Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/65—Tetracyclines
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
  • A61K31/425—Thiazoles
  • A61K31/429—Thiazoles condensed with heterocyclic ring systems
  • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K38/00—Medicinal preparations containing peptides
  • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/04—Antibacterial agents

Definitions

• the present invention relates to an antibiotic composition
• an antibiotic composition comprising, in an injectable form, a synergistic mixture of an antibiotic of the oxytetracycline type and of an antibiotic of the benzylpenlcillin type in order to combat certain diseases due to bacteria.
• antibiotics are currently widely used for the treatment of mammals, in particular in veterinary medicine.
• PFIZER Belgian Patent No. 505,709
• antibiotic compositions containing simultaneously an antibiotic of the oxytetracycline or terramycin type and an antibiotic of the penicillin type are surprisingly effective against many different types of bacteria, in particular against various infectious microorganisms of the Salmonella and Pseudomonas groups, when used individually, these have only a low therapeutic value with respect to said microorganisms.
• diseases caused by Salmonella there may be mentioned for humans, paratyphoid fever, salmonellosis septicemia, salmonellous enterocolitis, pneumonia and osteomyelitis.
• Certain bacteria from the Salmonella group are also the cause of dangerous diseases in animals, such as infection due to Salmonella pullorum in poultry.
• the present invention is also based on obtaining a surprising synergy of the two above-mentioned antibiotics.
• an antibiotic composition comprising, in an injectable form, a synergistic mixture of an antibiotic of the oxytetracycline type and of an antibiotic of the benzylpenicillin type in order to combat certain diseases due to bacteria, essentially characterized in that it comprises, in addition to the two above-mentioned antibiotics, also an antibiotic of the Miltimycin type in an oxytetracycline: benzylpenicillin: Multimycin weight ratio comprised in a range varying from 10 to 30, preferably 20 of the first compound, 90 to 70, preferably 80 of the second compound and 1 to 15, preferably 7 of the third compound.
• the synergistic composition of the invention finds its preferred veterinary application, given its effectiveness, in combating all infections of the mucous membranes, in particular mycoses caused by fungi and all necrotic diseases, for example necrosis, lingual necrobacillosis of the calves and canker.
• Another field of application is the treatment of peritonitis, metritis, infectious pneumonia in foals (coryne bacteria flu) and the "white bad in cattle” (ulcers on the hooves) or panaris.
• a galenical form of the antibiotic composition according to the invention was prepared by mixing the following constituents for 100 ml:
• the mixing is carried out first by mixing together the compounds 1 / and 2 / then adding the compound 3 / thereafter, after which all the compounds listed under 4 / and 5 / are added thereto.
• the preparation in liquid form at the dosages indicated above is injected at the rate of 20 ml per 100 kg of body weight into calves, the blood count being able to go up to 50 ml per head of adult cattle.
• This dosage represents 6.25 million IU of antibiotics for 20 ml.
• composition described has been found to be particularly effective in combating infections of the mucous membranes, in particular mycoses caused by fungi which, in many cases would have, in the absence of treatment with the synergistic composition of the invention, required cattle slaughter or surgical procedures. A young animal severely affected by Lingual necrobacillosis who refused to drink was cured within 24 hours.
• composition has also been found to be very effective in the treatment of the other conditions mentioned above, while the use of the antibiotics mentioned in isolation has practically no effect.
• the invention covers all the synergistic compositions of the invention with the supports, diluents and excipients usually used in pharmacology.
• the invention extends to all these variants of application, composition or preparation.
• An antibiotic composition comprising simultaneously oxytetracyclin, procain benzylpenicillin and colistin sulphate has a combined synergy activity susceptible to cure necrotic diseases and mucosa troubles for which no efficient remedy has been found heretofore.
• An antibiotic composition comprising simultaneously oxytetracycline, procaine benzylpenicillin and colistin sulfate exerts a combined synergistic action capable of curing necrotic diseases and affections of the mucous membranes for which there are no valid remedies to date.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Epidemiology (AREA)
• Communicable Diseases (AREA)
• Oncology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Gastroenterology & Hepatology (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Immunology (AREA)
• Proteomics, Peptides & Aminoacids (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=19730090

Family Applications (1)

Country Status (9)

Families Citing this family (2)

Family Cites Families (3)

• 1984
  • 1984-05-02 JP JP59501885A patent/JPH01500746A/ja active Pending
  • 1984-05-02 CA CA000453413A patent/CA1221635A/fr not_active Expired
  • 1984-05-02 EP EP84901729A patent/EP0150186A1/de not_active Withdrawn
  • 1984-05-02 ZA ZA843277A patent/ZA843277B/xx unknown
  • 1984-05-02 WO PCT/BE1984/000012 patent/WO1984004249A2/fr not_active Application Discontinuation
  • 1984-05-02 IT IT20759/84A patent/IT1180166B/it active
  • 1984-05-02 IE IE1088/84A patent/IE57352B1/en not_active IP Right Cessation
  • 1984-05-03 PT PT78540A patent/PT78540B/pt not_active IP Right Cessation
• 1985
  • 1985-01-03 DK DK3585A patent/DK3585D0/da not_active Application Discontinuation

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