EP0118525A1 - Programmable drug infusion device - Google Patents
Programmable drug infusion deviceInfo
- Publication number
- EP0118525A1 EP0118525A1 EP83902916A EP83902916A EP0118525A1 EP 0118525 A1 EP0118525 A1 EP 0118525A1 EP 83902916 A EP83902916 A EP 83902916A EP 83902916 A EP83902916 A EP 83902916A EP 0118525 A1 EP0118525 A1 EP 0118525A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- syringe
- keyboard
- key
- parameters
- program
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940079593 drug Drugs 0.000 title claims abstract description 34
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 238000001802 infusion Methods 0.000 title claims abstract description 30
- 238000002347 injection Methods 0.000 claims abstract description 20
- 239000007924 injection Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 6
- 230000002452 interceptive effect Effects 0.000 claims description 10
- 230000006870 function Effects 0.000 claims description 8
- 238000001647 drug administration Methods 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims 2
- 239000000284 extract Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 230000000694 effects Effects 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- KKEBXNMGHUCPEZ-UHFFFAOYSA-N 4-phenyl-1-(2-sulfanylethyl)imidazolidin-2-one Chemical compound N1C(=O)N(CCS)CC1C1=CC=CC=C1 KKEBXNMGHUCPEZ-UHFFFAOYSA-N 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000005298 acute pain Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008533 pain sensitivity Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000011422 pharmacological therapy Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
Definitions
- the present invention relates to a programmable infusion device for the administration of pharmaceutical drugs. More specifically, the invention consists of an apparatus which makes it possible to, on the one hand, institute controlled drug administration to patients and, on the other hand-, for specific purposes allow the patient to exert an influence on the number of infusions administered to him by patient control over the start function of the device.
- the medical background to the present invention is as follows: During the last decades there has been a substantial increase in our knowledge regarding the process of absorption, distribution, metabolism and exertion of drugs from the body. It is now possible to take drug kinetics into account when planning drug treatment. In order to establish a therapeutic blood concentration as quickly as possible and to maintain this concentration for the desired period of treatment, it is often advantageous to give the drug intravenously. Initially, all of the drug is in the blood and the well vascularized tissues. There is a large concentration gradient between the blood and the less vascularized tissues, resulting in a rapid absorption of drug into the tissues. As the drug is absorbed ihto the tissues, the concentration gradient will fall and eventually a dynamic equilibrium state between blood and the tissues arises. Thereafter the drug will be eliminated from the blood and tissues at equal rates due to metabolism and/or excretion.
- OMPI depots rapidly. Thereafter the drug should be administered more slowly in order to maintain or only slowly increase the blood and tissue concentrations. This principle has been used for a long period as regards antiarythmic drugs, anticonvulsants and occasionally also antiasthmatic drugs.
- the present invention is the first device known to us that can be programmed to give both loading and maintenance infusions automatically without the need for intervention as the switch over from one rate to another is made.
- a second theoretical consideration relevant to the present invention is the following:
- the therapeutic effect of a drug usually varies directly with the alterations in drug concentration in the biophase - that locus in the organism where the drug has its point of action.
- the concentration in the biophase depends on the blood concentration since the blood is the vehicle of transportation from absorption site to the biophase. Potent drugs often have a narrow therapeutic blood concentration interval. When the drug concentration lies within the limits of this interval the relationship between wanted and unwanted effects is favorable. However, if the blood concentration falls below this level the desired effects may disappear completely, while an increasing number of adverse effects are encountered if the concentration rises substantially above the therapeutic concentration range.
- PCA patient-controlled analgesia
- This analgesic regiven implies that patients with acute pain are allowed to self-administer small doses of a potent analgesic intravenously- with the aid of a programmable infusion device.
- the device is a motor syringe, which can be activated by the patient using a pushbutton switch. The syringe will then issue a preset dose as an intravenous bolus. The total amount of drug available to the patient is limited by the size of the preset dose and the preset minimum time .interval lock.
- the patient's own perception of pain and of the effectiveness of the therapy will control drug administration as in a feed-back system, with certain restrictions imposed for reasons of safety.
- Demanalg is a syringe pump controller manufactured by KP Enterprises Ltd, Canada. This device lacks a pump driver mechanism altogether and therefore must be supplemented with a conventional motor syringe or pump.
- the present invention does not have the limitations of previously known devices but .constitutes a programmable infusion device that is designed to accomplish both interactive, dosi etric and volumetric control over drug administration.
- Fig. 1 shows a perspective view of a presently preferred embodiment of the programmable infusion apparatus in accordance with the present invention
- Fig.2 shows a perspective view of the drive mechanism in the apparatus
- Fig. 3 shows a block diagram of the electronic control circuit of the apparatus .
- the programmable infusion apparatus 1 in accordance with the invention comprises a syringe assembly 2 (shown in detail in Fig. 2).
- the syringe assembly 2 comprises an injection syringe 3.
- the movable piston of the injection • syringe 3 is connected to a. push rod 5, which can be inserted into a co-operating recess 6 in a syringe piston driver 7.
- Injection syringe 3. is detachably mounted in the assembly 2, which is mounted on a mounting plate 8.
- the driving mechanism of the syringe piston driver which is mounted under the mounting plate 8, has a carriage 9 that is connected to the syringe piston driver 7 and moves in a slot provided in mounting plate 8 and upon activation drives piston 4 of syringe 3 the desired distance.
- Syringe piston driver 7 is connected to carriage 9, which comprises an inner taped hole 10, through which a driving screw 11 extends.
- Driving screw 11, which is journalled in blocks 12 with ball-bearings, is driven to rotate by the aid of a stepping motor 13 over a gear unit 15 and an intermediate clutch 16.
- Stepping motor 13 is mounted in a suitable mounting block 14.
- a more compact version of the syringe assembly shown in Fig. 2 is obtained if screw 11 is reversed so that the stepping motor is located immediately under syringe 3.
- the infusion apparatus 1 in accordance with the present invention further comprises a handle H by the aid of which the patient himself has the means of controlling the injection of the drug in the syringe by pushing a button that is provided on handle H. Furthermore, the
- O PI apparatus 1 comprises a display D and a keyboard, which preferably is somewhat tilted in relation to the vertical plane to facilitate input of dosing data.
- the keyboard comprises the following keys.
- the key MODE SEL is used to select a mode of -operation. If, for instance, the key is pushed the interactive mode will be active. The next time the key is pushed the dosimetric mode will be chosen. If the key is pushed once more the volumetric mode will be chosen. Upon pushing the key still another time the apparatus will return to the interactive mode.
- the keyboard comprises a key ENTER/SHOW, abbreviated to E/S below. With this key and the numeric keys 0 - 9 parameter values relating to dilution, dosing, etc. for all the operating modes of apparatus 1 are entered. When these data have been entered the infusion or injection process is started by pushing the key START.
- the keyboard comprises a key[ ⁇ ] and a key _ by the aid of which the syringe plunger holder can be moved to both of its end positions.
- the apparatus 1- can also be provided with a printer (not shown) for registration of essential data, for instance times, doses, etc.
- the printer preferably is provided under the keyboard.
- the keyboard comprises a key PRINT and a key LINE FEED.
- the keyboard can also comprise two light emitting diodes 20 indicating which mode (interactive, dosimetric, volumetric) that is active.
- the described keyboard is preferably covered by a protective foil of a transparent plastic to protect the keys against moisture and dirt.
- This foil should be elastic to permit pushing of the keys.
- Display D is preferably provided above the keyboard and ⁇ ean in the preferred embodiment display a line consisting of 16 characters.
- This button is also preferably covered by a protective foil.
- the whole apparatus 1 is preferably portable in a handle 22. Furthermore, the apparatus can be mounted on for instance a frame by the aid of a mounting screw 23 that sideways reaches into a vertical slot on the back of the. apparatus (not shown). With this design it is even possible to mount the apparatus directly on a bed post of a hospital bed.
- the heart of the system is a microprocessor CPU, for instance of type 8085 from Intel.
- This processor is controlled by a crystal oscillator K-, with a frequency of for instance 6.144 MHz.
- the processor is over its bus connected to a ROM memory, for instance an EPROM of type 2716 and containing 8 kbytes.
- This ROM memory stors the program that controls the apparatus 1.
- the processor is connected to a RAM memory, for instance of type 2114 and containing 1 kbyte.
- the processor is also preferably connected to a real time clock T, which is controlled by a crystal oscillator K2 with a frequency of for instance 32 KHz.
- Real time clock T is used for time measurement in order to guarantee that the proper measures are performed at the right time during the injection or infusion • process.
- Real time clock T is preferably driven by accumulators, for instance rechargeable nickel-cadmium-accumulators of 12V. These are automatically loaded while the apparatus 1 is on and then drive clock T even when the power has been turned off. , '
- the processor CPU is connected to two l/ ⁇ -circuits , for instance of type 8155. Of these circuits one is connected to input means while the other is connected to output means. Thus , one i /O- circuit is connected to keyboard TG and to patient handle H.
- the other l/ ⁇ -circuit can for instance be provided to activate different alarm functions A, for instance a stop in the administration from the syringe due to clumping or the like, air in the hose from the syringe, that the accumulator has to be recharged, etc.
- this circuit controls dif ferent indicators 1/ for instance lamps, light emitting diodes and an acoustical alarm.
- Suitable printers are a "Micro Dot Printer" from the firm Epson that prints 16 characters per row in a character matrix of 5 . 7 points .
- the processor CPU is furthermore over a buffer B, for instance of type 74 LS 241, connected to display D, which for instance can comprise four elements of type DL-2416 each consisting of 4 characters , that is a total of 16 characters.
- Stepping motor 13 and this current regulator are in Fig. 3 des ignated with the common designation M.
- the apparatus 1 When the apparatus 1 is turned on by pushing button 21 the apparatus can be driven in three modes depending on the setting of the key MODE SEL. In the following discussion it is assumed that this key has been operated in such a way that the lamp 20 indicating volumetric mode is activated. The apparatus will now on display D ask for the infusion rate (ml per hour) and thereafter for the total volume (ml). After entering each of these parameters with the numerical keys 0 - 9 the key marked
- E/S is pushed. This will enter the value in question into the RAM memory.
- parameter total volume there are two possibilities. Either a value specifying the total volume is entered, . which means that during the subsequent program execution the syringe will be controlled until this volume has been consumed. The other alternative is to ⁇ enter no value but to indicate an unspecified volume by directly pushing the key E/S. In this case the administration will progress with the specified rate until the program is stopped manually or the syringe is empty.
- the key E/S has a double-function.
- the first function is to input (Enter) the keyed-in values in the RAM memory
- the second function is to display (Show) the values of the parameters and relevant data that presently are stored in the RAM memory.
- this display (Show) it is also possible to change the values of the parameters stored in the RAM memory by keying- in new values.
- it is desirable to change the parameter that presently is displayed on display D one keys in a new value with keys 0 - 9 and thereafter pushes the E/S-key. Thereby the new value will replace the old value and subsequently the next parameter will be displayed on display D.
- What has been said above regarding the E/S-key is true in volumetric, dosimetric as well as interactive mode.
- INFUSION RATE ml/h rate of infusion (0.1 - 99.9 ml per hour) :
- the apparatus in accordance with the present invention is very flexible and can be adjusted to different demands by simple entering of parameters.
- the apparatus can give both single injections over short time periods and/or slow injections over long time periods
- the apparatus in accordance with the invention can give injections and/or infusions of predetermined amounts of drugs with a predetermined rate it is possible to utilize pharmacokinetic principles in quite a different way from what has hitherto been possible in treatment of a number of disease states, such as epileptic seizures, cardiac arythmias, postoperative pain, asthma, etc.
- the equipment can be made to give both a loading dose as well as a maintenance dose that maintains the blood concentration on a constant level.
- the equipment can be activated from a remote location by a simple pushbutton or the like.
- the apparatus in accordance with the present invention can be used in the following ways.
- a pre-set dose of for instance 1 - 99 mg can be given after reception of a remote signal (for instance when the patient pushes a handle button).
- the dose can be given with any chosen injection rate, for instance 0.1 - 99.9 ml per hour.
- the volume that is to be injected can be computed from information regarding dilution of the drug and the desired dosis.
- An additional pre-set dose can be given in addition to the first dose by another, slower injection rate.
- This second injection (called “infusion") follows immediately after the first dose and its injection rate can be chosen independently of the injection rate of the first dose.
- the infus ion can be given with any chos en rate, for instance 0. 1 - 99.9 ml per hour .
- An acoustic alarm is provided in case a pre-set dose is exceeded. Furthermore, an acoustic alarm is provided for an emptied syringe.
- the piston of the syringe can be moved fast forward or reverse with the aid of special control keys * tj
- the apparatus can be pre— set with a time limit against too frequent dos es . This is set to 0 - 99 minutes and operates in such a way that this time limit is only influences by the f irst rapid bolus dose but not the second, slow infusion dose.
- An optical signal can be provided on the apparatus and on the. possible remote alarm, indicating that the dose has been administered and when the apparatus can be made to administer another bolus dose.
- the printer unit provided in the apparatus will register ' for instance each given dose and the time and s ize of the dose.
- an optical sensor . for an optional valve device can be provided.
- the apparatus can be set to deliver volumes exceeding the internal volume of the syringe.
- the drive mechanism will then automatically reverse and aspirate fluid from a container attached to a s ide port 24 of the valve 25.
- the syringe can be made with a one-way valve and with a hol low piston provided with another one-way valve at one end thereof . It is then
- OMPI possible to connect the container directly with the syringe piston.
- the sensor can also be mounted at the top of the syringe drive mechanism.
- cover 17 is provided with a mechanical and electronic lock.
- the mechanical lock will prevent access to the syringe during operation of the apparatus.
- the electronic lock will prevent manipulation of the keyboard by deactivation of its keys.
- the apparatus in accordance with the invention is very flexible and makes possible treatment with' a number of different drugs in accordance with the latest pharmacokinetic principles and can be made to operate both independently as well as triggered by the patient himself.
- the apparatus should be especially useful for intensive care units in hospitals. It should also be useful on adult and pediatric wards for treatment of asthma, cardiac arythmias, diabetic ckoma and several other emergency states in addition to acute pain states.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8205181 | 1982-09-10 | ||
SE8205181A SE432054B (sv) | 1982-09-10 | 1982-09-10 | Programmerbart injektions-och infusionsaggregat |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0118525A1 true EP0118525A1 (en) | 1984-09-19 |
Family
ID=20347801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP83902916A Withdrawn EP0118525A1 (en) | 1982-09-10 | 1983-09-09 | Programmable drug infusion device |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0118525A1 (it) |
JP (1) | JPS59501698A (it) |
AU (1) | AU2030683A (it) |
IT (1) | IT1169806B (it) |
SE (1) | SE432054B (it) |
WO (1) | WO1984000894A1 (it) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0164904B1 (en) * | 1984-05-10 | 1991-02-27 | The University Of Melbourne | Method of determining an infusion rate profile and infusion device |
US4676776A (en) * | 1985-01-18 | 1987-06-30 | Intelligent Medicine, Inc. | Device and method for effecting application of a therapeutic agent |
US5088981A (en) * | 1985-01-18 | 1992-02-18 | Howson David C | Safety enhanced device and method for effecting application of a therapeutic agent |
FR2603488A1 (fr) * | 1986-09-04 | 1988-03-11 | Cupissol Didier | Dispositif programmable et a fonctionnement autonome pour distribuer des substances liquides medicamenteuses dans le corps d'un patient |
CA1329946C (en) * | 1987-12-04 | 1994-05-31 | Paul A. Koenig | User interface for medication infusion system |
US5041086A (en) * | 1987-12-04 | 1991-08-20 | Pacesetter Infusion, Ltd. | Clinical configuration of multimode medication infusion system |
GB8909891D0 (en) * | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
DE69210873T2 (de) * | 1991-03-14 | 1997-01-16 | Sharp Kk | Peristaltische intravenöse Infusionspumpe mit Anzeige einer gewählten Anwendung |
JPH06510448A (ja) * | 1991-09-11 | 1994-11-24 | ザ ユニバーシティー オブ メルボルン | 静脈内薬剤注入方法 |
PT597817E (pt) * | 1992-11-12 | 2003-11-28 | Baxter Int | Metodo e aparelho para dialise renal |
US5719761A (en) * | 1993-01-15 | 1998-02-17 | Alaris Medical Systems, Inc. | Configuration control system for configuring multiple biomedical devices |
FR2740345A1 (fr) * | 1995-10-26 | 1997-04-30 | Neftel Frederic | Dispositif d'automedication |
GB2351907A (en) * | 1999-03-27 | 2001-01-17 | Univ College London Hospitals | Syringe filler |
AU2001223397A1 (en) | 2000-02-01 | 2001-08-14 | Disetronic Licensing Ag | Configurable device and method for releasing a substance |
IL156245A0 (en) | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
US8231578B2 (en) | 2007-02-28 | 2012-07-31 | Hospira, Inc. | System and method for sequencing channels in a multi-channel infusion pump |
US8517990B2 (en) | 2007-12-18 | 2013-08-27 | Hospira, Inc. | User interface improvements for medical devices |
CA2844807C (en) | 2011-08-19 | 2022-07-26 | Hospira, Inc. | Systems and methods for a graphical interface including a graphical representation of medical data |
WO2013090709A1 (en) | 2011-12-16 | 2013-06-20 | Hospira, Inc. | System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy |
CA2868801C (en) | 2012-03-30 | 2021-07-13 | Hospira, Inc. | Air detection system and method for detecting air in a pump of an infusion system |
WO2014022513A1 (en) | 2012-07-31 | 2014-02-06 | Hospira, Inc. | Patient care system for critical medications |
AU2014268355B2 (en) | 2013-05-24 | 2018-06-14 | Icu Medical, Inc. | Multi-sensor infusion system for detecting air or an occlusion in the infusion system |
CA2913915C (en) | 2013-05-29 | 2022-03-29 | Hospira, Inc. | Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system |
CA2913918C (en) | 2013-05-29 | 2022-02-15 | Hospira, Inc. | Infusion system and method of use which prevents over-saturation of an analog-to-digital converter |
EP3110474B1 (en) | 2014-02-28 | 2019-12-18 | ICU Medical, Inc. | Infusion system and method which utilizes dual wavelength optical air-in-line detection |
US11344673B2 (en) | 2014-05-29 | 2022-05-31 | Icu Medical, Inc. | Infusion system and pump with configurable closed loop delivery rate catch-up |
US11344668B2 (en) | 2014-12-19 | 2022-05-31 | Icu Medical, Inc. | Infusion system with concurrent TPN/insulin infusion |
US10850024B2 (en) | 2015-03-02 | 2020-12-01 | Icu Medical, Inc. | Infusion system, device, and method having advanced infusion features |
ES2912378T3 (es) | 2016-05-13 | 2022-05-25 | Icu Medical Inc | Sistema de bomba de infusión con purga automática de línea común |
US11324888B2 (en) | 2016-06-10 | 2022-05-10 | Icu Medical, Inc. | Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion |
US10089055B1 (en) | 2017-12-27 | 2018-10-02 | Icu Medical, Inc. | Synchronized display of screen content on networked devices |
US11278671B2 (en) | 2019-12-04 | 2022-03-22 | Icu Medical, Inc. | Infusion pump with safety sequence keypad |
AU2021311443A1 (en) | 2020-07-21 | 2023-03-09 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
US11135360B1 (en) | 2020-12-07 | 2021-10-05 | Icu Medical, Inc. | Concurrent infusion with common line auto flush |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3895631A (en) * | 1974-02-04 | 1975-07-22 | Alza Corp | Liquid infusion unit |
DE2452909B2 (de) * | 1974-10-29 | 1979-06-13 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Gerat zur Infusion von Flüssigkeiten in den menschlichen oder tierischen Körper |
DE2451424B2 (de) * | 1974-10-29 | 1979-02-08 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Gerät zur Infusion von Flüssigkeiten in den menschlichen oder tierischen Körper |
DE2513467C3 (de) * | 1975-03-26 | 1979-10-31 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Gerät zur Infusion von Flüssigkeiten in den menschlichen oder tierischen Körper |
DE2758467C2 (de) * | 1977-12-28 | 1985-04-04 | Siemens AG, 1000 Berlin und 8000 München | Vorrichtung zur vorprogrammierbaren Infusion von Flüssigkeiten |
SE429196B (en) * | 1979-12-05 | 1983-08-22 | Carl Anders Olof Tamsen | Programmable unit which is preferably intended for patient-controlled analgesic therapy |
-
1982
- 1982-09-10 SE SE8205181A patent/SE432054B/sv not_active IP Right Cessation
-
1983
- 1983-09-09 IT IT22832/83A patent/IT1169806B/it active
- 1983-09-09 JP JP58503009A patent/JPS59501698A/ja active Pending
- 1983-09-09 EP EP83902916A patent/EP0118525A1/en not_active Withdrawn
- 1983-09-09 AU AU20306/83A patent/AU2030683A/en not_active Abandoned
- 1983-09-09 WO PCT/SE1983/000320 patent/WO1984000894A1/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO8400894A1 * |
Also Published As
Publication number | Publication date |
---|---|
SE432054B (sv) | 1984-03-19 |
JPS59501698A (ja) | 1984-10-11 |
SE8205181D0 (sv) | 1982-09-10 |
WO1984000894A1 (en) | 1984-03-15 |
IT8322832A0 (it) | 1983-09-09 |
AU2030683A (en) | 1984-03-29 |
IT1169806B (it) | 1987-06-03 |
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