EP0092140B1 - Mikrotestplatte - Google Patents

Mikrotestplatte Download PDF

Info

Publication number
EP0092140B1
EP0092140B1 EP83103517A EP83103517A EP0092140B1 EP 0092140 B1 EP0092140 B1 EP 0092140B1 EP 83103517 A EP83103517 A EP 83103517A EP 83103517 A EP83103517 A EP 83103517A EP 0092140 B1 EP0092140 B1 EP 0092140B1
Authority
EP
European Patent Office
Prior art keywords
plate
frame
vessels
microtitration plate
central part
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP83103517A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0092140A1 (de
Inventor
Hans-Detlef Dr. Dopatka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to AT83103517T priority Critical patent/ATE21048T1/de
Publication of EP0092140A1 publication Critical patent/EP0092140A1/de
Application granted granted Critical
Publication of EP0092140B1 publication Critical patent/EP0092140B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays

Definitions

  • the invention relates to a microtest plate in which the peripheral areas and the central part heat up evenly when placed on a base with a higher temperature, so that there is no temperature gradient between reaction solutions in vessels at the edge and those in the central part.
  • This plate therefore has properties that avoid the so-called edge effect of conventional plates.
  • the frame effect is caused by a temperature difference between the marginal depressions and the other wells of the microtest plate during the immunological reactions and the enzyme reaction of the ELISA (Burt et al., J. Immunol. Meth. (1979) 31, 231).
  • temperature-dependent reactions such as antigen-antibody binding or an enzyme reaction proceed faster than in the rest of the plate. This manifests itself in an increased color intensity of the affected cells in the ELISA.
  • the temperature gradient between the edge depressions and the center of the plate results from the faster heating of the plate edge. This can be explained both by the support of the plate on a heat-conducting base, for example the metal floor of an incubator, and by the thermal insulation of the center of the plate by the air cushion under the plate. The higher the incubation temperatures and the shorter the incubation times, the stronger the frame effect is normally.
  • the frame effect can be reduced by stacking the plates on one another and eliminated by floating the microtiter plate without bubbles in a warm water bath or using suitable heating fans.
  • the invention has for its object to provide a micro test plate, that is, a device which consists essentially of a plate-shaped carrier with several vessels, which ensures a uniform temperature change in the content of all vessels when the device is on a base with a higher Temperature is applied.
  • the shape of a conventional microtest plate is changed according to the invention so that the heatability of the edge depressions over the plate edge (frame) is greatly reduced and at the same time the heatability of the other plate depressions is increased. Both heat transport effects work together in such a way that the frame effect is eliminated.
  • the opening 4 reduces the heat transfer of the rapidly warming frame to the peripheral vessels.
  • the heated webs emit the heat evenly to the respectively adjacent vessels, the heating by the web itself taking place faster than via the connection points with the frame.
  • the remaining influence of the frame is compensated for by the bevel of the web towards the frame.
  • micro test plate according to the invention is torsionally stable, machine-compatible, stackable and can be labeled.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Paints Or Removers (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Laminated Bodies (AREA)
  • Micromachines (AREA)
  • Electron Beam Exposure (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
EP83103517A 1982-04-19 1983-04-12 Mikrotestplatte Expired EP0092140B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT83103517T ATE21048T1 (de) 1982-04-19 1983-04-12 Mikrotestplatte.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3214317 1982-04-19
DE19823214317 DE3214317A1 (de) 1982-04-19 1982-04-19 Mikrotiterplatte

Publications (2)

Publication Number Publication Date
EP0092140A1 EP0092140A1 (de) 1983-10-26
EP0092140B1 true EP0092140B1 (de) 1986-07-30

Family

ID=6161224

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83103517A Expired EP0092140B1 (de) 1982-04-19 1983-04-12 Mikrotestplatte

Country Status (8)

Country Link
US (1) US4545958A (da)
EP (1) EP0092140B1 (da)
JP (1) JPS58190763A (da)
AT (1) ATE21048T1 (da)
CA (1) CA1216735A (da)
DE (2) DE3214317A1 (da)
DK (1) DK169883A (da)
ES (1) ES271504Y (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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US4701754A (en) * 1985-04-18 1987-10-20 Fmc Corporation Indicator device for substance receiving wells in a microtiter plate
FI852736A0 (fi) * 1985-07-10 1985-07-10 Labsystems Oy Termosterbar kyvettenhet.
US5110556A (en) * 1986-10-28 1992-05-05 Costar Corporation Multi-well test plate
US5084246A (en) * 1986-10-28 1992-01-28 Costar Corporation Multi-well test plate
GR871619B (en) * 1986-10-31 1988-03-03 Genetic Systems Corp Automated patient sample analysis instrument
DE3810862A1 (de) * 1988-03-30 1989-10-12 Molter Gmbh Dr Laborhilfsgeraet
US5002889A (en) * 1988-10-21 1991-03-26 Genetic Systems Corporation Reaction well shape for a microwell tray
AT394323B (de) * 1989-11-02 1992-03-10 Slt Labinstruments Gmbh Temperierkammer, insbesondere fuer die temperierung des inhalts einer mikrotitrationsplatte, und verfahren zur steuerung eines heizkreises hiefuer
JPH05157684A (ja) * 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd 吸光光度計
DE9203583U1 (de) * 1992-03-17 1992-05-07 Alcan Deutschland GmbH, 3400 Göttingen Näpfchenplatte
US5319436A (en) * 1992-05-28 1994-06-07 Packard Instrument Company, Inc. Microplate farming wells with transparent bottom walls for assays using light measurements
DE4217868C2 (de) * 1992-05-29 1995-01-26 Univ Schiller Jena Temperierbare Multiküvette
US5716798A (en) * 1992-09-22 1998-02-10 Becton Dickinson And Company Enhanced detection of microorganisms in samples
AU5283393A (en) * 1992-10-14 1994-05-09 Andrew George Bosanquet Method and apparatus for conducting tests, particularly comparative tests
US5731157A (en) * 1993-12-30 1998-03-24 The Procter And Gamble Company Two-site allergen immunoassay
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
US5985594A (en) 1995-11-14 1999-11-16 Idexx Laboratories, Inc. Method for quantification of biological material in a sample
US7122338B2 (en) * 1995-11-14 2006-10-17 Biocontrol Systems, Inc. Method for quantification of biological material in a sample
USD403077S (en) * 1997-05-12 1998-12-22 Neogen Corporation Microorganism culture tray
US6229603B1 (en) 1997-06-02 2001-05-08 Aurora Biosciences Corporation Low background multi-well plates with greater than 864 wells for spectroscopic measurements
US5910287A (en) * 1997-06-03 1999-06-08 Aurora Biosciences Corporation Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6426050B1 (en) 1997-05-16 2002-07-30 Aurora Biosciences Corporation Multi-well platforms, caddies, lids and combinations thereof
US6063338A (en) * 1997-06-02 2000-05-16 Aurora Biosciences Corporation Low background multi-well plates and platforms for spectroscopic measurements
US6517781B1 (en) 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6096562A (en) * 1997-10-27 2000-08-01 Nalge Nunc International Corporation Multi-slide assembly including slide, frame and strip cap, and methods thereof
US6825042B1 (en) 1998-02-24 2004-11-30 Vertex Pharmaceuticals (San Diego) Llc Microplate lid
US6861035B2 (en) * 1998-02-24 2005-03-01 Aurora Discovery, Inc. Multi-well platforms, caddies, lids and combinations thereof
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
EP1071942A1 (en) 1998-04-17 2001-01-31 LJL Biosystems, Inc. Sample-holding devices and systems
US7115231B1 (en) 1998-06-09 2006-10-03 Symyx Technologies, Inc. Parallel reactor with knife-edge seal
US7005029B2 (en) * 1999-10-26 2006-02-28 Nalge Nunc International Corporation Method of making a multi-well test plate having adhesively secured transparent bottom panel
WO2002061858A2 (en) 2000-11-17 2002-08-08 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
US6800491B2 (en) 2001-06-08 2004-10-05 Nalge Nunc International Corporation Robotic reservoir without liquid hangup
EP1438137A4 (en) * 2001-09-20 2010-07-07 Johnson & Johnson Pharm Res CONDUCTING MICROTITER PLATE
EP1461157A4 (en) * 2001-12-07 2008-11-05 Beckman Coulter Inc EXTRACTION, SEGMENTED SAMPLE SYSTEM
WO2004098764A2 (en) 2003-04-30 2004-11-18 Aurora Discovery, Inc. Multi-well plate providing a high-density storage and assay platform
DE602004016009D1 (de) * 2003-09-03 2008-10-02 Cedi Diagnostics B V Verfahren zur erfassung von mehreren analyten
US20050173059A1 (en) * 2004-02-11 2005-08-11 Nalge Nunc International Corporation Methods of making a multi-well test plate having an adhesively secured transparent bottom panel
JP4875066B2 (ja) * 2005-05-06 2012-02-15 カリパー・ライフ・サイエンシズ・インク． 除去された周囲を有するマイクロタイタープレート
CN103412118A (zh) * 2013-08-13 2013-11-27 厦门市云鹏科技发展有限公司 一种底部通透的遮光酶标板及遮光酶标板装置
USD757350S1 (en) * 2014-01-07 2016-05-24 Koninklijke Philips N.V. Lighting fixture
JP1726558S (ja) * 2021-11-03 2022-10-05 ラベル
USD1013204S1 (en) * 2022-05-26 2024-01-30 Singular Genomics Systems, Inc. Microplate assembly
USD1013205S1 (en) * 2022-05-26 2024-01-30 Singular Genomics Systems, Inc. Microplate assembly
USD1021135S1 (en) * 2022-05-31 2024-04-02 Tecan Trading Ag Tray for pipetting tips

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078020A (en) * 1962-04-04 1963-02-19 Richard N Boonstra Horticultural carrying apparatus
US3356462A (en) * 1966-08-09 1967-12-05 Cooke Engineering Company Disposable microtitration plate
DK111786B (da) * 1967-09-18 1968-10-07 J Sorensen Bakke til plantepotter.
US3713771A (en) * 1971-05-13 1973-01-30 B Taylor Method for organized assay and bendable test tube rack therefor
USRE27756E (en) * 1971-06-29 1973-09-11 Automated incubation apparatus
DE7402859U (de) * 1974-01-29 1974-04-25 Waldeck A & Co Haltevorrichtung für Gläser o. dgl
US3992265A (en) * 1975-12-31 1976-11-16 American Cyanamid Company Antibiotic susceptibility testing
AU2416177A (en) * 1976-06-22 1978-10-19 Dynatech Lab Test tray for antibiotic efficiency against organisms
US4252897A (en) * 1978-05-03 1981-02-24 Axford Herbert George Method and apparatus for bacteria testing
JPS5563762A (en) * 1978-11-08 1980-05-14 Toshiba Corp Automatic chemical analysis device
FI790692A (fi) * 1979-03-01 1980-09-02 Suovaniemi Finnpipette Mikrokyvettenhet
DE3266735D1 (en) * 1981-02-18 1985-11-14 Eisai Co Ltd An enzyme immuno-assay for simultaneously measuring a plurality of samples and test vessel for carrying out this method
JPS57174084A (en) * 1981-04-17 1982-10-26 Eisai Co Ltd Container for test

Also Published As

Publication number Publication date
DE3364865D1 (de) 1986-09-04
ES271504Y (es) 1984-04-01
DE3214317A1 (de) 1983-12-15
CA1216735A (en) 1987-01-20
US4545958A (en) 1985-10-08
DK169883D0 (da) 1983-04-18
ES271504U (es) 1983-10-01
DK169883A (da) 1983-10-20
JPS58190763A (ja) 1983-11-07
EP0092140A1 (de) 1983-10-26
ATE21048T1 (de) 1986-08-15

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