EP0080283B1 - Tripeptides contenant la N-carboxyalcoylproline - Google Patents
Tripeptides contenant la N-carboxyalcoylproline Download PDFInfo
- Publication number
- EP0080283B1 EP0080283B1 EP82305879A EP82305879A EP0080283B1 EP 0080283 B1 EP0080283 B1 EP 0080283B1 EP 82305879 A EP82305879 A EP 82305879A EP 82305879 A EP82305879 A EP 82305879A EP 0080283 B1 EP0080283 B1 EP 0080283B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- proline
- compound according
- alanyl
- prolyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 0 CC(C)(C(*)C1)N(**)C1C(*N1C(CC(O)=O)CCC1)=O Chemical compound CC(C)(C(*)C1)N(**)C1C(*N1C(CC(O)=O)CCC1)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- This compound (24.2 g, 0.0096 m) was condensed with 2.25 g (0.0072 m) of L-alanyl-L-proline, benzyl ester hydrochloride in the dicyclohexylcarbodiimide procedure to give 0.8 g of N-(2-carbethoxy)ethyl-L-propyl-alanyl-L-proline, benzyl ester.
- the pro-drug precursor was hydrolyzed with barium hydroxide in aqueous methanol to give 0.498 g (64%) of N-(2-carboxyethyl)-L-prolyl-L-alanyl-L-proline, m.p. 133-136°.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT82305879T ATE17736T1 (de) | 1981-11-06 | 1982-11-05 | N-carboxyalkylprolin-enthaltende tripeptide. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31872181A | 1981-11-06 | 1981-11-06 | |
US318721 | 1981-11-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0080283A1 EP0080283A1 (fr) | 1983-06-01 |
EP0080283B1 true EP0080283B1 (fr) | 1986-01-29 |
Family
ID=23239338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP82305879A Expired EP0080283B1 (fr) | 1981-11-06 | 1982-11-05 | Tripeptides contenant la N-carboxyalcoylproline |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0080283B1 (fr) |
JP (1) | JPS5890537A (fr) |
KR (1) | KR880002594B1 (fr) |
AT (1) | ATE17736T1 (fr) |
AU (1) | AU562011B2 (fr) |
CA (1) | CA1247085A (fr) |
CS (1) | CS235030B2 (fr) |
DD (1) | DD206553A5 (fr) |
DE (1) | DE3268884D1 (fr) |
DK (1) | DK480682A (fr) |
ES (1) | ES517144A0 (fr) |
FI (1) | FI75175C (fr) |
GR (1) | GR77368B (fr) |
HU (1) | HU187808B (fr) |
IE (1) | IE53982B1 (fr) |
IL (1) | IL67070A (fr) |
NO (1) | NO160081C (fr) |
NZ (1) | NZ202232A (fr) |
PH (1) | PH18708A (fr) |
PL (1) | PL136098B1 (fr) |
PT (1) | PT75769B (fr) |
RO (1) | RO84706B (fr) |
YU (1) | YU245582A (fr) |
ZA (1) | ZA827816B (fr) |
ZW (1) | ZW23282A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0500989B1 (fr) * | 1991-02-27 | 1998-12-09 | Lacer, S.A. | Agents antihypertensifs dipeptidiques N-(pyridyl-alpha-substituée) carbonyle |
CA2223625C (fr) | 1995-06-06 | 2003-06-03 | Pfizer Inc. | (indole-2-carbonyl-)-amides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase |
KR100241643B1 (ko) | 1995-06-06 | 2000-03-02 | 디. 제이. 우드 | 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체 |
CA2224062C (fr) * | 1995-06-06 | 2001-09-04 | Pfizer Limited | (indole-2-carbonyl-)-glycinamides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
KR20040013679A (ko) * | 2002-08-08 | 2004-02-14 | 현대산업개발 주식회사 | 실내 공기 상태 표시장치 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
-
1982
- 1982-10-20 NZ NZ202232A patent/NZ202232A/en unknown
- 1982-10-26 ZA ZA827816A patent/ZA827816B/xx unknown
- 1982-10-26 IL IL67070A patent/IL67070A/xx unknown
- 1982-10-27 ZW ZW232/82A patent/ZW23282A1/xx unknown
- 1982-10-27 PH PH28047A patent/PH18708A/en unknown
- 1982-10-29 PT PT75769A patent/PT75769B/pt unknown
- 1982-10-29 DK DK480682A patent/DK480682A/da not_active Application Discontinuation
- 1982-11-02 YU YU02455/82A patent/YU245582A/xx unknown
- 1982-11-03 RO RO108968A patent/RO84706B/ro unknown
- 1982-11-04 AU AU90173/82A patent/AU562011B2/en not_active Ceased
- 1982-11-04 GR GR69726A patent/GR77368B/el unknown
- 1982-11-05 FI FI823798A patent/FI75175C/fi not_active IP Right Cessation
- 1982-11-05 CS CS827906A patent/CS235030B2/cs unknown
- 1982-11-05 HU HU823574A patent/HU187808B/hu unknown
- 1982-11-05 KR KR8205004A patent/KR880002594B1/ko active
- 1982-11-05 EP EP82305879A patent/EP0080283B1/fr not_active Expired
- 1982-11-05 AT AT82305879T patent/ATE17736T1/de not_active IP Right Cessation
- 1982-11-05 CA CA000414962A patent/CA1247085A/fr not_active Expired
- 1982-11-05 JP JP57195195A patent/JPS5890537A/ja active Pending
- 1982-11-05 IE IE2647/82A patent/IE53982B1/en unknown
- 1982-11-05 DE DE8282305879T patent/DE3268884D1/de not_active Expired
- 1982-11-05 DD DD82244613A patent/DD206553A5/de unknown
- 1982-11-05 ES ES517144A patent/ES517144A0/es active Granted
- 1982-11-05 NO NO823693A patent/NO160081C/no unknown
- 1982-11-06 PL PL1982238893A patent/PL136098B1/pl unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19821112 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
ITF | It: translation for a ep patent filed |
Owner name: JACOBACCI & PERANI S.P.A. |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
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AK | Designated contracting states |
Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
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Ref country code: NL Effective date: 19910601 |
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GBPC | Gb: european patent ceased through non-payment of renewal fee | ||
NLV4 | Nl: lapsed or anulled due to non-payment of the annual fee | ||
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