EP0143306A2 - Dispositif pour l'entreposage cryogénique d'échantillons biologiques ou pharmaceutiques - Google Patents

Dispositif pour l'entreposage cryogénique d'échantillons biologiques ou pharmaceutiques Download PDF

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Publication number
EP0143306A2
EP0143306A2 EP84112450A EP84112450A EP0143306A2 EP 0143306 A2 EP0143306 A2 EP 0143306A2 EP 84112450 A EP84112450 A EP 84112450A EP 84112450 A EP84112450 A EP 84112450A EP 0143306 A2 EP0143306 A2 EP 0143306A2
Authority
EP
European Patent Office
Prior art keywords
box
ampoules
boxes
pins
base plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84112450A
Other languages
German (de)
English (en)
Other versions
EP0143306B1 (fr
EP0143306A3 (en
Inventor
Wolfgang Volker
Klemens Thoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Messer Griesheim GmbH
Original Assignee
Messer Griesheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Messer Griesheim GmbH filed Critical Messer Griesheim GmbH
Priority to AT84112450T priority Critical patent/ATE38892T1/de
Publication of EP0143306A2 publication Critical patent/EP0143306A2/fr
Publication of EP0143306A3 publication Critical patent/EP0143306A3/de
Application granted granted Critical
Publication of EP0143306B1 publication Critical patent/EP0143306B1/fr
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D25/00—Charging, supporting, and discharging the articles to be cooled
    • F25D25/005—Charging, supporting, and discharging the articles to be cooled using containers

Definitions

  • the invention relates to a device for cryogenic storage of biological or pharmaceutical samples according to the preamble of claim 1.
  • Such samples are stored in ampoules, which in turn are stored in well-insulating containers, the interior of which is kept at the desired low temperature by means of liquid nitrogen.
  • the ampoules are spatially separated from one another by rods or walls of the lattice-like inserts, which increases the space requirement of each ampoule.
  • the invention has for its object to find a compact and easy-to-use storage for the ampoules.
  • the pins arranged in each box are generally of the same length.
  • a defined unequal length of the pins makes it possible to precisely determine the location of each ampoule with respect to the pins and thus within the box.
  • a box made, for example, of ND-PE can be sealed in that one of the pins fastened to the inside of the base plate has a longitudinal bore and that another pin is attached to the inside of the cover plate in position over this pin, which is through the longitudinal hole protrudes through the base plate, which is also drilled through at this point, so that this pin is welded to the base plate can, with the success that the upper and lower parts of the box can no longer be separated from one another without destruction.
  • each blanket has at least one projection which can be snapped into a recess arranged in the cover and / or base plate of the upper and lower part of a box.
  • This latching point can be arranged particularly favorably in a groove-like depression which extends in the interior of the box in the position of the pins.
  • FIG. 1 the inner wall of a container for storing 24 tower-like boxes is shown at 8. These boxes are stored in the container either in the gas or in the liquid phase of nitrogen. Each of the boxes 10 has a number 1, 2, 3, ... 24 on its upper side to identify the same. A strap is attached to the top of the boxes 10 to easily remove the boxes from the container to be able to lift out.
  • the box 10 has a rectangular plan area and is completely open on two sides that lie opposite one another.
  • Ceilings 14 are arranged one above the other in the box and are provided with projections 26. Boxes 18 can be snapped into these projections.
  • the projections 26 are equidistant from the ceiling edge 15.
  • the box consists of an upper part 22 and a lower part 20 (FIG. 3).
  • a groove-like depression 32 is formed in the base plate 28 of the lower part 20 and extends almost over the entire length of the box.
  • the box is guided along this recess 32 on the projection 26 when inserted into the box 10 on the blanket 14.
  • the projections 26 are arranged on the ceiling 14 at a distance from one another which corresponds to the maximum outer diameter of a box.
  • the box 10 shown in Fig. 2 and 3 is thus designed for three boxes 18 arranged side by side. Of course, any number of boxes can be placed next to each other on the covers 14 of each box 10.
  • the height of the ceilings 14 corresponds to the maximum height of the box 18 in the closed state.
  • the box maintains slight contact with the two ceilings 14 which delimit it from above and below, both when it is pushed into the box and when it is stored therein. This prevents boxes which are stored in the liquid phase of the medium cooling the container 8 are able to swim.
  • Pins 40, 42 are arranged in the interior of the lower part 20 of the box 18. These pins are equidistant from the side walls 24 of the lower part 20. The axial spacing of these pins is equal to the outside diameter of the ampoules 16, which are to be stored in the box 18, both from these side walls 24 and from one another. It is of course also possible to arrange several rows of pins in parallel in a box. With the help of these pins and, if necessary, the outer walls of the box, the ampoules are clearly fixed in their intended position, so that the ampoules in the box cannot slip or tip over.
  • the pins 40 are generally of the same height. It is possible to make the pins too long. With such a defined unequal length of the pins, it is possible to precisely determine the position of a specific pin in the box and thus also the position of each ampoule in this box.
  • a pin 46 fastened to the upper part 22 protrudes through a longitudinal bore 44 of a pin 42 fastened in the lower part 20 into the groove-like recess 32 of the base plate 28, so that the pin 46 is fastened to the underside of the base plate 28 can.
  • a box made of ND-PE is well suited for the case of cryogenic storage. A box made from this material can now be sealed particularly easily by welding this pin 46 to the base plate 28 from below. As a result, the box 18 can only be broken by breaking the seal or by detaching the pin 42 from the bottom Part 20 or the pin 46 can be opened from the upper part 22.
  • the groove-like depression 32 (FIG. 5) has transverse walls at two points 34, 36, so that a depression 30 is formed between them, into which a projection 26 of the ceiling 14 can be snapped.
  • One of the transverse walls ends in a flat inclination 38 in the longitudinal direction of the box 18 in the recess 32, in contrast to the wall at the point 36. This ensures that the box 18 has only one end face over the projection 26 in the ceiling 14 can be inserted. This improves the possibility of defining the position of the ampoules in the box and thus ultimately in the container 8, since the box 18 can also be identified with respect to its “front” and “back” side.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Packaging Frangible Articles (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Sampling And Sample Adjustment (AREA)
EP84112450A 1983-11-24 1984-10-16 Dispositif pour l'entreposage cryogénique d'échantillons biologiques ou pharmaceutiques Expired EP0143306B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84112450T ATE38892T1 (de) 1983-11-24 1984-10-16 Vorrichtung zur tiefkalten lagerung von biologischen oder pharmazeutischen proben.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3342489A DE3342489C2 (de) 1983-11-24 1983-11-24 Vorrichtung zur tiefkalten Lagerung von biologischen oder pharmazeutischen Proben
DE3342489 1983-11-24

Publications (3)

Publication Number Publication Date
EP0143306A2 true EP0143306A2 (fr) 1985-06-05
EP0143306A3 EP0143306A3 (en) 1986-03-12
EP0143306B1 EP0143306B1 (fr) 1988-11-23

Family

ID=6215149

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84112450A Expired EP0143306B1 (fr) 1983-11-24 1984-10-16 Dispositif pour l'entreposage cryogénique d'échantillons biologiques ou pharmaceutiques

Country Status (6)

Country Link
US (1) US4630873A (fr)
EP (1) EP0143306B1 (fr)
AT (1) ATE38892T1 (fr)
DE (1) DE3342489C2 (fr)
ES (1) ES291667Y (fr)
ZA (1) ZA849131B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0200579A1 (fr) * 1985-03-26 1986-11-05 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Dispositif de stockage de tubes dans un récipient cryogénique
EP0286236A2 (fr) * 1987-04-09 1988-10-12 Nalge Company Cadre de rangement pour conteneurs en forme de boîte
EP2085727A1 (fr) * 2008-01-31 2009-08-05 L'Air Liquide Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Panier de rangement pour conteneur cryogénique, module élémentaire, procédé de réalisation du panier et utilisation de celui-ci
WO2013005022A3 (fr) * 2011-07-05 2014-01-03 Tully Marks Innovations Ltd Appareil de support et procédé de transport d'un article

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403550B (de) * 1992-08-18 1998-03-25 Robocon Lab Ind Roboter Inkubator
DE29508438U1 (de) * 1995-05-20 1995-09-21 Bäumer, Robert, 48282 Emsdetten Vorrichtung zum Lagern von Rückstellproben
US5689961A (en) * 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
DE19716913A1 (de) * 1997-04-23 1998-11-05 Mingers Bernd Dipl Ing Modulare Lagervorrichtung zur tiefkalten Aufbewahrung von mit tiefgefrorener Zellsuspension befüllten, flächigen Kunststoffbeuteln
DE19725641C2 (de) * 1997-06-18 1999-06-10 Messer Griesheim Gmbh Vorrichtung zur tiefkalten Lagerung von pharmazeutischen Proben
DE10324397A1 (de) * 2003-05-28 2005-01-20 Hte Ag The High Throughput Experimentation Company Modulares Probenhalterungssystem
KR101064321B1 (ko) 2009-04-03 2011-09-14 주식회사 비스 액체질소용기 시료보관용 랙
GB2520521A (en) * 2013-11-22 2015-05-27 Stratec Biomedical Ag Universal Rack System

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1665681A (en) * 1923-02-03 1928-04-10 Charles B Telling Ice-cream-brick container
FR1112529A (fr) * 1954-10-12 1956-03-15 Emballage
FR1118144A (fr) * 1954-12-31 1956-05-31 Emballage
FR1229879A (fr) * 1959-03-23 1960-09-12 Classeur de tubes ou récipients analogues en forme de boîte ou étui, notamment pour traitements thérapeutiques
US3103278A (en) * 1960-10-10 1963-09-10 Allied Chem Vertical and lateral interlocking packing case
US3160306A (en) * 1962-03-30 1964-12-08 Phillips Petroleum Co Storage and transportation case
US3184071A (en) * 1962-12-12 1965-05-18 Eastman Kodak Co Plastic case for containers
FR1454447A (fr) * 1965-07-29 1966-02-11 Boîte à tiroir avec dispositif de blocage du tiroir et bande de garantie
US3245573A (en) * 1961-01-17 1966-04-12 Plasticase Inc Beverage bottle carrier
DE1486219A1 (de) * 1964-01-09 1969-04-10 Blendax Werke Schneider Co Tubenbehaelter
US3987891A (en) * 1975-07-07 1976-10-26 Plastic Research Products, Inc. Moisture proof safety container for pills and the like
DE2528152A1 (de) * 1975-06-24 1977-01-20 Ratiomed Gmbh Vorrichtung fuer die aufnahme von probetraegern
FR2359422A1 (fr) * 1976-07-23 1978-02-17 Dynatech Holdings Ltd Plaque pour micro-tests
FR2461216A1 (fr) * 1979-07-10 1981-01-30 Saelens Bernard Boites de rangement pour congelateurs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US774879A (en) * 1902-09-05 1904-11-15 William G Hullhorst Instrument-holder for dentists.
US1093677A (en) * 1910-03-01 1914-04-21 Frank M Ashley Inkstand.
US2465644A (en) * 1944-10-25 1949-03-29 Lyman W Graves Battery case
US2730423A (en) * 1953-05-22 1956-01-10 Joseph P Mock Cabinet drawer stop construction
US3082050A (en) * 1960-12-13 1963-03-19 Arthur F Baxter Portable cabinet
US3327885A (en) * 1964-10-06 1967-06-27 Phillips Petroleum Co Bottle carrier
SE354714B (fr) * 1968-08-14 1973-03-19 Nordisk Ventilator

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1665681A (en) * 1923-02-03 1928-04-10 Charles B Telling Ice-cream-brick container
FR1112529A (fr) * 1954-10-12 1956-03-15 Emballage
FR1118144A (fr) * 1954-12-31 1956-05-31 Emballage
FR1229879A (fr) * 1959-03-23 1960-09-12 Classeur de tubes ou récipients analogues en forme de boîte ou étui, notamment pour traitements thérapeutiques
US3103278A (en) * 1960-10-10 1963-09-10 Allied Chem Vertical and lateral interlocking packing case
US3245573A (en) * 1961-01-17 1966-04-12 Plasticase Inc Beverage bottle carrier
US3160306A (en) * 1962-03-30 1964-12-08 Phillips Petroleum Co Storage and transportation case
US3184071A (en) * 1962-12-12 1965-05-18 Eastman Kodak Co Plastic case for containers
DE1486219A1 (de) * 1964-01-09 1969-04-10 Blendax Werke Schneider Co Tubenbehaelter
FR1454447A (fr) * 1965-07-29 1966-02-11 Boîte à tiroir avec dispositif de blocage du tiroir et bande de garantie
DE2528152A1 (de) * 1975-06-24 1977-01-20 Ratiomed Gmbh Vorrichtung fuer die aufnahme von probetraegern
US3987891A (en) * 1975-07-07 1976-10-26 Plastic Research Products, Inc. Moisture proof safety container for pills and the like
FR2359422A1 (fr) * 1976-07-23 1978-02-17 Dynatech Holdings Ltd Plaque pour micro-tests
FR2461216A1 (fr) * 1979-07-10 1981-01-30 Saelens Bernard Boites de rangement pour congelateurs

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0200579A1 (fr) * 1985-03-26 1986-11-05 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Dispositif de stockage de tubes dans un récipient cryogénique
EP0286236A2 (fr) * 1987-04-09 1988-10-12 Nalge Company Cadre de rangement pour conteneurs en forme de boîte
EP0286236A3 (fr) * 1987-04-09 1990-02-07 Nalge Company Cadre de rangement pour conteneurs en forme de boíte
EP2085727A1 (fr) * 2008-01-31 2009-08-05 L'Air Liquide Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude Panier de rangement pour conteneur cryogénique, module élémentaire, procédé de réalisation du panier et utilisation de celui-ci
FR2927163A1 (fr) * 2008-01-31 2009-08-07 Air Liquide Panier de rangement pour conteneur cryogenique, module elementaire et procede de realisation du panier
WO2013005022A3 (fr) * 2011-07-05 2014-01-03 Tully Marks Innovations Ltd Appareil de support et procédé de transport d'un article

Also Published As

Publication number Publication date
EP0143306B1 (fr) 1988-11-23
DE3342489C2 (de) 1986-10-23
ZA849131B (en) 1985-09-25
US4630873A (en) 1986-12-23
EP0143306A3 (en) 1986-03-12
DE3342489A1 (de) 1985-06-05
ES291667U (es) 1986-05-01
ES291667Y (es) 1987-01-16
ATE38892T1 (de) 1988-12-15

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