EG18046A - Anti-tumor method and compounds - Google Patents

Anti-tumor method and compounds

Info

Publication number
EG18046A
EG18046A EG592/86A EG59286A EG18046A EG 18046 A EG18046 A EG 18046A EG 592/86 A EG592/86 A EG 592/86A EG 59286 A EG59286 A EG 59286A EG 18046 A EG18046 A EG 18046A
Authority
EG
Egypt
Prior art keywords
compounds
tumor method
tumor
Prior art date
Application number
EG592/86A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of EG18046A publication Critical patent/EG18046A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EG592/86A 1985-09-23 1986-09-21 Anti-tumor method and compounds EG18046A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77935485A 1985-09-23 1985-09-23
US88867586A 1986-07-24 1986-07-24

Publications (1)

Publication Number Publication Date
EG18046A true EG18046A (en) 1991-08-30

Family

ID=27119572

Family Applications (1)

Application Number Title Priority Date Filing Date
EG592/86A EG18046A (en) 1985-09-23 1986-09-21 Anti-tumor method and compounds

Country Status (21)

Country Link
EP (1) EP0222475B1 (fr)
JP (1) JPH0662548B2 (fr)
KR (1) KR880000204B1 (fr)
CN (1) CN1013198B (fr)
AU (1) AU587064B2 (fr)
CY (1) CY1659A (fr)
DE (1) DE3667168D1 (fr)
DK (1) DK160981C (fr)
EG (1) EG18046A (fr)
ES (1) ES2001698A6 (fr)
GR (1) GR862353B (fr)
HK (1) HK88692A (fr)
HU (1) HU200597B (fr)
IE (1) IE59588B1 (fr)
IL (1) IL80032A (fr)
MX (1) MX9203126A (fr)
NZ (1) NZ217597A (fr)
PT (1) PT83389B (fr)
SG (1) SG66892G (fr)
SU (1) SU1545939A3 (fr)
UA (1) UA5953A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845128A (en) * 1984-06-27 1989-07-04 Eli Lilly And Company N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides
CA1331464C (fr) * 1987-05-12 1994-08-16 Eli Lilly And Company Methode et composes antitumoraux
HU202487B (en) * 1988-03-04 1991-03-28 Mta Koezponti Kemiai Kutato In Process for producing n-sulfonylureas
ZA915371B (en) * 1990-07-17 1993-03-31 Lilly Co Eli Antitumor compositions and methods of treatment
US5216026A (en) * 1990-07-17 1993-06-01 Eli Lilly And Company Antitumor compositions and methods of treatment
US5262440A (en) * 1991-12-10 1993-11-16 Eli Lilly And Company Antitumor compositions and methods of treatment
US5258406A (en) * 1991-12-20 1993-11-02 Eli Lilly And Company Sulfonimidamides
US5234955A (en) * 1991-12-20 1993-08-10 Eli Lilly And Company Antitumor compositions and methods of treatment
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
US5169860A (en) * 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
US5270329A (en) * 1992-12-10 1993-12-14 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2110524A1 (fr) * 1992-12-10 1994-06-11 Gerald Burr Grindey Compositions antitumorales et methodes de traitement
ZA941500B (en) * 1993-03-10 1995-09-04 Lilly Co Eli Antitumor compositions and methods of treatment
US6063911A (en) * 1993-12-01 2000-05-16 Marine Polymer Technologies, Inc. Methods and compositions for treatment of cell proliferative disorders
CA2212405C (fr) * 1996-08-07 2005-05-10 Takashi Suzuki Methode de traitement des eaux usees
AU709107B2 (en) * 1996-08-22 1999-08-19 Dong Wha Pharmaceutical Industrial Co., Ltd. Arylsulfonylimidazolone derivatives as an antitumor agent
ES2156550B1 (es) * 1999-04-19 2002-02-01 Univ Navarra Publica Derivados de benzo(b) tiofenosulfonamida-1,1-dioxido y su uso como agentes antineoplasicos.
EP2364699A1 (fr) 2004-09-13 2011-09-14 Eisai R&D Management Co., Ltd. Utilisation conjointe d'un composé à base de sulfonamide avec un inhibiteur de l'angiogénèse
JP5134247B2 (ja) * 2004-09-13 2013-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有化合物の血管新生阻害物質との併用
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006090932A1 (fr) * 2005-02-28 2006-08-31 Eisai R & D Managemant Co., Ltd. Marqueur de substitution pour compose de sulfonamide
KR20070114774A (ko) * 2005-02-28 2007-12-04 에자이 알앤드디 매니지먼트 가부시키가이샤 술폰아미드 화합물의 혈관 신생 저해 물질과의 신규 병용
SI1859793T1 (sl) * 2005-02-28 2011-08-31 Eisai R&D Man Co Ltd Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka
JPWO2007123274A1 (ja) 2006-04-20 2009-09-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の新規感受性マーカー
JP2012136435A (ja) * 2009-03-30 2012-07-19 Eisai R & D Management Co Ltd 腫瘍組織の感受性を検査する方法
CN102993106B (zh) * 2012-12-24 2015-06-17 武汉武药制药有限公司 格列吡嗪的合成新路线
GB201618240D0 (en) * 2016-10-27 2016-12-14 Trade Vehicle Locks Ltd Apparatus for locking a door of a vehicle

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1144259B (de) * 1956-05-29 1963-02-28 Hoechst Ag Verfahren zur Herstellung von Sulfonylharnstoffen
US3097242A (en) * 1960-06-29 1963-07-09 Olin Mathieson Hydrindene sulfonylureas
DE1159937B (de) * 1960-06-29 1963-12-27 Heyden Chem Fab Verfahren zur Herstellung von Hydrindensulfonylharnstoffen
DE1240866B (de) * 1961-06-29 1967-05-24 Heyden Chem Fab Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen
US4634465A (en) * 1982-07-16 1987-01-06 Ciba-Geigy Corporation Fused N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'triazinylureas
IT1161220B (it) * 1983-04-21 1987-03-18 Montedison Spa Diidro-benzofurano derivati ad attivita' erbicida
US4845128A (en) * 1984-06-27 1989-07-04 Eli Lilly And Company N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides

Also Published As

Publication number Publication date
IL80032A (en) 1992-07-15
DK160981B (da) 1991-05-13
KR880000204B1 (ko) 1988-03-12
ES2001698A6 (es) 1988-06-01
IE59588B1 (en) 1994-03-09
HUT46657A (en) 1988-11-28
SG66892G (en) 1992-09-04
DK446986A (da) 1987-03-24
CY1659A (en) 1993-05-14
CN86106428A (zh) 1987-03-18
DE3667168D1 (de) 1990-01-04
MX9203126A (es) 1992-07-01
GR862353B (en) 1987-01-19
HU200597B (en) 1990-07-28
SU1545939A3 (ru) 1990-02-23
PT83389B (pt) 1989-05-12
AU6294286A (en) 1987-03-26
DK160981C (da) 1991-10-28
AU587064B2 (en) 1989-08-03
CN1013198B (zh) 1991-07-17
EP0222475A1 (fr) 1987-05-20
NZ217597A (en) 1989-06-28
UA5953A1 (uk) 1994-12-29
KR870003086A (ko) 1987-04-15
JPH0662548B2 (ja) 1994-08-17
IE862503L (en) 1987-03-23
PT83389A (en) 1986-10-01
HK88692A (en) 1992-11-20
DK446986D0 (da) 1986-09-18
JPS6296459A (ja) 1987-05-02
EP0222475B1 (fr) 1989-11-29

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