatives
DE2736064A1 (de) * 1977-08-10 1979-02-22 Bayer Ag Antimalaria-mittel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1083730A (en) * 1964-10-01 1967-09-20 Bayer Ag Chromone and thiochromone guanylhydrazones
DE2020230A1 (de) * 1969-04-28 1970-11-12 Agronomique Inst Nat Rech Amidinohydrazone und deren Verwendung als antivirale Mittel
US4076726A (en) * 1974-06-01 1978-02-28 Akzona Incorporated Amidino-hydrazone derivatives
DE2736064A1 (de) * 1977-08-10 1979-02-22 Bayer Ag Antimalaria-mittel

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243982A1 (fr) 1986-05-02 1987-11-04 Mochida Pharmaceutical Co., Ltd. Dérivés de la 1-acyl-2,3-dihydro-4(1H)-quinoléinon-4-oxime, leur procédé de préparation, compositions pharmaceutiques et intermédiaires
WO1987006580A1 (fr) * 1986-05-02 1987-11-05 Mochida Pharmaceutical Co., Ltd. Derives de 1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime
US4839368A (en) * 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
US5077410A (en) * 1986-05-02 1991-12-31 Mochida Pharmaceutical Co., Ltd. Intermediate compounds of 1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime derivatives
EP0315115A2 (fr) * 1987-10-31 1989-05-10 Mochida Pharmaceutical Co., Ltd. Dérivés de la 1-acyl-2,3-dihydro-4(1H)quinolone-4-oxine, procédé de leur production et leur utilisation
US4968680A (en) * 1987-10-31 1990-11-06 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof
EP0315115A3 (fr) * 1987-10-31 1991-02-27 Mochida Pharmaceutical Co., Ltd. Dérivés de la 1-acyl-2,3-dihydro-4(1H)quinolone-4-oxine, procédé de leur production et leur utilisation
EP0456133A1 (fr) * 1990-05-07 1991-11-13 Ciba-Geigy Ag Hydrazones
WO1992003421A2 (fr) * 1990-08-17 1992-03-05 E.I. Du Pont De Nemours And Company Pyrazolines, pyrazolidines et hydrazines arthropodicides
WO1992003421A3 (fr) * 1990-08-17 1992-10-29 Du Pont Pyrazolines, pyrazolidines et hydrazines arthropodicides
US8269011B2 (en) 2007-06-06 2012-09-18 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US8642619B2 (en) 2007-06-06 2014-02-04 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US9045464B2 (en) 2007-06-06 2015-06-02 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US9403773B2 (en) 2007-06-06 2016-08-02 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US8304546B2 (en) 2008-12-05 2012-11-06 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US8592593B2 (en) 2008-12-05 2013-11-26 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
USRE45108E1 (en) 2008-12-05 2014-09-02 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition
US9018229B2 (en) 2008-12-05 2015-04-28 Otsuka Pharmaceutical Co., Ltd. Quinolone compound and pharmaceutical composition

Also Published As

Publication number Publication date
FI851736L (fi) 1985-11-06
DK199885D0 (da) 1985-05-02
GR851073B (fr) 1985-11-25
KR850008672A (ko) 1985-12-21
HUT38609A (en) 1986-06-30
DK199885A (da) 1985-11-06
ES8607271A1 (es) 1986-05-16
JPS60239454A (ja) 1985-11-28
FI851736A0 (fi) 1985-05-02
ZA853328B (en) 1985-12-24
DE3416695A1 (de) 1985-11-07
AU4200885A (en) 1985-11-07
ES542615A0 (es) 1986-05-16

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19850420

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI NL SE

17Q First examination report despatched

Effective date: 19860609

STAA Information on the status of an ep patent application or granted ep patent

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18W Application withdrawn

Withdrawal date: 19860918

RIN1 Information on inventor provided before grant (corrected)

Inventor name: STEGELMEIER, HARTMUT, DR.

Inventor name: MORICH, FRANK-JOACHIM, DR.

Inventor name: KNORR, ANDREAS, DR.